P-cadherin Monoclonal Antibody (12H6) | Invitrogen 32-4000 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

P-cadherin Monoclonal Antibody (12H6)

catalog :

32-4000

quantity :

100 µg

price :

425 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

12H6

reactivity :

human, mouse, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:200; loading ...; tbl 2	Hes O, Condom Mundo E, Peckova K, Lopez J, Martinek P, Vanecek T, et al. Biphasic Squamoid Alveolar Renal Cell Carcinoma: A Distinctive Subtype of Papillary Renal Cell Carcinoma?. Am J Surg Pathol. 2016;40:664-75 pubmed publisher
western blot; human; 1:1000	Brueggmann D, Templeman C, Starzinski Powitz A, Rao N, Gayther S, Lawrenson K. Novel three-dimensional in vitro models of ovarian endometriosis. J Ovarian Res. 2014;7:17 pubmed publisher
western blot; human; fig 4	Lee J, Mhawech Fauceglia P, Lee N, Parsanian L, Lin Y, Gayther S, et al. A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro. Lab Invest. 2013;93:528-42 pubmed publisher
immunocytochemistry; mouse; fig 1 western blot; mouse; fig 1 immunocytochemistry; human; fig 1	Thuault S, Hayashi S, Lagirand Cantaloube J, Plutoni C, Comunale F, Delattre O, et al. P-cadherin is a direct PAX3-FOXO1A target involved in alveolar rhabdomyosarcoma aggressiveness. Oncogene. 2013;32:1876-87 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200; fig 7	Petersson F, Gatalica Z, Grossmann P, Perez Montiel M, Alvarado Cabrero I, Bulimbasic S, et al. Sporadic hybrid oncocytic/chromophobe tumor of the kidney: a clinicopathologic, histomorphologic, immunohistochemical, ultrastructural, and molecular cytogenetic study of 14 cases. Virchows Arch. 2010;456:355-65 pubmed publisher
western blot; human; fig 6	Wu J, Yan H, Chen W, Chen W, Wang C, Chi Y, et al. JNK signaling pathway is required for bFGF-mediated surface cadherin downregulation on HUVEC. Exp Cell Res. 2008;314:421-9 pubmed publisher
western blot; human; 1:1000; fig 2	Hanekamp E, Gielen S, De Ruiter P, Chadha Ajwani S, Huikeshoven F, Burger C, et al. Differences in invasive capacity of endometrial cancer cell lines expressing different progesterone receptor isotypes: possible involvement of cadherins. J Soc Gynecol Investig. 2005;12:278-84 pubmed
	Xue M, Yao S, Hu M, Li W, Hao T, Zhou F, et al. HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway. Nucleic Acids Res. 2014;42:9862-79 pubmed publisher

product information

Product Type :

Antibody

Product Name :

P-cadherin Monoclonal Antibody (12H6)

Catalog # :

32-4000

Quantity :

100 µg

Price :

425 USD

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Canine, Human

Applications :

Immunofluorescence: 2-10 µg/mL, Immunohistochemistry: 1:50, Western Blot: 1-3 µg/mL

Species :

Canine, Human

Clone :

12H6

Isotype :

IgG1

Storage :

-20°C

Description :

P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.

Immunogen :

Human P-Cadherin fusion protein.

Format :

Liquid

Applications w/Dilutions :

Immunofluorescence: 2-10 µg/mL, Immunohistochemistry: 1:50, Western Blot: 1-3 µg/mL

Aliases :

AI385538; CADH3; cadherin 15, M-cadherin (myotubule); cadherin 3; cadherin 3, type 1, P-cadherin (placental); cadherin-3; Cadp; calcium-dependent adhesion protein, placental; CDH15; CDH3; CDHP; HJMD; PCAD; P-cadherin; Placental cadherin; Placental-cadherin; RPE-specific cadherin

more info or order :

Invitrogen product webpage