alpha Internexin Monoclonal Antibody (2E3) | Invitrogen 32-3600 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

alpha Internexin Monoclonal Antibody (2E3)

catalog :

32-3600

quantity :

100 µg

price :

US 425.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2E3

reactivity :

human, mouse, rat, domestic rabbit

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:800; loading ...	van der Zee J, Gijselinck I, Van Mossevelde S, Perrone F, Dillen L, Heeman B, et al. TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Hum Mutat. 2017;38:297-309 pubmed publisher
immunohistochemistry - paraffin section; human; 1:800; loading ...	Gelpi E, Hoftberger R, Graus F, Ling H, Holton J, Dawson T, et al. Neuropathological criteria of anti-IgLON5-related tauopathy. Acta Neuropathol. 2016;132:531-43 pubmed publisher
immunohistochemistry - paraffin section; human; fig 3	Inoue K, Fujimura H, Ueda K, Matsumura T, Itoh K, Sakoda S. An autopsy case of neuronal intermediate filament inclusion disease with regard to immunophenotypic and topographical analysis of the neuronal inclusions. Neuropathology. 2015;35:545-52 pubmed publisher
western blot; human	Wong T, Chiu W, Breedveld G, Li K, Verkerk A, Hondius D, et al. PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology. Brain. 2014;137:1361-73 pubmed publisher
immunohistochemistry - paraffin section; human	Ishida M, Iwai M, Yoshida K, Kagotani A, Okabe H. Signet-ring cell melanoma with sentinel lymph node metastasis: A case report with immunohistochemical analysis and review of the clinicopathological features. Oncol Lett. 2014;7:65-68 pubmed
immunohistochemistry; human; 1:250	Shintaku M, Yoneda H, Hirato J, Nagaishi M, Okabe H. Gliosarcoma with ependymal and PNET-like differentiation. Clin Neuropathol. 2013;32:508-14 pubmed publisher
immunohistochemistry - paraffin section; human; 1:300; fig 1	Troakes C, Maekawa S, Wijesekera L, Rogelj B, SiklÃ³s L, Bell C, et al. An MND/ALS phenotype associated with C9orf72 repeat expansion: abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline. Neuropathology. 2012;32:505-14 pubmed publisher
immunohistochemistry; mouse; fig 2	Akins M, Greer C. Cytoskeletal organization of the developing mouse olfactory nerve layer. J Comp Neurol. 2006;494:358-67 pubmed
	Dobson Stone C, Luty A, Thompson E, Blumbergs P, Brooks W, Short C, et al. Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis. Acta Neuropathol. 2013;125:523-33 pubmed publisher
	Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus Hernandez M, Ansorge O, et al. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain. 2011;134:2595-609 pubmed publisher
	Menon R, Baborie A, Jaros E, Mann D, Ray P, Larner A. What's in a name? Neuronal intermediate filament inclusion disease (NIFID), frontotemporal lobar degeneration-intermediate filament (FTLD-IF) or frontotemporal lobar degeneration-fused in sarcoma (FTLD-FUS)?. J Neurol Neurosurg Psychiatry. 2011;82:1412-4 pubmed publisher

product information

Product Type :

Antibody

Product Name :

alpha Internexin Monoclonal Antibody (2E3)

Catalog # :

32-3600

Quantity :

100 µg

Price :

US 425.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rabbit, Rat

Applications :

ELISA: 1 µg/mL, Immunocytochemistry: 2 µg/mL, Immunohistochemistry: 1-5 µg/mL, Western Blot: 0.1-0.5 µg/mL

Species :

Human, Mouse, Rabbit, Rat

Clone :

2E3

Isotype :

IgG1

Storage :

-20°C

Description :

alpha-Internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest.

Immunogen :

Full-length recombinant rat alpha-internexin protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1 µg/mL, Immunocytochemistry: 2 µg/mL, Immunohistochemistry: 1-5 µg/mL, Western Blot: 0.1-0.5 µg/mL

Aliases :

66 kDa neurofilament protein; Alpha-internexin; alpha-Inx; AV028420; FLJ18662; FLJ57501; Ina; Inexa; internexin neuronal intermediate filament protein alpha; internexin neuronal intermediate filament protein, alpha; internexin, alpha; Intlaa; LOW QUALITY PROTEIN: alpha-internexin; MGC12702; NEF5; Neuro; Neurofilament 5; neurofilament 5 (66kD); Neurofilament 66; neurofilament-66; neurofilament-66, tax-binding protein; Nf66; NF-66; TXBP-1

more info or order :

Invitrogen product webpage