EAAC1 Monoclonal Antibody (35-A9) | Invitrogen 32-1000 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

EAAC1 Monoclonal Antibody (35-A9)

catalog :

32-1000

quantity :

100 µg

price :

US 398.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

35-A9

reactivity :

human, rat

application :

western blot, ELISA, immunoprecipitation

citations: 3

Reference
Ghosh M, Shapiro L. In vitro Ag Cross-presentation and in vivo Ag Cross-presentation by Dendritic Cells in the Mouse. Bio Protoc. 2012;2:e305 pubmed
Dunlop J, Beal McIlvain H, She Y, Howland D. Impaired spinal cord glutamate transport capacity and reduced sensitivity to riluzole in a transgenic superoxide dismutase mutant rat model of amyotrophic lateral sclerosis. J Neurosci. 2003;23:1688-96 pubmed
Shashidharan P, Huntley G, Murray J, Buku A, Moran T, Walsh M, et al. Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody. Brain Res. 1997;773:139-48 pubmed

product information

Product Type :

Antibody

Product Name :

EAAC1 Monoclonal Antibody (35-A9)

Catalog # :

32-1000

Quantity :

100 µg

Price :

US 398.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Rat

Applications :

ELISA: 0.1-1.0 µg/mL, Immunoprecipitation: 1-5 µg, Western Blot: 2-4 µg/mL

Species :

Human, Rat

Clone :

35-A9

Isotype :

IgG2b

Storage :

-20°C

Description :

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous systems. To maintain glutamate levels below excitoxic levels, excess glutamate at excitatory synaptic clefts is removed by ion-coupled glutamate transporters. Four glutamate transporters have been identified: the sodium-dependent GLAST-1, GLT-1, EAAC-1 and the chloride-dependent EAAT-4. EAAC-1 is expressed in the CNS and also found in kidney and small intestine. Structural features of glutamate transporters are believed to include eight membrane-spanning alpha-helices and a loop-pore structure which is unique among secondary transporters but may resemble loop-pores found in ion channels. A second distinctive structural feature is the presence of a highly amphipathic membrane-spanning helix that provides a hydrophilic path through the membrane. Mice with homozygous deletions of the EAAC-1 transporter gene develop dicarboxylic aminoaciduria and display reduced spontaneous locomotor activity although no neurodegeneration was observed over a period of 12 months.

Immunogen :

Synthetic peptide corresponding to amino acids 161-177 of the rat glutamate transporter EAAC1 sequence.

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.1-1.0 µg/mL, Immunoprecipitation: 1-5 µg, Western Blot: 2-4 µg/mL

Aliases :

D130048G10Rik; DCBXA; EAAC1; EAAC2; EAAT3; excitatory amino acid carrier 1; excitatory amino acid carrier 2; excitatory amino acid transporter 3; excitatory amino acid transporter-3; excitatory amino-acid carrier 1; glutamate transporter mEAAC2; MEAAC1; Neuronal and epithelial glutamate transporter; REAAC1; SCZD18; SLC1A1; Sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Solute carrier family 1 A1 (brain glutamate transporter); solute carrier family 1 member 1; solute carrier family 1, member 1