product summary
Loading...
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
NMDAR1 Monoclonal Antibody (54.1)
catalog :
32-0500
quantity :
100 µg
price :
US 375.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
54.1
reactivity :
little skate, human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - free floating section
more info or order :
Invitrogen product webpage
citations: 33
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2g
Frank R, Zhu F, Komiyama N, Grant S. Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes. J Neurochem. 2017;142:504-511 pubmed publisher
  • western blot; rat; loading ...; fig 3a
Sierra Valdez F, Ruiz Suárez J, Delint Ramirez I. Pentobarbital modifies the lipid raft-protein interaction: A first clue about the anesthesia mechanism on NMDA and GABAA receptors. Biochim Biophys Acta. 2016;1858:2603-2610 pubmed publisher
  • immunohistochemistry; mouse; 1:50; fig 3
  • western blot; mouse; fig 3
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
  • western blot; human; fig 1
Shen J, Wang R, He Z, Huang H, He X, Zhou J, et al. NMDA receptors participate in the progression of diabetic kidney disease by decreasing Cdc42-GTP activation in podocytes. J Pathol. 2016;240:149-60 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Frank R, Komiyama N, Ryan T, Zhu F, O Dell T, Grant S. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun. 2016;7:11264 pubmed publisher
  • western blot; rat; 1:5000
Li M, Yang S, Xing B, Ferguson B, Gulchina Y, Li Y, et al. LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment. Exp Neurol. 2015;273:190-201 pubmed publisher
  • immunocytochemistry; mouse; 1:1500
Ferreira J, Schmidt J, Rio P, Águas R, Rooyakkers A, Li K, et al. GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome. J Neurosci. 2015;35:8462-79 pubmed publisher
  • western blot; mouse; 1:1000
Abazyan S, Yang E, Abazyan B, Xia M, Yang C, Rojas C, et al. Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism. J Neurosci Res. 2014;92:1659-68 pubmed publisher
  • western blot; rat
Kennard J, Guevremont D, Mason Parker S, Abraham W, Williams J. Redistribution of ionotropic glutamate receptors detected by laser microdissection of the rat dentate gyrus 48 h following LTP induction in vivo. PLoS ONE. 2014;9:e92972 pubmed publisher
  • immunocytochemistry; rat; fig 2
She K, Ferreira J, Carvalho A, Craig A. Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors. J Biol Chem. 2012;287:27432-45 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; fig 3
She K, Craig A. NMDA receptors mediate synaptic competition in culture. PLoS ONE. 2011;6:e24423 pubmed publisher
  • western blot; rat; fig 5
Gibbs S, Chattopadhyaya B, Desgent S, Awad P, Clerk Lamalice O, Levesque M, et al. Long-term consequences of a prolonged febrile seizure in a dual pathology model. Neurobiol Dis. 2011;43:312-21 pubmed publisher
  • western blot; rat; fig 5
Kennard J, Barmanray R, Sampurno S, Ozturk E, Reid C, Paradiso L, et al. Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg. Neurobiol Dis. 2011;42:48-54 pubmed publisher
  • immunohistochemistry - free floating section; little skate; 1:1000; fig 3
Zhang Z, Bodznick D. The importance of N-methyl-D-aspartate (NMDA) receptors in subtraction of electrosensory reafference in the dorsal nucleus of skates. J Exp Biol. 2010;213:2700-9 pubmed publisher
  • western blot; rat; 1:400; fig 4
Ouardouz M, Lema P, Awad P, Di Cristo G, Carmant L. N-methyl-D-aspartate, hyperpolarization-activated cation current (Ih) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus. Eur J Neurosci. 2010;31:1252-60 pubmed publisher
  • western blot; human
Thompson P, Egbufoama S, Vawter M. SNAP-25 reduction in the hippocampus of patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27:411-7 pubmed
Coley A, Gao W. PSD-95 deficiency disrupts PFC-associated function and behavior during neurodevelopment. Sci Rep. 2019;9:9486 pubmed publisher
Marcello E, Musardo S, Vandermeulen L, Pelucchi S, Gardoni F, Santo N, et al. Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena. Mol Neurobiol. 2019;: pubmed publisher
Mockett B, Guevremont D, Elder M, Parfitt K, Peppercorn K, Morrissey J, et al. Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha. J Neurosci. 2019;39:3188-3203 pubmed publisher
Zhang Y, Akumuo R, Espana R, Yan C, Gao W, Li Y. The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory. Neuropharmacology. 2018;141:113-125 pubmed publisher
Xing B, Han G, Wang M, Snyder M, Gao W. Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β. Neuropharmacology. 2018;137:359-371 pubmed publisher
Gulchina Y, Xu S, Snyder M, Elefant F, Gao W. Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia. J Neurochem. 2017;143:320-333 pubmed publisher
Li M, Gulchina Y, Monaco S, Xing B, Ferguson B, Li Y, et al. Juvenile treatment with a novel mGluR2 agonist/mGluR3 antagonist compound, LY395756, reverses learning deficits and cognitive flexibility impairments in adults in a neurodevelopmental model of schizophrenia. Neurobiol Learn Mem. 2017;140:52-61 pubmed publisher
Beard R, Reynolds J, Bearden S. Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of ?-catenin in response to homocysteine. Vascul Pharmacol. 2012;56:159-67 pubmed publisher
Delint Ramirez I, Fernández E, Bayés A, Kicsi E, Komiyama N, Grant S. In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93. J Neurosci. 2010;30:8162-70 pubmed publisher
Kennard J, Guevremont D, Mason Parker S, Abraham W, Williams J. Increased expression, but not postsynaptic localisation, of ionotropic glutamate receptors during the late-phase of long-term potentiation in the dentate gyrus in vivo. Neuropharmacology. 2009;56:66-72 pubmed publisher
Williams J, Guevremont D, Mason Parker S, Luxmanan C, Tate W, Abraham W. Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals. J Neurosci. 2007;27:14171-8 pubmed
Bigini P, Gardoni F, Barbera S, Cagnotto A, Fumagalli E, Longhi A, et al. Expression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler mice. BMC Neurosci. 2006;7:71 pubmed
Roussignol G, Ango F, Romorini S, Tu J, Sala C, Worley P, et al. Shank expression is sufficient to induce functional dendritic spine synapses in aspiny neurons. J Neurosci. 2005;25:3560-70 pubmed
Williams J, Guevremont D, Kennard J, Mason Parker S, Tate W, Abraham W. Long-term regulation of N-methyl-D-aspartate receptor subunits and associated synaptic proteins following hippocampal synaptic plasticity. Neuroscience. 2003;118:1003-13 pubmed
Morrison B, Janssen W, Gordon J, Morrison J. Light and electron microscopic distribution of the AMPA receptor subunit, GluR2, in the spinal cord of control and G86R mutant superoxide dismutase transgenic mice. J Comp Neurol. 1998;395:523-34 pubmed
Hof P, Vissavajjhala P, Rosenthal R, Fiskum G, Morrison J. Distribution of glutamate receptor subunit proteins GluR2(4), GluR5/6/7, and NMDAR1 in the canine and primate cerebral cortex: a comparative immunohistochemical analysis. Brain Res. 1996;723:77-89 pubmed
Siegel S, Brose N, Janssen W, Gasic G, Jahn R, Heinemann S, et al. Regional, cellular, and ultrastructural distribution of N-methyl-D-aspartate receptor subunit 1 in monkey hippocampus. Proc Natl Acad Sci U S A. 1994;91:564-8 pubmed
Jones K, Oblinger M. Androgenic regulation of tubulin gene expression in axotomized hamster facial motoneurons. J Neurosci. 1994;14:3620-7 pubmed
product information
Product Type :
Antibody
Product Name :
NMDAR1 Monoclonal Antibody (54.1)
Catalog # :
32-0500
Quantity :
100 µg
Price :
US 375.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human, Mouse, Non-human primate, Rat
Applications :
ELISA: 0.1-1 µg/mL, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:10-1:50, Immunoprecipitation: 1-3 µg/mL, Western Blot: 1-5 µg/mL
Species :
Human, Mouse, Non-human primate, Rat
Clone :
54.1
Isotype :
IgG2a
Storage :
-20°C
Description :
NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
Immunogen :
Fusion protein containing sequence from the intracellular loop between transmembrane regions III and IV of NMDAR1.
Format :
Liquid
Applications w/Dilutions :
ELISA: 0.1-1 µg/mL, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:10-1:50, Immunoprecipitation: 1-3 µg/mL, Western Blot: 1-5 µg/mL
Aliases :
GluN1; GluRdelta1; Glurz1; GluRzeta1; glutamate [NMDA] receptor subunit zeta 1; glutamate [NMDA] receptor subunit zeta-1; glutamate ionotropic receptor NMDA type subunit 1; glutamate receptor; glutamate receptor ionotropic, NMDA 1; glutamate receptor subunit zeta 1; glutamate receptor, ionotropic, NMDA1 (zeta 1); glutamate receptor, ionotropic, N-methyl D-aspartate 1; GRIN1; M100174; MRD8; neurotransmitter receptor; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDA1; Nmdar; NMDAR1; NMD-R1; NMDZ1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor 1; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMZ1; NR1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; Rgsc174; RP11-350O14.1
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA