GluR2 Monoclonal Antibody (6C4) | Invitrogen 32-0300 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GluR2 Monoclonal Antibody (6C4)

catalog :

32-0300

quantity :

100 µg

price :

US 375.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6C4

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 21

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 7	Frank R, Komiyama N, Ryan T, Zhu F, O Dell T, Grant S. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun. 2016;7:11264 pubmed publisher
western blot; mouse; 1:1000; fig 2,4,5,6	Hao J, Sun N, Lei L, Li X, Yao B, Sun K, et al. L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating dopamine D1 receptor/PKA signaling pathway. Cell Death Dis. 2015;6:e1965 pubmed publisher
immunohistochemistry; mouse; 1:75; fig 4	Vazquez Sanroman D, Carbó Gas M, Leto K, Cerezo Garcia M, Gil Miravet I, Sanchis Segura C, et al. Cocaine-induced plasticity in the cerebellum of sensitised mice. Psychopharmacology (Berl). 2015;232:4455-67 pubmed publisher
immunocytochemistry; human	Busskamp V, Lewis N, Guye P, Ng A, Shipman S, Byrne S, et al. Rapid neurogenesis through transcriptional activation in human stem cells. Mol Syst Biol. 2014;10:760 pubmed publisher
western blot; mouse; 1:200	Ho V, Dallalzadeh L, Karathanasis N, Keles M, Vangala S, Grogan T, et al. GluA2 mRNA distribution and regulation by miR-124 in hippocampal neurons. Mol Cell Neurosci. 2014;61:1-12 pubmed publisher
western blot; rat	Kennard J, Guevremont D, Mason Parker S, Abraham W, Williams J. Redistribution of ionotropic glutamate receptors detected by laser microdissection of the rat dentate gyrus 48 h following LTP induction in vivo. PLoS ONE. 2014;9:e92972 pubmed publisher
western blot; rat; fig 4	Eckert M, Guevremont D, Williams J, Abraham W. Rapid visual stimulation increases extrasynaptic glutamate receptor expression but not visual-evoked potentials in the adult rat primary visual cortex. Eur J Neurosci. 2013;37:400-6 pubmed publisher
western blot; mouse; 1:1000; fig 7	Gould T, O Donnell K, Dow E, Du J, Chen G, Manji H. Involvement of AMPA receptors in the antidepressant-like effects of lithium in the mouse tail suspension test and forced swim test. Neuropharmacology. 2008;54:577-87 pubmed
immunoprecipitation; rat; fig 6	Shukla K, Kim J, Blundell J, Powell C. Learning-induced glutamate receptor phosphorylation resembles that induced by long term potentiation. J Biol Chem. 2007;282:18100-7 pubmed
	Morise J, Yamamoto S, Midorikawa R, Takamiya K, Nonaka M, Takematsu H, et al. Distinct Cell Surface Expression Patterns of N-Glycosylation Site Mutants of AMPA-Type Glutamate Receptor under the Homo-Oligomeric Expression Conditions. Int J Mol Sci. 2020;21: pubmed publisher
	Goldwaser E, Acharya N, Wu H, Godsey G, Sarkar A, DeMarshall C, et al. Evidence that Brain-Reactive Autoantibodies Contribute to Chronic Neuronal Internalization of Exogenous Amyloid-β1-42 and Key Cell Surface Proteins During Alzheimer's Disease Pathogenesis. J Alzheimers Dis. 2020;74:345-361 pubmed publisher
	Mockett B, Guevremont D, Elder M, Parfitt K, Peppercorn K, Morrissey J, et al. Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha. J Neurosci. 2019;39:3188-3203 pubmed publisher
	Wall M, Collins D, Chery S, Allen Z, Pastuzyn E, George A, et al. The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility. Neuron. 2018;98:1124-1132.e7 pubmed publisher
	Zhong C, Akmentin W, DU C, Role L, Talmage D. Axonal Type III Nrg1 Controls Glutamate Synapse Formation and GluA2 Trafficking in Hippocampal-Accumbens Connections. Eneuro. 2017;4: pubmed publisher
	Zhou Y, Kaiser T, Monteiro P, Zhang X, Van der Goes M, Wang D, et al. Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects. Neuron. 2016;89:147-62 pubmed publisher
	Kennard J, Guevremont D, Mason Parker S, Abraham W, Williams J. Increased expression, but not postsynaptic localisation, of ionotropic glutamate receptors during the late-phase of long-term potentiation in the dentate gyrus in vivo. Neuropharmacology. 2009;56:66-72 pubmed publisher
	Williams J, Guevremont D, Mason Parker S, Luxmanan C, Tate W, Abraham W. Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals. J Neurosci. 2007;27:14171-8 pubmed
	Quinlan E, Lebel D, Brosh I, Barkai E. A molecular mechanism for stabilization of learning-induced synaptic modifications. Neuron. 2004;41:185-92 pubmed
	Moga D, Janssen W, Vissavajjhala P, Czelusniak S, Moran T, Hof P, et al. Glutamate receptor subunit 3 (GluR3) immunoreactivity delineates a subpopulation of parvalbumin-containing interneurons in the rat hippocampus. J Comp Neurol. 2003;462:15-28 pubmed
	Hof P, Lee P, Yeung G, Wang R, Podos S, Morrison J. Glutamate receptor subunit GluR2 and NMDAR1 immunoreactivity in the retina of macaque monkeys with experimental glaucoma does not identify vulnerable neurons. Exp Neurol. 1998;153:234-41 pubmed
	Verdoorn T, Burnashev N, Monyer H, Seeburg P, Sakmann B. Structural determinants of ion flow through recombinant glutamate receptor channels. Science. 1991;252:1715-8 pubmed

product information

Product Type :

Antibody

Product Name :

GluR2 Monoclonal Antibody (6C4)

Catalog # :

32-0300

Quantity :

100 µg

Price :

US 375.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

ELISA: 0.5-5 µg/mL, Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:100, Western Blot: 2 µg/mL

Species :

Human, Mouse, Non-human primate, Rat

Clone :

6C4

Isotype :

IgG1, kappa

Storage :

-20°C

Description :

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5 -methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD.

Immunogen :

Fusion protein containing amino acids 175-430 from the N-terminal region of GluR2.

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.5-5 µg/mL, Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:100, Western Blot: 2 µg/mL

Aliases :

AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; GluA2; Glur2; GluR-2; GLURB; GluR-B; GluR-K2; glutamate ionotropic receptor AMPA type subunit 2; glutamate receptor; glutamate receptor 2; glutamate receptor B; glutamate receptor B flip isoform; glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA2 (alpha 2); GRIA2; HBGR2; OTTHUMP00000165324; OTTHUMP00000220942; OTTHUMP00000220943

more info or order :

Invitrogen product webpage