This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Mouse TRANCE (RANKL) (soluble) Recombinant Protein, PeproTech
catalog :
315-11C-50UG
quantity :
50 ug
price :
US 722.00
citations: 16
Reference
Zhou X, Liu J, Zheng Y, Zhang Z, Wu Y, Yang W, et al. SM22α-lineage niche cells regulate intramembranous bone regeneration via PDGFRβ-triggered hydrogen sulfide production. Cell Rep. 2022;39:110750 pubmed publisher
Wang Z, Luo Z, Li F, Cao J, Rao S, Liu Y, et al. Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox. Nat Commun. 2022;13:1453 pubmed publisher
Tominari T, Sanada A, Ichimaru R, Matsumoto C, Hirata M, Itoh Y, et al. Gram-positive bacteria cell wall-derived lipoteichoic acid induces inflammatory alveolar bone loss through prostaglandin E production in osteoblasts. Sci Rep. 2021;11:13353 pubmed publisher
Jin F, Li J, Zhang Y, Liu X, Cai M, Liu M, et al. A functional motif of long noncoding RNA Nron against osteoporosis. Nat Commun. 2021;12:3319 pubmed publisher
Zhang H, Wang A, Shen G, Wang X, Liu G, Yang F, et al. Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis. Aging (Albany NY). 2021;13:11296-11314 pubmed publisher
Zhang B, Li Y, Wu Q, Xie L, Barwick B, Fu C, et al. Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer. Nat Commun. 2021;12:1714 pubmed publisher
Chevalier C, Kieser S, Çolakoğlu M, Hadadi N, Brun J, Rigo D, et al. Warmth Prevents Bone Loss Through the Gut Microbiota. Cell Metab. 2020;32:575-590.e7 pubmed publisher
Wang W, Li Y, Hao J, He Y, Dong X, Fu Y, et al. The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the Mesenteric Lymph Node Restrains Intestinal Humoral Immunity. Cell Rep. 2020;32:107936 pubmed publisher
Kim J, Oh S, Lee M, Song J, Jeong B, Yang J, et al. CUEDC2 controls osteoblast differentiation and bone formation via SOCS3-STAT3 pathway. Cell Death Dis. 2020;11:344 pubmed publisher
Go E, Oh J, Park J, Lee S, Lee N. Spi-C positively regulates RANKL-mediated osteoclast differentiation and function. Exp Mol Med. 2020;52:691-701 pubmed publisher
Li J, Li X, Liu D, Hamamura K, Wan Q, Na S, et al. eIF2α signaling regulates autophagy of osteoblasts and the development of osteoclasts in OVX mice. Cell Death Dis. 2019;10:921 pubmed publisher
Wang S, Li G, Tan C, He R, Kang L, Lu J, et al. FOXF2 reprograms breast cancer cells into bone metastasis seeds. Nat Commun. 2019;10:2707 pubmed publisher
Shin Y, Won Y, Yang J, Chun J. CYTL1 regulates bone homeostasis in mice by modulating osteogenesis of mesenchymal stem cells and osteoclastogenesis of bone marrow-derived macrophages. Cell Death Dis. 2019;10:47 pubmed publisher
Di Lorenzo G, Velho R, Winter D, Thelen M, Ahmadi S, Schweizer M, et al. Lysosomal Proteome and Secretome Analysis Identifies Missorted Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse Cells. Mol Cell Proteomics. 2018;17:1612-1626 pubmed publisher
Bartelt A, Behler Janbeck F, Beil F, Koehne T, Müller B, Schmidt T, et al. Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling. Bone Res. 2018;6:4 pubmed publisher
Gyori D, Csete D, Benko S, Kulkarni S, Mandl P, Dobó Nagy C, et al. The phosphoinositide 3-kinase isoform PI3K? regulates osteoclast-mediated bone resorption in humans and mice. Arthritis Rheumatol. 2014;66:2210-21 pubmed publisher
product information
Product Type :
Protein
Product Name :
Mouse TRANCE (RANKL) (soluble) Recombinant Protein, PeproTech
Catalog # :
315-11C-50UG
Quantity :
50 ug
Price :
US 722.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Mouse
Applications :
Functional Assay: Assay-dependent
Species :
Mouse
Storage :
-20 C
Description :
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Format :
Lyophilized
Applications w/Dilutions :
Functional Assay: Assay-dependent
Aliases :
CD254; H-RANK-L; hRANKL2; Ly109l; M-Rank-L; ODF; OPG; OPG ligand; OPGL; OPTB2; Osteoclast differentiation factor; osteoprotegerin ligand; Rankl; rank-l; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; RP11-86N24.2; sOdf; srankl; TNF-related activation-induced cytokine; Tnfsf11; TNLG6B; Trance; tumor necrosis factor (ligand) superfamily member 11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; tumor necrosis factor superfamily member 11; tumor necrosis factor-related activation-induced cytokine
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA