This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Mouse TRANCE (RANKL) (soluble) Recombinant Protein, PeproTech
catalog :
315-11-1MG
quantity :
1 mg
price :
US 5616
citations: 194
Reference
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Pang C, Wen L, Qin H, Zhu B, Lu X, Luo S. Sotrastaurin, a PKC inhibitor, attenuates RANKL-induced bone resorption and attenuates osteochondral pathologies associated with the development of OA. J Cell Mol Med. 2020;24:8452-8465 pubmed publisher
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Zheng W, Ding B, Li X, Liu D, Yokota H, Zhang P. Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β-catenin signaling. FASEB J. 2020;34:3399-3412 pubmed publisher
Wang J, Guan H, Liu H, Lei Z, Kang H, Guo Q, et al. Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss. J Cell Mol Med. 2020;24:2294-2307 pubmed publisher
Zhao X, Cui P, Hu G, Wang C, Jiang L, Zhao J, et al. PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation. J Mol Cell Biol. 2020;12:55-70 pubmed publisher
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Kang J, Choi Y, Seo B, Jo U, Park S, Kim Y, et al. A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment. Sci Rep. 2019;9:8726 pubmed publisher
Dong L, Wu J, Chen K, Xie J, Wang Y, Li D, et al. Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis. Front Immunol. 2019;10:1239 pubmed publisher
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Kang I, Kim C. NADPH oxidase gp91phox contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1. Sci Rep. 2016;6:38014 pubmed publisher
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Oh E, Lee H, Kim H, Park Y, Seo J, Park J, et al. Serum amyloid A inhibits RANKL-induced osteoclast formation. Exp Mol Med. 2015;47:e194 pubmed publisher
Garimella M, Kour S, Piprode V, Mittal M, Kumar A, Rani L, et al. Adipose-Derived Mesenchymal Stem Cells Prevent Systemic Bone Loss in Collagen-Induced Arthritis. J Immunol. 2015;195:5136-48 pubmed publisher
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Jeschke A, Catala Lehnen P, Sieber S, Bickert T, Schweizer M, Koehne T, et al. Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells. J Immunol. 2015;195:3675-84 pubmed publisher
Neri T, Muggeo S, Paulis M, Caldana M, Crisafulli L, Strina D, et al. Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts. Stem Cell Reports. 2015;5:558-68 pubmed publisher
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Drobek A, Kralova J, Skopcova T, Kucova M, Novák P, Angelisová P, et al. PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk. J Immunol. 2015;195:3416-26 pubmed publisher
Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, et al. IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis. J Clin Invest. 2015;125:3269-79 pubmed publisher
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Guo T, Zhang L, Konermann A, Zhou H, Jin F, Liu W. Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force. Sci Rep. 2015;5:8016 pubmed publisher
Katsuyama E, Miyamoto H, Kobayashi T, Sato Y, Hao W, Kanagawa H, et al. Interleukin-1 receptor-associated kinase-4 (IRAK4) promotes inflammatory osteolysis by activating osteoclasts and inhibiting formation of foreign body giant cells. J Biol Chem. 2015;290:716-26 pubmed publisher
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Li S, Miller C, Giannopoulou E, Hu X, Ivashkiv L, Zhao B. RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis. J Clin Invest. 2014;124:5057-73 pubmed publisher
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Shimamura M, Nakagami H, Osako M, Kurinami H, Koriyama H, Zhengda P, et al. OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice. Proc Natl Acad Sci U S A. 2014;111:8191-6 pubmed publisher
Yamasaki T, Ariyoshi W, Okinaga T, Adachi Y, Hosokawa R, Mochizuki S, et al. The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase. J Biol Chem. 2014;289:19191-203 pubmed publisher
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product information
Product Type :
Protein
Product Name :
Mouse TRANCE (RANKL) (soluble) Recombinant Protein, PeproTech
Catalog # :
315-11-1MG
Quantity :
1 mg
Price :
US 5616
Clonality :
Recombinant
Purity :
HPLC, SDS-PAGE
Reactivity :
Mouse
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Mouse
Storage :
-20°C
Description :
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
CD254; H-RANK-L; hRANKL2; Ly109l; M-Rank-L; ODF; OPG; OPG ligand; OPGL; OPTB2; Osteoclast differentiation factor; osteoprotegerin ligand; Rankl; rank-l; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; RP11-86N24.2; sOdf; srankl; TNF-related activation-induced cytokine; Tnfsf11; TNLG6B; Trance; tumor necrosis factor (ligand) superfamily member 11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; tumor necrosis factor superfamily member 11; tumor necrosis factor-related activation-induced cytokine
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA