This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human TRAIL (TNFSF10) (soluble) Recombinant Protein, PeproTech
catalog :
310-04-250UG
quantity :
250 ug
price :
US 608.00
citations: 95
Reference
Lin C, Traets J, Vredevoogd D, Visser N, Peeper D. TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling. EMBO J. 2023;42:e111614 pubmed publisher
Ib xe1 xf1 ez Molero S, van Vliet A, Poźniak J, Hummelink K, Terry A, Monkhorst K, et al. SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response. Oncoimmunology. 2022;11:2139074 pubmed publisher
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Locquet M, Ichim G, Bisaccia J, Dutour A, Lebecque S, Castets M, et al. Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma. Sci Rep. 2021;11:10609 pubmed publisher
Crosley P, Färkkilä A, Jenner A, Burlot C, Cardinal O, Potts K, et al. Procaspase-Activating Compound-1 Synergizes with TRAIL to Induce Apoptosis in Established Granulosa Cell Tumor Cell Line (KGN) and Explanted Patient Granulosa Cell Tumor Cells In Vitro. Int J Mol Sci. 2021;22: pubmed publisher
Miles M, Hawkins C. In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations. Cell Death Dis. 2020;11:680 pubmed publisher
Jiang Y, Wen T, Yan R, Kim S, Stowell S, Wang W, et al. O-glycans on death receptors in cells modulate their sensitivity to TRAIL-induced apoptosis through affecting on their stability and oligomerization. FASEB J. 2020;34:11786-11801 pubmed publisher
Braunstein I, Engelman R, Yitzhaki O, Ziv T, Galardon E, Benhar M. Opposing effects of polysulfides and thioredoxin on apoptosis through caspase persulfidation. J Biol Chem. 2020;295:3590-3600 pubmed publisher
Uddin M, Pimentel J, Chatterjee M, Allen J, Zhuang Z, Wu G. Targeting PP2A inhibits the growth of triple-negative breast cancer cells. Cell Cycle. 2020;19:592-600 pubmed publisher
Wang M, LAW M, Davis B, Yaaghubi E, Ghilardi A, Ferreira R, et al. Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway. Cell Death Discov. 2019;5:153 pubmed publisher
Hope J, Lopez Cavestany M, Wang W, Reinhart King C, King M. Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability. Cell Death Dis. 2019;10:837 pubmed publisher
Lee S, Quan K, Byun H, Park I, Kang K, Piao X, et al. Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis. Sci Rep. 2019;9:13505 pubmed publisher
Nieddu V, Piredda R, Bexell D, Barton J, Anderson J, Sebire N, et al. Engineered human mesenchymal stem cells for neuroblastoma therapeutics. Oncol Rep. 2019;42:35-42 pubmed publisher
Saini S, Sripada L, Tulla K, Qiao G, Kunda N, Maker A, et al. MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer. Endocr Relat Cancer. 2019;26:551-563 pubmed publisher
Deveaux W, Hayashi K, Selvarajoo K. Defining rules for cancer cell proliferation in TRAIL stimulation. NPJ Syst Biol Appl. 2019;5:5 pubmed publisher
Spano C, Grisendi G, Golinelli G, Rossignoli F, Prapa M, Bestagno M, et al. Soluble TRAIL Armed Human MSC As Gene Therapy For Pancreatic Cancer. Sci Rep. 2019;9:1788 pubmed publisher
Zhu Z, Liu J, Yang C, Li M, Wu R, Xiong Z. Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells. Cell Death Dis. 2019;10:118 pubmed publisher
Nalli A, Brown L, Thomas C, Sayers T, Porco J, Henrich C. Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs. Sci Rep. 2018;8:17519 pubmed publisher
Golinelli G, Grisendi G, Prapa M, Bestagno M, Spano C, Rossignoli F, et al. Targeting GD2-positive glioblastoma by chimeric antigen receptor empowered mesenchymal progenitors. Cancer Gene Ther. 2018;: pubmed publisher
Lincoln F, Imig D, Boccellato C, Juric V, Noonan J, Kontermann R, et al. Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism. Cell Death Dis. 2018;9:1112 pubmed publisher
Da xdf ler Plenker J, Paschen A, Putschli B, Rattay S, Schmitz S, Goldeck M, et al. Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity toward autologous melanoma cells. Int J Cancer. 2019;144:1645-1656 pubmed publisher
Shiloh R, Gilad Y, Ber Y, Eisenstein M, Aweida D, Bialik S, et al. Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy. Nat Commun. 2018;9:1759 pubmed publisher
Legler K, Hauser C, Egberts J, Willms A, Heneweer C, Boretius S, et al. The novel TRAIL-receptor agonist APG350 exerts superior therapeutic activity in pancreatic cancer cells. Cell Death Dis. 2018;9:445 pubmed publisher
Yulis M, Quirós M, Hilgarth R, Parkos C, Nusrat A. Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines. Cell Death Dis. 2018;9:389 pubmed publisher
Zhang N, Liu X, Liu L, Deng Z, Zeng Q, Pang W, et al. Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma. Cell Death Dis. 2018;9:230 pubmed publisher
Delannoy A, Wilhelm E, Eilebrecht S, Alvarado Cuevas E, Benecke A, Bell B. BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis. Cell Death Dis. 2018;9:70 pubmed publisher
Elia A, Henry Grant R, Adiseshiah C, Marboeuf C, Buckley R, Clemens M, et al. Implication of 4E-BP1 protein dephosphorylation and accumulation in pancreatic cancer cell death induced by combined gemcitabine and TRAIL. Cell Death Dis. 2017;8:3204 pubmed publisher
Miles M, Hawkins C. Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine. Cell Death Dis. 2017;8:e3062 pubmed publisher
Xu L, Zhang Y, Qu X, Che X, Guo T, Li C, et al. DR5-Cbl-b/c-Cbl-TRAF2 complex inhibits TRAIL-induced apoptosis by promoting TRAF2-mediated polyubiquitination of caspase-8 in gastric cancer cells. Mol Oncol. 2017;11:1733-1751 pubmed publisher
Oh Y, Deng L, Deng J, Sun S. The proteasome deubiquitinase inhibitor b-AP15 enhances DR5 activation-induced apoptosis through stabilizing DR5. Sci Rep. 2017;7:8027 pubmed publisher
Brasacchio D, Alsop A, Noori T, Lufti M, Iyer S, Simpson K, et al. Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization. Cell Death Differ. 2017;24:961-970 pubmed publisher
Carr R, Qiao G, Qin J, Jayaraman S, Prabhakar B, Maker A. Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis. Cell Death Discov. 2016;2:16067 pubmed publisher
Chen L, Xia G, Qiu F, Wu C, Denmon A, Zi X. Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2? and inhibits tumor growth. Sci Rep. 2016;6:32582 pubmed publisher
Mohammadpour H, Pourfathollah A, Nikougoftar Zarif M, Shahbazfar A. Irradiation enhances susceptibility of tumor cells to the antitumor effects of TNF-α activated adipose derived mesenchymal stem cells in breast cancer model. Sci Rep. 2016;6:28433 pubmed publisher
Zhou W, Feng X, Han Han -, Guo S, Wang G. Synergistic effects of combined treatment with histone deacetylase inhibitor suberoylanilide hydroxamic acid and TRAIL on human breast cancer cells. Sci Rep. 2016;6:28004 pubmed publisher
Oh Y, Deng J, Yue P, Sun S. Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells. Sci Rep. 2016;6:26803 pubmed publisher
Choi J, Lim J, Wickramanayake D, Wagley Y, Kim J, Lee H, et al. Characterization of MUDENG, a novel anti-apoptotic protein. Oncogenesis. 2016;5:e221 pubmed publisher
Fauster A, Rebsamen M, Huber K, Bigenzahn J, Stukalov A, Lardeau C, et al. A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis. Cell Death Dis. 2015;6:e1767 pubmed publisher
Li J, Sharkey C, King M. Piperlongumine and immune cytokine TRAIL synergize to promote tumor death. Sci Rep. 2015;5:9987 pubmed publisher
Henrich C, Brooks A, Erickson K, Thomas C, Bokesch H, Tewary P, et al. Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation. Cell Death Dis. 2015;6:e1666 pubmed publisher
Grisendi G, Spano C, D Souza N, Rasini V, Veronesi E, Prapa M, et al. Mesenchymal progenitors expressing TRAIL induce apoptosis in sarcomas. Stem Cells. 2015;33:859-69 pubmed publisher
Koh D, Han D, Ryu H, Choi W, Jeon B, Kim M, et al. KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes. Proc Natl Acad Sci U S A. 2014;111:15078-83 pubmed publisher
Edagawa M, Kawauchi J, Hirata M, Goshima H, Inoue M, Okamoto T, et al. Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through . J Biol Chem. 2014;289:21544-61 pubmed publisher
Jazirehi A, Kurdistani S, Economou J. Histone deacetylase inhibitor sensitizes apoptosis-resistant melanomas to cytotoxic human T lymphocytes through regulation of TRAIL/DR5 pathway. J Immunol. 2014;192:3981-9 pubmed publisher
Teng Y, Gao M, Wang J, Kong Q, Hua H, Luo T, et al. Inhibition of eIF2? dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells. Cell Death Dis. 2014;5:e1060 pubmed publisher
Ma H, Rao L, Wang H, Mao Z, Lei R, Yang Z, et al. Transcriptome analysis of glioma cells for the dynamic response to ?-irradiation and dual regulation of apoptosis genes: a new insight into radiotherapy for glioblastomas. Cell Death Dis. 2013;4:e895 pubmed publisher
Burckstummer T, Banning C, Hainzl P, Schobesberger R, Kerzendorfer C, Pauler F, et al. A reversible gene trap collection empowers haploid genetics in human cells. Nat Methods. 2013;10:965-71 pubmed publisher
King H, Cobbold L, Pichon X, Pöyry T, Wilson L, Booden H, et al. Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs. Cell Death Differ. 2014;21:161-71 pubmed publisher
Xu J, Xu Z, Zhou J, Zhuang Z, Wang E, Boerner J, et al. Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. J Biol Chem. 2013;288:33263-71 pubmed publisher
Gupta S, Francis S, Nair M, Mo Y, Aggarwal B. Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-C. J Biol Chem. 2013;288:32343-56 pubmed publisher
Matthews G, Lefebure M, Doyle M, Shortt J, Ellul J, Chesi M, et al. Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma. Cell Death Dis. 2013;4:e798 pubmed publisher
Turner A, Li L, Pilli T, Qian L, Wiley E, Setty S, et al. MADD knock-down enhances doxorubicin and TRAIL induced apoptosis in breast cancer cells. PLoS ONE. 2013;8:e56817 pubmed publisher
Reuss D, Mucha J, Hagenlocher C, Ehemann V, Kluwe L, Mautner V, et al. Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS. PLoS ONE. 2013;8:e57152 pubmed publisher
Hong S, Kim H, Kim J, Ha H, Kim Y, Bae E, et al. Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. J Biol Chem. 2013;288:3560-70 pubmed publisher
Zhang S, Li G, Zhao Y, Liu G, Wang Y, Ma X, et al. Smac mimetic SM-164 potentiates APO2L/TRAIL- and doxorubicin-mediated anticancer activity in human hepatocellular carcinoma cells. PLoS ONE. 2012;7:e51461 pubmed publisher
Lane D, Matte I, Rancourt C, Pich xe9 A. Osteoprotegerin (OPG) protects ovarian cancer cells from TRAIL-induced apoptosis but does not contribute to malignant ascites-mediated attenuation of TRAIL-induced apoptosis. J Ovarian Res. 2012;5:34 pubmed publisher
Grunert M, Gottschalk K, Kapahnke J, Gündisch S, Kieser A, Jeremias I. The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-?B by TRAIL. Cell Death Dis. 2012;3:e414 pubmed publisher
Le Goff A, Ji Z, Leclercq B, Bourette R, Mougel A, Guerardel C, et al. Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling. J Biol Chem. 2012;287:35382-96 pubmed publisher
Hsieh Y, Chien K, Lin S, Sabu S, Hsu R, Chi L, et al. Photofrin binds to procaspase-3 and mediates photodynamic treatment-triggered methionine oxidation and inactivation of procaspase-3. Cell Death Dis. 2012;3:e347 pubmed publisher
Kong R, Jia G, Cheng Z, Wang Y, Mu M, Wang S, et al. Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5. PLoS ONE. 2012;7:e37222 pubmed publisher
Huang D, Chao Y, Tai M, Yu Y, Lin W. STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death. J Biomed Sci. 2012;19:35 pubmed publisher
Agard N, Mahrus S, Trinidad J, Lynn A, Burlingame A, Wells J. Global kinetic analysis of proteolysis via quantitative targeted proteomics. Proc Natl Acad Sci U S A. 2012;109:1913-8 pubmed publisher
Furusawa Y, Fujiwara Y, Campbell P, Zhao Q, Ogawa R, Hassan M, et al. DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines. PLoS ONE. 2012;7:e29012 pubmed publisher
Vindrieux D, R xe9 veiller M, Chantepie J, Yakoub S, Deschildre C, Ruffion A, et al. Down-regulation of DcR2 sensitizes androgen-dependent prostate cancer LNCaP cells to TRAIL-induced apoptosis. Cancer Cell Int. 2011;11:42 pubmed publisher
Chen Q, Zhang X, Massagué J. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell. 2011;20:538-49 pubmed publisher
Stolfi C, Caruso R, Franzè E, Rizzo A, Rotondi A, Monteleone I, et al. 2-methoxy-5-amino-N-hydroxybenzamide sensitizes colon cancer cells to TRAIL-induced apoptosis by regulating death receptor 5 and survivin expression. Mol Cancer Ther. 2011;10:1969-81 pubmed publisher
Xie Z, Quan M, Liu F, Cao J, Zhang J. 5-allyl-7-gen-difluoromethoxychrysin enhances TRAIL-induced apoptosis in human lung carcinoma A549 cells. BMC Cancer. 2011;11:322 pubmed publisher
Maurer G, Brucker D, Bähr O, Harter P, Hattingen E, Walenta S, et al. Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. BMC Cancer. 2011;11:315 pubmed publisher
Tang H, Qin Y, Li J, Gong X. The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells. BMC Biol. 2011;9:18 pubmed publisher
Siegelin M, Dohi T, Raskett C, Orlowski G, Powers C, Gilbert C, et al. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest. 2011;121:1349-60 pubmed publisher
Fu L, Lin Y, Elrod H, Yue P, Oh Y, Li B, et al. c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL. Mol Cancer. 2010;9:315 pubmed publisher
Jang J, Jeon Y, Choi Y, Kim C. Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression. Mol Cancer. 2010;9:262 pubmed publisher
Grabarczyk P, Nähse V, Delin M, Przybylski G, Depke M, Hildebrandt P, et al. Increased expression of bcl11b leads to chemoresistance accompanied by G1 accumulation. PLoS ONE. 2010;5: pubmed publisher
Goncharenko Khaider N, Lane D, Matte I, Rancourt C, Pich xe9 A. The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells. Oncogene. 2010;29:5523-36 pubmed publisher
Kauh J, Fan S, Xia M, Yue P, Yang L, Khuri F, et al. c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589. PLoS ONE. 2010;5:e10376 pubmed publisher
Xu J, Zhou J, Wei W, Wu G. Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells. PLoS ONE. 2010;5:e10226 pubmed publisher
Fan S, Li Y, Yue P, Khuri F, Sun S. The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation. Neoplasia. 2010;12:346-56 pubmed
Qiu J, Xiao J, Han C, Li N, Shen X, Jiang H, et al. Potentiation of tumor necrosis factor-alpha-induced tumor cell apoptosis by a small molecule inhibitor for anti-apoptotic protein hPEBP4. J Biol Chem. 2010;285:12241-7 pubmed publisher
Lane D, Matte I, Rancourt C, Piche A. The prosurvival activity of ascites against TRAIL is associated with a shorter disease-free interval in patients with ovarian cancer. J Ovarian Res. 2010;3:1 pubmed publisher
Chen S, Fu L, Raja S, Yue P, Khuri F, Sun S. Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis. Mol Cancer. 2010;9:23 pubmed publisher
Szliszka E, Czuba Z, Bronikowska J, Mertas A, Paradysz A, Krol W. Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells. Evid Based Complement Alternat Med. 2011;2011:535172 pubmed publisher
Roth P, Kissel M, Herrmann C, Eisele G, Leban J, Weller M, et al. SC68896, a novel small molecule proteasome inhibitor, exerts antiglioma activity in vitro and in vivo. Clin Cancer Res. 2009;15:6609-18 pubmed publisher
Elias A, Siegelin M, Steinmüller A, von Deimling A, Lass U, Korn B, et al. Epigenetic silencing of death receptor 4 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in gliomas. Clin Cancer Res. 2009;15:5457-65 pubmed publisher
Norian L, Kucaba T, Earel J, Knutson T, Vanoosten R, Griffith T. Synergistic Induction of Apoptosis in Primary B-CLL Cells after Treatment with Recombinant Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Histone Deacetylase Inhibitors. J Oncol. 2009;2009:408038 pubmed
Menon L, Kelly K, Yang H, Kim S, Black P, Carroll R. Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy. Stem Cells. 2009;27:2320-30 pubmed publisher
Morioka S, Omori E, Kajino T, Kajino Sakamoto R, Matsumoto K, Ninomiya Tsuji J. TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP. Oncogene. 2009;28:2257-65 pubmed publisher
Wang C, Qi R, Li N, Wang Z, An H, Zhang Q, et al. Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. J Biol Chem. 2009;284:16183-90 pubmed publisher
Szliszka E, Czuba Z, Jernas K, Kr xf3 l W. Dietary flavonoids sensitize HeLa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Int J Mol Sci. 2008;9:56-64 pubmed publisher
Autefage H, Albinet V, Garcia V, Berges H, Nicolau M, Therville N, et al. Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner. J Biol Chem. 2009;284:11507-16 pubmed publisher
Xu L, Qu X, Zhang Y, Hu X, Yang X, Hou K, et al. Oxaliplatin enhances TRAIL-induced apoptosis in gastric cancer cells by CBL-regulated death receptor redistribution in lipid rafts. FEBS Lett. 2009;583:943-8 pubmed publisher
Lundqvist A, Yokoyama H, Smith A, Berg M, Childs R. Bortezomib treatment and regulatory T-cell depletion enhance the antitumor effects of adoptively infused NK cells. Blood. 2009;113:6120-7 pubmed publisher
Sun B, Moibi J, Mak A, Xiao Z, Roa W, Moore R. Response of bladder carcinoma cells to TRAIL and antisense oligonucleotide, Bcl-2 or clusterin treatments. J Urol. 2009;181:1361-71 pubmed publisher
Fakler M, Loeder S, Vogler M, Schneider K, Jeremias I, Debatin K, et al. Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance. Blood. 2009;113:1710-22 pubmed publisher
Mulherkar N, Prasad K, Prabhakar B. MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells. J Biol Chem. 2007;282:11715-21 pubmed
Hao C, Beguinot F, Condorelli G, Trencia A, Van Meir E, Yong V, et al. Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells. Cancer Res. 2001;61:1162-70 pubmed
product information
Product Type :
Protein
Product Name :
Human TRAIL (TNFSF10) (soluble) Recombinant Protein, PeproTech
Catalog # :
310-04-250UG
Quantity :
250 ug
Price :
US 608.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
TRAIL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TRAIL preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of TRAIL protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Receptors for TRAIL include two death domain containing receptors, death receptor 4 (DR4) and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. TRAIL is a type II membrane protein and expressed in a variety of human tissues. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
A330042I21Rik; AI448571; Apo-2 ligand; APO2L; Apo-2L; CD253; CD253 antigen; chemokine tumor necrosis factor ligand superfamily member 10; Ly81; Protein TRAIL; TL2; TN; TNF superfamily member 10; TNF-related apoptosis inducing ligand; TNF-related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; Tnfsf10; TNLG6A; TRAIL; TRAIL protein; TRAIL/APO2L; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; tumor necrosis factor ligand 6A; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA