This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human CD40 Ligand (TNFSF5) (soluble) Recombinant Protein, PeproTech
catalog :
310-02-10UG
quantity :
10 ug
price :
US 93.50
citations: 45
Reference
Tsai D, Wang C, Schiro P, Chen N, Tseng J. Tracking B Cell Memory to SARS-CoV-2 Using Rare Cell Analysis System. Vaccines (Basel). 2023;11: pubmed publisher
Luo X, Wu X, Wang A, Chen Y, Peng Y, Deng C, et al. mTORC1-GLUT1-mediated glucose metabolism drives hyperactivation of B cells in primary Sjogren's syndrome. Immunology. 2023;168:432-443 pubmed publisher
Atene C, Fiorcari S, Mesini N, Alboni S, Martinelli S, Maccaferri M, et al. Indoleamine 2, 3-Dioxygenase 1 Mediates Survival Signals in Chronic Lymphocytic Leukemia via Kynurenine/Aryl Hydrocarbon Receptor-Mediated MCL1 Modulation. Front Immunol. 2022;13:832263 pubmed publisher
Chen Z, Zhou S, Li J, Li H, Huang C, Guo Q, et al. SDF-1α Facilitates Mesenchymal Stem Cells to Induce Regulatory B Cell Differentiation from Patients with Immune Thrombocytopenia. Stem Cells Int. 2021;2021:3254488 pubmed publisher
Mandolesi M, Sheward D, Hanke L, Ma J, Pushparaj P, Perez Vidakovics L, et al. SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses. Cell Rep Med. 2021;2:100252 pubmed publisher
Thomas F, Holmes K, Kreuz S, Hillmen P, Lefevre P. DAPK3 participates in the mRNA processing of immediate early genes in chronic lymphocytic leukaemia. Mol Oncol. 2020;14:1268-1281 pubmed publisher
Elmetwali T, Salman A, Wei W, Hussain S, Young L, Palmer D. CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation. Sci Rep. 2020;10:342 pubmed publisher
Auladell M, Nguyen T, Garcillán B, Mackay F, Kedzierska K, Fox A. Distinguishing naive- from memory-derived human B cells during acute responses. Clin Transl Immunology. 2019;8:e01090 pubmed publisher
Roco J, Mesin L, Binder S, Nefzger C, Gonzalez Figueroa P, Canete P, et al. Class-Switch Recombination Occurs Infrequently in Germinal Centers. Immunity. 2019;51:337-350.e7 pubmed publisher
Shinde P, Fernandes S, Melinkeri S, Kale V, Limaye L. Compromised functionality of monocyte-derived dendritic cells in multiple myeloma patients may limit their use in cancer immunotherapy. Sci Rep. 2018;8:5705 pubmed publisher
De S, Zhang B, Shih T, Singh S, Winkler A, Donnelly R, et al. B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation. Front Immunol. 2017;8:1938 pubmed publisher
Carabia J, Carpio C, Abrisqueta P, Jimenez I, Purroy N, Calpe E, et al. Microenvironment regulates the expression of miR-21 and tumor suppressor genes PTEN, PIAS3 and PDCD4 through ZAP-70 in chronic lymphocytic leukemia. Sci Rep. 2017;7:12262 pubmed publisher
Arkatkar T, Du S, Jacobs H, Dam E, Hou B, Buckner J, et al. B cell-derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity. J Exp Med. 2017;214:3207-3217 pubmed publisher
Guo B, Zhang L, Chiorazzi N, Rothstein T. IL-4 rescues surface IgM expression in chronic lymphocytic leukemia. Blood. 2016;128:553-62 pubmed publisher
Jackson S, Jacobs H, Arkatkar T, Dam E, Scharping N, Kolhatkar N, et al. B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J Exp Med. 2016;213:733-50 pubmed publisher
Brook M, Tomlinson G, Miles K, Smith R, Rossi A, Hiemstra P, et al. Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation. Proc Natl Acad Sci U S A. 2016;113:4350-5 pubmed publisher
Meyer T, Robles Carrillo L, Davila M, Brodie M, Desai H, Rivera Amaya M, et al. CD32a antibodies induce thrombocytopenia and type II hypersensitivity reactions in FCGR2A mice. Blood. 2015;126:2230-8 pubmed publisher
Qiu X, Klausen C, Cheng J, Leung P. CD40 ligand induces RIP1-dependent, necroptosis-like cell death in low-grade serous but not serous borderline ovarian tumor cells. Cell Death Dis. 2015;6:e1864 pubmed publisher
Liu Y, Bezverbnaya K, Zhao T, Parsons M, Shi M, Treanor B, et al. Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation. J Immunol. 2015;194:5851-60 pubmed publisher
Carmi Y, Spitzer M, Linde I, Burt B, Prestwood T, Perlman N, et al. Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity. Nature. 2015;521:99-104 pubmed publisher
García Carmona Y, Cols M, Ting A, Radigan L, Yuk F, Zhang L, et al. Differential induction of plasma cells by isoforms of human TACI. Blood. 2015;125:1749-58 pubmed publisher
Gordon S, Doster M, Kines R, Keele B, Brocca Cofano E, Guan Y, et al. Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremia. J Immunol. 2014;193:6172-83 pubmed publisher
Woyach J, Smucker K, Smith L, Lozanski A, Zhong Y, Ruppert A, et al. Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy. Blood. 2014;123:1810-7 pubmed publisher
Nasi A, Fekete T, Krishnamurthy A, Snowden S, Rajnav xf6 lgyi E, Catrina A, et al. Dendritic cell reprogramming by endogenously produced lactic acid. J Immunol. 2013;191:3090-9 pubmed publisher
Fedorchenko O, Stiefelhagen M, Peer Zada A, Barthel R, Mayer P, Eckei L, et al. CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia. Blood. 2013;121:4126-36 pubmed publisher
Saada S, Marget P, Fauchais A, Lise M, Chemin G, Sindou P, et al. Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes. J Immunol. 2012;189:5293-303 pubmed publisher
Blix E, Irish J, Husebekk A, Delabie J, Forfang L, Tierens A, et al. Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma. BMC Cancer. 2012;12:478 pubmed publisher
Zhang T, Wu M, Sentman C. An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo. J Immunol. 2012;189:2290-9 pubmed publisher
Yang D, Postnikov Y, Li Y, Tewary P, de la Rosa G, Wei F, et al. High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses. J Exp Med. 2012;209:157-71 pubmed publisher
Ejlerskov P, Christensen D, Beyaie D, Burritt J, Paclet M, Gorlach A, et al. NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages. J Biol Chem. 2012;287:4835-52 pubmed publisher
Maia S, Pelletier M, Ding J, Hsu Y, Sallan S, Rao S, et al. Aberrant expression of functional BAFF-system receptors by malignant B-cell precursors impacts leukemia cell survival. PLoS ONE. 2011;6:e20787 pubmed publisher
Herman S, Gordon A, Hertlein E, Ramanunni A, Zhang X, Jaglowski S, et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood. 2011;117:6287-96 pubmed publisher
Nuber N, Curioni Fontecedro A, Matter C, Soldini D, Tiercy J, von Boehmer L, et al. Fine analysis of spontaneous MAGE-C1/CT7-specific immunity in melanoma patients. Proc Natl Acad Sci U S A. 2010;107:15187-92 pubmed publisher
Sundling C, Forsell M, O Dell S, Feng Y, Chakrabarti B, Rao S, et al. Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates. J Exp Med. 2010;207:2003-17 pubmed publisher
Robles Carrillo L, Meyer T, Hatfield M, Desai H, Davila M, Langer F, et al. Anti-CD40L immune complexes potently activate platelets in vitro and cause thrombosis in FCGR2A transgenic mice. J Immunol. 2010;185:1577-83 pubmed publisher
Hertlein E, Triantafillou G, Sass E, Hessler J, Zhang X, Jarjoura D, et al. Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cells. Blood. 2010;116:2554-8 pubmed publisher
Herman S, Gordon A, Wagner A, Heerema N, Zhao W, Flynn J, et al. Phosphatidylinositol 3-kinase-? inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116:2078-88 pubmed publisher
Hatfield M, Meyer T, Meyer J, Robles Carrillo L, Francis J, Amirkhosravi A. Contribution of surface localization to platelet activation by CD154 antibodies and introduction of a novel approach for studying immune complex activity. Thromb Res. 2011;127:571-5 pubmed publisher
Herling M, Patel K, Weit N, Lilienthal N, Hallek M, Keating M, et al. High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia. Blood. 2009;114:4675-86 pubmed publisher
Plander M, Seegers S, Ugocsai P, Diermeier Daucher S, Iv xe1 nyi J, Schmitz G, et al. Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles. Leukemia. 2009;23:2118-28 pubmed publisher
Miles K, Clarke D, Lu W, Sibinska Z, Beaumont P, Davidson D, et al. Dying and necrotic neutrophils are anti-inflammatory secondary to the release of alpha-defensins. J Immunol. 2009;183:2122-32 pubmed publisher
Izhak L, Wildbaum G, Zohar Y, Anunu R, Klapper L, Elkeles A, et al. A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2. J Immunol. 2009;183:732-9 pubmed publisher
Fu L, Lin Lee Y, Pham L, Tamayo A, Yoshimura L, Ford R. BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells. Blood. 2009;113:4627-36 pubmed publisher
Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng P, Keats J, Wang H, et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol. 2008;9:1364-70 pubmed publisher
Ohtani T, Nakagawa S, Kurosawa M, Mizuashi M, Ozawa M, Aiba S. Cellular basis of the role of diesel exhaust particles in inducing Th2-dominant response. J Immunol. 2005;174:2412-9 pubmed
product information
Product Type :
Protein
Product Name :
Human CD40 Ligand (TNFSF5) (soluble) Recombinant Protein, PeproTech
Catalog # :
310-02-10UG
Quantity :
10 ug
Price :
US 93.50
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
CD154; CD40 antigen ligand; CD40 ligand; CD40 ligand CD154; CD40 ligand, membrane form; CD40 ligand, soluble form; CD40L; CD40-L; Cd40lg; gp39; hCD40L; H-CD-40-L; HIGM1; IGM; IMD3; Ly62; Ly-62; M-CD-40-L; RP23-153G22.3; T-B cell-activating molecule; T-BAM; T-cell antigen Gp39; TNF-related activation protein; TNFSF5; TRAP; tumor necrosis factor (ligand) superfamily member 5; tumor necrosis factor (ligand) superfamily, member 5; tumor necrosis factor ligand superfamily member 5
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA