Human CXCL12 (SDF-1b) Recombinant Protein, PeproTech | Invitrogen 300-28B-500UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human CXCL12 (SDF-1b) Recombinant Protein, PeproTech

catalog :

300-28B-500UG

quantity :

500 ug

price :

US 2090.00

citations: 20

Reference
Gorchs L, Oosthoek M, Yucel Lindberg T, Moro C, Kaipe H. Chemokine Receptor Expression on T Cells Is Modulated by CAFs and Chemokines Affect the Spatial Distribution of T Cells in Pancreatic Tumors. Cancers (Basel). 2022;14: pubmed publisher
Wu S, Yuan W, Luo W, Nie K, Wu X, Meng X, et al. miR-126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis-associated colorectal cancer. Mol Oncol. 2022;16:3465-3489 pubmed publisher
Colado A, El xed as E, Sarapura Mart xed nez V, Cordini G, Morande P, Bezares F, et al. Immunomodulatory effects of different intravenous immunoglobulin preparations in chronic lymphocytic leukemia. Sci Rep. 2021;11:12926 pubmed publisher
Gimenez N, Tripathi R, Giró A, Rosich L, Lopez Guerra M, López Oreja I, et al. Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia. Sci Rep. 2020;10:22153 pubmed publisher
Lee A, Deruaz M, Lynch C, Davies G, Singh K, Alenazi Y, et al. A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins. J Biol Chem. 2019;: pubmed publisher
Alenazi Y, Singh K, Davies G, Eaton J, Elders P, Kawamura A, et al. Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets. Sci Rep. 2018;8:6333 pubmed publisher
Singh K, Davies G, Alenazi Y, Eaton J, Kawamura A, Bhattacharya S. Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities. Sci Rep. 2017;7:4267 pubmed publisher
Choi Y, Burdick M, Strieter B, Mehrad B, Strieter R. CXCR4, but not CXCR7, discriminates metastatic behavior in non-small cell lung cancer cells. Mol Cancer Res. 2014;12:38-47 pubmed publisher
Arvidsson Y, Bergström A, Arvidsson L, Kristiansson E, Ahlman H, Nilsson O. Hypoxia stimulates CXCR4 signalling in ileal carcinoids. Endocr Relat Cancer. 2010;17:303-16 pubmed publisher
Marquez Curtis L, Jalili A, Deiteren K, Shirvaikar N, Lambeir A, Janowska Wieczorek A. Carboxypeptidase M expressed by human bone marrow cells cleaves the C-terminal lysine of stromal cell-derived factor-1alpha: another player in hematopoietic stem/progenitor cell mobilization?. Stem Cells. 2008;26:1211-20 pubmed publisher
Fox J, Najarro P, Smith G, Struyf S, Proost P, Pease J. Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist. J Biol Chem. 2006;281:36652-61 pubmed
Alejo A, Ruiz Argüello M, Ho Y, Smith V, Saraiva M, Alcami A. A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus. Proc Natl Acad Sci U S A. 2006;103:5995-6000 pubmed
Vermi W, Riboldi E, Wittamer V, Gentili F, Luini W, Marrelli S, et al. Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin. J Exp Med. 2005;201:509-15 pubmed
Murga M, Fernandez Capetillo O, Tosato G. Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2. Blood. 2005;105:1992-9 pubmed
Selleri C, Montuori N, Ricci P, Visconte V, Carriero M, Sidenius N, et al. Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization. Blood. 2005;105:2198-205 pubmed
Hirata T, Furukawa Y, Yang B, Hieshima K, Fukuda M, Kannagi R, et al. Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus. J Biol Chem. 2004;279:51775-82 pubmed
Rosenkilde M, McLean K, Holst P, Schwartz T. The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins. J Biol Chem. 2004;279:32524-33 pubmed
Rosenkilde M, Gerlach L, Jakobsen J, Skerlj R, Bridger G, Schwartz T. Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor. J Biol Chem. 2004;279:3033-41 pubmed
Wang J, Guan E, Roderiquez G, Calvert V, Alvarez R, Norcross M. Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages. J Biol Chem. 2001;276:49236-43 pubmed
Moir S, Lapointe R, Malaspina A, Ostrowski M, Cole C, Chun T, et al. CD40-Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: potential role of B lymphocytes as a viral reservoir. J Virol. 1999;73:7972-80 pubmed

product information

Product Type :

Protein

Product Name :

Human CXCL12 (SDF-1b) Recombinant Protein, PeproTech

Catalog # :

300-28B-500UG

Quantity :

500 ug

Price :

US 2090.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Storage :

-20 C

Description :

CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

Format :

Lyophilized

Applications w/Dilutions :

ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent

Aliases :

12-O-tetradecanoylphorbol 13-acetate repressed protein 1; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); CXC; CXC motif chemokine; C-X-C motif chemokine 12; C-X-C motif chemokine ligand 12; CXCL; CXCL12; Intercrine reduced in hepatomas; IRH; PBSF; pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; SCYB12; Sdf1; SDF-1; sdf-1 beta; SDF-1 gamma; SDF1A; SDF-1-alpha(3-67); SDF1B; SDF-1-beta(3-72); Stromal cell-derived factor 1; stromal cell-derived factor-1 gamma; thymic lymphoma cell-stimulating factor; TLSF; Tpar1