This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human G-CSF Recombinant Protein, PeproTech
catalog :
300-23-2UG
quantity :
2 ug
price :
US 93.50
citations: 143
Reference
Tambe M, Unterberger S, Kriegbaum M, V xe4 nttinen I, Olgac E, V xe4 h xe4 Koskela M, et al. Venetoclax triggers sublethal apoptotic signaling in venetoclax-resistant acute myeloid leukemia cells and induces vulnerability to PARP inhibition and azacitidine. Cell Death Dis. 2024;15:750 pubmed publisher
Fowler J, Zheng S, Nguyen A, Chen A, Xiong X, Chai T, et al. Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells. Dev Cell. 2024;59:1110-1131.e22 pubmed publisher
Nooti S, Naylor M, Long T, Groll B, Manu -. LucFlow: A method to measure Luciferase reporter expression in single cells. PLoS ONE. 2023;18:e0292317 pubmed publisher
Tian L, Li H, Zhao P, Liu Y, Lu Y, Zhong R, et al. C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages. iScience. 2023;26:107771 pubmed publisher
Fan Y, Mizoguchi Y, Tatematsu M, Linder M, Frenz S, Choi J, et al. Analyzing mitochondrial respiration of human induced pluripotent stem cell-derived myeloid progenitors using Seahorse technology. STAR Protoc. 2023;4:102073 pubmed publisher
Pietraforte I, Butera A, Gaddini L, Mennella A, Palazzo R, Campanile D, et al. CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells. Int J Mol Sci. 2022;24: pubmed publisher
Xie S, Shi D, Ouyang Y, Lin F, Chen X, Jiang T, et al. SHMT2 promotes tumor growth through VEGF and MAPK signaling pathway in breast cancer. Am J Cancer Res. 2022;12:3405-3421 pubmed
Chang Y, Syahirah R, Wang X, Jin G, Torregrosa Allen S, Elzey B, et al. Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy. Cell Rep. 2022;40:111128 pubmed publisher
Hug N, Aitken S, Longman D, Raab M, Armes H, Mann A, et al. A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation. RNA. 2022;28:1224-1238 pubmed publisher
Canals Hernaez D, Hughes M, Li Y, Mainero Rocca I, Dean P, Brassard J, et al. Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models. Front Oncol. 2022;12:856424 pubmed publisher
Nystrom S, Li G, Datta S, Soldano K, Silas D, Weins A, et al. JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids. JCI Insight. 2022;7: pubmed publisher
You Y, Stelzl P, Joseph D, Aldo P, Maxwell A, Dekel N, et al. TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion. Front Immunol. 2021;12:737401 pubmed publisher
Tsui M, Min W, Ng S, Dobbs K, Notarangelo L, Dror Y, et al. The Use of Induced Pluripotent Stem Cells to Study the Effects of Adenosine Deaminase Deficiency on Human Neutrophil Development. Front Immunol. 2021;12:748519 pubmed publisher
Bent E, Mill xe1 n Barea L, Zhuang I, Goulet D, Fr xf6 se J, Hemann M. Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy. Nat Commun. 2021;12:6218 pubmed publisher
Simeoni F, Romero Camarero I, Camera F, Amaral F, Sinclair O, Papachristou E, et al. Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia. Cell Rep. 2021;36:109725 pubmed publisher
D xed az de la Guardia R, Velasco Hernandez T, Guti xe9 rrez Ag xfc era F, Roca Ho H, Molina O, Nombela Arrieta C, et al. Engraftment characterization of risk-stratified AML in NSGS mice. Blood Adv. 2021;5:4842-4854 pubmed publisher
Nguyen G, Xu S, Adams W, Leong J, Bunnell S, Mansour M, et al. Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation. iScience. 2021;24:102871 pubmed publisher
Lee J, Koh J, Yi K, Kim Y, Park S, Kim E, et al. Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets. Nat Commun. 2021;12:4567 pubmed publisher
Reyes M, Filbin M, Bhattacharyya R, Sonny A, Mehta A, Billman K, et al. Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro. Sci Transl Med. 2021;13: pubmed publisher
Di Marcantonio D, Martinez E, Kanefsky J, Huhn J, Gabbasov R, Gupta A, et al. ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia. Mol Cell. 2021;81:2752-2764.e6 pubmed publisher
Cheng Y, Xie W, Pickering B, Chu K, Savino A, Yang X, et al. N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cancer Cell. 2021;39:958-972.e8 pubmed publisher
Zhang Y, Chen Y, Li Y, Huang F, Luo B, Yuan Y, et al. The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Thom xe9 C, Ferreira G, Pereira Martins D, Augusto Dos Santos G, Almeida Silveira D, Weinh xe4 user I, et al. The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia. Mol Cell Proteomics. 2021;20:100091 pubmed publisher
Owen N, Minko I, Moellmer S, Cammann S, Lloyd R, McCullough A. Enhanced cytarabine-induced killing in OGG1-deficient acute myeloid leukemia cells. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Cunningham S, Hackstein H. Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties. Transfusion. 2021;61:1845-1855 pubmed publisher
Mian S, Abarrategi A, Kong K, Rouault Pierre K, WOOD H, Oedekoven C, et al. Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells. Blood Cancer Discov. 2021;2:135-145 pubmed publisher
Hasan M, Nair S, O Leary J, Thompson Snipes L, Nyarige V, Wang J, et al. Implication of TIGIT+ human memory B cells in immune regulation. Nat Commun. 2021;12:1534 pubmed publisher
Alicea Torres K, Sanseviero E, Gui J, Chen J, Veglia F, Yu Q, et al. Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway. Nat Commun. 2021;12:1717 pubmed publisher
Goldfarb A, Freeman K, Sahu R, Elagib K, Holy M, Arneja A, et al. Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia. Nat Commun. 2021;12:1645 pubmed publisher
Vadodaria K, Mendes A, Mei A, Racha V, Erikson G, Shokhirev M, et al. Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes. Stem Cell Reports. 2021;16:825-835 pubmed publisher
Naseri M, Z xf6 ller M, Hadjati J, Ghods R, Ranaei Pirmardan E, Kiani J, et al. Dendritic cells loaded with exosomes derived from cancer stem cell-enriched spheroids as a potential immunotherapeutic option. J Cell Mol Med. 2021;25:3312-3326 pubmed publisher
Trizzino M, Zucco A, Deliard S, Wang F, Barbieri E, Veglia F, et al. EGR1 is a gatekeeper of inflammatory enhancers in human macrophages. Sci Adv. 2021;7: pubmed publisher
Rao S, Yao Y, Soares de Brito J, Yao Q, Shen A, Watkinson R, et al. Dissecting ELANE neutropenia pathogenicity by human HSC gene editing. Cell Stem Cell. 2021;: pubmed publisher
Yao Y, Yang J, Qin Q, Tang C, Li Z, Chen L, et al. Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation. Commun Biol. 2020;3:790 pubmed publisher
Jordan P, Gerstmeier J, Pace S, Bilancia R, Rao Z, Börner F, et al. Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution. Cell Rep. 2020;33:108247 pubmed publisher
Gómez V, Eykyn T, Mustapha R, Flores Borja F, Male V, Barber P, et al. Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells. Sci Signal. 2020;13: pubmed publisher
Scholz F, Grau M, Menzel L, Graband A, Zapukhlyak M, Leutz A, et al. The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions. Proc Natl Acad Sci U S A. 2020;117:26328-26339 pubmed publisher
Krotova K, Khodayari N, Oshins R, Aslanidi G, Brantly M. Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway. Sci Rep. 2020;10:15874 pubmed publisher
Piseddu I, R xf6 hrle N, Knott M, Moder S, Eiber S, Schnell K, et al. Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF. J Immunol. 2020;205:2056-2065 pubmed publisher
Su A, Ling F, Vaganay C, Sodaro G, Benaksas C, Dal Bello R, et al. The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies. Cancer Discov. 2020;10:1894-1911 pubmed publisher
Johnson D, Okondo M, Orth E, Rao S, Huang H, Ball D, et al. DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes. Cell Death Dis. 2020;11:628 pubmed publisher
Gebru M, Atkinson J, Young M, Zhang L, Tang Z, Liu Z, et al. Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia. Blood. 2020;136:1067-1079 pubmed publisher
Zabkiewicz J, Lazenby M, Edwards G, Bygrave C, Omidvar N, Zhuang L, et al. Combination of a mitogen-activated protein kinase inhibitor with the tyrosine kinase inhibitor pacritinib combats cell adhesion-based residual disease and prevents re-expansion of FLT3-ITD acute myeloid leukaemia. Br J Haematol. 2020;191:231-242 pubmed publisher
Waclawiczek A, Hamilton A, Rouault Pierre K, Abarrategi A, Albornoz M, Miraki Moud F, et al. Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia. J Clin Invest. 2020;130:3038-3050 pubmed publisher
Xie M, Zhang S, Dong F, Zhang Q, Wang J, Wang C, et al. Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells. Haematologica. 2021;106:1647-1658 pubmed publisher
Panda S, Wigerblad G, Jiang L, Jiménez Andrade Y, Iyer V, Shen Y, et al. IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints. Proc Natl Acad Sci U S A. 2020;117:3103-3113 pubmed publisher
Nguyen C, Bauer K, Hackl H, Schlerka A, Koller E, Hladik A, et al. All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia. Cell Death Dis. 2019;10:944 pubmed publisher
Williams M, Amaral F, Simeoni F, Somervaille T. A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia. J Clin Invest. 2020;130:1217-1232 pubmed publisher
Li Y, Thomas D, Deutzmann A, Majeti R, Felsher D, Dill D. Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index. Sci Rep. 2019;9:16775 pubmed publisher
Sharon D, Cathelin S, Mirali S, Di Trani J, Yanofsky D, Keon K, et al. Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response. Sci Transl Med. 2019;11: pubmed publisher
Zeng Y, Liu C, Gong Y, Bai Z, Hou S, He J, et al. Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos. Immunity. 2019;51:930-948.e6 pubmed publisher
Stuart H, Stirparo G, Lohoff T, Bates L, Kinoshita M, Lim C, et al. Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem Cell. 2019;25:388-406.e8 pubmed publisher
Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C, Papaemmanuil E, et al. Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome. Cancer Cell. 2019;36:123-138.e10 pubmed publisher
Sheng Y, Ji Z, Zhao H, Wang J, Cheng C, Xu W, et al. Downregulation of the histone methyltransferase SETD2 promotes imatinib resistance in chronic myeloid leukaemia cells. Cell Prolif. 2019;:e12611 pubmed publisher
Hsu J, Reilly A, Hayes B, Clough C, Konnick E, Torok Storb B, et al. Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes. Blood. 2019;: pubmed publisher
Tusa I, Cheloni G, Poteti M, Gozzini A, DeSouza N, Shan Y, et al. Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells. Stem Cell Reports. 2018;11:929-943 pubmed publisher
Toofan P, Busch C, Morrison H, O Brien S, Jørgensen H, Copland M, et al. Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal. Cell Death Dis. 2018;9:927 pubmed publisher
Jalali S, Price Troska T, Paludo J, Villasboas J, Kim H, Yang Z, et al. Soluble PD-1 ligands regulate T-cell function in Waldenstrom macroglobulinemia. Blood Adv. 2018;2:1985-1997 pubmed publisher
Johnson D, Taabazuing C, Okondo M, Chui A, Rao S, Brown F, et al. DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia. Nat Med. 2018;24:1151-1156 pubmed publisher
Seren S, Rashed Abouzaid M, Eulenberg Gustavus C, Hirschfeld J, Nasr Soliman H, Jerke U, et al. Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis. J Biol Chem. 2018;293:12415-12428 pubmed publisher
Sumide K, Matsuoka Y, Kawamura H, Nakatsuka R, Fujioka T, Asano H, et al. A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells. Nat Commun. 2018;9:2202 pubmed publisher
Kim M, Yu K, Kenderian S, Ruella M, Chen S, Shin T, et al. Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia. Cell. 2018;173:1439-1453.e19 pubmed publisher
Maclean G, McEldoon J, Huang J, Allred J, Canver M, Orkin S. Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells. Sci Rep. 2018;8:8001 pubmed publisher
Skucha A, Ebner J, Schmöllerl J, Roth M, Eder T, César Razquin A, et al. MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity. Nat Commun. 2018;9:1983 pubmed publisher
Biechonski S, Olender L, Zipin Roitman A, Yassin M, Aqaqe N, Marcu Malina V, et al. Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation. Sci Rep. 2018;8:6071 pubmed publisher
Chennupati V, Veiga D, Maslowski K, Andina N, Tardivel A, Yu E, et al. Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation. J Clin Invest. 2018;128:1597-1614 pubmed publisher
Vo L, Kinney M, Liu X, Zhang Y, Barragan J, Sousa P, et al. Regulation of embryonic haematopoietic multipotency by EZH1. Nature. 2018;553:506-510 pubmed publisher
Böiers C, Richardson S, Laycock E, Zriwil A, Turati V, Brown J, et al. A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1. Dev Cell. 2018;44:362-377.e7 pubmed publisher
Wu X, Dao Thi V, Huang Y, Billerbeck E, Saha D, Hoffmann H, et al. Intrinsic Immunity Shapes Viral Resistance of Stem Cells. Cell. 2018;172:423-438.e25 pubmed publisher
di Tullio A, Rouault Pierre K, Abarrategi A, Mian S, Grey W, Gribben J, et al. The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia. Nat Commun. 2017;8:1679 pubmed publisher
Ring N, Herndler Brandstetter D, Weiskopf K, Shan L, Volkmer J, George B, et al. Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proc Natl Acad Sci U S A. 2017;114:E10578-E10585 pubmed publisher
Zhao H, Wang X, Yi P, Si Y, Tan P, He J, et al. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nat Commun. 2017;8:1428 pubmed publisher
Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin G, Wang J, et al. Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. Cell. 2017;170:1079-1095.e20 pubmed publisher
di Tullio A, Passaro D, Rouault Pierre K, Purewal S, Bonnet D. Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation. Stem Cell Reports. 2017;9:5-11 pubmed publisher
Karjalainen R, Pemovska T, Popa M, Liu M, Javarappa K, Majumder M, et al. JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML. Blood. 2017;130:789-802 pubmed publisher
Eulenberg Gustavus C, Bahring S, Maass P, Luft F, Kettritz R. Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets. J Exp Med. 2017;214:2089-2101 pubmed publisher
Junk D, Bryson B, Smigiel J, Parameswaran N, Bartel C, Jackson M. Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling. Oncogene. 2017;36:4001-4013 pubmed publisher
Spencer D, Russler Germain D, Ketkar S, Helton N, Lamprecht T, Fulton R, et al. CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression. Cell. 2017;168:801-816.e13 pubmed publisher
Min C, Moore N, Shearstone J, Quayle S, Huang P, Van Duzer J, et al. Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia. PLoS ONE. 2017;12:e0169128 pubmed publisher
Adair J, Waters T, Haworth K, Kubek S, Trobridge G, Hocum J, et al. Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy. Nat Commun. 2016;7:13173 pubmed publisher
Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel M, et al. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016;7:292-305 pubmed publisher
Pikman Y, Puissant A, Alexe G, Furman A, Chen L, Frumm S, et al. Targeting MTHFD2 in acute myeloid leukemia. J Exp Med. 2016;213:1285-306 pubmed publisher
Korfi K, Smith M, Swan J, Somervaille T, Dhomen N, Marais R. BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors. Cell Death Dis. 2016;7:e2177 pubmed publisher
Koya J, Kataoka K, Sato T, Bando M, Kato Y, Tsuruta Kishino T, et al. DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation. Nat Commun. 2016;7:10924 pubmed publisher
Bararia D, Kwok H, Welner R, Numata A, Sárosi M, Yang H, et al. Acetylation of C/EBPα inhibits its granulopoietic function. Nat Commun. 2016;7:10968 pubmed publisher
Moreno Lorenzana D, Avilés Vazquez S, Sandoval Esquivel M, Alvarado Moreno A, Ortiz Navarrete V, Torres Martínez H, et al. CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI. Cell Cycle. 2016;15:1276-87 pubmed publisher
Mian S, Rouault Pierre K, Smith A, Seidl T, Pizzitola I, Kizilors A, et al. SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment. Nat Commun. 2015;6:10004 pubmed publisher
Garate Z, Quintana Bustamante O, Crane A, Olivier E, Poirot L, Galetto R, et al. Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells. Stem Cell Reports. 2015;5:1053-1066 pubmed publisher
Six E, Lagresle Peyrou C, Susini S, de Chappedelaine C, Sigrist N, Sadek H, et al. AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages. Cell Death Dis. 2015;6:e1856 pubmed publisher
Conte S, Katayama S, Vesterlund L, Karimi M, Dimitriou M, Jansson M, et al. Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts. Br J Haematol. 2015;171:478-90 pubmed publisher
Li H, Bergeron S, Annis M, Siegel P, Juncker D. Serial analysis of 38 proteins during the progression of human breast tumor in mice using an antibody colocalization microarray. Mol Cell Proteomics. 2015;14:1024-37 pubmed publisher
Otto O, Rosendahl P, Mietke A, Golfier S, Herold C, Klaue D, et al. Real-time deformability cytometry: on-the-fly cell mechanical phenotyping. Nat Methods. 2015;12:199-202, 4 p following 202 pubmed publisher
Fisser M, Rommer A, Steinleitner K, Heller G, Herbst F, Wiese M, et al. Induction of the proapoptotic tumor suppressor gene Cell Adhesion Molecule 1 by chemotherapeutic agents is repressed in therapy resistant acute myeloid leukemia. Mol Carcinog. 2015;54:1815-9 pubmed publisher
Haemmerle R, Phaltane R, Rothe M, Schr xf6 der S, Schambach A, Moritz T, et al. Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model. Mol Ther Nucleic Acids. 2014;3:e200 pubmed publisher
Wang C, Sather B, Wang X, Adair J, Khan I, Singh S, et al. Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells. Blood. 2014;124:913-23 pubmed publisher
Haldar M, Kohyama M, So A, Kc W, Wu X, Briseño C, et al. Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 2014;156:1223-1234 pubmed publisher
Traer E, Javidi Sharifi N, Agarwal A, Dunlap J, English I, Martinez J, et al. Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations. Blood. 2014;123:1516-24 pubmed publisher
Nievergall E, Ramshaw H, Yong A, Biondo M, Busfield S, Vairo G, et al. Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells. Blood. 2014;123:1218-28 pubmed publisher
Krupka C, Kufer P, Kischel R, Zugmaier G, Bögeholz J, Köhnke T, et al. CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330. Blood. 2014;123:356-65 pubmed publisher
Casucci M, Nicolis Di Robilant B, Falcone L, Camisa B, Norelli M, Genovese P, et al. CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma. Blood. 2013;122:3461-72 pubmed publisher
Fernandez I, Ooi T, Roy K. Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous Notch and tetramer-TCR signaling. Stem Cells. 2014;32:93-104 pubmed publisher
Kung Sutherland M, Walter R, Jeffrey S, Burke P, Yu C, Kostner H, et al. SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML. Blood. 2013;122:1455-63 pubmed publisher
Bolton Gillespie E, Schemionek M, Klein H, Flis S, Hoser G, Lange T, et al. Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells. Blood. 2013;121:4175-83 pubmed publisher
Kumkhaek C, Aerbajinai W, Liu W, Zhu J, Uchida N, Kurlander R, et al. MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway. Blood. 2013;121:3216-27 pubmed publisher
Pelosi E, Castelli G, Martin Padura I, Bordoni V, Santoro S, Conigliaro A, et al. Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium. PLoS ONE. 2012;7:e51109 pubmed publisher
Li X, Ha C, Fu D, Xiao M. Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation. PLoS ONE. 2012;7:e48700 pubmed publisher
Gupta M, Maurer M, Wellik L, Law M, Han J, Ozsan N, et al. Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP. Blood. 2012;120:4400-6 pubmed publisher
Dass xe9 E, Volpe G, Walton D, Wilson N, Del Pozzo W, O Neill L, et al. Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells. Blood Cancer J. 2012;2:e76 pubmed publisher
Skavland J, Jørgensen K, Hadziavdic K, Hovland R, Jonassen I, Bruserud O, et al. Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia. Blood Cancer J. 2011;1:e4 pubmed publisher
Zhang Y, Yan X, Sashida G, Zhao X, Rao Y, Goyama S, et al. Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells. Blood. 2012;120:1118-29 pubmed publisher
Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, et al. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2r?KO mice. J Immunol. 2012;188:6145-55 pubmed publisher
Tian L, Sun S. Ubiquitin fusion expression and tissue-dependent targeting of hG-CSF in transgenic tobacco. BMC Biotechnol. 2011;11:91 pubmed publisher
Joha S, Nugues A, Hetuin D, Berthon C, Dezitter X, Dauphin V, et al. GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells. Oncogene. 2012;31:1419-30 pubmed publisher
Pronier E, Almire C, Mokrani H, Vasanthakumar A, Simon A, da Costa Reis Monte Mor B, et al. Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors. Blood. 2011;118:2551-5 pubmed publisher
Pollari E, Savchenko E, Jaronen M, Kanninen K, Malm T, Wojciechowski S, et al. Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis. J Neuroinflammation. 2011;8:74 pubmed publisher
Matthes T, Dunand Sauthier I, Santiago Raber M, Krause K, Donze O, Passweg J, et al. Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow. Blood. 2011;118:1838-44 pubmed publisher
Shin J, Lee J, Lee J, Min W, Schuchman E, Jin H, et al. Combined effects of hematopoietic progenitor cell mobilization from bone marrow by granulocyte colony stimulating factor and AMD3100 and chemotaxis into the brain using stromal cell-derived factor-1α in an Alzheimer's disease mouse model. Stem Cells. 2011;29:1075-89 pubmed publisher
Melichar H, Li O, Ross J, Haber H, Cado D, Nolla H, et al. Comparative study of hematopoietic differentiation between human embryonic stem cell lines. PLoS ONE. 2011;6:e19854 pubmed publisher
Gibbs K, Gilbert P, Sachs K, Zhao F, Blau H, Weissman I, et al. Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments. Blood. 2011;117:4226-33 pubmed publisher
Tanturli M, Giuntoli S, Barbetti V, Rovida E, Dello Sbarba P. Hypoxia selects bortezomib-resistant stem cells of chronic myeloid leukemia. PLoS ONE. 2011;6:e17008 pubmed publisher
Sun H, Kapuria V, Peterson L, Fang D, Bornmann W, Bartholomeusz G, et al. Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis. Blood. 2011;117:3151-62 pubmed publisher
Yeung J, Esposito M, Gandillet A, Zeisig B, Griessinger E, Bonnet D, et al. ?-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer Cell. 2010;18:606-18 pubmed publisher
Gilbert L, Hemann M. DNA damage-mediated induction of a chemoresistant niche. Cell. 2010;143:355-66 pubmed publisher
Ersvaer E, Liseth K, Skavland J, Gjertsen B, Bruserud Ø. Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. BMC Immunol. 2010;11:38 pubmed publisher
Felli N, Cianetti L, Pelosi E, Carè A, Liu C, Calin G, et al. Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states. BMC Syst Biol. 2010;4:85 pubmed publisher
Kondo A, Yamashita T, Tamura H, Zhao W, Tsuji T, Shimizu M, et al. Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes. Blood. 2010;116:1124-31 pubmed publisher
Chang Y, Hua W, Yao C, Hwang S, Hung Y, Kuan C, et al. Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells. J Biol Chem. 2010;285:20595-606 pubmed publisher
Bullock G, Delehanty L, Talbot A, Gonias S, Tong W, Rouault T, et al. Iron control of erythroid development by a novel aconitase-associated regulatory pathway. Blood. 2010;116:97-108 pubmed publisher
Jurkin J, Schichl Y, Koeffel R, Bauer T, Richter S, Konradi S, et al. miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation. J Immunol. 2010;184:4955-65 pubmed publisher
De La Luz Sierra M, Sakakibara S, Gasperini P, Salvucci O, Jiang K, McCormick P, et al. The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1. Blood. 2010;115:3970-9 pubmed publisher
Robert G, Ben Sahra I, Puissant A, Colosetti P, Belhacene N, Gounon P, et al. Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS ONE. 2009;4:e7889 pubmed publisher
Oehler V, Guthrie K, Cummings C, Sabo K, Wood B, Gooley T, et al. The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells. Blood. 2009;114:3299-308 pubmed publisher
Hagn M, Schwesinger E, Ebel V, Sontheimer K, Maier J, Beyer T, et al. Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21. J Immunol. 2009;183:1838-45 pubmed publisher
Eberhard Y, McDermott S, Wang X, Gronda M, Venugopal A, Wood T, et al. Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood. 2009;114:3064-73 pubmed publisher
Kandilci A, Grosveld G. Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation. Blood. 2009;114:1596-606 pubmed publisher
Starnes L, Sorrentino A, Pelosi E, Ballarino M, Morsilli O, Biffoni M, et al. NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression. Blood. 2009;114:1753-63 pubmed publisher
Platzer B, Richter S, Kneidinger D, Waltenberger D, Woisetschläger M, Strobl H. Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells. J Immunol. 2009;183:66-74 pubmed publisher
Ford A, Palmi C, Bueno C, Hong D, Cardus P, Knight D, et al. The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells. J Clin Invest. 2009;119:826-36 pubmed publisher
Gu Y, Harley I, Henderson L, Aronow B, Vietor I, Huber L, et al. Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature. 2009;458:1039-42 pubmed publisher
Verhagen A, Wallace M, Goradia A, Jones S, Croom H, Metcalf D, et al. A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency. J Immunol. 2009;182:2020-9 pubmed publisher
Pendino F, Nguyen E, Jonassen I, Dysvik B, Azouz A, Lanotte M, et al. Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. Blood. 2009;113:3172-81 pubmed publisher
Andrade R, Wessendarp M, Portillo J, Yang J, Gomez F, Durbin J, et al. TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. J Immunol. 2005;175:6014-21 pubmed
Metcalf D, Mifsud S, Di Rago L. Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells. Stem Cells. 2002;20:460-9 pubmed
product information
Product Type :
Protein
Product Name :
Human G-CSF Recombinant Protein, PeproTech
Catalog # :
300-23-2UG
Quantity :
2 ug
Price :
US 93.50
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described. The pleotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts and bone marrow cells. G-CSF has been shown to have specific effects on the proliferation, differentiation and activation of hematopoietic cells. G-CSF is also expressed by various transformed cells such as carcinoma cells and myeloblastic leukemia cells. G-CSF is encoded by two distinct DNA sequences, resulting in a full size, high activity and a shorter, low activity isoform of G-CSF. G-CSF is highly conserved among species and has been shown to exert its biological functions through interaction with its receptor expressed on the surface of hematopoietic progenitors, neutrophilic granulocytes and certain carcinoma cell lines. Clinical use of G-CSF has been approved for several therapeutic applications, treatment of neonatal infections, therapy of acute myocardial infarction, granulocyte transfusion in patients with neutropenia, in severe infections and sepsis, therapy in chronic autoimmune neutropenia, treatment of acute myeloid leukemias, Sweet's syndrome and AIDS. Further, G-CSF has been shown to be a marker protein for different carcinomas such as bladder cancer and dysfunction of the protein has been linked to Kostmann Syndrome.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
C17orf33; colony stimulating factor 3; colony stimulating factor 3 (granulocyte); CSF 3; CSF3; CSF3OS; Csfg; filgrastim; GCSF; G-CSF; Granulocyte colony-stimulating factor; granulocyte-colony stimulating factor; gsf3; lenograstim; MGC45931; MGI-IG; Pluripoietin; RP23-395E10.4
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA