This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human Oncostatin M (227 aa) Recombinant Protein, PeproTech
catalog :
300-10-100UG
quantity :
100 ug
price :
US 1204.00
citations: 62
Reference
Jin Z, Huang Q, Peng J, Liu Z, Hu R, Wu J, et al. MiR-125a-3p alleviates hyperproliferation of keratinocytes and psoriasis-like inflammation by targeting TLR4/NF-κB pathway. Postepy Dermatol Alergol. 2023;40:447-461 pubmed publisher
Lalone V, Aizenshtadt A, Goertz J, Skottvoll F, Mota M, You J, et al. Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging. Cell Rep Methods. 2023;3:100440 pubmed publisher
Hu Z, Wu Y, Xiao R, Zhao J, Chen Y, Wu L, et al. Correction of F8 intron 1 inversion in hemophilia A patient-specific iPSCs by CRISPR/Cas9 mediated gene editing. Front Genet. 2023;14:1115831 pubmed publisher
Chen Y, Chen L, Wu X, Zhao Y, Wang Y, Jiang D, et al. Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice. Nat Commun. 2023;14:1521 pubmed publisher
Wu X, Jiang D, Yang Y, Li S, Ding Q. Modeling drug-induced liver injury and screening for anti-hepatofibrotic compounds using human PSC-derived organoids. Cell Regen. 2023;12:6 pubmed publisher
Wu H, Tang X, Wang Y, Wang N, Chen Q, Xie J, et al. Dextran sulfate prevents excess aggregation of human pluripotent stem cells in 3D culture by inhibiting ICAM1 expression coupled with down-regulating E-cadherin through activating the Wnt signaling pathway. Stem Cell Res Ther. 2022;13:218 pubmed publisher
Cai H, Cheng X, Wang X. ATP7B gene therapy of autologous reprogrammed hepatocytes alleviates copper accumulation in a mouse model of Wilson's disease. Hepatology. 2022;76:1046-1057 pubmed publisher
Gadomski S, Fielding C, Garc xed a Garc xed a A, Korn C, Kapeni C, Ashraf S, et al. A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise. Cell Stem Cell. 2022;29:528-544.e9 pubmed publisher
Zhang Y, Guo A, Lyu C, Bi R, Wu Z, Li W, et al. Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion. iScience. 2021;24:103303 pubmed publisher
Huang C, Zhong W, Ren X, Huang X, Li Z, Chen C, et al. MiR-193b-3p-ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes. Cell Death Dis. 2021;12:963 pubmed publisher
Chen H, Xia K, Huang W, Li H, Wang C, Ma Y, et al. Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates. Cell Discov. 2021;7:75 pubmed publisher
Meseguer Ripolles J, Lucendo Villarin B, Tucker C, Ferreira Gonzalez S, Homer N, Wang Y, et al. Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure. iScience. 2021;24:102552 pubmed publisher
Meseguer Ripolles J, Kasarinaite A, Lucendo Villarin B, Hay D. Protocol for automated production of human stem cell derived liver spheres. STAR Protoc. 2021;2:100502 pubmed publisher
Sinton M, Meseguer Ripolles J, Lucendo Villarin B, Drake A, Hay D. Modeling human hepatic steatosis in pluripotent stem cell-derived hepatocytes. STAR Protoc. 2021;2:100493 pubmed publisher
Chen S, Himeno M, Koui Y, Sugiyama M, Nishitsuji H, Mizokami M, et al. Modulation of hepatitis B virus infection by epidermal growth factor secreted from liver sinusoidal endothelial cells. Sci Rep. 2020;10:14349 pubmed publisher
Thompson W, Takebe T. Generation of multi-cellular human liver organoids from pluripotent stem cells. Methods Cell Biol. 2020;159:47-68 pubmed publisher
Kim J, Im I, Kim H, Jeon J, Kang E, Jo S, et al. Live-cell screening platform using human-induced pluripotent stem cells expressing fluorescence-tagged cytochrome P450 1A1. FASEB J. 2020;34:9141-9155 pubmed publisher
Jo H, Han H, Jung I, Ju J, Park S, Moon S, et al. Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives. Sci Rep. 2020;10:3939 pubmed publisher
Ohta S, Ikemoto T, Wada Y, Saito Y, Yamada S, Imura S, et al. A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells. Sci Rep. 2019;9:18731 pubmed publisher
Pettinato G, Lehoux S, Ramanathan R, Salem M, He L, Muse O, et al. Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells. Sci Rep. 2019;9:8920 pubmed publisher
Wang Y, Tatham M, Schmidt Heck W, Swann C, Singh Dolt K, Meseguer Ripolles J, et al. Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation. iScience. 2019;16:206-217 pubmed publisher
Kuroda T, Yasuda S, Tachi S, Matsuyama S, Kusakawa S, Tano K, et al. SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation. Nat Commun. 2019;10:2175 pubmed publisher
Wang Y, Xie L, Tian E, Li X, Wen Z, Li L, et al. Oncostatin M inhibits differentiation of rat stem Leydig cells in vivo and in vitro. J Cell Mol Med. 2019;23:426-438 pubmed publisher
Li H, Zhu L, Chen H, Li T, Han Q, Wang S, et al. Generation of Functional Hepatocytes from Human Adipose-Derived MYC+ KLF4+ GMNN+ Stem Cells Analyzed by Single-Cell RNA-Seq Profiling. Stem Cells Transl Med. 2018;7:792-805 pubmed publisher
Kirchmeyer M, Servais F, Hamdorf M, Nazarov P, Ginolhac A, Halder R, et al. Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets. J Leukoc Biol. 2018;104:987-1002 pubmed publisher
Zhang H, Xu Z, Lin H, Li M, Xia T, Cui K, et al. TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis. Nat Commun. 2018;9:3441 pubmed publisher
Schöbel A, Rösch K, Herker E. Functional innate immunity restricts Hepatitis C Virus infection in induced pluripotent stem cell-derived hepatocytes. Sci Rep. 2018;8:3893 pubmed publisher
Ong J, Serra M, Segal J, Cujba A, Ng S, Butler R, et al. Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications. Stem Cell Reports. 2018;10:693-702 pubmed publisher
Travers J, Rochman M, Caldwell J, Besse J, Miracle C, Rothenberg M. IL-33 is induced in undifferentiated, non-dividing esophageal epithelial cells in eosinophilic esophagitis. Sci Rep. 2017;7:17563 pubmed publisher
Kotaka M, Toyoda T, Yasuda K, Kitano Y, Okada C, Ohta A, et al. Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells. Sci Rep. 2017;7:16734 pubmed publisher
Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, et al. JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. J Clin Invest. 2017;127:4498-4515 pubmed publisher
Ayaub E, Dubey A, Imani J, Botelho F, Kolb M, Richards C, et al. Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis. Sci Rep. 2017;7:13281 pubmed publisher
Zhang M, Wang J, Deng C, Jiang M, Feng X, Xia K, et al. Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production. Cell Death Dis. 2017;8:e3123 pubmed publisher
Zeitvogel J, Jokmin N, Rieker S, Klug I, Brandenberger C, Werfel T. GATA3 regulates FLG and FLG2 expression in human primary keratinocytes. Sci Rep. 2017;7:11847 pubmed publisher
Schwerd T, Twigg S, Aschenbrenner D, Manrique S, Miller K, Taylor I, et al. A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis. J Exp Med. 2017;214:2547-2562 pubmed publisher
Junk D, Bryson B, Smigiel J, Parameswaran N, Bartel C, Jackson M. Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling. Oncogene. 2017;36:4001-4013 pubmed publisher
Kim H, Kim J, Choi Y, Chun H, Im I, Han Y, et al. Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells. Sci Rep. 2016;6:21684 pubmed publisher
Cameron K, Tan R, Schmidt Heck W, Campos G, Lyall M, Wang Y, et al. Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes. Stem Cell Reports. 2015;5:1250-1262 pubmed publisher
Im I, Jang M, Park S, Lee S, Choi J, Yoo H, et al. Mitochondrial Respiratory Defect Causes Dysfunctional Lactate Turnover via AMP-activated Protein Kinase Activation in Human-induced Pluripotent Stem Cell-derived Hepatocytes. J Biol Chem. 2015;290:29493-505 pubmed publisher
Kido T, Koui Y, Suzuki K, Kobayashi A, Miura Y, Chern E, et al. CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells. Stem Cell Reports. 2015;5:508-15 pubmed publisher
Villarin B, Cameron K, Szkolnicka D, Rashidi H, Bates N, Kimber S, et al. Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance. Adv Healthc Mater. 2015;4:1820-5 pubmed publisher
Siller R, Greenhough S, Naumovska E, Sullivan G. Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells. Stem Cell Reports. 2015;4:939-52 pubmed publisher
Dasgupta M, Dermawan J, Willard B, Stark G. STAT3-driven transcription depends upon the dimethylation of K49 by EZH2. Proc Natl Acad Sci U S A. 2015;112:3985-90 pubmed publisher
Jiang M, Cai B, Tuo Y, Wang J, Zang Z, Tu X, et al. Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction. Cell Res. 2014;24:1466-85 pubmed publisher
Xu H, Tsang K, Wang Y, Chan J, Xu G, Gao W. Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and ?-catenin signaling. J Biol Chem. 2014;289:26290-301 pubmed publisher
Szkolnicka D, Farnworth S, Lucendo Villarin B, Hay D. Deriving functional hepatocytes from pluripotent stem cells. Curr Protoc Stem Cell Biol. 2014;30:1G.5.1-12 pubmed publisher
Duan C, Shi J, Chen J, Wang B, Yu Y, Qin X, et al. Leukemia propagating cells rebuild an evolving niche in response to therapy. Cancer Cell. 2014;25:778-93 pubmed publisher
Xu D, Nishimura T, Zheng M, Wu M, Su H, Sato N, et al. Enabling autologous human liver regeneration with differentiated adipocyte stem cells. Cell Transplant. 2014;23:1573-84 pubmed publisher
van Rompaey L, Galien R, van der Aar E, Clément Lacroix P, Nelles L, Smets B, et al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol. 2013;191:3568-77 pubmed publisher
Przybyla L, Theunissen T, Jaenisch R, Voldman J. Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells. 2013;31:1097-106 pubmed publisher
Jones G, Moschidou D, Puga Iglesias T, Kuleszewicz K, Vanleene M, Shefelbine S, et al. Ontological differences in first compared to third trimester human fetal placental chorionic stem cells. PLoS ONE. 2012;7:e43395 pubmed publisher
Drechsler J, Grötzinger J, Hermanns H. Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor. PLoS ONE. 2012;7:e43155 pubmed publisher
Kajiwara M, Aoi T, Okita K, Takahashi R, Inoue H, Takayama N, et al. Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012;109:12538-43 pubmed publisher
D Alessio J, Ng R, Willenbring H, Tjian R. Core promoter recognition complex changes accompany liver development. Proc Natl Acad Sci U S A. 2011;108:3906-11 pubmed publisher
Funakoshi N, Duret C, Pascussi J, Blanc P, Maurel P, Daujat Chavanieu M, et al. Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes. Stem Cell Rev Rep. 2011;7:518-31 pubmed publisher
Baertschiger R, Serre Beinier V, Morel P, Bosco D, Peyrou M, Clement S, et al. Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver. PLoS ONE. 2009;4:e6657 pubmed publisher
Su H, Yeh H, Wang S, Shen M, Chen T, Kiela P, et al. Cell confluence-induced activation of signal transducer and activator of transcription-3 (Stat3) triggers epithelial dome formation via augmentation of sodium hydrogen exchanger-3 (NHE3) expression. J Biol Chem. 2007;282:9883-94 pubmed
Metz S, Wiesinger M, Vogt M, Lauks H, Schmalzing G, Heinrich P, et al. Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins. J Biol Chem. 2007;282:1238-48 pubmed
Komyod W, Bauer U, Heinrich P, Haan S, Behrmann I. Are STATS arginine-methylated?. J Biol Chem. 2005;280:21700-5 pubmed
Metcalf D, Mifsud S, Di Rago L. Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells. Stem Cells. 2002;20:460-9 pubmed
Richardson R, Starr R, Angus L, Hilton D. A somatic cell genetic system for dissecting hemopoietic cytokine signal transduction. J Biol Chem. 2002;277:25624-30 pubmed
Olivier C, Auguste P, Chabbert M, Leli xe8 vre E, Chevalier S, Gascan H. Identification of a gp130 cytokine receptor critical site involved in oncostatin M response. J Biol Chem. 2000;275:5648-56 pubmed
product information
Product Type :
Protein
Product Name :
Human Oncostatin M (227 aa) Recombinant Protein, PeproTech
Catalog # :
300-10-100UG
Quantity :
100 ug
Price :
US 1204.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
MGC20461; OncoM; oncostatin M; oncostatin-M; OSM
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA