Human CCL3 (MIP-1 alpha) Recombinant Protein, PeproTech | Invitrogen 300-08-1MG product information

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product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human CCL3 (MIP-1 alpha) Recombinant Protein, PeproTech

catalog :

300-08-1MG

quantity :

1 mg

price :

US 3470.00

citations: 57

Reference
Nystrom S, Li G, Datta S, Soldano K, Silas D, Weins A, et al. JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids. JCI Insight. 2022;7: pubmed publisher
Luo A, Meng M, Wang G, Han R, Zhang Y, Jing X, et al. Myeloid-Derived Suppressor Cells Recruited by Chemokine (C-C Motif) Ligand 3 Promote the Progression of Breast Cancer via Phosphoinositide 3-Kinase-Protein Kinase B-Mammalian Target of Rapamycin Signaling. J Breast Cancer. 2020;23:141-161 pubmed publisher
Chan L, Li C, Xia W, Hsu J, Lee H, Cha J, et al. IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. J Clin Invest. 2019;129:3324-3338 pubmed publisher
Lee A, Deruaz M, Lynch C, Davies G, Singh K, Alenazi Y, et al. A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins. J Biol Chem. 2019;: pubmed publisher
Fox J, Kausar F, Day A, Osborne M, Hussain K, Mueller A, et al. CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration. Sci Rep. 2018;8:9466 pubmed publisher
Dang T, Liou G. Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt. Sci Rep. 2018;8:7718 pubmed publisher
Alenazi Y, Singh K, Davies G, Eaton J, Elders P, Kawamura A, et al. Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets. Sci Rep. 2018;8:6333 pubmed publisher
Singh K, Davies G, Alenazi Y, Eaton J, Kawamura A, Bhattacharya S. Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities. Sci Rep. 2017;7:4267 pubmed publisher
Singh T, Zhang H, Borek I, Wolf P, Hedrick M, Singh S, et al. Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation. Nat Commun. 2016;7:13581 pubmed publisher
Karlshøj S, Amarandi R, Larsen O, Daugvilaite V, Steen A, Brvar M, et al. Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5). J Biol Chem. 2016;291:26860-26874 pubmed publisher
Epaulard O, Adam L, Poux C, Zurawski G, Salabert N, Rosenbaum P, et al. Macrophage- and neutrophil-derived TNF-? instructs skin langerhans cells to prime antiviral immune responses. J Immunol. 2014;193:2416-26 pubmed publisher
Lee R, Perry B, Heywood J, Reese C, Bonner M, Hatfield C, et al. Caveolin-1 regulates chemokine receptor 5-mediated contribution of bone marrow-derived cells to dermal fibrosis. Front Pharmacol. 2014;5:140 pubmed publisher
Duan C, Shi J, Chen J, Wang B, Yu Y, Qin X, et al. Leukemia propagating cells rebuild an evolving niche in response to therapy. Cancer Cell. 2014;25:778-93 pubmed publisher
Jin J, Colin P, Staropoli I, Lima Fernandes E, Ferret C, Demir A, et al. Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry. J Biol Chem. 2014;289:19042-52 pubmed publisher
Bednar F, Song C, Bardi G, Cornwell W, Rogers T. Cross-desensitization of CCR1, but not CCR2, following activation of the formyl peptide receptor FPR1. J Immunol. 2014;192:5305-13 pubmed publisher
Traer E, Javidi Sharifi N, Agarwal A, Dunlap J, English I, Martinez J, et al. Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations. Blood. 2014;123:1516-24 pubmed publisher
Blanchetot C, Verzijl D, Mujić Delić A, Bosch L, Rem L, Leurs R, et al. Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine function. J Biol Chem. 2013;288:25173-82 pubmed publisher
Knolle M, Nakajima T, Hergrueter A, Gupta K, Polverino F, Craig V, et al. Adam8 limits the development of allergic airway inflammation in mice. J Immunol. 2013;190:6434-49 pubmed publisher
Bolton Gillespie E, Schemionek M, Klein H, Flis S, Hoser G, Lange T, et al. Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells. Blood. 2013;121:4175-83 pubmed publisher
Steen A, Thiele S, Guo D, Hansen L, Frimurer T, Rosenkilde M. Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7. J Biol Chem. 2013;288:12511-21 pubmed publisher
Thiele S, Steen A, Jensen P, Mokrosinski J, Frimurer T, Rosenkilde M. Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach. J Biol Chem. 2011;286:37543-54 pubmed publisher
Bolton M, Garry R. Sequence similarity between the erythrocyte binding domain 1 of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV-1 strain MN reveals binding residues for the Duffy Antigen Receptor for Chemokines. Virol J. 2011;8:45 pubmed publisher
Yung S, Parenti D, Murphy P. Host chemokines bind to Staphylococcus aureus and stimulate protein A release. J Biol Chem. 2011;286:5069-77 pubmed publisher
Struyf S, Salogni L, Burdick M, Vandercappellen J, Gouwy M, Noppen S, et al. Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. Blood. 2011;117:480-8 pubmed publisher
Kirouac D, Ito C, Csaszar E, Roch A, Yu M, Sykes E, et al. Dynamic interaction networks in a hierarchically organized tissue. Mol Syst Biol. 2010;6:417 pubmed publisher
Rius C, Abu Taha M, Hermenegildo C, Piqueras L, Cerda Nicolas J, Issekutz A, et al. Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-?B activation and peroxisome proliferator-activated receptor-gamma upregulation. J Immunol. 2010;185:3718-27 pubmed publisher
Hanley T, Blay Puryear W, Gummuluru S, Viglianti G. PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection. PLoS Pathog. 2010;6:e1000981 pubmed publisher
Rodríguez Bayona B, Ramos Amaya A, Pérez Venegas J, Rodriguez C, Brieva J. Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients. Arthritis Res Ther. 2010;12:R108 pubmed publisher
Madigan J, Freeman D, Menzies F, Forrow S, Nelson S, Young A, et al. Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipients. J Immunol. 2010;184:3202-12 pubmed publisher
Quintero P, Knolle M, Cala L, Zhuang Y, Owen C. Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice. J Immunol. 2010;184:1575-88 pubmed publisher
Carbone T, Nasorri F, Pennino D, Eyerich K, Foerster S, Cifaldi L, et al. CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses. J Immunol. 2010;184:1102-10 pubmed publisher
Savino B, Borroni E, Torres N, Proost P, Struyf S, Mortier A, et al. Recognition versus adaptive up-regulation and degradation of CC chemokines by the chemokine decoy receptor D6 are determined by their N-terminal sequence. J Biol Chem. 2009;284:26207-15 pubmed publisher
Abu Taha M, Rius C, Hermenegildo C, Noguera I, Cerda Nicolas J, Issekutz A, et al. Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan. J Immunol. 2009;183:1393-402 pubmed publisher
Salogni L, Musso T, Bosisio D, Mirolo M, Jala V, Haribabu B, et al. Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14. Blood. 2009;113:5848-56 pubmed publisher
Helmy A, Carpenter K, Skepper J, Kirkpatrick P, Pickard J, Hutchinson P. Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery. J Neurotrauma. 2009;26:549-61 pubmed publisher
Bryan J, Shelver D. Streptococcus agalactiae CspA is a serine protease that inactivates chemokines. J Bacteriol. 2009;191:1847-54 pubmed publisher
Vassiliou E, Kesler O, Tadros J, Ganea D. Bone marrow-derived dendritic cells generated in the presence of resolvin E1 induce apoptosis of activated CD4+ T cells. J Immunol. 2008;181:4534-44 pubmed
Abu Nabah Y, Losada M, Estellés R, Mateo T, Company C, Piqueras L, et al. CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration. Arterioscler Thromb Vasc Biol. 2007;27:2370-6 pubmed
Mateo T, Naim Abu Nabah Y, Losada M, Estell xe9 s R, Company C, Bedrina B, et al. A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles. Blood. 2007;110:1895-902 pubmed
Ponte A, Marais E, Gallay N, Langonne A, Delorme B, Herault O, et al. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells. 2007;25:1737-45 pubmed
Cappello P, Fraone T, Barberis L, Costa C, Hirsch E, Elia A, et al. CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells. J Immunol. 2006;177:6143-51 pubmed
Yurchenko E, Tritt M, Hay V, Shevach E, Belkaid Y, Piccirillo C. CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med. 2006;203:2451-60 pubmed
Hirata T, Furukawa Y, Yang B, Hieshima K, Fukuda M, Kannagi R, et al. Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus. J Biol Chem. 2004;279:51775-82 pubmed
Pilette C, Francis J, Till S, Durham S. CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge. Eur Respir J. 2004;23:876-84 pubmed
Toh K, Kukita T, Wu Z, Kukita A, Sandra F, Tang Q, et al. Possible involvement of MIP-1alpha in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant-induced arthritis. Lab Invest. 2004;84:1092-102 pubmed
Trentin L, Cabrelle A, Facco M, Carollo D, Miorin M, Tosoni A, et al. Homeostatic chemokines drive migration of malignant B cells in patients with non-Hodgkin lymphomas. Blood. 2004;104:502-8 pubmed
Huang R, Lin Y, Shi Q, Flowers L, Ramachandran S, Horowitz I, et al. Enhanced protein profiling arrays with ELISA-based amplification for high-throughput molecular changes of tumor patients' plasma. Clin Cancer Res. 2004;10:598-609 pubmed
Alvarez Arias D, Navenot J, Zhang W, Broach J, Peiper S. Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2. J Biol Chem. 2003;278:36513-21 pubmed
Honczarenko M, Le Y, Glodek A, Majka M, Campbell J, Ratajczak M, et al. CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor. Blood. 2002;100:2321-9 pubmed
Bryan S, Jose P, Topping J, Wilhelm R, Soderberg C, Kertesz D, et al. Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 2002;165:1602-9 pubmed
Tiffany H, Lavigne M, Cui Y, Wang J, Leto T, Gao J, et al. Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain. J Biol Chem. 2001;276:23645-52 pubmed
Aliberti J, Reis e Sousa C, Schito M, Hieny S, Wells T, Huffnagle G, et al. CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells. Nat Immunol. 2000;1:83-7 pubmed
Sabroe I, Peck M, Van Keulen B, Jorritsma A, Simmons G, Clapham P, et al. A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J Biol Chem. 2000;275:25985-92 pubmed
Majka M, Ratajczak J, Lee B, Honczarenko M, Douglas R, Kowalska M, et al. The role of HIV-related chemokine receptors and chemokines in human erythropoiesis in vitro. Stem Cells. 2000;18:128-38 pubmed
Kitaura M, Suzuki N, Imai T, Takagi S, Suzuki R, Nakajima T, et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J Biol Chem. 1999;274:27975-80 pubmed
Oppermann M, Mack M, Proudfoot A, Olbrich H. Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. J Biol Chem. 1999;274:8875-85 pubmed
Sabroe I, Hartnell A, Jopling L, Bel S, Ponath P, Pease J, et al. Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways. J Immunol. 1999;162:2946-55 pubmed

product information

Product Type :

Protein

Product Name :

Human CCL3 (MIP-1 alpha) Recombinant Protein, PeproTech

Catalog # :

300-08-1MG

Quantity :

1 mg

Price :

US 3470.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Storage :

-20 C

Description :

Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.

Format :

Lyophilized

Applications w/Dilutions :

ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent

Aliases :

AI323804; C-C motif chemokine 3; C-C motif chemokine ligand 3; CCL3; chemokine (C-C motif) ligand 3; G0/G1 switch regulatory protein 19-1; G0S19-1; Heparin-binding chemotaxis protein; H-MIP-1-alpha; L2G25B; LD78ALPHA; LD78-alpha; LD78-alpha(4-69); Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); macrophage inflammatory protein 1-alpha; macrophage inflammatory protein-1alpha; MIP1 (a); mip1 alpha; MIP-1 alpha; MIP1-(a); MIP1A; MIP-1a; MIP-1alpha; MIP-1-alpha; MIP1-alpha; MIP-1-alpha(4-69); PAT 464.1; RP23-320E6.7; Scya3; SIS-alpha; SIS-beta; small inducible cytokine A3; small inducible cytokine A3 (homologous to mouse Mip-1a); small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein; TY-5