This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human CCL5 (RANTES) Recombinant Protein, PeproTech
catalog :
300-06-20UG
quantity :
20 ug
price :
US 227.00
citations: 97
Reference
Purvis G, McNeill E, Wright B, Channon K, Greaves D. Ly6Chi Monocytes Are Metabolically Reprogrammed in the Blood during Inflammatory Stimulation and Require Intact OxPhos for Chemotaxis and Monocyte to Macrophage Differentiation. Cells. 2024;13: pubmed publisher
Albanese M, Chen H, Gapp M, Muenchhoff M, Yang H, Peterhoff D, et al. Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells. Cell Rep Med. 2024;5:101483 pubmed publisher
Baram T, Oren N, Erlichman N, Meshel T, Ben Baruch A. Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer. Cancers (Basel). 2022;14: pubmed publisher
Erlichman N, Baram T, Meshel T, Morein D, Da adoosh B, Ben Baruch A. Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes. Cancers (Basel). 2022;14: pubmed publisher
Gurusamy M, Tischner D, Shao J, Klatt S, Zukunft S, Bonnavion R, et al. G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. Nat Commun. 2021;12:6798 pubmed publisher
You Y, Stelzl P, Joseph D, Aldo P, Maxwell A, Dekel N, et al. TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion. Front Immunol. 2021;12:737401 pubmed publisher
Ofir Birin Y, Ben Ami Pilo H, Cruz Camacho A, Rudik A, Rivkin A, Revach O, et al. Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration. Nat Commun. 2021;12:4851 pubmed publisher
Wang W, Tang Y, Xiao Q, Lee W, Cheng B, Niu Z, et al. Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer. Nat Commun. 2021;12:4441 pubmed publisher
De Groof T, Bergkamp N, Heukers R, Giap T, Bebelman M, Goeij de Haas R, et al. Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies. Nat Commun. 2021;12:4357 pubmed publisher
Wang Y, Mohseni M, Grauel A, Diez J, Guan W, Liang S, et al. SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms. Sci Rep. 2021;11:1399 pubmed publisher
Yacov N, Kafri P, Salem Y, Propheta Meiran O, Feldman B, Breitbart E, et al. MOSPD2 is a therapeutic target for the treatment of CNS inflammation. Clin Exp Immunol. 2020;201:105-120 pubmed publisher
Huang R, Wang S, Wang N, Zheng Y, Zhou J, Yang B, et al. CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling. Cell Death Dis. 2020;11:234 pubmed publisher
Waldeck S, Rassner M, Keye P, Follo M, Herchenbach D, Endres C, et al. CCL5 mediates target-kinase independent resistance to FLT3 inhibitors in FLT3-ITD-positive AML. Mol Oncol. 2020;14:779-794 pubmed publisher
Z x142 otkowska A, Andronowska A. Chemokines as the modulators of endometrial epithelial cells remodelling. Sci Rep. 2019;9:12968 pubmed publisher
Lee A, Deruaz M, Lynch C, Davies G, Singh K, Alenazi Y, et al. A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins. J Biol Chem. 2019;: pubmed publisher
Liubomirski Y, Lerrer S, Meshel T, Morein D, Rubinstein Achiasaf L, Sprinzak D, et al. Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer. Front Immunol. 2019;10:804 pubmed publisher
Liubomirski Y, Lerrer S, Meshel T, Rubinstein Achiasaf L, Morein D, Wiemann S, et al. Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer. Front Immunol. 2019;10:757 pubmed publisher
Xiang P, Jin S, Yang Y, Sheng J, He Q, Song Y, et al. Infiltrating CD4+ T cells attenuate chemotherapy sensitivity in prostate cancer via CCL5 signaling. Prostate. 2019;79:1018-1031 pubmed publisher
Park M, Cho H, Roh S, Kim S, Myoung J. Cell Type-Specific Interferon-γ-mediated Antagonism of KSHV Lytic Replication. Sci Rep. 2019;9:2372 pubmed publisher
Muccioli M, Nandigam H, Loftus T, Singh M, Venkatesh A, Wright J, et al. Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues. Oncotarget. 2018;9:36666-36683 pubmed publisher
Jalali S, Price Troska T, Paludo J, Villasboas J, Kim H, Yang Z, et al. Soluble PD-1 ligands regulate T-cell function in Waldenstrom macroglobulinemia. Blood Adv. 2018;2:1985-1997 pubmed publisher
Heukers R, Fan T, de Wit R, van Senten J, De Groof T, Bebelman M, et al. The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth. Oncogene. 2018;37:4110-4121 pubmed publisher
Alenazi Y, Singh K, Davies G, Eaton J, Elders P, Kawamura A, et al. Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets. Sci Rep. 2018;8:6333 pubmed publisher
McNaughton E, Eustace A, King S, Sessions R, Kay A, Farris M, et al. Novel Anti-Inflammatory Peptides Based on Chemokine-Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis. J Immunol. 2018;200:3201-3217 pubmed publisher
Zhang Y, Wu Y, Qi H, Xiao J, Gong H, Zhang Y, et al. A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma. Sci Rep. 2017;7:15038 pubmed publisher
Buskermolen J, Roffel S, Gibbs S. Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets. J Cell Physiol. 2017;232:2996-3005 pubmed publisher
Michlmayr D, Bardina S, Rodriguez C, Pletnev A, Lim J. Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance. J Immunol. 2016;196:4622-31 pubmed publisher
Almeida C, Caires H, Vasconcelos D, Barbosa M. NAP-2 Secreted by Human NK Cells Can Stimulate Mesenchymal Stem/Stromal Cell Recruitment. Stem Cell Reports. 2016;6:466-473 pubmed publisher
Franciszkiewicz K, Boutet M, Gauthier L, Vergnon I, Peeters K, Duc O, et al. Synaptic release of CCL5 storage vesicles triggers CXCR4 surface expression promoting CTL migration in response to CXCL12. J Immunol. 2014;193:4952-61 pubmed publisher
Chen C, Feng X, Liao H, Jin W, Zhang J, Wang Y, et al. Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection. Sci Rep. 2014;4:6359 pubmed publisher
Jin J, Colin P, Staropoli I, Lima Fernandes E, Ferret C, Demir A, et al. Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry. J Biol Chem. 2014;289:19042-52 pubmed publisher
Martínez Muñoz L, Barroso R, Dyrhaug S, Navarro G, Lucas P, Soriano S, et al. CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface. Proc Natl Acad Sci U S A. 2014;111:E1960-9 pubmed publisher
Wong T, Doyle A, Lee J, Jelinek D. Eosinophils regulate peripheral B cell numbers in both mice and humans. J Immunol. 2014;192:3548-58 pubmed publisher
Pei X, Sun Q, Zhang Y, Wang P, Peng X, Guo C, et al. PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2. J Immunol. 2014;192:1878-86 pubmed publisher
Blanchetot C, Verzijl D, Mujić Delić A, Bosch L, Rem L, Leurs R, et al. Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine function. J Biol Chem. 2013;288:25173-82 pubmed publisher
Knolle M, Nakajima T, Hergrueter A, Gupta K, Polverino F, Craig V, et al. Adam8 limits the development of allergic airway inflammation in mice. J Immunol. 2013;190:6434-49 pubmed publisher
Steen A, Thiele S, Guo D, Hansen L, Frimurer T, Rosenkilde M. Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7. J Biol Chem. 2013;288:12511-21 pubmed publisher
Liberman A, Esser M, Marx N, Burgmaier M. Glucagon-like peptide-1(9-36) inhibits chemokine-induced migration of human CD4-positive lymphocytes. PLoS ONE. 2013;8:e58445 pubmed publisher
Touboul C, Lis R, Al Farsi H, Raynaud C, Warfa M, Althawadi H, et al. Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model. J Transl Med. 2013;11:28 pubmed publisher
Whittall C, Kehoe O, King S, Rot A, Patterson A, Middleton J. A chemokine self-presentation mechanism involving formation of endothelial surface microstructures. J Immunol. 2013;190:1725-36 pubmed publisher
Miller W, Zagorski W, Brenneman J, Avery D, Miller J, O Connor C. US28 is a potent activator of phospholipase C during HCMV infection of clinically relevant target cells. PLoS ONE. 2012;7:e50524 pubmed publisher
Swaminathan G, Rossi F, Sierra L, Gupta A, Navas Martin S, MARTIN GARCIA J. A role for microRNA-155 modulation in the anti-HIV-1 effects of Toll-like receptor 3 stimulation in macrophages. PLoS Pathog. 2012;8:e1002937 pubmed publisher
Wang S, Wu H, Liu S, Wang P, Ou W, Chou W, et al. CCL5 and CCR5 interaction promotes cell motility in human osteosarcoma. PLoS ONE. 2012;7:e35101 pubmed publisher
Jin W, Chen C, Liao H, Gong L, Yuan X, Zhao B, et al. Downregulation of the AU-rich RNA-binding protein ZFP36 in chronic HBV patients: implications for anti-inflammatory therapy. PLoS ONE. 2012;7:e33356 pubmed publisher
Yang D, Postnikov Y, Li Y, Tewary P, de la Rosa G, Wei F, et al. High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses. J Exp Med. 2012;209:157-71 pubmed publisher
Thiele S, Steen A, Jensen P, Mokrosinski J, Frimurer T, Rosenkilde M. Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach. J Biol Chem. 2011;286:37543-54 pubmed publisher
Lebre M, Vergunst C, Choi I, Aarrass S, Oliveira A, Wyant T, et al. Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis. PLoS ONE. 2011;6:e21772 pubmed publisher
Greene T, Alarcon S, Thomas A, Berdougo E, Doranz B, Breslin P, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS ONE. 2011;6:e20123 pubmed publisher
Elsawa S, Almada L, Ziesmer S, Novak A, Witzig T, Ansell S, et al. GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment. J Biol Chem. 2011;286:21524-34 pubmed publisher
Bolton M, Garry R. Sequence similarity between the erythrocyte binding domain 1 of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV-1 strain MN reveals binding residues for the Duffy Antigen Receptor for Chemokines. Virol J. 2011;8:45 pubmed publisher
Yung S, Parenti D, Murphy P. Host chemokines bind to Staphylococcus aureus and stimulate protein A release. J Biol Chem. 2011;286:5069-77 pubmed publisher
Crawford M, Burdick M, Glomski I, Boyer A, Barr J, Mehrad B, et al. Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection. PLoS Pathog. 2010;6:e1001199 pubmed publisher
Zhu Y, Bertics P. Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils. J Immunol. 2011;186:516-26 pubmed publisher
Kirouac D, Ito C, Csaszar E, Roch A, Yu M, Sykes E, et al. Dynamic interaction networks in a hierarchically organized tissue. Mol Syst Biol. 2010;6:417 pubmed publisher
Rius C, Abu Taha M, Hermenegildo C, Piqueras L, Cerda Nicolas J, Issekutz A, et al. Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-?B activation and peroxisome proliferator-activated receptor-gamma upregulation. J Immunol. 2010;185:3718-27 pubmed publisher
Vinet Oliphant H, Alvarez X, Buza E, Borda J, Mohan M, Aye P, et al. Neurokinin-1 receptor (NK1-R) expression in the brains of SIV-infected rhesus macaques: implications for substance P in NK1-R immune cell trafficking into the CNS. Am J Pathol. 2010;177:1286-97 pubmed publisher
Tewary P, Yang D, de la Rosa G, Li Y, Finn M, Krensky A, et al. Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin. Blood. 2010;116:3465-74 pubmed publisher
Buatois V, Fagète S, Magistrelli G, Chatel L, Fischer N, Kosco Vilbois M, et al. Pan-CC chemokine neutralization restricts splenocyte egress and reduces inflammation in a model of arthritis. J Immunol. 2010;185:2544-54 pubmed publisher
Hanley T, Blay Puryear W, Gummuluru S, Viglianti G. PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection. PLoS Pathog. 2010;6:e1000981 pubmed publisher
Clements D, Markwick L, Puri N, Johnson S. Role of the CXCR4/CXCL12 axis in lymphangioleiomyomatosis and angiomyolipoma. J Immunol. 2010;185:1812-21 pubmed publisher
Madigan J, Freeman D, Menzies F, Forrow S, Nelson S, Young A, et al. Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipients. J Immunol. 2010;184:3202-12 pubmed publisher
Anand A, Prasad A, Bradley R, Deol Y, Nagaraja T, Ren X, et al. HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1. Blood. 2009;114:3588-600 pubmed publisher
Urbinati C, Nicoli S, Giacca M, David G, Fiorentini S, Caruso A, et al. HIV-1 Tat and heparan sulfate proteoglycan interaction: a novel mechanism of lymphocyte adhesion and migration across the endothelium. Blood. 2009;114:3335-42 pubmed publisher
Richter R, Casarosa P, Ständker L, Munch J, Springael J, Nijmeijer S, et al. Significance of N-terminal proteolysis of CCL14a to activity on the chemokine receptors CCR1 and CCR5 and the human cytomegalovirus-encoded chemokine receptor US28. J Immunol. 2009;183:1229-37 pubmed publisher
Abu Taha M, Rius C, Hermenegildo C, Noguera I, Cerda Nicolas J, Issekutz A, et al. Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan. J Immunol. 2009;183:1393-402 pubmed publisher
Izhak L, Wildbaum G, Zohar Y, Anunu R, Klapper L, Elkeles A, et al. A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2. J Immunol. 2009;183:732-9 pubmed publisher
Egesten A, Olin A, Linge H, Yadav M, M rgelin M, Karlsson A, et al. SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines. PLoS ONE. 2009;4:e4769 pubmed publisher
Koenen R, von Hundelshausen P, Nesmelova I, Zernecke A, Liehn E, Sarabi A, et al. Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice. Nat Med. 2009;15:97-103 pubmed publisher
Bryan J, Shelver D. Streptococcus agalactiae CspA is a serine protease that inactivates chemokines. J Bacteriol. 2009;191:1847-54 pubmed publisher
Chernova I, Lai J, Li H, Schwartz L, Tuluc F, Korchak H, et al. Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R). J Leukoc Biol. 2009;85:154-64 pubmed publisher
Nguyen K, Fohner A, Booker J, Dong C, Krensky A, Nadeau K. XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma. J Immunol. 2008;181:5386-95 pubmed
Vassiliou E, Kesler O, Tadros J, Ganea D. Bone marrow-derived dendritic cells generated in the presence of resolvin E1 induce apoptosis of activated CD4+ T cells. J Immunol. 2008;181:4534-44 pubmed
Truman L, Ford C, Pasikowska M, Pound J, Wilkinson S, Dumitriu I, et al. CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood. 2008;112:5026-36 pubmed publisher
Abu Nabah Y, Losada M, Estellés R, Mateo T, Company C, Piqueras L, et al. CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration. Arterioscler Thromb Vasc Biol. 2007;27:2370-6 pubmed
Mateo T, Naim Abu Nabah Y, Losada M, Estell xe9 s R, Company C, Bedrina B, et al. A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles. Blood. 2007;110:1895-902 pubmed
Ponte A, Marais E, Gallay N, Langonne A, Delorme B, Herault O, et al. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells. 2007;25:1737-45 pubmed
Yurchenko E, Tritt M, Hay V, Shevach E, Belkaid Y, Piccirillo C. CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med. 2006;203:2451-60 pubmed
Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek A, Silberstein L. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells. 2006;24:1030-41 pubmed
Carlos C, Dong H, Howard O, Oppenheim J, Hanisch F, Finn O. Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity. J Immunol. 2005;175:1628-35 pubmed
Smith D, Galkina E, Ley K, Huo Y. GRO family chemokines are specialized for monocyte arrest from flow. Am J Physiol Heart Circ Physiol. 2005;289:H1976-84 pubmed
Tadagaki K, Nakano K, Yamanishi K. Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors. J Virol. 2005;79:7068-76 pubmed
Kim M, Day C, Morrison N. MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation. J Biol Chem. 2005;280:16163-9 pubmed
Hirata T, Furukawa Y, Yang B, Hieshima K, Fukuda M, Kannagi R, et al. Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus. J Biol Chem. 2004;279:51775-82 pubmed
Trentin L, Cabrelle A, Facco M, Carollo D, Miorin M, Tosoni A, et al. Homeostatic chemokines drive migration of malignant B cells in patients with non-Hodgkin lymphomas. Blood. 2004;104:502-8 pubmed
Rodr xed guez Frade J, del Real G, Serrano A, Hernanz Falc xf3 n P, Soriano S, Vila Coro A, et al. Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor. EMBO J. 2004;23:66-76 pubmed
Honczarenko M, Le Y, Glodek A, Majka M, Campbell J, Ratajczak M, et al. CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor. Blood. 2002;100:2321-9 pubmed
Zhang L, Soares M, Guan Y, Matheravidathu S, Wnek R, Johnson K, et al. Functional expression and characterization of macaque C-C chemokine receptor 3 (CCR3) and generation of potent antagonistic anti-macaque CCR3 monoclonal antibodies. J Biol Chem. 2002;277:33799-810 pubmed publisher
Azenshtein E, Luboshits G, Shina S, Neumark E, Shahbazian D, Weil M, et al. The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity. Cancer Res. 2002;62:1093-102 pubmed
Tiffany H, Lavigne M, Cui Y, Wang J, Leto T, Gao J, et al. Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain. J Biol Chem. 2001;276:23645-52 pubmed
Aliberti J, Reis e Sousa C, Schito M, Hieny S, Wells T, Huffnagle G, et al. CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells. Nat Immunol. 2000;1:83-7 pubmed
Majka M, Ratajczak J, Lee B, Honczarenko M, Douglas R, Kowalska M, et al. The role of HIV-related chemokine receptors and chemokines in human erythropoiesis in vitro. Stem Cells. 2000;18:128-38 pubmed
Schweickart V, Epp A, Raport C, Gray P. CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. J Biol Chem. 2000;275:9550-6 pubmed
Luboshits G, Shina S, Kaplan O, Engelberg S, Nass D, Lifshitz Mercer B, et al. Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma. Cancer Res. 1999;59:4681-7 pubmed
Kitaura M, Suzuki N, Imai T, Takagi S, Suzuki R, Nakajima T, et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J Biol Chem. 1999;274:27975-80 pubmed
Struyf S, Proost P, Schols D, De Clercq E, Opdenakker G, Lenaerts J, et al. CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3. J Immunol. 1999;162:4903-9 pubmed
Oppermann M, Mack M, Proudfoot A, Olbrich H. Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. J Biol Chem. 1999;274:8875-85 pubmed
Sabroe I, Hartnell A, Jopling L, Bel S, Ponath P, Pease J, et al. Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways. J Immunol. 1999;162:2946-55 pubmed
product information
Product Type :
Protein
Product Name :
Human CCL5 (RANTES) Recombinant Protein, PeproTech
Catalog # :
300-06-20UG
Quantity :
20 ug
Price :
US 227.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
beta-chemokine RANTES; CC chemokine; C-C motif chemokine 5; C-C motif chemokine ligand 5; CCL5; chemokine (C-C motif) ligand 5; D17S136E; EoCP; eosinophil chemotactic cytokine; MGC17164; MuRantes; OTTHUMP00000197106; RANTES; RANTES protein; RANTES(3-68); RANTES(4-68); regulated upon activation normal T-cell expressed and secreted; regulated upon activation, normally T-expressed, and presumably secreted; Scya5; SIS d; SISd; SIS-delta; SISd; small inducible cytokine A5; small inducible cytokine subfamily A (Cys-Cys), member 5; small-inducible cytokine A5; T cell-specific protein P228; T-cell specific protein p288; T-cell-specific protein RANTES; TCP228; Unknown (protein for MGC:127014)
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA