This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Mouse CXCL13 (BLC/BCA-1) Recombinant Protein, PeproTech
catalog :
250-24-50UG
quantity :
50 ug
price :
US 418.00
citations: 28
Reference
Ma L, Yu L, Jiang B, Wang J, Guo X, Huang Y, et al. ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons. J Exp Med. 2021;218: pubmed publisher
Delvecchio F, Fincham R, Spear S, Clear A, Roy Luzarraga M, Balkwill F, et al. Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice. Cell Mol Gastroenterol Hepatol. 2021;12:1543-1565 pubmed publisher
Cruz Z xe1 rate D, L xf3 pez Ortega O, Gir xf3 n P xe9 rez D, Gonzalez Suarez A, Garc xed a Cordero J, Schnoor M, et al. Myo1g is required for efficient adhesion and migration of activated B lymphocytes to inguinal lymph nodes. Sci Rep. 2021;11:7197 pubmed publisher
Shen Y, Zhang Y, Chen L, Du J, Bao H, Xing Y, et al. Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice. J Neuroinflammation. 2020;17:335 pubmed publisher
Shi J, Hou S, Fang Q, Liu X, Liu X, Qi H. PD-1 Controls Follicular T Helper Cell Positioning and Function. Immunity. 2018;49:264-274.e4 pubmed publisher
Kara E, Bastow C, McKenzie D, Gregor C, Fenix K, Babb R, et al. Atypical chemokine receptor 4 shapes activated B cell fate. J Exp Med. 2018;215:801-813 pubmed publisher
Singh K, Davies G, Alenazi Y, Eaton J, Kawamura A, Bhattacharya S. Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities. Sci Rep. 2017;7:4267 pubmed publisher
Wu X, Cao D, Zhang X, Jiang B, Zhao L, Qian B, et al. CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain. Sci Rep. 2016;6:34836 pubmed publisher
Kusuyama J, Komorizono A, Bandow K, Ohnishi T, Matsuguchi T. CXCL3 positively regulates adipogenic differentiation. J Lipid Res. 2016;57:1806-1820 pubmed
Jiang B, Cao D, Zhang X, Zhang Z, He L, Li C, et al. CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. J Clin Invest. 2016;126:745-61 pubmed publisher
Rubtsov A, Rubtsova K, Kappler J, Jacobelli J, Friedman R, Marrack P. CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs. J Immunol. 2015;195:71-9 pubmed publisher
Elgueta R, Marks E, Nowak E, Menezes S, Benson M, Raman V, et al. CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen. J Immunol. 2015;194:505-13 pubmed publisher
Al Shami A, Crisostomo J, Wilkins C, Xu N, Humphries J, Chang W, et al. Integrin-? FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model. J Immunol. 2013;191:3789-98 pubmed publisher
Barrio L, Sáez de Guinoa J, Carrasco Y. TLR4 signaling shapes B cell dynamics via MyD88-dependent pathways and Rac GTPases. J Immunol. 2013;191:3867-75 pubmed publisher
Sáez de Guinoa J, Barrio L, Carrasco Y. Vinculin arrests motile B cells by stabilizing integrin clustering at the immune synapse. J Immunol. 2013;191:2742-51 pubmed publisher
Zhang F, Wei W, Chai H, Xie X. Aurintricarboxylic acid ameliorates experimental autoimmune encephalomyelitis by blocking chemokine-mediated pathogenic cell migration and infiltration. J Immunol. 2013;190:1017-25 pubmed publisher
Zhang H, Zhu Z, Meadows G. Chronic alcohol consumption impairs distribution and compromises circulation of B cells in B16BL6 melanoma-bearing mice. J Immunol. 2012;189:1340-8 pubmed publisher
Kobayashi M, Nakamura K, Cornforth M, Suzuki F. Role of M2b macrophages in the acceleration of bacterial translocation and subsequent sepsis in mice exposed to whole body [137Cs] γ-irradiation. J Immunol. 2012;189:296-303 pubmed publisher
Sáez de Guinoa J, Barrio L, Mellado M, Carrasco Y. CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics. Blood. 2011;118:1560-9 pubmed publisher
Jang I, Cronshaw D, Xie L, Fang G, Zhang J, Oh H, et al. Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction. Proc Natl Acad Sci U S A. 2011;108:7926-31 pubmed publisher
Al Shami A, Wilkins C, Crisostomo J, Seshasayee D, Martin F, Xu N, et al. The adaptor protein Sh2d3c is critical for marginal zone B cell development and function. J Immunol. 2010;185:327-34 pubmed publisher
Guo F, Velu C, Grimes H, Zheng Y. Rho GTPase Cdc42 is essential for B-lymphocyte development and activation. Blood. 2009;114:2909-16 pubmed publisher
Sakthivel S, Singh U, Singh S, Taub D, Novakovic K, Lillard J. CXCL10 blockade protects mice from cyclophosphamide-induced cystitis. J Immune Based Ther Vaccines. 2008;6:6 pubmed publisher
Bahar M, Kenyon J, Putz M, Abrescia N, Pease J, Wise E, et al. Structure and function of A41, a vaccinia virus chemokine binding protein. PLoS Pathog. 2008;4:e5 pubmed publisher
Al Alwan M, Du Q, Hou S, Nashed B, Fan Y, Yang X, et al. Follicular dendritic cell secreted protein (FDC-SP) regulates germinal center and antibody responses. J Immunol. 2007;178:7859-67 pubmed
Ha S, Tsuji M, Suzuki K, Meek B, Yasuda N, Kaisho T, et al. Regulation of B1 cell migration by signals through Toll-like receptors. J Exp Med. 2006;203:2541-50 pubmed
Rubtsov A, Strauch P, Digiacomo A, Hu J, Pelanda R, Torres R. Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response. Immunity. 2005;23:527-38 pubmed
Bowman E, Kuklin N, Youngman K, Lazarus N, Kunkel E, Pan J, et al. The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells. J Exp Med. 2002;195:269-75 pubmed
product information
Product Type :
Protein
Product Name :
Mouse CXCL13 (BLC/BCA-1) Recombinant Protein, PeproTech
Catalog # :
250-24-50UG
Quantity :
50 ug
Price :
US 418.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Mouse
Applications :
Functional Assay: Assay-dependent
Species :
Mouse
Storage :
-20 C
Description :
CXCL13, also known as BCA-1 and Angie, is a small chemokine strongly expressed in the secondary lymphoid organs. It preferentially promotes the migration of B lymphocytes (both B-1 and B-2) to the follicles of the spleen, lymph nodes, and Peyer's patches. It is produced by macrophages, and in mouse the highest constitutive producers include large peritoneal macrophages, Kuppfer cells and lung macrophages (both CD11c+ and CD11c-). The cellular ligand for CXCL13 is CXCR5 also known as BLR-1 (Burkitt’s Lymphoma Receptor 1). CXCR5 is expressed on B cells, Tfh cells and, to a lower degree, some memory T cell populations. CXCL13 plays an important role in the development of chronic lymphocytic leukemia (CCL). CXCL13 is also a plasma biomarker for germinal center activity and generation of broadly neutralizing antibodies against HIV.
Format :
Lyophilized
Applications w/Dilutions :
Functional Assay: Assay-dependent
Aliases :
4631412M08Rik; Angie; ANGIE2; B cell-attracting chemokine 1; b lymphocyte chemoattractant; BCA1; BCA-1; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); BLC; BLR1L; B-lymphocyte chemoattractant; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; chem; chemokine (C-X-C motif) ligand 13; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); CXC; CXC chemokine BLC; CXC motif chemokine; CXC motif chemokine 13; C-X-C motif chemokine 13; C-X-C motif chemokine ligand 13; CXCL; Cxcl13; SCYB13; small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); small inducible cytokine subfamily B (Cys-X-Cys), member 13; small-inducible cytokine B13
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA