This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Mouse CCL3 (MIP-1 alpha) Recombinant Protein, PeproTech
catalog :
250-09-10UG
quantity :
10 ug
price :
US 227.00
citations: 40
Reference
Xiao Y, Cong M, Li J, He D, Wu Q, Tian P, et al. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell. 2021;39:423-437.e7 pubmed publisher
Galeano Niño J, Pageon S, Tay S, Colakoglu F, Kempe D, Hywood J, et al. Cytotoxic T cells swarm by homotypic chemokine signalling. elife. 2020;9: pubmed publisher
He H, Xu P, Zhang X, Liao M, Dong Q, Cong T, et al. Aging-induced IL27Ra signaling impairs hematopoietic stem cells. Blood. 2020;136:183-198 pubmed publisher
Morales Hernández A, Martinat A, Chabot A, Kang G, McKinney Freeman S. Elevated Oxidative Stress Impairs Hematopoietic Progenitor Function in C57BL/6 Substrains. Stem Cell Reports. 2018;11:334-347 pubmed publisher
Zitzer N, Snyder K, Meng X, Taylor P, Efebera Y, Devine S, et al. MicroRNA-155 Modulates Acute Graft-versus-Host Disease by Impacting T Cell Expansion, Migration, and Effector Function. J Immunol. 2018;200:4170-4179 pubmed publisher
Yagawa Y, Robertson Tessi M, Zhou S, Anderson A, MULE J, Mailloux A. Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy. Sci Rep. 2017;7:15996 pubmed publisher
Wang Y, Liu J, Cui J, Sun M, Du W, Chen T, et al. MiR218 Modulates Wnt Signaling in Mouse Cardiac Stem Cells by Promoting Proliferation and Inhibiting Differentiation through a Positive Feedback Loop. Sci Rep. 2016;6:20968 pubmed publisher
Marciniak E, Faivre E, Dutar P, Alves Pires C, Demeyer D, Caillierez R, et al. The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory. Sci Rep. 2015;5:15862 pubmed publisher
Patel J, McNeill E, Douglas G, Hale A, de Bono J, Lee R, et al. RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling. Nat Commun. 2015;6:6614 pubmed publisher
Leong J, Schneider S, Sullivan R, Parikh B, Anthony B, Singh A, et al. PTEN regulates natural killer cell trafficking in vivo. Proc Natl Acad Sci U S A. 2015;112:E700-9 pubmed publisher
Bufe B, Schumann T, Kappl R, Bogeski I, Kummerow C, Podgórska M, et al. Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens. J Biol Chem. 2015;290:7369-87 pubmed publisher
Fulkerson P, Schollaert K, Bouffi C, Rothenberg M. IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation. J Immunol. 2014;193:4043-52 pubmed publisher
Kovács M, Németh T, Jakus Z, Sitaru C, Simon E, Futosi K, et al. The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. J Exp Med. 2014;211:1993-2011 pubmed publisher
Haim Y, Unger N, Souroujon M, Mittelman M, Neumann D. Resistance of LPS-activated bone marrow derived macrophages to apoptosis mediated by dexamethasone. Sci Rep. 2014;4:4323 pubmed publisher
Liou G, Döppler H, Necela B, Krishna M, Crawford H, Raimondo M, et al. Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-?B and MMPs. J Cell Biol. 2013;202:563-77 pubmed publisher
Knolle M, Nakajima T, Hergrueter A, Gupta K, Polverino F, Craig V, et al. Adam8 limits the development of allergic airway inflammation in mice. J Immunol. 2013;190:6434-49 pubmed publisher
Worth A, Metelo J, Bouma G, Moulding D, Fritzsche M, Vernay B, et al. Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration. Blood. 2013;121:72-84 pubmed publisher
Schlecker E, Stojanovic A, Eisen C, Quack C, Falk C, Umansky V, et al. Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth. J Immunol. 2012;189:5602-11 pubmed publisher
Lionakis M, Fischer B, Lim J, Swamydas M, Wan W, Richard Lee C, et al. Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis. PLoS Pathog. 2012;8:e1002865 pubmed publisher
He Z, Zhang H, Yang C, Zhou Y, Zhou Y, Han G, et al. The interaction between different types of activated RAW 264.7 cells and macrophage inflammatory protein-1 alpha. Radiat Oncol. 2011;6:86 pubmed publisher
Kroetz D, Deepe G. An aberrant thymus in CCR5-/- mice is coupled with an enhanced adaptive immune response in fungal infection. J Immunol. 2011;186:5949-55 pubmed publisher
Buatois V, Fagète S, Magistrelli G, Chatel L, Fischer N, Kosco Vilbois M, et al. Pan-CC chemokine neutralization restricts splenocyte egress and reduces inflammation in a model of arthritis. J Immunol. 2010;185:2544-54 pubmed publisher
Blundell M, Bouma G, Metelo J, Worth A, Calle Y, Cowell L, et al. Phosphorylation of WASp is a key regulator of activity and stability in vivo. Proc Natl Acad Sci U S A. 2009;106:15738-43 pubmed publisher
Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka A, et al. Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. J Biol Chem. 2009;284:28599-606 pubmed publisher
Saudemont A, Garcon F, Yadi H, Roche Molina M, Kim N, Segonds Pichon A, et al. p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease. Proc Natl Acad Sci U S A. 2009;106:5795-800 pubmed publisher
Sarantos M, Zhang H, Schaff U, Dixit N, Hayenga H, Lowell C, et al. Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase. J Immunol. 2008;181:8660-9 pubmed
Sakthivel S, Singh U, Singh S, Taub D, Novakovic K, Lillard J. CXCL10 blockade protects mice from cyclophosphamide-induced cystitis. J Immune Based Ther Vaccines. 2008;6:6 pubmed publisher
Zhu Q, Egelston C, Vivekanandhan A, Uematsu S, Akira S, Klinman D, et al. Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines. Proc Natl Acad Sci U S A. 2008;105:16260-5 pubmed publisher
Hsu D, Chernyavsky A, Chen H, Yu L, Grando S, Liu F. Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells. J Invest Dermatol. 2009;129:573-83 pubmed publisher
Liu H, Wen G, Han J, Hong T, Zhuo D, Liu Z, et al. Inhibition of gluconeogenesis in primary hepatocytes by stromal cell-derived factor-1 (SDF-1) through a c-Src/Akt-dependent signaling pathway. J Biol Chem. 2008;283:30642-9 pubmed publisher
Kohlmeier J, Miller S, Smith J, Lu B, Gerard C, Cookenham T, et al. The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections. Immunity. 2008;29:101-13 pubmed publisher
Thompson B, Jin Y, Wu K, Colvin R, Luster A, Birnbaumer L, et al. Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling. J Biol Chem. 2007;282:9547-55 pubmed
Wysocki C, Jiang Q, Panoskaltsis Mortari A, Taylor P, McKinnon K, Su L, et al. Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. Blood. 2005;106:3300-7 pubmed
Weller C, Collington S, Brown J, Miller H, Al Kashi A, Clark P, et al. Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors. J Exp Med. 2005;201:1961-71 pubmed
Jing H, Yen J, Ganea D. A novel signaling pathway mediates the inhibition of CCL3/4 expression by prostaglandin E2. J Biol Chem. 2004;279:55176-86 pubmed
Lillard J, Singh U, Boyaka P, Singh S, Taub D, McGhee J. MIP-1alpha and MIP-1beta differentially mediate mucosal and systemic adaptive immunity. Blood. 2003;101:807-14 pubmed
Wright D, Bowman E, Wagers A, Butcher E, Weissman I. Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med. 2002;195:1145-54 pubmed
Bowman E, Kuklin N, Youngman K, Lazarus N, Kunkel E, Pan J, et al. The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells. J Exp Med. 2002;195:269-75 pubmed
Michalec L, Choudhury B, Postlethwait E, Wild J, Alam R, Lett Brown M, et al. CCL7 and CXCL10 orchestrate oxidative stress-induced neutrophilic lung inflammation. J Immunol. 2002;168:846-52 pubmed
Tager A, Dufour J, Goodarzi K, Bercury S, von Andrian U, Luster A. BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis. J Exp Med. 2000;192:439-46 pubmed
product information
Product Type :
Protein
Product Name :
Mouse CCL3 (MIP-1 alpha) Recombinant Protein, PeproTech
Catalog # :
250-09-10UG
Quantity :
10 ug
Price :
US 227.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Mouse
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Mouse
Storage :
-20 C
Description :
Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
AI323804; C-C motif chemokine 3; C-C motif chemokine ligand 3; CCL3; chemokine (C-C motif) ligand 3; G0/G1 switch regulatory protein 19-1; G0S19-1; Heparin-binding chemotaxis protein; H-MIP-1-alpha; L2G25B; LD78ALPHA; LD78-alpha; LD78-alpha(4-69); Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); macrophage inflammatory protein 1-alpha; macrophage inflammatory protein-1alpha; MIP1 (a); mip1 alpha; MIP-1 alpha; MIP1-(a); MIP1A; MIP-1a; MIP-1alpha; MIP-1-alpha; MIP1-alpha; MIP-1-alpha(4-69); PAT 464.1; RP23-320E6.7; Scya3; SIS-alpha; SIS-beta; small inducible cytokine A3; small inducible cytokine A3 (homologous to mouse Mip-1a); small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein; TY-5
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA