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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Ly-6C Monoclonal Antibody (HK1.4), PE-Cyanine7, eBioscience™
catalog :
25-5932-82
quantity :
100 µg
price :
US 373
clonality :
monoclonal
host :
rat
conjugate :
PE/Cy7
clone name :
HK1.4
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 70
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s3h
Chu C, Murdock M, Jing D, Won T, Chung H, Kressel A, et al. The microbiota regulate neuronal function and fear extinction learning. Nature. 2019;574:543-548 pubmed publisher
  • flow cytometry; mouse
Vila Leahey A, Rogers D, Marshall J. The impact of ranitidine on monocyte responses in the context of solid tumors. Oncotarget. 2016;7:10891-904 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Roffê E, Marino A, Weaver J, Wan W, de Araújo F, Hoffman V, et al. Trypanosoma cruzi Causes Paralyzing Systemic Necrotizing Vasculitis Driven by Pathogen-Specific Type I Immunity in Mice. Infect Immun. 2016;84:1123-1136 pubmed publisher
Toth K, Lénárt N, Berki P, Fekete R, Szabadits E, Pósfai B, et al. The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner. PLoS Biol. 2022;20:e3001526 pubmed publisher
Uhl F, Vanherle L, Matthes F, Meissner A. Therapeutic CFTR Correction Normalizes Systemic and Lung-Specific S1P Level Alterations Associated with Heart Failure. Int J Mol Sci. 2022;23: pubmed publisher
Matei D, Menon M, Alber D, Smith A, Nedjat Shokouhi B, Fasano A, et al. Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease. Med (N Y). 2021;2:864-883.e9 pubmed publisher
Wang B, Li J, Jiao J, Xu M, Luo Y, Wang F, et al. Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response. Aging (Albany NY). 2021;13:18879-18893 pubmed publisher
Delvecchio F, Fincham R, Spear S, Clear A, Roy Luzarraga M, Balkwill F, et al. Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice. Cell Mol Gastroenterol Hepatol. 2021;12:1543-1565 pubmed publisher
Larson Casey J, Gu L, Kang J, Dhyani A, Carter A. NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression. J Biol Chem. 2021;297:100810 pubmed publisher
Liu L, Wu Y, Wang B, Jiang Y, Lin L, Li X, et al. DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization. Cell Death Dis. 2021;12:500 pubmed publisher
Vonderhaar E, Barnekow N, McAllister D, McOlash L, Eid M, Riese M, et al. STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol. 2021;12:41-58 pubmed publisher
Dos Santos L, Torres T, Diniz S, Goncalves R, Caballero Flores G, Nunez G, et al. Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen. Cell Rep. 2021;34:108613 pubmed publisher
Zhao J, Chen S, Zhu L, Zhang L, Liu J, Xu D, et al. Antitumor Effect and Immune Response of Nanosecond Pulsed Electric Fields in Pancreatic Cancer. Front Oncol. 2020;10:621092 pubmed publisher
Zhao Y, Li Z, Su L, Ballesteros Tato A, Katz J, Michalek S, et al. Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection. J Leukoc Biol. 2020;108:1037-1050 pubmed publisher
Clark N, Martinez L, Murdock S, DeLigio J, Olex A, Effi C, et al. Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells. Cell Rep. 2020;33:108482 pubmed publisher
Still K, Batista S, O Brien C, Oyesola O, Früh S, Webb L, et al. Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling. PLoS Pathog. 2020;16:e1009027 pubmed publisher
Wang Z, Zheng G, Li G, Wang M, Ma Z, Li H, et al. Methylprednisolone alleviates multiple sclerosis by expanding myeloid-derived suppressor cells via glucocorticoid receptor β and S100A8/9 up-regulation. J Cell Mol Med. 2020;24:13703-13714 pubmed publisher
Shimada B, Yang Y, Zhu J, Wang S, Suen A, Kronstadt S, et al. Extracellular miR-146a-5p Induces Cardiac Innate Immune Response and Cardiomyocyte Dysfunction. Immunohorizons. 2020;4:561-572 pubmed publisher
Ma C, Yang D, Wang B, Wu C, Wu Y, Li S, et al. Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation. Sci Adv. 2020;6:eaaz6717 pubmed publisher
Feuerstein R, Forde A, Lohrmann F, Kolter J, Ramirez N, Zimmermann J, et al. Resident macrophages acquire innate immune memory in staphylococcal skin infection. elife. 2020;9: pubmed publisher
Patra D, Kim J, Zhang Q, Tycksen E, Sandell L. Site-1 protease ablation in the osterix-lineage in mice results in bone marrow neutrophilia and hematopoietic stem cell alterations. Biol Open. 2020;9: pubmed publisher
Kim E, Woodruff M, Grigoryan L, Maier B, Lee S, Mandal P, et al. Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway. elife. 2020;9: pubmed publisher
Shiuan E, Inala A, Wang S, Song W, Youngblood V, Chen J, et al. Host deficiency in ephrin-A1 inhibits breast cancer metastasis. F1000Res. 2020;9:217 pubmed publisher
Patras K, Coady A, Babu P, Shing S, Ha A, Rooholfada E, et al. Host Cathelicidin Exacerbates Group B Streptococcus Urinary Tract Infection. mSphere. 2020;5: pubmed publisher
Jiang J, Hong L, Lu Y. Effects of Hypertonic Saline and Hydroxyethyl Starch on Myeloid-Derived Suppressor Cells in Hemorrhagic Shock Mice under Secondary Bacterial Attack. Biomed Res Int. 2020;2020:5417201 pubmed publisher
Saclier M, Lapi M, Bonfanti C, Rossi G, Antonini S, Messina G. The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration. Cells. 2020;9: pubmed publisher
Boeck M, Thien A, Wolf J, Hagemeyer N, Laich Y, Yusuf D, et al. Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model. Glia. 2020;68:1859-1873 pubmed publisher
Li X, Yang Y, Qin S, Kong F, Yan C, Cheng W, et al. The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis. BMC Immunol. 2020;21:7 pubmed publisher
Zhang X, Li J, Luo S, Wang M, Huang Q, Deng Z, et al. IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation. Arterioscler Thromb Vasc Biol. 2020;40:597-610 pubmed publisher
Reed Geaghan E, Croxford A, Becher B, Landreth G. Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model. J Exp Med. 2020;217: pubmed publisher
Wang L, Li Y, Wang X, Wang P, Essandoh K, Cui S, et al. GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype. Cells. 2020;9: pubmed publisher
Sidwell T, Liao Y, Garnham A, Vasanthakumar A, Gloury R, Blume J, et al. Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis. Nat Commun. 2020;11:252 pubmed publisher
De Cicco P, Ercolano G, Rubino V, Terrazzano G, Ruggiero G, Cirino G, et al. Modulation of the functions of myeloid-derived suppressor cells : a new strategy of hydrogen sulfide anti-cancer effects. Br J Pharmacol. 2020;177:884-897 pubmed publisher
Larson Casey J, Vaid M, Gu L, He C, Cai G, Ding Q, et al. Increased flux through the mevalonate pathway mediates fibrotic repair without injury. J Clin Invest. 2019;129:4962-4978 pubmed publisher
Martinez L, Robila V, Clark N, Du W, Idowu M, Rutkowski M, et al. Regulatory T Cells Control the Switch From in situ to Invasive Breast Cancer. Front Immunol. 2019;10:1942 pubmed publisher
Hou X, Chen G, Bracamonte Baran W, Choi H, Diny N, Sung J, et al. The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis. Cell Rep. 2019;28:172-189.e7 pubmed publisher
Kotov D, Mitchell J, Pengo T, Ruedl C, Way S, Langlois R, et al. TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2. J Immunol. 2019;202:2535-2545 pubmed publisher
Ren G, Zhang X, Xiao Y, Zhang W, Wang Y, Ma W, et al. ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination. EMBO J. 2019;38: pubmed publisher
Gubernatorova E, Gorshkova E, Namakanova O, Zvartsev R, Hidalgo J, Drutskaya M, et al. Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation. Front Immunol. 2018;9:2718 pubmed publisher
Rolot M, Dougall A, Chetty A, Javaux J, Chen T, Xiao X, et al. Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection. Nat Commun. 2018;9:4516 pubmed publisher
Castaneda D, Dhommée C, Baranek T, Dalloneau E, Lajoie L, Valayer A, et al. Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment. Front Immunol. 2018;9:2259 pubmed publisher
Yi S, Zhai J, Niu R, Zhu G, Wang M, Liu J, et al. Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge. Nat Commun. 2018;9:3879 pubmed publisher
Moreno A, Porchia B, Pagni R, Souza P, Pegoraro R, Rodrigues K, et al. The Combined Use of Melatonin and an Indoleamine 2,3-Dioxygenase-1 Inhibitor Enhances Vaccine-Induced Protective Cellular Immunity to HPV16-Associated Tumors. Front Immunol. 2018;9:1914 pubmed publisher
Patel B, Bansal S, Ismahil M, Hamid T, Rokosh G, Mack M, et al. CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload. JACC Basic Transl Sci. 2018;3:230-244 pubmed publisher
Rijal D, Ariana A, Wight A, Kim K, Alturki N, Aamir Z, et al. Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1. J Biol Chem. 2018;293:11913-11927 pubmed publisher
Jin X, Liu L, Zhang Y, Xiang Y, Yin G, Lu Y, et al. Advanced Glycation End Products Enhance Murine Monocyte Proliferation in Bone Marrow and Prime Them into an Inflammatory Phenotype through MAPK Signaling. J Diabetes Res. 2018;2018:2527406 pubmed publisher
Barnette D, Cahill T, Gunadasa Rohling M, Carr C, Freeman M, Riley P. iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction. JCI Insight. 2018;3: pubmed publisher
Thion M, Low D, Silvin A, Chen J, Grisel P, Schulte Schrepping J, et al. Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner. Cell. 2018;172:500-516.e16 pubmed publisher
Lerman I, Garcia Hernandez M, Rangel Moreno J, Chiriboga L, Pan C, Nastiuk K, et al. Infiltrating Myeloid Cells Exert Protumorigenic Actions via Neutrophil Elastase. Mol Cancer Res. 2017;15:1138-1152 pubmed publisher
Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra A, Gassa A, et al. Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression. Nat Commun. 2017;8:14447 pubmed publisher
Patel B, Ismahil M, Hamid T, Bansal S, Prabhu S. Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure. PLoS ONE. 2017;12:e0170781 pubmed publisher
Liu J, Xue Y, Dong D, Xiao C, Lin C, Wang H, et al. CCR2- and CCR2+ corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion. Mucosal Immunol. 2017;10:1145-1159 pubmed publisher
Lynch T, Ismahil M, Jegga A, Zilliox M, Troidl C, Prabhu S, et al. Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation. J Mol Cell Cardiol. 2017;102:83-93 pubmed publisher
Nalbandian A, Khan A, Srivastava R, Llewellyn K, Tan B, Shukr N, et al. Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy. Inflammation. 2017;40:21-41 pubmed publisher
Kolb R, Phan L, Borcherding N, Liu Y, Yuan F, Janowski A, et al. Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Nat Commun. 2016;7:13007 pubmed publisher
Cantoni C, Cignarella F, Ghezzi L, Mikesell B, Bollman B, Berrien Elliott M, et al. Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Acta Neuropathol. 2017;133:61-77 pubmed publisher
Vila Leahey A, Oldford S, Marignani P, Wang J, Haidl I, Marshall J. Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice. Oncoimmunology. 2016;5:e1151591 pubmed publisher
Menendez C, Jinkins J, Carr D. Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency. J Immunol. 2016;197:1262-75 pubmed publisher
Ochi T, Feng Y, Kitamoto S, Nagao Kitamoto H, Kuffa P, Atarashi K, et al. Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine. Sci Rep. 2016;6:27634 pubmed publisher
Sanders L, Schoenhard J, Saleh M, Mukherjee A, Ryzhov S, McMaster W, et al. BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction. Circ Res. 2016;119:434-49 pubmed publisher
Xu Y, Liu Y, Yang C, Kang L, Wang M, Hu J, et al. Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses. Immunology. 2016;149:157-71 pubmed publisher
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Pflugh D, Maher S, Bothwell A. Ly-6 superfamily members Ly-6A/E, Ly-6C, and Ly-6I recognize two potential ligands expressed by B lymphocytes. J Immunol. 2002;169:5130-6 pubmed
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product information
Product Type :
Antibody
Product Name :
Ly-6C Monoclonal Antibody (HK1.4), PE-Cyanine7, eBioscience™
Catalog # :
25-5932-82
Quantity :
100 µg
Price :
US 373
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.125 µg/test
Species :
Mouse
Clone :
HK1.4
Isotype :
IgG2c, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
Granulocytes are a category of white blood cells characterised by the presence of granules in their cytoplasm. They are also called polymorphonuclear leukocytes (PMN or PML) because of the varying shapes of the nucleus, which is usually lobed into three segments. In common parlance, the term polymorphonuclear leukocyte often refers specifically to neutrophil granulocytes, the most abundant of the granulocytes. Granulocytes or PMN are released from the bone marrow by the regulatory complement proteins.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.125 µg/test
Aliases :
AA682074; AA959465; Ly6c; Ly-6C; Ly6c1; Ly-6C1; Ly6c2; lymphocyte antigen 6 complex, locus C; lymphocyte antigen 6 complex, locus C1; lymphocyte antigen 6C1; Lymphocyte antigen Ly-6C
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA