This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD366 (TIM3) Monoclonal Antibody (RMT3-23), PE-Cyanine7, eBioscience
catalog :
25-5870-80
quantity :
25 ug
price :
US 151.00
clonality :
monoclonal
host :
rat
conjugate :
PE/Cy7
clone name :
RMT3-23

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 24
Reference
Guney M, Nagalekshmi K, McCauley S, Carbone C, Aydemir O, Luban J. IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus. Proc Natl Acad Sci U S A. 2024;121:e2404349121 pubmed publisher
Li W, Zhao C, Li W, Gong Y, Ma K, Lu Y, et al. BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8+ T cell infiltration in colorectal cancer. J Transl Med. 2023;21:737 pubmed publisher
Dan J, Cai J, Zhong Y, Wang C, Huang S, Zeng Y, et al. Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine. Cell Rep Med. 2023;4:101229 pubmed publisher
Chen L, Fan Z, Chang J, Yang R, Hou H, Guo H, et al. Sequence-based drug design as a concept in computational drug design. Nat Commun. 2023;14:4217 pubmed publisher
Canale F, Neumann J, von Renesse J, Loggi E, Pecoraro M, Vogel I, et al. Proteomics of immune cells from liver tumors reveals immunotherapy targets. Cell Genom. 2023;3:100331 pubmed publisher
Liu M, Wang X, Du X, Wu W, Zhang Y, Zhang P, et al. Soluble CTLA-4 mutants ameliorate immune-related adverse events but preserve efficacy of CTLA-4- and PD-1-targeted immunotherapy. Sci Transl Med. 2023;15:eabm5663 pubmed publisher
Cheng H, Qiu Y, Xu Y, Chen L, Ma K, Tao M, et al. Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness. Nat Metab. 2023;5:314-330 pubmed publisher
Palacios L, Peyret V, Viano M, Geysels R, Chocobar Y, Volpini X, et al. TIM3 Expression in Anaplastic-Thyroid-Cancer-Infiltrating Macrophages: An Emerging Immunotherapeutic Target. Biology (Basel). 2022;11: pubmed publisher
Wang W, Wu S, Cen Z, Zhang Y, Chen Y, Huang Y, et al. Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy. Cell Rep. 2022;41:111582 pubmed publisher
Xie F, Zhou X, Su P, Li H, Tu Y, Du J, et al. Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling. Nat Commun. 2022;13:4461 pubmed publisher
Ma K, Sun L, Shen M, Zhang X, Xiao Z, Wang J, et al. Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion. iScience. 2022;25:104347 pubmed publisher
Liu J, Liu Y, Panda S, Liu A, Lei J, Burd I. Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation. Front Immunol. 2021;12:718563 pubmed publisher
Sun Y, Lu D, Yin Y, Song J, Liu Y, Hao W, et al. PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer. Nat Commun. 2021;12:5147 pubmed publisher
Doo D, Meza Perez S, Londoño A, Goldsberry W, Katre A, Boone J, et al. Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer. Ther Adv Med Oncol. 2020;12:1758835920913798 pubmed publisher
Calvo Barreiro L, Eixarch H, Ponce Alonso M, Castillo M, Lebrón Galán R, Mestre L, et al. A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis. Cells. 2020;9: pubmed publisher
Goldsberry W, Meza Perez S, Londoño A, Katre A, Mott B, Roane B, et al. Inhibiting WNT Ligand Production for Improved Immune Recognition in the Ovarian Tumor Microenvironment. Cancers (Basel). 2020;12: pubmed publisher
Del Alcazar D, Wang Y, He C, Wendel B, Del Rio Estrada P, Lin J, et al. Mapping the Lineage Relationship between CXCR5+ and CXCR5- CD4+ T Cells in HIV-Infected Human Lymph Nodes. Cell Rep. 2019;28:3047-3060.e7 pubmed publisher
Jiang H, Shin D, Nguyen T, Fueyo J, Fan X, Henry V, et al. Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas. Clin Cancer Res. 2019;25:6801-6814 pubmed publisher
Hou N, Jiang N, Zou Y, Piao X, Liu S, Li S, et al. Down-Regulation of Tim-3 in Monocytes and Macrophages in Plasmodium Infection and Its Association with Parasite Clearance. Front Microbiol. 2017;8:1431 pubmed publisher
Chen L, Yi X, Goswami S, Ahn Y, Roybal J, Yang Y, et al. Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression. Oncoimmunology. 2016;5:e1234570 pubmed publisher
Hou N, Piao X, Liu S, Wu C, Chen Q. Tim-3 induces Th2-biased immunity and alternative macrophage activation during Schistosoma japonicum infection. Infect Immun. 2015;83:3074-82 pubmed publisher
Chen L, Gibbons D, Goswami S, Cortez M, Ahn Y, Byers L, et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nat Commun. 2014;5:5241 pubmed publisher
Nakayama M, Akiba H, Takeda K, Kojima Y, Hashiguchi M, Azuma M, et al. Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation. Blood. 2009;113:3821-30 pubmed publisher
Guerrero A, Fries B. Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response. Infect Immun. 2008;76:4322-31 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD366 (TIM3) Monoclonal Antibody (RMT3-23), PE-Cyanine7, eBioscience
Catalog # :
25-5870-80
Quantity :
25 ug
Price :
US 151.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 ug/test
Species :
Mouse
Clone :
RMT3-23
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test
Aliases :
CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA