This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Arginase 1 Monoclonal Antibody (A1exF5), PE-Cyanine7, eBioscience
catalog :
25-3697-80
quantity :
25 ug
price :
US 182.00
clonality :
monoclonal
host :
rat
conjugate :
PE/Cy7
clone name :
A1exF5
reactivity :
human, mouse
application :
flow cytometry
citations: 28
Reference
Deng G, Zheng B, Dou M, Gao Y, Zhang X, Niu Z, et al. Scutellarin alleviates renal ischemia-reperfusion injury by inhibiting the MAPK pathway and pro-inflammatory macrophage polarization. FASEB J. 2024;38:e23769 pubmed publisher
Yang J, Xie Y, Xia Z, Ji S, Yang X, Yue D, et al. HucMSC-Exo Induced N2 Polarization of Neutrophils: Implications for Angiogenesis and Tissue Restoration in Wound Healing. Int J Nanomedicine. 2024;19:3555-3575 pubmed publisher
Zimarino C, MOODY W, Davidson S, Munir H, Shields J. Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells. iScience. 2024;27:109546 pubmed publisher
Yang F, Akhtar M, Zhang D, El Mayta R, Shin J, Dorsey J, et al. An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Sci Adv. 2024;10:eadj4678 pubmed publisher
Yang J, Shuai J, Siow L, Lu J, Sun M, An W, et al. MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment. Bone Res. 2024;12:2 pubmed publisher
Liu Y, Zhan Z, Kang Z, Li M, Lv Y, Li S, et al. Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma. Acta Pharm Sin B. 2023;13:4748-4764 pubmed publisher
Bokil A, Le Boulvais B xf8 rkja M, Wolowczyk C, Lamsal A, Prestvik W, Nonstad U, et al. Discovery of a new marker to identify myeloid cells associated with metastatic breast tumours. Cancer Cell Int. 2023;23:279 pubmed publisher
Sheng W, Qin H, Wang T, Zhao J, Fang C, Zhang P, et al. Advanced phosphocreatine-grafted chitosan hydrogel promote wound healing by macrophage modulation. Front Bioeng Biotechnol. 2023;11:1199939 pubmed publisher
Brigo N, Neumaier E, Pfeifhofer Obermair C, Grubwieser P, Engl S, Berger S, et al. Timing of Interleukin-4 Stimulation of Macrophages Determines Their Anti-Microbial Activity during Infection with Salmonella enterica Serovar Typhimurium. Cells. 2023;12: pubmed publisher
Feng L, Luo G, Li Y, Zhang C, Liu Y, Liu Y, et al. Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis. Vet Res. 2023;54:25 pubmed publisher
van Elsas M, Labrie C, Etzerodt A, Charoentong P, van Stigt Thans J, van Hall T, et al. Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy. J Immunother Cancer. 2023;11: pubmed publisher
Li C, Anuraga G, Chang C, Weng T, Hsu H, Ta H, et al. Repurposing nitric oxide donating drugs in cancer therapy through immune modulation. J Exp Clin Cancer Res. 2023;42:22 pubmed publisher
Liao W, Foo H, Tran T, Chai C, Wong W. Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function. Br J Pharmacol. 2023;180:1056-1071 pubmed publisher
Wu H, Liu K, Zhang J. LINC00240/miR-155 axis regulates function of trophoblasts and M2 macrophage polarization via modulating oxidative stress-induced pyroptosis in preeclampsia. Mol Med. 2022;28:119 pubmed publisher
Liu Y, Zhai R, Tong J, Yu Y, Yang L, Gu Y, et al. Angiotensin 1-7 and its analogue decrease blood pressure but aggravate renal damage in preeclamptic mice. Exp Anim. 2022;71:519-528 pubmed publisher
Jung S, Hwang B, Shin S, Park E, Park S, Kim C, et al. Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts. Nat Commun. 2022;13:4580 pubmed publisher
Kremenovic M, Chan A, Feng B, B xe4 riswyl L, Robatel S, Gruber T, et al. BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma. J Immunother Cancer. 2022;10: pubmed publisher
Gao T, Huang F, Wang W, Xie Y, Wang B. Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages. Cell Mol Biol Lett. 2022;27:27 pubmed publisher
Dichtl S, Sanin D, Koss C, Willenborg S, Petzold A, Tanzer M, et al. Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF. Life Sci Alliance. 2022;5: pubmed publisher
Trofimova O, Korotkaja K, Skrastina D, Jansons J, Spunde K, Isaguliants M, et al. Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model. Vaccines (Basel). 2021;9: pubmed publisher
Dichtl S, Lindenthal L, Zeitler L, Behnke K, Schlösser D, Strobl B, et al. Lactate and IL6 define separable paths of inflammatory metabolic adaptation. Sci Adv. 2021;7: pubmed publisher
Nagarajan D, Pearson J, Brentville V, Metheringham R, Pockley A, Durrant L, et al. ImmunoBody®-HAGE derived vaccine induces immunity to HAGE and delays the growth and metastasis of HAGE-expressing tumours in vivo. Immunol Cell Biol. 2021;: pubmed publisher
Hu C, Chu C, Liu L, Wang C, Jin S, Yang R, et al. Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing. Sci Adv. 2021;7: pubmed publisher
Deng J, Tan S, Liu R, Yu W, Chen H, Tang N, et al. Chinese Medicine Formula PSORI-CM02 Alleviates Psoriatic Dermatitis via M-MDSCs and Th17 Crosstalk. Front Pharmacol. 2020;11:563433 pubmed publisher
Hu Q, Peng J, Jiang L, Li W, Su Q, Zhang J, et al. Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma. Cell Death Dis. 2020;11:925 pubmed publisher
Mirando A, Patil A, Rafie C, Christmas B, Pandey N, Stearns V, et al. Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide. Oncoimmunology. 2020;9:1760685 pubmed publisher
Sharma M, Schlegel M, Afonso M, Brown E, RAHMAN K, Weinstock A, et al. Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression. Circ Res. 2020;127:335-353 pubmed publisher
Kurelac I, Iommarini L, Vatrinet R, Amato L, De Luise M, Leone G, et al. Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses. Nat Commun. 2019;10:903 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Arginase 1 Monoclonal Antibody (A1exF5), PE-Cyanine7, eBioscience
Catalog # :
25-3697-80
Quantity :
25 ug
Price :
US 182.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Human, Mouse
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Human, Mouse
Clone :
A1exF5
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.
Immunogen :
E.coli-derived recombinant mouse Arginase 1
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
AI; A-I; AI type I arginase; AI256583; Arg1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA