CD365 (TIM1) Monoclonal Antibody (1D12-TIM1), PE-Cyanine7, eBioscience | Invitrogen 25-3659-41 product information

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product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD365 (TIM1) Monoclonal Antibody (1D12-TIM1), PE-Cyanine7, eBioscience

catalog :

25-3659-41

quantity :

25 Tests

price :

US 178.00

clonality :

monoclonal

host :

mouse

conjugate :

PE/Cy7

clone name :

1D12-TIM1

reactivity :

human

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

CD365 (TIM1) Monoclonal Antibody (1D12-TIM1), PE-Cyanine7, eBioscience

Catalog # :

25-3659-41

Quantity :

25 Tests

Price :

US 178.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.125 ug)/test

Species :

Human

Clone :

1D12-TIM1

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4. In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes. Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity. CD365 has also been implicated in the T cell co-stimulation. CD365 is primarily expressed in epithelial cells. It is also highly expressed in A549, 769-P and Caco-2 and cell lines. CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.

Immunogen :

IgV domain of human CD365

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.125 ug)/test

Aliases :

AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1