product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD279 (PD-1) Monoclonal Antibody (eBioJ105 (J105)), PE-Cyanine7, eBioscience
catalog :
25-2799-42
quantity :
100 Tests
price :
US 426.00
clonality :
monoclonal
host :
mouse
conjugate :
PE/Cy7
clone name :
eBioJ105 (J105)
reactivity :
human, mouse, rhesus macaque
application :
flow cytometry
more info or order :
citations: 37
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig s9b
Weber E, Parker K, Sotillo E, Lynn R, Anbunathan H, Lattin J, et al. Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling. Science. 2021;372: pubmed publisher
  • flow cytometry; human; 1:25; loading ...; fig 1f
Stebegg M, Bignon A, Hill D, Silva Cayetano A, Krueger C, Vanderleyden I, et al. Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination. elife. 2020;9: pubmed publisher
  • flow cytometry; human; fig 1b
  • flow cytometry; mouse; fig 6c
Lynn R, Weber E, Sotillo E, Gennert D, Xu P, Good Z, et al. c-Jun overexpression in CAR T cells induces exhaustion resistance. Nature. 2019;576:293-300 pubmed publisher
  • flow cytometry; human; 1:100; fig 1c
Leclerc M, Voilin E, Gros G, Corgnac S, de Montpreville V, Validire P, et al. Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1. Nat Commun. 2019;10:3345 pubmed publisher
  • flow cytometry; human; loading ...; fig 1a
Hill D, Pierson W, Bolland D, Mkindi C, Carr E, Wang J, et al. The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes. J Exp Med. 2019;: pubmed publisher
Basak D, Mondal S, Srivastava S, Sarkar D, Sarkar I, Basu S, et al. Intratumoral PD1+CD38+Tim3+ CD8+ T Cells in Pre-BCG Tumor Tissues Are Associated with Poor Responsiveness to BCG Immunotherapy in Patients with Non-Muscle Invasive Bladder Cancer. Cells. 2023;12: pubmed publisher
Moncunill G, Carnes J, Chad Young W, Carpp L, De Rosa S, Campo J, et al. Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study. elife. 2022;11: pubmed publisher
Arena A, Stigliano A, Belcastro E, Giorda E, Rosado M, Grossi A, et al. p53 Activation Effect in the Balance of T Regulatory and Effector Cell Subsets in Patients With Thyroid Cancer and Autoimmunity. Front Immunol. 2021;12:728381 pubmed publisher
Singh Y, Trautwein C, Fendel R, Krickeberg N, Berezhnoy G, Bissinger R, et al. SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells. Heliyon. 2021;7:e07147 pubmed publisher
Smith N, Ruiter B, Virkud Y, Tu A, Monian B, Moon J, et al. Identification of antigen-specific TCR sequences based on biological and statistical enrichment in unselected individuals. JCI Insight. 2021;6: pubmed publisher
Corgnac S, Lecluse Y, Mami Chouaib F. Isolation of tumor-resident CD8+ T cells from human lung tumors. STAR Protoc. 2021;2:100267 pubmed publisher
Kim J, Kim S, Shin E, Jung J, Choi H, Jun K. Expression patterns of programmed death-1 and programmed death-1 ligand-1 on T cells in gastric cancer. Oncol Lett. 2019;18:2661-2669 pubmed publisher
Majzner R, Theruvath J, Nellan A, Heitzeneder S, Cui Y, Mount C, et al. CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors. Clin Cancer Res. 2019;25:2560-2574 pubmed publisher
Lee S, Adriani G, Ceccarello E, Pavesi A, Tan A, Bertoletti A, et al. Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model. Front Immunol. 2018;9:416 pubmed publisher
Clarridge K, Blazkova J, Einkauf K, Petrone M, Refsland E, Justement J, et al. Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals. PLoS Pathog. 2018;14:e1006792 pubmed publisher
Eckard A, Rosebush J, Lee S, O Riordan M, Habib J, Daniels J, et al. Increased Immune Activation and Exhaustion in HIV-infected Youth. Pediatr Infect Dis J. 2016;35:e370-e377 pubmed
Hurst J, Hoffmann M, Pace M, Williams J, Thornhill J, Hamlyn E, et al. Immunological biomarkers predict HIV-1 viral rebound after treatment interruption. Nat Commun. 2015;6:8495 pubmed publisher
Chowdhury A, Del Rio Estrada P, Del Rio P, Tharp G, Trible R, Amara R, et al. Decreased T Follicular Regulatory Cell/T Follicular Helper Cell (TFH) in Simian Immunodeficiency Virus-Infected Rhesus Macaques May Contribute to Accumulation of TFH in Chronic Infection. J Immunol. 2015;195:3237-47 pubmed publisher
de Mare Bredemeijer E, Shi X, Mancham S, van Gent R, van der Heide Mulder M, de Boer R, et al. Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen. J Immunol. 2015;195:1838-48 pubmed publisher
Metenou S, Coulibaly Y, Sturdevant D, Dolo H, Diallo A, Soumaoro L, et al. Highly heterogeneous, activated, and short-lived regulatory T cells during chronic filarial infection. Eur J Immunol. 2014;44:2036-47 pubmed publisher
Pen J, Keersmaecker B, Heirman C, Corthals J, Liechtenstein T, Escors D, et al. Interference with PD-L1/PD-1 co-stimulation during antigen presentation enhances the multifunctionality of antigen-specific T cells. Gene Ther. 2014;21:262-71 pubmed publisher
Legat A, Speiser D, Pircher H, Zehn D, Fuertes Marraco S. Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8?T Cells. Front Immunol. 2013;4:455 pubmed publisher
Kim E, Kwun J, Gibby A, Hong J, Farris A, Iwakoshi N, et al. Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. Am J Transplant. 2014;14:59-69 pubmed publisher
Hood S, Mee E, Perkins H, Bowen O, Dale J, Almond N, et al. Changes in immune cell populations in the periphery and liver of GBV-B-infected and convalescent tamarins (Saguinus labiatus). Virus Res. 2014;179:93-101 pubmed publisher
Kenway Lynch C, Das A, Pan D, Lackner A, Pahar B. Dynamics of cytokine/chemokine responses in intestinal CD4+ and CD8+ T Cells during Acute Simian Immunodeficiency Virus Infection. J Virol. 2013;87:11916-23 pubmed publisher
Knol A, Nguyen J, Pandolfino M, Quereux G, Brocard A, Peuvrel L, et al. Tissue biomarkers in melanoma patients treated with TIL. PLoS ONE. 2012;7:e48729 pubmed publisher
Kataoka T, Fujimoto M, Moriyoshi K, Koyanagi I, Ueshima C, Kono F, et al. PD-1 regulates the growth of human mastocytosis cells. Allergol Int. 2013;62:99-104 pubmed publisher
Shaw J, Hunt P, Critchfield J, McConnell D, Garcia J, Pollard R, et al. Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation. AIDS Res Hum Retroviruses. 2013;29:172-7 pubmed publisher
Brenchley J, Vinton C, Tabb B, Hao X, Connick E, Paiardini M, et al. Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections. Blood. 2012;120:4172-81 pubmed publisher
Bandyopadhyay G, Bankey P, Miller Graziano C. Trauma patients' elevated tumor necrosis related apoptosis inducing ligand (TRAIL) contributes to increased T cell apoptosis. Clin Immunol. 2012;145:44-54 pubmed publisher
Kroenke M, Eto D, Locci M, Cho M, Davidson T, Haddad E, et al. Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol. 2012;188:3734-44 pubmed publisher
Jegaskanda S, Reece J, De Rose R, Stambas J, Sullivan L, Brooks A, et al. Comparison of influenza and SIV specific CD8 T cell responses in macaques. PLoS ONE. 2012;7:e32431 pubmed publisher
Klatt N, Vinton C, Lynch R, Canary L, Ho J, Darrah P, et al. SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination. Blood. 2011;118:5803-12 pubmed publisher
Shaw J, Hunt P, Critchfield J, McConnell D, Garcia J, Pollard R, et al. Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers. J Virol. 2011;85:11422-34 pubmed publisher
Kim Y, Park S, Broxmeyer H. Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction. J Immunol. 2011;187:2291-301 pubmed publisher
Vagenas P, Aravantinou M, Williams V, Jasny E, Piatak M, Lifson J, et al. A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation. PLoS ONE. 2010;5:e12891 pubmed publisher
Iwai Y, Okazaki T, Nishimura H, Kawasaki A, Yagita H, Honjo T. Microanatomical localization of PD-1 in human tonsils. Immunol Lett. 2002;83:215-20 pubmed
product information
Product Type :
Antibody
Product Name :
CD279 (PD-1) Monoclonal Antibody (eBioJ105 (J105)), PE-Cyanine7, eBioscience
Catalog # :
25-2799-42
Quantity :
100 Tests
Price :
US 426.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Rhesus Monkey
Applications :
Flow Cytometry: 5 µL (0.5 µg)/test
Species :
Human, Rhesus Monkey
Clone :
eBioJ105 (J105)
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.5 µg)/test
Aliases :
CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA