product summary
Loading...
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD117 (c-Kit) Monoclonal Antibody (2B8), PE-Cyanine7, eBioscience
catalog :
25-1171-81
quantity :
50 ug
price :
US 164.00
clonality :
monoclonal
host :
rat
conjugate :
PE/Cy7
clone name :
2B8
reactivity :
mouse, pigs
application :
flow cytometry
more info or order :
citations: 112
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; fig 3
Jacoby E, Nguyen S, Fountaine T, Welp K, Gryder B, Qin H, et al. CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity. Nat Commun. 2016;7:12320 pubmed publisher
  • flow cytometry; mouse; fig 6
Li N, Yousefi M, Nakauka Ddamba A, Tobias J, Jensen S, Morrisey E, et al. Heterogeneity in readouts of canonical wnt pathway activity within intestinal crypts. Dev Dyn. 2016;245:822-33 pubmed publisher
  • flow cytometry; mouse; loading ...
Leiva M, Quintana J, Ligos J, Hidalgo A. Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability. Nat Commun. 2016;7:10222 pubmed publisher
  • flow cytometry; mouse
Schwartz C, Turqueti Neves A, Hartmann S, Yu P, Nimmerjahn F, Voehringer D. Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion. Proc Natl Acad Sci U S A. 2014;111:E5169-77 pubmed publisher
  • flow cytometry; mouse; fig s1
Becker A, Walcheck B, Bhattacharya D. ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors. Exp Hematol. 2015;43:44-52.e1-3 pubmed publisher
  • flow cytometry; mouse; fig 1
Wu X, Satpathy A, Kc W, Liu P, Murphy T, Murphy K. Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo. PLoS ONE. 2013;8:e64800 pubmed publisher
Chan A, Han L, Delaney C, Wang X, Mukhaleva E, Li M, et al. Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Sci Adv. 2024;10:eadk3127 pubmed publisher
Zhao M, Shao F, Yu D, Zhang J, Liu Z, Ma J, et al. Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis. Nat Commun. 2022;13:7600 pubmed publisher
Rossi G, Giger S, H xfc bscher T, Lutolf M. Gastruloids as in vitro models of embryonic blood development with spatial and temporal resolution. Sci Rep. 2022;12:13380 pubmed publisher
Li J, Li X, Sun W, Zhang J, Yan Q, Wu J, et al. Specific overexpression of SIRT1 in mesenchymal stem cells rescues hematopoiesis niche in BMI1 knockout mice through promoting CXCL12 expression. Int J Biol Sci. 2022;18:2091-2103 pubmed publisher
Lee D, Lee Y, Park S, Park H, Kang H, Kim J. Preventive Effects of a Human Hematopoietic Mesenchymal Stem Cell (hHMSC) Therapy in Ovalbumin-Induced Food Allergy. Biomedicines. 2022;10: pubmed publisher
Leong E, Pang Z, Stadnyk A, Lin T. Calcineurin Aα Contributes to IgE-Dependent Mast-Cell Mediator Secretion in Allergic Inflammation. J Innate Immun. 2022;14:320-334 pubmed publisher
Pattabiraman G, Liu Z, Paul M, Schaeffer A, Thumbikat P. mMCP7, a Mouse Ortholog of δ Tryptase, Mediates Pelvic Tactile Allodynia in a Model of Chronic Pelvic Pain. Front Pain Res (Lausanne). 2021;2:805136 pubmed publisher
Majumdar D, Pietras E, Pawar S. Analysis of Radiation-Induced Changes in Cell Cycle and DNA Damage of Murine Hematopoietic Stem Cells by Multi-Color Flow Cytometry. Curr Protoc. 2021;1:e216 pubmed publisher
Fu Z, Dean J, Xiong L, Dougherty M, Oliff K, Chen Z, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021;12:4462 pubmed publisher
Fang Q, Chen X, Zhang L, Li Y, Sun T, Yang C, et al. The essential roles of Mps1 in spermatogenesis and fertility in mice. Cell Death Dis. 2021;12:531 pubmed publisher
Cardenas R, Gonzalez R, Sanchez E, Ramos M, Cardenas E, Rodarte A, et al. SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis. J Biol Chem. 2021;296:100268 pubmed publisher
Furuyama S, Wu Q, Varnum Finney B, Sandstrom R, Meuleman W, Stamatoyannopoulos J, et al. Inaccessible LCG Promoters Act as Safeguards to Restrict T Cell Development to Appropriate Notch Signaling Environments. Stem Cell Reports. 2021;16:717-726 pubmed publisher
van den Berk P, Lancini C, Company C, Serresi M, Sanchez Bailon M, Hulsman D, et al. USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells. Cell Rep. 2020;33:108533 pubmed publisher
Hong Y, Singh N, Bamopoulos S, Gjerga E, Schmalbrock L, Balabanian K, et al. Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System. Biomedicines. 2020;8: pubmed publisher
Darzianiazizi M, Mehrani Y, Chan L, Mould R, Kulkarni R, Sharif S, et al. Type I Interferon α/β Receptor-Mediated Signaling Negatively Regulates Antiviral Cytokine Responses in Murine Bone-Marrow-Derived Mast Cells and Protects the Cells from Virus-Induced Cell Death. Int J Mol Sci. 2020;21: pubmed publisher
Hohsfield L, Najafi A, Ghorbanian Y, Soni N, Hingco E, Kim S, et al. Effects of long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells in the CNS. J Neuroinflammation. 2020;17:279 pubmed publisher
Sch xf6 pp T, Zoch A, Berrens R, Auchynnikava T, Kabayama Y, Vasiliauskait x117 L, et al. TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing. Nat Commun. 2020;11:3739 pubmed publisher
Shen C, Sheng Y, Zhu A, Robinson S, Jiang X, Dong L, et al. RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia. Cell Stem Cell. 2020;27:64-80.e9 pubmed publisher
Morales Torres C, Wu M, Hobor S, Wainwright E, Martin M, Patel H, et al. Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis. Nat Commun. 2020;11:1792 pubmed publisher
Zheng Y, Wang N, Wang S, Yang B, Situ H, Zhong L, et al. XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling. Cell Commun Signal. 2020;18:48 pubmed publisher
Dege C, Fegan K, Creamer J, Berrien Elliott M, Luff S, Kim D, et al. Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development. Dev Cell. 2020;53:229-239.e7 pubmed publisher
Ge Y, Miao Y, Gur Cohen S, Gomez N, Yang H, Nikolova M, et al. The aging skin microenvironment dictates stem cell behavior. Proc Natl Acad Sci U S A. 2020;117:5339-5350 pubmed publisher
Ho Y, del Toro R, Rivera Torres J, Rak J, Korn C, García García A, et al. Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging. Cell Stem Cell. 2019;25:407-418.e6 pubmed publisher
Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella J, Corneau S, et al. Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia. Cancer Cell. 2019;36:84-99.e8 pubmed publisher
Ng K, Yui M, Mehta A, Siu S, Irwin B, Pease S, et al. A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment. elife. 2018;7: pubmed publisher
Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, et al. Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation. Stem Cell Reports. 2018;11:988-997 pubmed publisher
Moretti F, Klapproth S, Ruppert R, Margraf A, Weber J, Pick R, et al. Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus. elife. 2018;7: pubmed publisher
Potůčková L, Dráberová L, Hálová I, Paulenda T, Draber P. Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein. Front Immunol. 2018;9:1771 pubmed publisher
Xu C, Gao X, Wei Q, Nakahara F, Zimmerman S, Mar J, et al. Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow. Nat Commun. 2018;9:2449 pubmed publisher
Lam J, van den Bosch M, Wegrzyn J, Parker J, Ibrahim R, Slowski K, et al. miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling. Nat Commun. 2018;9:2418 pubmed publisher
Schmidt K, Zhang Q, Tasdogan A, Petzold A, Dahl A, Arneth B, et al. The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice. elife. 2018;7: pubmed publisher
Kim S, Knight D, Jones L, Vervoort S, Ng A, Seymour J, et al. JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias. Genes Dev. 2018;32:849-864 pubmed publisher
Vasiliauskaite L, Berrens R, Ivanova I, Carrieri C, Reik W, Enright A, et al. Defective germline reprogramming rewires the spermatogonial transcriptome. Nat Struct Mol Biol. 2018;25:394-404 pubmed publisher
Yamamoto R, Wilkinson A, Ooehara J, Lan X, Lai C, Nakauchi Y, et al. Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment. Cell Stem Cell. 2018;22:600-607.e4 pubmed publisher
Bergiers I, Andrews T, Vargel Bölükbaşı Ö, Buness A, Janosz E, Lopez Anguita N, et al. Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis. elife. 2018;7: pubmed publisher
Alzubi J, Pallant C, Mussolino C, Howe S, Thrasher A, Cathomen T. Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model. Sci Rep. 2017;7:12475 pubmed publisher
Wang S, Xia P, Chen Y, Qu Y, Xiong Z, Ye B, et al. Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation. Cell. 2017;171:201-216.e18 pubmed publisher
Hewitt K, Katsumura K, Matson D, Devadas P, Tanimura N, Hebert A, et al. GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia. Dev Cell. 2017;42:213-225.e4 pubmed publisher
Kawasaki T, Ito K, Miyata H, Akira S, Kawai T. Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice. EMBO J. 2017;36:1707-1718 pubmed publisher
Vasiliauskaite L, Vitsios D, Berrens R, Carrieri C, Reik W, Enright A, et al. A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming. Nat Struct Mol Biol. 2017;24:604-606 pubmed publisher
Redgrave R, Tual Chalot S, Davison B, Singh E, Hall D, Amirrasouli M, et al. Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis. Stem Cell Reports. 2017;8:1287-1298 pubmed publisher
Ge Y, Gomez N, Adam R, Nikolova M, Yang H, Verma A, et al. Stem Cell Lineage Infidelity Drives Wound Repair and Cancer. Cell. 2017;169:636-650.e14 pubmed publisher
Hérault A, Binnewies M, Leong S, Calero Nieto F, Zhang S, Kang Y, et al. Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis. Nature. 2017;544:53-58 pubmed publisher
Douam F, Hrebikova G, Albrecht Y, Sellau J, Sharon Y, Ding Q, et al. Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome. Nat Commun. 2017;8:14781 pubmed publisher
Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez N, Birbrair A, et al. Differential cytokine contributions of perivascular haematopoietic stem cell niches. Nat Cell Biol. 2017;19:214-223 pubmed publisher
Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, et al. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. J Clin Invest. 2016;126:4537-4553 pubmed publisher
Abdel Malik R, Zippel N, Frömel T, Heidler J, Zukunft S, Walzog B, et al. AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis. Circ Res. 2017;120:99-109 pubmed publisher
Bellio M, Rodrigues C, Landin A, Hatzistergos K, Kuznetsov J, Florea V, et al. Physiological and hypoxic oxygen concentration differentially regulates human c-Kit+ cardiac stem cell proliferation and migration. Am J Physiol Heart Circ Physiol. 2016;311:H1509-H1519 pubmed publisher
Shi Y, Wu W, Chai Q, Li Q, Hou Y, Xia H, et al. LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration. Nat Commun. 2016;7:12369 pubmed publisher
Jonas B, Johnson C, Gratzinger D, Majeti R. Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity. PLoS ONE. 2016;11:e0159189 pubmed publisher
Li N, Nakauka Ddamba A, Tobias J, Jensen S, Lengner C. Mouse Label-Retaining Cells Are Molecularly and Functionally Distinct From Reserve Intestinal Stem Cells. Gastroenterology. 2016;151:298-310.e7 pubmed publisher
Mian Y, Zeleznik Le N. The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1. Leuk Res. 2016;46:51-60 pubmed publisher
Pietras E, Mirantes Barbeito C, Fong S, Loeffler D, Kovtonyuk L, Zhang S, et al. Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal. Nat Cell Biol. 2016;18:607-18 pubmed publisher
Carofino B, Ayanga B, Tracey L, Brooke Bisschop T, Justice M. PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL. Biol Open. 2016;5:645-53 pubmed publisher
Bambousková M, Polakovičová I, Hálová I, Goel G, Dráberová L, Bugajev V, et al. New Regulatory Roles of Galectin-3 in High-Affinity IgE Receptor Signaling. Mol Cell Biol. 2016;36:1366-82 pubmed publisher
Crisan M, Solaimani Kartalaei P, Neagu A, Karkanpouna S, Yamada Inagawa T, Purini C, et al. BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo. Stem Cell Reports. 2016;6:383-95 pubmed publisher
Thoms J, Knezevic K, Liu J, Glaros E, Thai T, Qiao Q, et al. Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr. Mol Cell Biol. 2016;36:1222-36 pubmed publisher
Liu J, Fu T, Song F, Xue Y, Xia C, Liu P, et al. Mast Cells Participate in Corneal Development in Mice. Sci Rep. 2015;5:17569 pubmed publisher
Ge Y, Zhang L, Nikolova M, Reva B, Fuchs E. Strand-specific in vivo screen of cancer-associated miRNAs unveils a role for miR-21(∗) in SCC progression. Nat Cell Biol. 2016;18:111-21 pubmed publisher
Johnson K, Kong G, Gao X, Chang Y, Hewitt K, Sanalkumar R, et al. Cis-regulatory mechanisms governing stem and progenitor cell transitions. Sci Adv. 2015;1:e1500503 pubmed publisher
Acar M, Kocherlakota K, Murphy M, Peyer J, Oguro H, Inra C, et al. Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal. Nature. 2015;526:126-30 pubmed publisher
Zoch A, Mayerl S, Schulz A, Greither T, Frappart L, Rübsam J, et al. Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation. PLoS ONE. 2015;10:e0129151 pubmed publisher
Balasubramani A, Larjo A, Bassein J, Chang X, Hastie R, Togher S, et al. Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex. Nat Commun. 2015;6:7307 pubmed publisher
Grajales Reyes G, Iwata A, Albring J, Wu X, Tussiwand R, Kc W, et al. Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor. Nat Immunol. 2015;16:708-17 pubmed publisher
Giannou A, Marazioti A, Spella M, Kanellakis N, Apostolopoulou H, Psallidas I, et al. Mast cells mediate malignant pleural effusion formation. J Clin Invest. 2015;125:2317-34 pubmed publisher
Bruns I, Lucas D, Pinho S, Ahmed J, Lambert M, Kunisaki Y, et al. Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nat Med. 2014;20:1315-20 pubmed publisher
Hodgkinson C, Gomez J, Payne A, Zhang L, Wang X, Dal Pra S, et al. Abi3bp regulates cardiac progenitor cell proliferation and differentiation. Circ Res. 2014;115:1007-16 pubmed publisher
Xia P, Wang S, Huang G, Zhu P, Li M, Ye B, et al. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med. 2014;211:2119-34 pubmed publisher
Saiman Y, Jiao J, Fiel M, Friedman S, Aloman C, Bansal M. Inhibition of the CXCL12/CXCR4 chemokine axis with AMD3100, a CXCR4 small molecule inhibitor, worsens murine hepatic injury. Hepatol Res. 2015;45:794-803 pubmed publisher
Ito K, Yamazaki S, Yamamoto R, Tajima Y, Yanagida A, Kobayashi T, et al. Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice. J Biol Chem. 2014;289:29892-911 pubmed publisher
Duong K, Das S, Yu S, Barr J, Jena S, Kim E, et al. Identification of hematopoietic-specific regulatory elements from the CD45 gene and use for lentiviral tracking of transplanted cells. Exp Hematol. 2014;42:761-72.e1-10 pubmed publisher
Gilmour J, Assi S, Jaegle U, Kulu D, van de Werken H, Clarke D, et al. A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification. Development. 2014;141:2391-401 pubmed publisher
Lin Q, Wesson R, Maeda H, Wang Y, Cui Z, Liu J, et al. Pharmacological mobilization of endogenous stem cells significantly promotes skin regeneration after full-thickness excision: the synergistic activity of AMD3100 and tacrolimus. J Invest Dermatol. 2014;134:2458-2468 pubmed publisher
Bakocevic N, Claser C, Yoshikawa S, Jones L, Chew S, Goh C, et al. CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections. Eur J Immunol. 2014;44:1823-34 pubmed publisher
Jiao J, Dragomir A, Kocabayoglu P, Rahman A, Chow A, Hashimoto D, et al. Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils. J Immunol. 2014;192:3374-82 pubmed publisher
Ramkumar C, Kong Y, Trabucco S, Gerstein R, Zhang H. Smurf2 regulates hematopoietic stem cell self-renewal and aging. Aging Cell. 2014;13:478-86 pubmed publisher
Honarpour N, Rose C, Brumbaugh J, Anderson J, Graham R, Sweredoski M, et al. F-box protein FBXL16 binds PP2A-B55? and regulates differentiation of embryonic stem cells along the FLK1+ lineage. Mol Cell Proteomics. 2014;13:780-91 pubmed publisher
Agudo J, Ruzo A, Tung N, Salmon H, Leboeuf M, Hashimoto D, et al. The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids. Nat Immunol. 2014;15:54-62 pubmed publisher
Kabata H, Moro K, Fukunaga K, Suzuki Y, Miyata J, Masaki K, et al. Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation. Nat Commun. 2013;4:2675 pubmed publisher
Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, et al. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature. 2013;502:637-43 pubmed publisher
Carofino B, Ayanga B, Justice M. A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech. 2013;6:1494-506 pubmed publisher
Lucas D, Scheiermann C, Chow A, Kunisaki Y, Bruns I, Barrick C, et al. Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration. Nat Med. 2013;19:695-703 pubmed publisher
Zhang Y, Yang P, Sun T, Li D, Xu X, Rui Y, et al. miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol. 2013;15:284-94 pubmed publisher
Bunting M, Comerford I, Seach N, Hammett M, Asquith D, Korner H, et al. CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity. Blood. 2013;121:118-28 pubmed publisher
Dahlin J, Feinstein R, Cui Y, Heyman B, Hallgren J. CD11c+ cells are required for antigen-induced increase of mast cells in the lung. J Immunol. 2012;189:3869-77 pubmed publisher
Manta C, Heupel E, Radulovic K, Rossini V, Garbi N, Riedel C, et al. CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium. Mucosal Immunol. 2013;6:177-88 pubmed publisher
Koyano Nakagawa N, Kweon J, Iacovino M, Shi X, Rasmussen T, Borges L, et al. Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Stem Cells. 2012;30:1611-23 pubmed publisher
Balkhi M, Willette Brown J, Zhu F, Chen Z, Liu S, Guttridge D, et al. IKK?-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 2012;119:5467-77 pubmed publisher
Gu P, Min J, Wang Y, Huang C, Peng T, Chai W, et al. CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J. 2012;31:2309-21 pubmed publisher
Agrawal V, Siu B, Chao H, Hirschi K, Raborn E, Johnson S, et al. Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation. Tissue Eng Part A. 2012;18:1454-63 pubmed publisher
Purtha W, Swiecki M, Colonna M, Diamond M, Bhattacharya D. Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses. Proc Natl Acad Sci U S A. 2012;109:E898-904 pubmed publisher
Zisa D, Shabbir A, Mastri M, Taylor T, Aleksic I, McDaniel M, et al. Intramuscular VEGF activates an SDF1-dependent progenitor cell cascade and an SDF1-independent muscle paracrine cascade for cardiac repair. Am J Physiol Heart Circ Physiol. 2011;301:H2422-32 pubmed publisher
Wang Y, Shen M, Chang S. Essential roles for Pot1b in HSC self-renewal and survival. Blood. 2011;118:6068-77 pubmed publisher
Zuber J, Shi J, Wang E, Rappaport A, Herrmann H, Sison E, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011;478:524-8 pubmed publisher
Heinonen K, Vanegas J, Lew D, Krosl J, Perreault C. Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway. PLoS ONE. 2011;6:e19279 pubmed publisher
Cook B, Liu S, Evans T. Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment. Blood. 2011;117:6489-97 pubmed publisher
Piconese S, Costanza M, Musio S, Tripodo C, Poliani P, Gri G, et al. Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient Kit W-sh/W-sh mice. Lab Invest. 2011;91:627-41 pubmed publisher
Laronda M, Jameson J. Sox3 functions in a cell-autonomous manner to regulate spermatogonial differentiation in mice. Endocrinology. 2011;152:1606-15 pubmed publisher
Jung Y, Shiozawa Y, Wang J, Patel L, Havens A, Song J, et al. Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche. Exp Hematol. 2011;39:151-166.e1 pubmed publisher
Varney M, Buchanan J, Dementieva Y, Hardman W, Sollars V. A high omega-3 fatty acid diet has different effects on early and late stage myeloid progenitors. Lipids. 2011;46:47-57 pubmed publisher
Morita Y, Ema H, Nakauchi H. Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J Exp Med. 2010;207:1173-82 pubmed publisher
Edelson B, Kc W, Juang R, Kohyama M, Benoit L, Klekotka P, et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J Exp Med. 2010;207:823-36 pubmed publisher
Benveniste P, Frelin C, Janmohamed S, Barbara M, Herrington R, Hyam D, et al. Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential. Cell Stem Cell. 2010;6:48-58 pubmed publisher
Shabbir A, Zisa D, Suzuki G, Lee T. Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol. 2009;296:H1888-97 pubmed publisher
Singh P, Yao Y, Weliver A, Broxmeyer H, Hong S, Chang C. Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow. Stem Cells. 2008;26:1009-16 pubmed publisher
Wen R, Chen Y, Bai L, Fu G, Schuman J, Dai X, et al. Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis. Mol Cell Biol. 2006;26:9364-76 pubmed
product information
Product Type :
Antibody
Product Name :
CD117 (c-Kit) Monoclonal Antibody (2B8), PE-Cyanine7, eBioscience
Catalog # :
25-1171-81
Quantity :
50 ug
Price :
US 164.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse, Porcine
Applications :
Flow Cytometry: 1 ug/test
Species :
Mouse, Porcine
Clone :
2B8
Isotype :
IgG2b, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test
Aliases :
belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA