product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD86 (B7-2) Monoclonal Antibody (GL1), PE-Cyanine7, eBioscience™
catalog :
25-0862-80
quantity :
25µg
price :
98.25 USD
clonality :
monoclonal
host :
rat
conjugate :
PE/Cy7
clone name :
GL1
reactivity :
human, mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 30
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig s4b
Sabol R, Bowles A, Côté A, Wise R, O Donnell B, Matossian M, et al. Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models. Breast Cancer Res. 2019;21:67 pubmed publisher
Fenninger F, Han J, Stanwood S, Nohara L, Arora H, Choi K, et al. Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction. Front Immunol. 2019;10:2473 pubmed publisher
Fujii S, Yoshida S, Inagaki E, Hatou S, Tsubota K, Takahashi M, et al. Immunological properties of neural crest cells derived from human induced pluripotent stem cells. Stem Cells Dev. 2018;: pubmed publisher
Kim H, Mun Y, Lee K, Park Y, Park J, Park J, et al. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat Commun. 2018;9:3630 pubmed publisher
Guo M, Xiao J, Sheng X, Zhang X, Tie Y, Wang L, et al. Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE-/- Mice by Skewing Macrophages to the M2 Phenotype. Front Pharmacol. 2018;9:464 pubmed publisher
Lee S, Shi X, Fan A, West B, Zhang J. Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain. Mol Pain. 2018;14:1744806918764979 pubmed publisher
Pan Y, Yu Y, Lin C, Lanier L, Chu C. Fc?RI ?-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells. Front Immunol. 2017;8:1424 pubmed publisher
Wang J, Gao Z, Qin S, Liu C, Zou L. Calreticulin is an effective immunologic adjuvant to tumor-associated antigens. Exp Ther Med. 2017;14:3399-3406 pubmed publisher
Wang J, Dai X, Hsu C, Ming C, He Y, Zhang J, et al. Discrimination of the heterogeneity of bone marrow‑derived dendritic cells. Mol Med Rep. 2017;16:6787-6793 pubmed publisher
Yang K, Xu C, Zhang Y, He S, Li D. Sestrin2 Suppresses Classically Activated Macrophages-Mediated Inflammatory Response in Myocardial Infarction through Inhibition of mTORC1 Signaling. Front Immunol. 2017;8:728 pubmed publisher
Grotzke J, Kozik P, Morel J, Impens F, Pietrosemoli N, Cresswell P, et al. Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export. Proc Natl Acad Sci U S A. 2017;114:E5910-E5919 pubmed publisher
Li C, Ying W, Huang Z, Brehm T, Morin A, Vella A, et al. IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages. Endocrinology. 2017;158:2837-2847 pubmed publisher
Hellström Erkenstam N, Smith P, Fleiss B, Nair S, Svedin P, Wang W, et al. Temporal Characterization of Microglia/Macrophage Phenotypes in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury. Front Cell Neurosci. 2016;10:286 pubmed publisher
Zhou Z, Tang Y, Jin X, Chen C, Lu Y, Liu L, et al. Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NF?B Pathway Suppression. J Diabetes Res. 2016;2016:4847812 pubmed
Li J, DU Y, Yan Z, Yan J, Zhuansun Y, Chen R, et al. CD80 and CD86 knockdown in dendritic cells regulates Th1/Th2 cytokine production in asthmatic mice. Exp Ther Med. 2016;11:878-884 pubmed
Xu X, Gao Y, Zhai Z, Zhang S, Shan F, Feng J. Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS. Hum Vaccin Immunother. 2016;12:2169-2180 pubmed
Lund L, Ingmer H, Frøkiær H. D-Alanylation of Teichoic Acids and Loss of Poly-N-Acetyl Glucosamine in Staphylococcus aureus during Exponential Growth Phase Enhance IL-12 Production in Murine Dendritic Cells. PLoS ONE. 2016;11:e0149092 pubmed publisher
Roberts R, Eitas T, Byrne J, Johnson B, Short P, McKinnon K, et al. Towards programming immune tolerance through geometric manipulation of phosphatidylserine. Biomaterials. 2015;72:1-10 pubmed publisher
Bencherif S, Warren Sands R, Ali O, Li W, Lewin S, Braschler T, et al. Injectable cryogel-based whole-cell cancer vaccines. Nat Commun. 2015;6:7556 pubmed publisher
Huang L, Kong Y, Wang J, Sun J, Shi Q, Qiu Y. Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway. Mol Med Rep. 2015;12:4187-4195 pubmed publisher
Kim J, Li W, Choi Y, Lewin S, Verbeke C, Dranoff G, et al. Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy. Nat Biotechnol. 2015;33:64-72 pubmed publisher
Qin Q, Wang Z, Pan P, Cao Z, Xia Q, Tan H, et al. Lung dendritic cells undergo maturation and polarization towards a T helper type 2-stimulating phenotype in a mouse model of asthma: Role of nerve growth factor. Exp Ther Med. 2014;8:1402-1408 pubmed
Bakhru P, Sirisaengtaksin N, Soudani E, Mukherjee S, Khan A, Jagannath C. BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9. Cell Immunol. 2014;287:53-61 pubmed publisher
Wang S, Wu B, Xue J, Wang M, Chen R, Wang B. Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge. Hum Vaccin Immunother. 2014;10:461-8 pubmed publisher
Kannan V, Brouwer N, Hanisch U, Regen T, Eggen B, Boddeke H. Histone deacetylase inhibitors suppress immune activation in primary mouse microglia. J Neurosci Res. 2013;91:1133-42 pubmed publisher
Choi J, Cheong T, Ha N, Ko Y, Cho C, Jeon J, et al. Orientia tsutsugamushi subverts dendritic cell functions by escaping from autophagy and impairing their migration. PLoS Negl Trop Dis. 2013;7:e1981 pubmed publisher
Chen Z, Zhang T, Li H, Chen F, Zou X, Ji J, et al. Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite. PLoS ONE. 2013;8:e51268 pubmed publisher
Kamphuis T, Meijerhof T, Stegmann T, Lederhofer J, Wilschut J, de Haan A. Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice. PLoS ONE. 2012;7:e36812 pubmed publisher
Vallerskog T, Martens G, Kornfeld H. Diabetic mice display a delayed adaptive immune response to Mycobacterium tuberculosis. J Immunol. 2010;184:6275-82 pubmed publisher
Lee S, Park Y, So T, Kwon B, Cheroutre H, Mittler R, et al. Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat Immunol. 2008;9:917-26 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD86 (B7-2) Monoclonal Antibody (GL1), PE-Cyanine7, eBioscience™
Catalog # :
25-0862-80
Quantity :
25µg
Price (USD) :
98.25 USD
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test
Species :
Mouse
Clone :
GL1
Isotype :
IgG2a, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance. CD80 appears to play a role distinct from CD80 in T helper cell differentiation. CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms of CD86. Additional transcript variants have been described for CD86, but their full-length sequences have not been determined. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test
Aliases :
Activation B7-2 antigen; B7; B7.2; B70; B7-2; B-lymphocyte activation antigen B7-2; BU63; Cd28l2; CD28LG2; CD86; CD86 antigen; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CD86 antigen precursor; CD86 molecule; CLS1; CTLA-4 counter-receptor B7.2; early T cell costimulatory molecule-1; early T-cell costimulatory molecule 1; ETC-1; FUN-1; LAB72; Ly58; Ly-58; MB7; MB7-2; membrane glycoprotein; MGC34413; T-lymphocyte activation antigen CD86; TS/A-2
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA