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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD33 Monoclonal Antibody (WM-53 (WM53)), PE-Cyanine7, eBioscience
catalog :
25-0338-42
quantity :
100 Tests
price :
US 402.00
clonality :
monoclonal
host :
mouse
conjugate :
PE/Cy7
clone name :
WM-53 (WM53)
reactivity :
human
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 30
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; fig 5
Kyttälä A, Moraghebi R, Valensisi C, Kettunen J, Andrus C, Pasumarthy K, et al. Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential. Stem Cell Reports. 2016;6:200-12 pubmed publisher
Wan Y, Mu X, Zhao J, Li L, Xu W, Zhang M. Myeloid‑derived suppressor cell accumulation induces Treg expansion and modulates lung malignancy progression. Biomed Rep. 2024;20:68 pubmed publisher
Zhou J, Wang H, Shu T, Wang J, Yang W, Li J, et al. Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis. iScience. 2023;26:107626 pubmed publisher
Weidenauer K, Schmidt C, Rohde C, Pauli C, Blank M, Heid D, et al. The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia. Leukemia. 2023;: pubmed publisher
Jianyi D, Haili G, Bo Y, Meiqin Y, Baoyou H, Haoran H, et al. Myeloid-derived suppressor cells cross-talk with B10 cells by BAFF/BAFF-R pathway to promote immunosuppression in cervical cancer. Cancer Immunol Immunother. 2023;72:73-85 pubmed publisher
Gabriely G, Ma D, Siddiqui S, Sun L, Skillin N, Abou El Hassan H, et al. Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells. iScience. 2021;24:103347 pubmed publisher
Hudec M, Riegerov xe1 K, Pala J, K xfa tna V, x10c ern xe1 M, O Leary V. Celiac Disease Defined by Over-Sensitivity to Gliadin Activation and Superior Antigen Presentation of Dendritic Cells. Int J Mol Sci. 2021;22: pubmed publisher
Ni H, Zhang L, Huang H, Dai S, Li J. Connecting METTL3 and intratumoural CD33+ MDSCs in predicting clinical outcome in cervical cancer. J Transl Med. 2020;18:393 pubmed publisher
Zhang C, Huang D, Baloche V, Zhang L, Xu J, Li B, et al. Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation. Oncogenesis. 2020;9:65 pubmed publisher
Lin K, Rutter J, Xie A, Pardieu B, Winn E, Bello R, et al. Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer. Nat Genet. 2020;52:408-417 pubmed publisher
Suzuki D, Flahou C, Yoshikawa N, Stirblyte I, Hayashi Y, Sawaguchi A, et al. iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity. Stem Cell Reports. 2020;14:49-59 pubmed publisher
Hough K, Trevor J, Strenkowski J, Wang Y, Chacko B, Tousif S, et al. Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells. Redox Biol. 2018;18:54-64 pubmed publisher
Hanazawa A, Ito R, Katano I, Kawai K, Goto M, Suemizu H, et al. Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice. Front Immunol. 2018;9:152 pubmed publisher
Fenouille N, Bassil C, Ben Sahra I, Benajiba L, Alexe G, Ramos A, et al. The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia. Nat Med. 2017;23:301-313 pubmed publisher
Pathangey L, McCurry D, Gendler S, Dominguez A, Gorman J, Pathangey G, et al. Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens. Oncotarget. 2017;8:10785-10808 pubmed publisher
Dabas R, Lee R, Servito M, Dharmani Khan P, Modi M, van Slyke T, et al. Antithymocyte Globulin at Clinically Relevant Concentrations Kills Leukemic Blasts. Biol Blood Marrow Transplant. 2016;22:815-24 pubmed publisher
Stockklausner C, Raffel S, Klermund J, Bandapalli O, Beier F, Brümmendorf T, et al. A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition. Aging (Albany NY). 2015;7:911-27 pubmed
Breton G, Lee J, Liu K, Nussenzweig M. Defining human dendritic cell progenitors by multiparametric flow cytometry. Nat Protoc. 2015;10:1407-22 pubmed publisher
Pallett L, Gill U, Quaglia A, Sinclair L, Jover Cobos M, Schurich A, et al. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Nat Med. 2015;21:591-600 pubmed publisher
Lathrop S, Binder K, Starr T, Cooper K, Chong A, Carmody A, et al. Replication of Salmonella enterica Serovar Typhimurium in Human Monocyte-Derived Macrophages. Infect Immun. 2015;83:2661-71 pubmed publisher
Koba C, Haruta M, Matsunaga Y, Matsumura K, Haga E, Sasaki Y, et al. Therapeutic effect of human iPS-cell-derived myeloid cells expressing IFN-? against peritoneally disseminated cancer in xenograft models. PLoS ONE. 2013;8:e67567 pubmed publisher
Carnevale J, Ross L, Puissant A, Banerji V, Stone R, DeAngelo D, et al. SYK regulates mTOR signaling in AML. Leukemia. 2013;27:2118-28 pubmed publisher
Cloke T, Munder M, Taylor G, Muller I, Kropf P. Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infection. PLoS ONE. 2012;7:e48939 pubmed publisher
Radomska H, Alberich Jorda M, Will B, Gonzalez D, Delwel R, Tenen D. Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBP?. J Clin Invest. 2012;122:2955-66 pubmed publisher
Braunstein I, Goodman N, Rosenbach M, Okawa J, Shah A, Krathen M, et al. Lenalidomide therapy in treatment-refractory cutaneous lupus erythematosus: histologic and circulating leukocyte profile and potential risk of a systemic lupus flare. J Am Acad Dermatol. 2012;66:571-82 pubmed publisher
Zhang H, Zhao C, Li X, Zhu Y, Gan C, Wang Y, et al. Study of monocyte membrane proteome perturbation during lipopolysaccharide-induced tolerance using iTRAQ-based quantitative proteomic approach. Proteomics. 2010;10:2780-9 pubmed publisher
Shamsasenjan K, Otsuyama K, Abroun S, Iqbal M, Mahmoud M, Asaoku H, et al. IL-6-induced activation of MYC is responsible for the down-regulation of CD33 expression in CD33+ myeloma cells. Int J Hematol. 2009;89:310-318 pubmed publisher
Schenk M, Bouchon A, Seibold F, Mueller C. TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Invest. 2007;117:3097-106 pubmed
McCully M, Chau T, Luke P, Blake P, Madrenas J. Characterization of human peritoneal dendritic cell precursors and their involvement in peritonitis. Clin Exp Immunol. 2005;139:513-25 pubmed
Schenk M, Bouchon A, Birrer S, Colonna M, Mueller C. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J Immunol. 2005;174:517-24 pubmed
product information
Product Type :
Antibody
Product Name :
CD33 Monoclonal Antibody (WM-53 (WM53)), PE-Cyanine7, eBioscience
Catalog # :
25-0338-42
Quantity :
100 Tests
Price :
US 402.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.25 ug)/test
Species :
Human
Clone :
WM-53 (WM53)
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. CD33 is also expressed on, and is a useful marker for, peripheral monocytes. CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD43 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.25 ug)/test
Aliases :
CD33; CD33 antigen; CD33 antigen (gp67); CD33 molecule; CD33 molecule transcript; FLJ00391; gp67; Myeloid cell surface antigen CD33; p67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC3; Siglec-3
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA