product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD21/CD35 Monoclonal Antibody (eBio8D9 (8D9)), PE-Cyanine7, eBioscience
catalog :
25-0211-82
quantity :
100 µg
price :
US 386
clonality :
monoclonal
host :
rat
conjugate :
PE/Cy7
clone name :
eBio8D9 (8D9)
reactivity :
mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 15
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 3a
Panda S, Facchinetti V, Voynova E, Hanabuchi S, Karnell J, Hanna R, et al. Galectin-9 inhibits TLR7-mediated autoimmunity in murine lupus models. J Clin Invest. 2018;128:1873-1887 pubmed publisher
  • flow cytometry; mouse; tbl s3
Pannu J, Belle J, Forster M, Duerr C, Shen S, Kane L, et al. Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation. PLoS ONE. 2015;10:e0117304 pubmed publisher
Jones D, Gaudette B, Wilmore J, Chernova I, Bortnick A, Weiss B, et al. mTOR has distinct functions in generating versus sustaining humoral immunity. J Clin Invest. 2016;126:4250-4261 pubmed publisher
Shrestha S, Noh J, Kim S, Ham H, Kim Y, Yun Y, et al. Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of neutrophils toward an antitumor phenotype. Oncoimmunology. 2016;5:e1067744 pubmed
Donius L, Orlando C, Weis J, Weis J. Generation of a novel Cr2 gene allele by homologous recombination that abrogates production of Cr2 but is sufficient for expression of Cr1. Immunobiology. 2014;219:53-63 pubmed publisher
Stolp J, Marino E, Batten M, Sierro F, Cox S, Grey S, et al. Intrinsic molecular factors cause aberrant expansion of the splenic marginal zone B cell population in nonobese diabetic mice. J Immunol. 2013;191:97-109 pubmed publisher
Donius L, Handy J, Weis J, Weis J. Optimal germinal center B cell activation and T-dependent antibody responses require expression of the mouse complement receptor Cr1. J Immunol. 2013;191:434-47 pubmed publisher
Biswas P, Kang K, Gupta S, Bhagat G, Pernis A. A murine autoimmune model of rheumatoid arthritis and systemic lupus erythematosus associated with deregulated production of IL-17 and IL-21. Methods Mol Biol. 2012;900:233-51 pubmed publisher
Maseda D, Smith S, DiLillo D, Bryant J, Candando K, Weaver C, et al. Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo. J Immunol. 2012;188:1036-48 pubmed publisher
Cox S, Stolp J, Hallahan N, Counotte J, Zhang W, Serreze D, et al. Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a ?-cell neo-self-antigen in type 1 diabetes prone NOD mice. Eur J Immunol. 2010;40:3413-25 pubmed publisher
DeKoter R, Geadah M, Khoosal S, Xu L, Thillainadesan G, Torchia J, et al. Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C. J Immunol. 2010;185:7374-84 pubmed publisher
Roundy K, Jacobson A, Weis J, Weis J. The in vitro derivation of phenotypically mature and diverse B cells from immature spleen and bone marrow precursors. Eur J Immunol. 2010;40:1139-49 pubmed publisher
Treese C, Mittag A, Lange F, Tarnok A, Loesche A, Emmrich F, et al. Characterization of fibroblasts responsible for cartilage destruction in arthritis. Cytometry A. 2008;73:351-60 pubmed publisher
Chen X, Esplin B, Garrett K, Welner R, Webb C, Kincade P. Retinoids accelerate B lineage lymphoid differentiation. J Immunol. 2008;180:138-45 pubmed
Kozono Y, Abe R, Kozono H, Kelly R, Azuma T, Holers V. Cross-linking CD21/CD35 or CD19 increases both B7-1 and B7-2 expression on murine splenic B cells. J Immunol. 1998;160:1565-72 pubmed
product information
Product Type :
Antibody
Product Name :
CD21/CD35 Monoclonal Antibody (eBio8D9 (8D9)), PE-Cyanine7, eBioscience
Catalog # :
25-0211-82
Quantity :
100 µg
Price :
US 386
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.125 µg/test
Species :
Mouse
Clone :
eBio8D9 (8D9)
Isotype :
IgG2a, lambda
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD35 encodes a membrane glycoprotein found on peripheral blood cells, glomerular podocytes, and follicular dendritic cells. The protein is a receptor for complement components C3b and C4b and regulates the activity of the complement cascade. Variation in this protein is the basis of the Knops blood group system. The two most common alleles, F and S, differ by 8 exons and are thought to be the result of an unequal crossover event. A secreted form of the protein present in plasma has been described, but its full length nature has not been determined.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.125 µg/test
Aliases :
C3b/C4b receptor; C3-binding protein; C3DR; CD21; CD35; CD35 antigen; Complement C3d receptor; complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; complement receptor 2; complement receptor type 1; complement receptor type 2; CR; Cr1; Cr-1; Cr2; Cr-2; CVID7; EBV receptor; Epstein-Barr virus receptor; expressed in B lymphocytes; SLEB9
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA