product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD4 Monoclonal Antibody (GK1.5), PE-Cyanine7, eBioscience™
catalog :
25-0041-81
quantity :
50 µg
price :
US 153
clonality :
monoclonal
host :
rat
conjugate :
PE/Cy7
clone name :
GK1.5
reactivity :
mouse
application :
flow cytometry, other
more info or order :
citations: 210
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:1000; loading ...; fig 3b, 3c
Cao S, Hung Y, Wang Y, Chung Y, Qi Y, Ouyang C, et al. Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors. Theranostics. 2022;12:6038-6056 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4e
Luoni M, Giannelli S, Indrigo M, Niro A, Massimino L, Iannielli A, et al. Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse
Cowan J, McCarthy N, Parnell S, White A, Bacon A, Serge A, et al. Differential requirement for CCR4 and CCR7 during the development of innate and adaptive ??T cells in the adult thymus. J Immunol. 2014;193:1204-12 pubmed publisher
  • flow cytometry; mouse
Dupont C, Christian D, Selleck E, Pepper M, Leney Greene M, Harms Pritchard G, et al. Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii. PLoS Pathog. 2014;10:e1004047 pubmed publisher
  • flow cytometry; mouse
Chognard G, Bellemare L, Pelletier A, Domínguez Punaro M, Beauchamp C, Guyon M, et al. The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation. PLoS ONE. 2014;9:e89092 pubmed publisher
  • other; mouse; fig 5
  • flow cytometry; mouse; fig 5
Koning J, Kooij G, de Vries H, Nolte M, Mebius R. Mesenchymal stem cells are mobilized from the bone marrow during inflammation. Front Immunol. 2013;4:49 pubmed publisher
Clubb J, Kudling T, Girych M, Haybout L, Pakola S, Hamdan F, et al. Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting. Front Immunol. 2023;14:1060540 pubmed publisher
Su C, Zhong Y, Zhao G, Hou J, Zhang S, Wang B. RSV pre-fusion F protein enhances the G protein antibody and anti-infectious responses. NPJ Vaccines. 2022;7:168 pubmed publisher
Hodgson R, Xu X, Anzilotti C, Deobagkar Lele M, Crockford T, Kepple J, et al. NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance. Commun Biol. 2022;5:1216 pubmed publisher
Chen J, Deng J, Zemans R, Bahmed K, Kosmider B, Zhang M, et al. Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection. Nat Commun. 2022;13:6759 pubmed publisher
Lamb T, Muthumalage T, Meehan Atrash J, Rahman I. Nose-Only Exposure to Cherry- and Tobacco-Flavored E-Cigarettes Induced Lung Inflammation in Mice in a Sex-Dependent Manner. Toxics. 2022;10: pubmed publisher
Chowdhury S, Kar A, Bhowmik D, Gautam A, Basak D, Sarkar I, et al. Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8+ T Cells. Cancer Res. 2022;82:2640-2655 pubmed publisher
Wu G, Murugesan G, Nagala M, McCraw A, Haslam S, Dell A, et al. Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses. Wellcome Open Res. 2021;6:134 pubmed publisher
Park J, Oladunni F, Rohaim M, Whittingham Dowd J, Tollitt J, Hodges M, et al. Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2. iScience. 2021;24:102941 pubmed publisher
Hamdan F, Ylösmäki E, Chiaro J, Giannoula Y, Long M, Fusciello M, et al. Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids. J Immunother Cancer. 2021;9: pubmed publisher
Deng J, Zhang B, Chu H, Wang X, Wang Y, Gong H, et al. Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampening protective immunity. EBioMedicine. 2021;70:103505 pubmed publisher
Yl xf6 sm xe4 ki E, Fusciello M, Martins B, Feola S, Hamdan F, Chiaro J, et al. Novel personalized cancer vaccine platform based on Bacillus Calmette-Guèrin. J Immunother Cancer. 2021;9: pubmed publisher
Devenport S, Singhal R, Radyk M, Taranto J, Kerk S, Chen B, et al. Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress. JCI Insight. 2021;6: pubmed publisher
Quixabeira D, Zafar S, Santos J, Cervera Carrascon V, Havunen R, Kudling T, et al. Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control. Front Immunol. 2021;12:674400 pubmed publisher
Amobi McCloud A, Muthuswamy R, Battaglia S, Yu H, Liu T, Wang J, et al. IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation. Front Immunol. 2021;12:678999 pubmed publisher
Glassman C, Su L, Majri Morrison S, Winkelmann H, Mo F, Li P, et al. Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist. elife. 2021;10: pubmed publisher
Steinbuck M, Seenappa L, Jakubowski A, McNeil L, Haqq C, Demuth P. A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2. Sci Adv. 2021;7: pubmed publisher
Sanmarco L, Wheeler M, Gutiérrez Vázquez C, Polonio C, Linnerbauer M, Pinho Ribeiro F, et al. Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021;: pubmed publisher
Still K, Batista S, O Brien C, Oyesola O, Früh S, Webb L, et al. Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling. PLoS Pathog. 2020;16:e1009027 pubmed publisher
Mao L, Zhou Y, Chen L, Hu L, Liu S, Zheng W, et al. Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury. Cell Biosci. 2020;10:121 pubmed publisher
Browning L, Miller C, Kuczma M, Pietrzak M, Jing Y, Rempala G, et al. Bone Morphogenic Proteins Are Immunoregulatory Cytokines Controlling FOXP3+ Treg Cells. Cell Rep. 2020;33:108219 pubmed publisher
Pierini S, Tanyi J, Simpkins F, George E, Uribe Herranz M, Drapkin R, et al. Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target. JCI Insight. 2020;5: pubmed publisher
Wang Q, Sundar I, Li D, Lucas J, Muthumalage T, McDonough S, et al. E-cigarette-Induced Pulmonary Inflammation and Dysregulated Repair are Mediated by nAChR α7 Receptor: Role of nAChR α7 in ACE2 Covid-19 receptor regulation. Res Sq. 2020;: pubmed publisher
Jiang X, DUDZINSKI S, Beckermann K, Young K, McKinley E, J McIntyre O, et al. MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy. J Immunother Cancer. 2020;8: pubmed publisher
Wang Q, Sundar I, Li D, Lucas J, Muthumalage T, McDonough S, et al. E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation. Respir Res. 2020;21:154 pubmed publisher
Yoon C, Ryu J, Hwang H, Kim M. Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model. Int J Mol Sci. 2020;21: pubmed publisher
Kroeger C, Roesler R, Wiese S, Hainzl A, Gatzka M. Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors. Int J Mol Sci. 2020;21: pubmed publisher
Wei Q, Nakahara F, Asada N, Zhang D, Gao X, Xu C, et al. Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression. Dev Cell. 2020;53:503-513.e5 pubmed publisher
Kim K, Ryu J, Ko J, Kim J, Kim H, Lee H, et al. FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress. Cell Death Dis. 2020;11:285 pubmed publisher
Aegerter H, Kulikauskaite J, Crotta S, Patel H, Kelly G, Hessel E, et al. Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection. Nat Immunol. 2020;21:145-157 pubmed publisher
Ciecko A, Foda B, Barr J, Ramanathan S, Atkinson M, Serreze D, et al. Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation. Cell Rep. 2019;29:3073-3086.e5 pubmed publisher
Walker J, Clark P, Crisp A, Barlow J, Szeto A, Ferreira A, et al. Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow. Immunity. 2019;: pubmed publisher
Yue W, Chen L, Yu L, Zhou B, Yin H, Ren W, et al. Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice. Nat Commun. 2019;10:2025 pubmed publisher
Nakahara F, Borger D, Wei Q, Pinho S, Maryanovich M, Zahalka A, et al. Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells. Nat Cell Biol. 2019;21:560-567 pubmed publisher
Devorkin L, Pavey N, Carleton G, Comber A, Ho C, Lim J, et al. Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity. Cell Rep. 2019;27:502-513.e5 pubmed publisher
Łyszkiewicz M, Winter S, Witzlau K, Föhse L, Brownlie R, Puchałka J, et al. miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity. PLoS Biol. 2019;17:e2006716 pubmed publisher
Zwick M, Ulas T, Cho Y, Ried C, Grosse L, Simon C, et al. Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells. Front Immunol. 2019;10:222 pubmed publisher
Ramakrishnan S, Zhang H, Ma X, Jung I, Schwartz A, Triner D, et al. Intestinal non-canonical NFκB signaling shapes the local and systemic immune response. Nat Commun. 2019;10:660 pubmed publisher
Tomaru U, Konno S, Miyajima S, Kimoto R, Onodera M, Kiuchi S, et al. Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells. Cell Rep. 2019;26:639-651.e2 pubmed publisher
Rojas O, Pröbstel A, Porfilio E, Wang A, Charabati M, Sun T, et al. Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10. Cell. 2019;176:610-624.e18 pubmed publisher
Ng K, Yui M, Mehta A, Siu S, Irwin B, Pease S, et al. A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment. elife. 2018;7: pubmed publisher
Lee S, Park K, Kim J, Min H, Seong R. Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments. EMBO Rep. 2018;19: pubmed publisher
Castaneda D, Dhommée C, Baranek T, Dalloneau E, Lajoie L, Valayer A, et al. Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment. Front Immunol. 2018;9:2259 pubmed publisher
Teo T, Lum F, Ghaffar K, Chan Y, Amrun S, Tan J, et al. Plasmodium co-infection protects against chikungunya virus-induced pathologies. Nat Commun. 2018;9:3905 pubmed publisher
Lian G, Gnanaprakasam J, Wang T, Wu R, Chen X, Liu L, et al. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. elife. 2018;7: pubmed publisher
Yu L, Yang F, Zhang F, Guo D, Li L, Wang X, et al. CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production. Cell Death Dis. 2018;9:905 pubmed publisher
McCall C, Zabalawi M, Liu T, Martin A, Long D, Buechler N, et al. Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival. JCI Insight. 2018;3: pubmed publisher
Halim T, Rana B, Walker J, Kerscher B, Knolle M, Jolin H, et al. Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells. Immunity. 2018;48:1195-1207.e6 pubmed publisher
Maryanovich M, Zahalka A, Pierce H, Pinho S, Nakahara F, Asada N, et al. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. Nat Med. 2018;24:782-791 pubmed publisher
Emmerson A, Trevelin S, Mongue Din H, Becker P, Ortiz C, Smyth L, et al. Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling. J Clin Invest. 2018;128:3088-3101 pubmed publisher
Pang P, Zheng K, Wu S, Xü H, Deng L, Shi Y, et al. Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis. Evid Based Complement Alternat Med. 2018;2018:4923062 pubmed publisher
Stüve P, Minarrieta L, Erdmann H, Arnold Schrauf C, Swallow M, Guderian M, et al. De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages. Front Immunol. 2018;9:495 pubmed publisher
O Reilly L, Putoczki T, Mielke L, Low J, Lin A, Preaudet A, et al. Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner. Immunity. 2018;48:570-583.e8 pubmed publisher
Quinn J, Kumar G, Agasing A, Ko R, Axtell R. Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation. Front Immunol. 2018;9:382 pubmed publisher
Xu Y, Ikeda S, Sumida K, Yamamoto R, Tanaka H, Minato N. Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells. Nat Commun. 2018;9:914 pubmed publisher
Lim D, Kim W, Lee C, Bae H, Kim J. Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung. Front Physiol. 2018;9:47 pubmed publisher
Li M, Gao J, Tang Y, Liu M, Wu S, Qu K, et al. Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells. Front Pharmacol. 2017;8:959 pubmed publisher
Quach D, Collins F, Parameswaran N, McCabe L, Britton R. Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice. mSphere. 2018;3: pubmed publisher
Linde N, Casanova Acebes M, Sosa M, Mortha A, Rahman A, Farias E, et al. Macrophages orchestrate breast cancer early dissemination and metastasis. Nat Commun. 2018;9:21 pubmed publisher
Min M, Yan B, Wang P, Landeck L, Chen J, Li W, et al. Rottlerin as a therapeutic approach?in psoriasis: Evidence from in vitro and in vivo studies. PLoS ONE. 2017;12:e0190051 pubmed publisher
Coelho M, de Carné Trécesson S, Rana S, Zecchin D, Moore C, Molina Arcas M, et al. Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA. Immunity. 2017;47:1083-1099.e6 pubmed publisher
Zhu D, Tan J, Maleken A, Muljadi R, Chan S, Lau S, et al. Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury. Stem Cell Res Ther. 2017;8:257 pubmed publisher
Chu F, Hu Y, Zhou Y, Guo M, Lu J, Zheng W, et al. MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway. Clin Exp Immunol. 2017;: pubmed publisher
Marsden M, Loy B, Wu X, Ramirez C, Schrier A, Murray D, et al. In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication. PLoS Pathog. 2017;13:e1006575 pubmed publisher
Azzam K, Madenspacher J, Cain D, Lai L, Gowdy K, Rai P, et al. Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces. JCI Insight. 2017;2: pubmed publisher
Tischner D, Grimm M, Kaur H, Staudenraus D, Carvalho J, Looso M, et al. Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation. JCI Insight. 2017;2: pubmed publisher
Ma J, Teng X, Wang X, Fan X, Wu Y, Tian M, et al. A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation. EBioMedicine. 2017;22:143-154 pubmed publisher
Cortes Perez N, Lozano Ojalvo D, Maiga M, Hazebrouck S, Adel Patient K. Intragastric administration of Lactobacillus casei BL23 induces regulatory FoxP3+ROR?t+ T cells subset in mice. Benef Microbes. 2017;8:433-438 pubmed publisher
Shigemoto Kuroda T, Oh J, Kim D, Jeong H, Park S, Lee H, et al. MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis. Stem Cell Reports. 2017;8:1214-1225 pubmed publisher
Pols T, Puchner T, Korkmaz H, Vos M, Soeters M, de Vries C. Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor. PLoS ONE. 2017;12:e0176715 pubmed publisher
Miao T, Symonds A, Singh R, Symonds J, Ogbe A, Omodho B, et al. Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation. J Exp Med. 2017;214:1787-1808 pubmed publisher
Cabezas Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer F, et al. Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy. Cell. 2017;169:807-823.e19 pubmed publisher
Viladomiu M, Bassaganya Riera J, Tubau Juni N, Kronsteiner B, Leber A, Philipson C, et al. Cooperation of Gastric Mononuclear Phagocytes with Helicobacter pylori during Colonization. J Immunol. 2017;198:3195-3204 pubmed publisher
Hensel J, Khattar V, Ashton R, Lee C, Siegal G, Ponnazhagan S. Location of tumor affects local and distant immune cell type and number. Immun Inflamm Dis. 2017;5:85-94 pubmed publisher
Huang R, Francois A, McGray A, Miliotto A, Odunsi K. Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer. Oncoimmunology. 2017;6:e1249561 pubmed publisher
Zamarin D, Holmgaard R, Ricca J, Plitt T, Palese P, Sharma P, et al. Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity. Nat Commun. 2017;8:14340 pubmed publisher
Berlato C, Khan M, Schioppa T, Thompson R, Maniati E, Montfort A, et al. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer. J Clin Invest. 2017;127:801-813 pubmed publisher
Engler J, Kursawe N, Solano M, Patas K, Wehrmann S, Heckmann N, et al. Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy. Proc Natl Acad Sci U S A. 2017;114:E181-E190 pubmed publisher
Zhou Y, Weng X, Dou R, Tan X, Zhang T, Fang J, et al. Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice. Acta Pharmacol Sin. 2017;38:201-210 pubmed publisher
Jones D, Gaudette B, Wilmore J, Chernova I, Bortnick A, Weiss B, et al. mTOR has distinct functions in generating versus sustaining humoral immunity. J Clin Invest. 2016;126:4250-4261 pubmed publisher
Chudnovskiy A, Mortha A, Kana V, Kennard A, Ramírez J, Rahman A, et al. Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome. Cell. 2016;167:444-456.e14 pubmed publisher
Gerriets V, Kishton R, Johnson M, Cohen S, Siska P, Nichols A, et al. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nat Immunol. 2016;17:1459-1466 pubmed publisher
Zhang S, Liu X, Mei L, Wang H, Fang F. Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice. BMC Complement Altern Med. 2016;16:334 pubmed publisher
Gurung H, Carr M, Carr D. Cornea lymphatics drive the CD8+ T-cell response to herpes simplex virus-1. Immunol Cell Biol. 2017;95:87-98 pubmed publisher
Ma J, Tian M, Fan X, Yu Q, Jing Y, Wang W, et al. Mycobacterium tuberculosis multistage antigens confer comprehensive protection against pre- and post-exposure infections by driving Th1-type T cell immunity. Oncotarget. 2016;7:63804-63815 pubmed publisher
Yoon J, Leyva Castillo J, Wang G, Galand C, Oyoshi M, Kumar L, et al. IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016;213:2147-66 pubmed publisher
Lund A, Wagner M, Fankhauser M, Steinskog E, Broggi M, Spranger S, et al. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. J Clin Invest. 2016;126:3389-402 pubmed publisher
Jonas B, Johnson C, Gratzinger D, Majeti R. Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity. PLoS ONE. 2016;11:e0159189 pubmed publisher
Herbin O, Regelmann A, Ramkhelawon B, Weinstein E, Moore K, Alexandropoulos K. Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1. Arterioscler Thromb Vasc Biol. 2016;36:1791-801 pubmed publisher
Seedhom M, Hickman H, Wei J, David A, Yewdell J. Protein Translation Activity: A New Measure of Host Immune Cell Activation. J Immunol. 2016;197:1498-506 pubmed publisher
Ben Shoshan S, Kagan P, Sultan M, Barabash Z, Dor C, Jacob Hirsch J, et al. ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis. RNA Biol. 2017;14:587-602 pubmed publisher
Menendez C, Jinkins J, Carr D. Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency. J Immunol. 2016;197:1262-75 pubmed publisher
Brinkman C, Iwami D, Hritzo M, Xiong Y, Ahmad S, Simon T, et al. Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration. Nat Commun. 2016;7:12021 pubmed publisher
Gu L, Deng W, Sun X, Zhou H, Xu Q. Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance. Mol Med Rep. 2016;14:1153-61 pubmed publisher
Chou T, Chuang Y, Hsieh W, Chang P, Liu H, Mo S, et al. Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1? for Th17 suppression. Nat Commun. 2016;7:11904 pubmed publisher
Ochi T, Feng Y, Kitamoto S, Nagao Kitamoto H, Kuffa P, Atarashi K, et al. Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine. Sci Rep. 2016;6:27634 pubmed publisher
Xu Y, Liu Y, Yang C, Kang L, Wang M, Hu J, et al. Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses. Immunology. 2016;149:157-71 pubmed publisher
Ruhland M, Loza A, Capietto A, Luo X, Knolhoff B, Flanagan K, et al. Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis. Nat Commun. 2016;7:11762 pubmed publisher
Choi I, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, et al. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep. 2016;15:2136-2146 pubmed publisher
Alrefai H, Muhammad K, Rudolf R, Pham D, Klein Hessling S, Patra A, et al. NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells. Nat Commun. 2016;7:11724 pubmed publisher
Anderson S, Shane H, Long C, Lukomska E, Meade B, Marshall N. Evaluation of the irritancy and hypersensitivity potential following topical application of didecyldimethylammonium chloride. J Immunotoxicol. 2016;13:557-66 pubmed publisher
Schleicher U, Paduch K, Debus A, Obermeyer S, König T, Kling J, et al. TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection. Cell Rep. 2016;15:1062-1075 pubmed publisher
Carofino B, Ayanga B, Tracey L, Brooke Bisschop T, Justice M. PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL. Biol Open. 2016;5:645-53 pubmed publisher
Wang S, Gao X, Shen G, Wang W, Li J, Zhao J, et al. Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity. Sci Rep. 2016;6:24249 pubmed publisher
Meininger I, Griesbach R, Hu D, Gehring T, Seeholzer T, Bertossi A, et al. Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells. Nat Commun. 2016;7:11292 pubmed publisher
Lee S, Hong S, Verma V, Lee Y, Duong T, Jeong K, et al. Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer. Oncoimmunology. 2016;5:e1081328 pubmed
Romano A, Hou X, Sertorio M, Dessein H, Cabantous S, Oliveira P, et al. FOXP3+ Regulatory T Cells in Hepatic Fibrosis and Splenomegaly Caused by Schistosoma japonicum: The Spleen May Be a Major Source of Tregs in Subjects with Splenomegaly. PLoS Negl Trop Dis. 2016;10:e0004306 pubmed publisher
Pallangyo C, Ziegler P, Greten F. IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis. J Exp Med. 2015;212:2253-66 pubmed publisher
Chukkapalli S, Velsko I, Rivera Kweh M, Zheng D, Lucas A, Kesavalu L. Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoE null Mice. PLoS ONE. 2015;10:e0143291 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD4 Monoclonal Antibody (GK1.5), PE-Cyanine7, eBioscience™
Catalog # :
25-0041-81
Quantity :
50 µg
Price :
US 153
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test
Species :
Mouse
Clone :
GK1.5
Isotype :
IgG2b, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test
Aliases :
CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 receptor; CD4, allele 1; cd4a; CD4mut; cell surface glycoprotein CD4; fCD4; L3T4; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); W3/25; W3/25 antigen
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA