This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Mouse IL-7 Recombinant Protein, PeproTech
catalog :
217-17-50UG
quantity :
50 ug
price :
US 722.00
citations: 367
Reference
Schapfl M, LoMastro G, Braun V, Hirai M, Levine M, Kiermaier E, et al. Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity. Nat Commun. 2024;15:8890 pubmed publisher
Silva Cayetano A, Fra Bido S, Robert P, Innocentin S, Burton A, Watson E, et al. Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging. Nat Immunol. 2023;24:1124-1137 pubmed publisher
xc5 kerstrand H, Boldrin E, Montano G, Vanhee S, Olsson K, Krausse N, et al. Enhanced protein synthesis is a defining requirement for neonatal B cell development. Front Immunol. 2023;14:1130930 pubmed publisher
Feng X, Sun R, Lee M, Chen X, Guo S, Geng H, et al. Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling. elife. 2023;12: pubmed publisher
Jiang X, Deng W, Tao S, Tang Z, Chen Y, Tian M, et al. A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma. Cell Discov. 2023;9:7 pubmed publisher
Lee M, Geitgey D, Hamilton J, Boss J, Scharer C, Spangle J, et al. Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs. Front Cell Dev Biol. 2022;10:909557 pubmed publisher
Wang L, Noyer L, Wang Y, Tao A, Li W, Zhu J, et al. ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages. J Gen Physiol. 2022;154: pubmed publisher
Das Gupta D, Paul C, Samel N, Bieringer M, Staudenraus D, Marini F, et al. IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity. Cell Death Differ. 2022;29:2163-2176 pubmed publisher
Erdogmus S, Concepcion A, Yamashita M, Sidhu I, Tao A, Li W, et al. Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function. Nat Commun. 2022;13:2033 pubmed publisher
Krzywinska E, Sobecki M, Nagarajan S, Zacharjasz J, Tambuwala M, Pelletier A, et al. The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut. J Exp Med. 2022;219: pubmed publisher
Hope J, Zhao M, Stairiker C, Kiernan C, Carey A, Mueller Y, et al. MicroRNA-139 Expression Is Dispensable for the Generation of Influenza-Specific CD8+ T Cell Responses. J Immunol. 2022;208:603-617 pubmed publisher
Wilfahrt D, Philips R, Lama J, Kizerwetter M, Shapiro M, McCue S, et al. Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation. elife. 2021;10: pubmed publisher
Nakajima T, Kanno T, Yokoyama S, Sasamoto S, Asou H, Tumes D, et al. ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice. J Exp Med. 2021;218: pubmed publisher
Chen X, MacNabb B, Flood B, Blazar B, Kline J. Divergent fates of antigen-specific CD8+ T cell clones in mice with acute leukemia. Cell Rep. 2021;37:109991 pubmed publisher
Stamos D, Clubb L, Mitra A, Chopp L, Nie J, Ding Y, et al. The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development. J Exp Med. 2021;218: pubmed publisher
Menzel L, Zschummel M, Crowley T, Franke V, Grau M, Ulbricht C, et al. Lymphocyte access to lymphoma is impaired by high endothelial venule regression. Cell Rep. 2021;37:109878 pubmed publisher
Spiljar M, Steinbach K, Rigo D, Su xe1 rez Zamorano N, Wagner I, Hadadi N, et al. Cold exposure protects from neuroinflammation through immunologic reprogramming. Cell Metab. 2021;33:2231-2246.e8 pubmed publisher
Zong L, Tanaka Yano M, Park B, Yanai H, Turhan F, Croteau D, et al. NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm-/- and old mice HSCs. NPJ Aging Mech Dis. 2021;7:25 pubmed publisher
Aloufi N, Ali A, Burke Schinkel S, Molyer B, Barros P, McBane J, et al. Soluble CD127 potentiates IL-7 activity in vivo in healthy mice. Immun Inflamm Dis. 2021;9:1798-1808 pubmed publisher
Kim S, Srivatsan S, Chavez M, Shirai C, White B, Ahmed T, et al. Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice. Cell Rep. 2021;36:109626 pubmed publisher
Akasu M, Shimada S, Kabashima A, Akiyama Y, Shimokawa M, Akahoshi K, et al. Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma. Sci Rep. 2021;11:16732 pubmed publisher
Cardoso F, Klein Wolterink R, Godinho Silva C, Domingues R, Ribeiro H, da Silva J, et al. Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit. Nature. 2021;597:410-414 pubmed publisher
Sun V, Sharpley M, Kaczor Urbanowicz K, Chang P, Montel Hagen A, Lopez S, et al. The Metabolic Landscape of Thymic T Cell Development In Vivo and In Vitro. Front Immunol. 2021;12:716661 pubmed publisher
Qiu J, Zhang J, Ji Y, Sun H, Gu Z, Sun Q, et al. Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity. Mucosal Immunol. 2021;14:1306-1322 pubmed publisher
Liu X, Yu J, Xu L, Umphred Wilson K, Peng F, Ding Y, et al. Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β-selection. elife. 2021;10: pubmed publisher
Liu C, Gong Y, Zhang H, Yang H, Zeng Y, Bian Z, et al. Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells. Cell Res. 2021;: pubmed publisher
Van Thillo Q, De Bie J, Seneviratne J, Demeyer S, Omari S, Balachandran A, et al. Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia. Nat Commun. 2021;12:4164 pubmed publisher
Giuffrida L, Sek K, Henderson M, Lai J, Chen A, Meyran D, et al. CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy. Nat Commun. 2021;12:3236 pubmed publisher
Strid T, Okuyama K, Tingvall Gustafsson J, Kuruvilla J, Jensen C, Lang S, et al. B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors. J Immunol. 2021;206:2700-2713 pubmed publisher
Ercolano G, Gomez Cadena A, Dumauthioz N, Vanoni G, Kreutzfeldt M, Wyss T, et al. PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions. Nat Commun. 2021;12:2538 pubmed publisher
Harberts A, Schmidt C, Schmid J, Reimers D, Koch Nolte F, Mittrücker H, et al. Interferon regulatory factor 4 controls effector functions of CD8+ memory T cells. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Dudek M, Pfister D, Donakonda S, Filpe P, Schneider A, Laschinger M, et al. Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH. Nature. 2021;592:444-449 pubmed publisher
Pease N, Nguyen P, Woodworth M, Ng K, Irwin B, Vaughan J, et al. Tunable, division-independent control of gene activation timing by a polycomb switch. Cell Rep. 2021;34:108888 pubmed publisher
Hasegawa H, Mizoguchi I, Orii N, Inoue S, Katahira Y, Yoneto T, et al. IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development. Sci Rep. 2021;11:5266 pubmed publisher
Huang H, Zhou P, Wei J, Long L, Shi H, Dhungana Y, et al. In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions. Cell. 2021;184:1245-1261.e21 pubmed publisher
Blumenfeld B, Masika H, Farago M, Yehuda Y, Halaseh L, Vardi O, et al. Chromosomal coordination and differential structure of asynchronous replicating regions. Nat Commun. 2021;12:1035 pubmed publisher
Bielecki P, Riesenfeld S, Hütter J, Torlai Triglia E, Kowalczyk M, Ricardo Gonzalez R, et al. Skin-resident innate lymphoid cells converge on a pathogenic effector state. Nature. 2021;592:128-132 pubmed publisher
Haque M, Xiong X, Lei F, Das J, Song J. An optimized protocol for the generation of HBV viral antigen-specific T lymphocytes from pluripotent stem cells. STAR Protoc. 2021;2:100264 pubmed publisher
Agliardi G, Liuzzi A, Hotblack A, De Feo D, Nuñez N, Stowe C, et al. Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma. Nat Commun. 2021;12:444 pubmed publisher
Bunse M, Pfeilschifter J, Bluhm J, Zschummel M, Joedicke J, Wirges A, et al. CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells. Nat Commun. 2021;12:240 pubmed publisher
Mullins G, Valentine K, Al Kuhlani M, Davini D, Jensen K, Hoyer K. T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice. Sci Rep. 2020;10:21994 pubmed publisher
Lepez A, Pirnay T, Denanglaire S, Perez Morga D, Vermeersch M, Leo O, et al. Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species. Sci Rep. 2020;10:21673 pubmed publisher
Tremblay C, Chiu S, Saw J, McCalmont H, Litalien V, Boyle J, et al. Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells. Nat Commun. 2020;11:6211 pubmed publisher
Almeida L, Dhillon LaBrooy A, Castro C, Adossa N, Carriche G, Guderian M, et al. Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis. Immunity. 2021;54:68-83.e6 pubmed publisher
Guendel F, Kofoed Branzk M, Gronke K, Tizian C, Witkowski M, Cheng H, et al. Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues. Immunity. 2020;53:1015-1032.e8 pubmed publisher
Kong H, Reczek C, McElroy G, Steinert E, Wang T, Sabatini D, et al. Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species. Sci Adv. 2020;6: pubmed publisher
Mori D, Gregoire C, Voisinne G, Celis Gutierrez J, Aussel R, Girard L, et al. The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation. J Exp Med. 2021;218: pubmed publisher
Montel Hagen A, Sun V, Casero D, Tsai S, Zampieri A, Jackson N, et al. In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells. Cell Rep. 2020;33:108320 pubmed publisher
Zeis P, Lian M, Fan X, Herman J, Hernandez D, Gentek R, et al. In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors. Immunity. 2020;53:775-792.e9 pubmed publisher
Huang H, Wu X, Meng D, Feng Y, Zhou L, Liu Z, et al. Liver X receptor β is required for the survival of single-positive thymocytes by regulating IL-7Rα expression. Cell Mol Immunol. 2021;18:1969-1980 pubmed publisher
Piseddu I, R xf6 hrle N, Knott M, Moder S, Eiber S, Schnell K, et al. Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF. J Immunol. 2020;205:2056-2065 pubmed publisher
Oba T, Hoki T, Yamauchi T, Keler T, Marsh H, Cao X, et al. A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells. J Immunol. 2020;205:1867-1877 pubmed publisher
Romero Wolf M, Shin B, Zhou W, Koizumi M, Rothenberg E, Hosokawa H. Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development. J Cell Biol. 2020;219: pubmed publisher
Kok L, Dijkgraaf F, Urbanus J, Bresser K, Vredevoogd D, Cardoso R, et al. A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool. J Exp Med. 2020;217: pubmed publisher
Pessoa Rodrigues C, Herman J, Herquel B, Valsecchi C, Stehle T, Grün D, et al. Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Sci Adv. 2020;6:eaaz4815 pubmed publisher
Qi X, Qiu J, Chang J, Ji Y, Yang Q, Cui G, et al. Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity. Mucosal Immunol. 2021;14:38-52 pubmed publisher
Bennion B, Croft C, Ai T, Qian W, Menos A, Miner C, et al. STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice. Cell Rep. 2020;31:107771 pubmed publisher
LaMarche N, Kane H, Kohlgruber A, Dong H, Lynch L, Brenner M. Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis. Cell Metab. 2020;32:243-258.e6 pubmed publisher
Monin L, Ushakov D, Arnesen H, Bah N, Jandke A, Muñoz Ruiz M, et al. γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis. Mucosal Immunol. 2020;13:969-981 pubmed publisher
Bresser K, Dijkgraaf F, Pritchard C, Huijbers I, Song J, Rohr J, et al. A mouse model that is immunologically tolerant to reporter and modifier proteins. Commun Biol. 2020;3:273 pubmed publisher
Witkowski M, Dolgalev I, Evensen N, Ma C, Chambers T, Roberts K, et al. Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2020;37:867-882.e12 pubmed publisher
Keller H, Kim H, Jo Y, Gress R, Hong C, Park J. The Abundance and Availability of Cytokine Receptor IL-2Rβ (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells. J Immunol. 2020;204:3227-3235 pubmed publisher
Chen Y, Kung J. Rapid Death of Follicular B Cells and Burkitt Lymphoma Cells Effectuated by Xbp1s. J Immunol. 2020;204:3236-3247 pubmed publisher
Morita K, He S, Nowak R, Wang J, Zimmerman M, Fu C, et al. Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2. Cell. 2020;181:702-715.e20 pubmed publisher
Raynor J, Liu C, Dhungana Y, Guy C, Chapman N, Shi H, et al. Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions. J Exp Med. 2020;217: pubmed publisher
Donado C, Cao A, Simmons D, Croker B, Brennan P, Brenner M. A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling. Cell Rep. 2020;31:107466 pubmed publisher
Gang E, Kim H, Hsieh Y, Ruan Y, Ogana H, Lee S, et al. Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia. Blood. 2020;136:210-223 pubmed publisher
Hurtz C, Wertheim G, Loftus J, Blumenthal D, Lehman A, Li Y, et al. Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL. J Clin Invest. 2020;130:3637-3653 pubmed publisher
Petrova T, Pesic J, Pardali K, Gaestel M, Arthur J. p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells. Sci Rep. 2020;10:3479 pubmed publisher
Zenke S, Palm M, Braun J, Gavrilov A, Meiser P, Böttcher J, et al. Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics. Immunity. 2020;52:313-327.e7 pubmed publisher
Roy D, Chen J, Mamane V, Ma E, Muhire B, Sheldon R, et al. Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming. Cell Metab. 2020;31:250-266.e9 pubmed publisher
Ramezani Rad P, Leung C, Apgar J, Rickert R. E3 Ubiquitin Ligase Fbw7 Regulates the Survival of Mature B Cells. J Immunol. 2020;204:1535-1542 pubmed publisher
Oatley M, Bölükbaşı Ö, Svensson V, Shvartsman M, Ganter K, Zirngibl K, et al. Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition. Nat Commun. 2020;11:586 pubmed publisher
Wiede F, Lu K, Du X, Liang S, Hochheiser K, Dodd G, et al. PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours. EMBO J. 2020;39:e103637 pubmed publisher
Ma E, Verway M, Johnson R, Roy D, Steadman M, Hayes S, et al. Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells. Immunity. 2019;51:856-870.e5 pubmed publisher
Meyer L, Huang B, Delgado Martín C, Roy R, Hechmer A, Wandler A, et al. Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes. J Clin Invest. 2020;130:863-876 pubmed publisher
Yin M, Baslan T, Walker R, Zhu Y, Freeland A, Matsukawa T, et al. A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia. JCI Insight. 2019;4: pubmed publisher
Pinto I, Duque M, Gon xe7 alves J, Akkapeddi P, Oliveira M, Cabrita R, et al. NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling. Oncogene. 2020;39:975-986 pubmed publisher
Maluski M, Ghosh A, Herbst J, Scholl V, Baumann R, Huehn J, et al. Chimeric antigen receptor-induced BCL11B suppression propagates NK-like cell development. J Clin Invest. 2019;129:5108-5122 pubmed publisher
Abramowitz L, Harly C, Das A, Bhandoola A, Hanover J. Blocked O-GlcNAc cycling disrupts mouse hematopoeitic stem cell maintenance and early T cell development. Sci Rep. 2019;9:12569 pubmed publisher
Kusakabe M, Sun A, Tyshchenko K, Wong R, Nanda A, Shanna C, et al. Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia. Nat Commun. 2019;10:2913 pubmed publisher
Mariani S, Li Z, Rice S, Krieg C, Fragkogianni S, Robinson M, et al. Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells. Immunity. 2019;: pubmed publisher
Gong Z, Shang B, Chu Y, Chen X, Li Q, Liu K, et al. Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development. Cell Death Dis. 2019;10:440 pubmed publisher
Zheng M, Li D, Zhao Z, Shytikov D, Xu Q, Jin X, et al. Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Zhu Y, Zhao Y, Zou L, Zhang D, Aki D, Liu Y. The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control. J Exp Med. 2019;: pubmed publisher
Pfeifer M, Brem R, Lippert T, Boulianne B, Ho H, Robinson M, et al. SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors. J Immunol. 2019;202:3423-3433 pubmed publisher
Komuczki J, Tuzlak S, Friebel E, Hartwig T, Spath S, Rosenstiel P, et al. Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β. Immunity. 2019;: pubmed publisher
Luong Gardiol N, Siddiqui I, Pizzitola I, Jeevan Raj B, Charmoy M, Huang Y, et al. γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2019;35:649-663.e10 pubmed publisher
Lee H, Lee J, Kim D, Lim S, Kang I, Choi J. Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis. Nat Commun. 2019;10:709 pubmed publisher
Lin Y, Kobayashi M, Azevedo Portilho N, Mishra A, Gao H, Liu Y, et al. Long-Term Engraftment of ESC-Derived B-1 Progenitor Cells Supports HSC-Independent Lymphopoiesis. Stem Cell Reports. 2019;12:572-583 pubmed publisher
Miret J, Kirschmeier P, Koyama S, Zhu M, Li Y, Naito Y, et al. Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity. J Immunother Cancer. 2019;7:32 pubmed publisher
Miyamoto C, Kojo S, Yamashita M, Moro K, Lacaud G, Shiroguchi K, et al. Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation. Nat Commun. 2019;10:447 pubmed publisher
Weijenborg Campos L, Pini Zenatti P, Granato Pissinato L, Libanio Rodrigues G, Artico L, Rafael Guimar xe3 es T, et al. Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity. Blood. 2019;133:1259-1263 pubmed publisher
Li S, Bostick J, Ye J, Qiu J, Zhang B, Urban J, et al. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018;49:915-928.e5 pubmed publisher
Yamamoto T, Endo Y, Onodera A, Hirahara K, Asou H, Nakajima T, et al. DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells. Nat Commun. 2018;9:4231 pubmed publisher
Boulais P, Mizoguchi T, Zimmerman S, Nakahara F, Vivié J, Mar J, et al. The Majority of CD45- Ter119- CD31- Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors. Immunity. 2018;49:627-639.e6 pubmed publisher
Chen Y, Su Y, Kung J. B Cell Development sans B Cell Receptor Responsiveness Due to Unfolded Protein Response-Triggered Mef2c Protein Degradation. J Immunol. 2018;201:2885-2898 pubmed publisher
Giambra V, Gusscott S, Gracias D, Song R, Lam S, Panelli P, et al. Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity. Cell Stem Cell. 2018;23:714-726.e7 pubmed publisher
Sardina J, Collombet S, Tian T, Gomez A, Di Stefano B, Berenguer C, et al. Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate. Cell Stem Cell. 2018;23:727-741.e9 pubmed publisher
Kauts M, De Leo B, Rodríguez Seoane C, Ronn R, Glykofrydis F, Maglitto A, et al. Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells. Stem Cell Reports. 2018;11:1009-1020 pubmed publisher
Tremblay C, Saw J, Chiu S, Wong N, Tsyganov K, Ghotb S, et al. Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells. Nat Commun. 2018;9:3535 pubmed publisher
Vanden Bempt M, Demeyer S, Broux M, De Bie J, Bornschein S, Mentens N, et al. Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2018;34:271-285.e7 pubmed publisher
Guo H, Barberi T, Suresh R, Friedman A. Progression from the Common Lymphoid Progenitor to B/Myeloid PreproB and ProB Precursors during B Lymphopoiesis Requires C/EBPα. J Immunol. 2018;201:1692-1704 pubmed publisher
van Hoeven V, Munneke J, Cornelissen A, Omar S, Spruit M, Kleijer M, et al. Mesenchymal Stromal Cells Stimulate the Proliferation and IL-22 Production of Group 3 Innate Lymphoid Cells. J Immunol. 2018;201:1165-1173 pubmed publisher
Seshadri S, Pope R, Zenewicz L. Glucocorticoids Inhibit Group 3 Innate Lymphocyte IL-22 Production. J Immunol. 2018;201:1267-1274 pubmed publisher
Jensen C, Åhsberg J, Sommarin M, Strid T, Somasundaram R, Okuyama K, et al. Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis. J Exp Med. 2018;215:1947-1963 pubmed publisher
Dominguez Soto A, Simón Fuentes M, de Las Casas Engel M, Cuevas V, López Bravo M, Domínguez Andrés J, et al. IVIg Promote Cross-Tolerance against Inflammatory Stimuli In Vitro and In Vivo. J Immunol. 2018;201:41-52 pubmed publisher
Fahl S, Daamen A, Crittenden R, Bender T. c-Myb Coordinates Survival and the Expression of Genes That Are Critical for the Pre-BCR Checkpoint. J Immunol. 2018;200:3450-3463 pubmed publisher
Pinazza M, Ghisi M, Minuzzo S, Agnusdei V, Fossati G, Ciminale V, et al. Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells. Oncogene. 2018;37:3839-3851 pubmed publisher
Zhang J, He Z, Sen S, Wang F, Zhang Q, Sun Z. TCF-1 Inhibits IL-17 Gene Expression To Restrain Th17 Immunity in a Stage-Specific Manner. J Immunol. 2018;200:3397-3406 pubmed publisher
Xiao G, Chan L, Klemm L, Braas D, Chen Z, Geng H, et al. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018;173:470-484.e18 pubmed publisher
Bhatt B, Zeng P, Zhu H, Sivaprakasam S, Li S, Xiao H, et al. Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation. J Immunol. 2018;200:2905-2914 pubmed publisher
Wang Q, Wang H, Wang J, Venugopal J, Kleiman K, Guo C, et al. Angiotensin II-induced Hypertension is Reduced by Deficiency of P-selectin Glycoprotein Ligand-1. Sci Rep. 2018;8:3223 pubmed publisher
Li Q, Li D, Zhang X, Wan Q, Zhang W, Zheng M, et al. E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor. Immunity. 2018;48:258-270.e5 pubmed publisher
Cortes J, Ambesi Impiombato A, Couronné L, Quinn S, Kim C, da Silva Almeida A, et al. RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis. Cancer Cell. 2018;33:259-273.e7 pubmed publisher
Gan T, Li B, Mishra B, Jones K, Ernst P. MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation. J Immunol. 2018;200:1682-1691 pubmed publisher
Ferdinand J, Richard A, Meylan F, Al Shamkhani A, Siegel R. Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells. J Immunol. 2018;200:1360-1369 pubmed publisher
Rodriguez Fraticelli A, Wolock S, Weinreb C, Panero R, Patel S, Jankovic M, et al. Clonal analysis of lineage fate in native haematopoiesis. Nature. 2018;553:212-216 pubmed publisher
Kostrzewski T, Borg A, Meng Y, Filipovic I, Male V, Wack A, et al. Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development. J Immunol. 2018;200:1370-1381 pubmed publisher
Zhang Y, Li N, Suh H, Irvine D. Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity. Nat Commun. 2018;9:6 pubmed publisher
Steinbuck M, Arakcheeva K, Winandy S. Novel TCR-Mediated Mechanisms of Notch Activation and Signaling. J Immunol. 2018;200:997-1007 pubmed publisher
Tober J, Maijenburg M, Li Y, Gao L, Hadland B, Gao P, et al. Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1. J Exp Med. 2018;215:645-659 pubmed publisher
Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, et al. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity. 2017;47:1100-1113.e6 pubmed publisher
Milanovic M, Fan D, Belenki D, Däbritz J, Zhao Z, Yu Y, et al. Senescence-associated reprogramming promotes cancer stemness. Nature. 2018;553:96-100 pubmed publisher
Wang Y, Xiao M, Tao C, Chen J, Wang Z, Yang J, et al. Inactivation of mTORC1 Signaling in Osterix-expressing Cells Impairs B-cell Differentiation. J Bone Miner Res. 2017;: pubmed publisher
Yu J, Choi S, Kim H, Lee N, Yun H, Kim S, et al. Generation of an osteoblast-based artificial niche that supports in vitro B lymphopoiesis. Exp Mol Med. 2017;49:e400 pubmed publisher
Ko J, Koh J, So J, Jeon Y, Kim H, Chung D. Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay. Sci Rep. 2017;7:14940 pubmed publisher
Minutti C, Drube S, Blair N, Schwartz C, McCrae J, McKenzie A, et al. Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion. Immunity. 2017;47:710-722.e6 pubmed publisher
Pike K, Hatzihristidis T, Bussières Marmen S, Robert F, Desai N, Miranda Saavedra D, et al. TC-PTP regulates the IL-7 transcriptional response during murine early T cell development. Sci Rep. 2017;7:13275 pubmed publisher
Vaeth M, Maus M, Klein Hessling S, Freinkman E, Yang J, Eckstein M, et al. Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming. Immunity. 2017;47:664-679.e6 pubmed publisher
Alzubi J, Pallant C, Mussolino C, Howe S, Thrasher A, Cathomen T. Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model. Sci Rep. 2017;7:12475 pubmed publisher
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, et al. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. 2017;199:2777-2793 pubmed publisher
Wang S, Xia P, Chen Y, Qu Y, Xiong Z, Ye B, et al. Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation. Cell. 2017;171:201-216.e18 pubmed publisher
Salerno F, Paolini N, Stark R, von Lindern M, Wolkers M. Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8+ T cells. Proc Natl Acad Sci U S A. 2017;114:9677-9682 pubmed publisher
Tanaka T, Nakajima Takagi Y, Aoyama K, Tara S, Oshima M, Saraya A, et al. Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies. J Exp Med. 2017;214:2901-2913 pubmed publisher
Goel S, Decristo M, Watt A, BrinJones H, Sceneay J, Li B, et al. CDK4/6 inhibition triggers anti-tumour immunity. Nature. 2017;548:471-475 pubmed publisher
Haymaker C, Yang Y, Wang J, Zou Q, Sahoo A, Alekseev A, et al. Absence of Grail promotes CD8+ T cell anti-tumour activity. Nat Commun. 2017;8:239 pubmed publisher
Wiede F, Dudakov J, Lu K, Dodd G, Butt T, Godfrey D, et al. PTPN2 regulates T cell lineage commitment and αβ versus γδ specification. J Exp Med. 2017;214:2733-2758 pubmed publisher
Liu B, Ye B, Zhu X, Huang G, Yang L, Zhu P, et al. IL-7R? glutamylation and activation of transcription factor Sall3 promote group 3 ILC development. Nat Commun. 2017;8:231 pubmed publisher
Stein M, Dütting S, Mougiakakos D, Bösl M, Fritsch K, Reimer D, et al. A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1. Cell Death Differ. 2017;24:1239-1252 pubmed publisher
Miyazaki M, Miyazaki K, Chen K, Jin Y, Turner J, Moore A, et al. The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development. Immunity. 2017;46:818-834.e4 pubmed publisher
Spranger S, Dai D, Horton B, Gajewski T. Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy. Cancer Cell. 2017;31:711-723.e4 pubmed publisher
Robinette M, Bando J, Song W, Ulland T, Gilfillan S, Colonna M. IL-15 sustains IL-7R-independent ILC2 and ILC3 development. Nat Commun. 2017;8:14601 pubmed publisher
Stephen T, Payne K, Chaurio R, Allegrezza M, Zhu H, Perez Sanz J, et al. SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells. Immunity. 2017;46:51-64 pubmed publisher
Cho J, Kim H, Ju Y, Kye Y, Lee G, Lee S, et al. CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells. Nat Commun. 2016;7:13373 pubmed publisher
Lundberg V, Berglund M, Skogberg G, Lindgren S, Lundqvist C, Gudmundsdottir J, et al. Thymic exosomes promote the final maturation of thymocytes. Sci Rep. 2016;6:36479 pubmed publisher
Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey R, et al. Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia. Nat Commun. 2016;7:13331 pubmed publisher
Young K, Borikar S, Bell R, Kuffler L, Philip V, Trowbridge J. Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging. J Exp Med. 2016;213:2259-2267 pubmed
Stevens M, Maire C, Chou N, Murakami M, Knoff D, Kikuchi Y, et al. Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate. Nat Biotechnol. 2016;34:1161-1167 pubmed publisher
Hu X, García M, Weng L, Jung X, Murakami J, Kumar B, et al. Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche. Nat Commun. 2016;7:13095 pubmed publisher
Kristiansen T, Jaensson Gyllenbäck E, Zriwil A, Bjorklund T, Daniel J, Sitnicka E, et al. Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level. Immunity. 2016;45:346-57 pubmed publisher
Goplen N, Saxena V, Knudson K, Schrum A, Gil D, Daniels M, et al. IL-12 Signals through the TCR To Support CD8 Innate Immune Responses. J Immunol. 2016;197:2434-43 pubmed publisher
Ahmed T, Tsuji Tamura K, Ogawa M. CXCR4 Signaling Negatively Modulates the Bipotential State of Hemogenic Endothelial Cells Derived from Embryonic Stem Cells by Attenuating the Endothelial Potential. Stem Cells. 2016;34:2814-2824 pubmed publisher
Chen I, Caprioli A, Ohnuki H, Kwak H, Porcher C, Tosato G. EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta. Sci Rep. 2016;6:27195 pubmed publisher
Cao W, Guo J, Wen X, Miao L, Lin F, Xu G, et al. CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation. Nat Commun. 2016;7:11687 pubmed publisher
Blas Rus N, Bustos Morán E, Perez de Castro I, de Carcer G, Borroto A, Camafeita E, et al. Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun. 2016;7:11389 pubmed publisher
Verbist K, Guy C, Milasta S, Liedmann S, Kaminski M, Wang R, et al. Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. Nature. 2016;532:389-93 pubmed publisher
Salerno F, Guislain A, Cansever D, Wolkers M. TLR-Mediated Innate Production of IFN-? by CD8+ T Cells Is Independent of Glycolysis. J Immunol. 2016;196:3695-705 pubmed publisher
Cheng Y, Chikwava K, Wu C, Zhang H, Bhagat A, Pei D, et al. LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors. J Clin Invest. 2016;126:1267-81 pubmed publisher
Gomez Rodriguez J, Meylan F, Handon R, Hayes E, Anderson S, Kirby M, et al. Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4. Nat Commun. 2016;7:10857 pubmed publisher
Haque M, Song J, Fino K, Sandhu P, Song X, Lei F, et al. Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity. Sci Rep. 2016;6:20588 pubmed publisher
Kim J, Kim W, Moon U, Kim H, Choi H, Sin J, et al. Intratumorally Establishing Type 2 Innate Lymphoid Cells Blocks Tumor Growth. J Immunol. 2016;196:2410-23 pubmed publisher
von Wnuck Lipinski K, Sattler K, Peters S, Weske S, Keul P, Klump H, et al. Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in Mice. J Immunol. 2016;196:1655-65 pubmed publisher
Dépis F, Kwon H, Mathis D, Benoist C. Unstable FoxP3+ T regulatory cells in NZW mice. Proc Natl Acad Sci U S A. 2016;113:1345-50 pubmed publisher
Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, et al. B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia. J Biol Chem. 2016;291:4723-31 pubmed publisher
Corpuz T, Stolp J, Kim H, Pinget G, Gray D, Cho J, et al. Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines. J Immunol. 2016;196:645-54 pubmed publisher
Chan S, Lindquist L, Hansen M, Girtman M, Pease L, Bram R. Calcium-Modulating Cyclophilin Ligand Is Essential for the Survival of Activated T Cells and for Adaptive Immunity. J Immunol. 2015;195:5648-56 pubmed publisher
Regelin M, Blume J, Pommerencke J, Vakilzadeh R, Witzlau K, Łyszkiewicz M, et al. Responsiveness of Developing T Cells to IL-7 Signals Is Sustained by miR-17∼92. J Immunol. 2015;195:4832-40 pubmed publisher
Schmaler M, Broggi M, Lagarde N, Stöcklin B, King C, Finke D, et al. IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice. Proc Natl Acad Sci U S A. 2015;112:13330-5 pubmed publisher
Wang C, Liu X, Li Z, Chai Y, Jiang Y, Wang Q, et al. CD8(+)NKT-like cells regulate the immune response by killing antigen-bearing DCs. Sci Rep. 2015;5:14124 pubmed publisher
Duque Afonso J, Feng J, Scherer F, Lin C, Wong S, Wang Z, et al. Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. J Clin Invest. 2015;125:3667-80 pubmed publisher
Preston G, Sinclair L, Kaskar A, Hukelmann J, Navarro M, Ferrero I, et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015;34:2008-24 pubmed publisher
Suzuki M, Morita R, Hirata Y, Shichita T, Yoshimura A. Spred1, a Suppressor of the Ras-ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells. J Immunol. 2015;195:1273-81 pubmed publisher
Kamimura D, Katsunuma K, Arima Y, Atsumi T, Jiang J, Bando H, et al. KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR. Nat Commun. 2015;6:7474 pubmed publisher
Ungerbäck J, Åhsberg J, Strid T, Somasundaram R, Sigvardsson M. Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors. J Exp Med. 2015;212:1109-23 pubmed publisher
Thompson B, Bhansali R, Diebold L, Cook D, Stolzenburg L, Casagrande A, et al. DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. J Exp Med. 2015;212:953-70 pubmed publisher
Yu Y, Wang C, Clare S, Wang J, Lee S, Brandt C, et al. The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development. J Exp Med. 2015;212:865-74 pubmed publisher
Ebel M, Awe O, Kaplan M, Kansas G. Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK. J Immunol. 2015;194:5781-8 pubmed publisher
Willinger T, Staron M, Ferguson S, De Camilli P, Flavell R. Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes. Proc Natl Acad Sci U S A. 2015;112:4423-8 pubmed publisher
Baumann C, Bonilla W, Fröhlich A, Helmstetter C, Peine M, Hegazy A, et al. T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses. Proc Natl Acad Sci U S A. 2015;112:4056-61 pubmed publisher
Chen Z, Shojaee S, Buchner M, Geng H, Lee J, Klemm L, et al. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015;521:357-61 pubmed publisher
He M, He Y. c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway. J Immunol. 2015;194:3444-51 pubmed publisher
Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, et al. ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling. Nat Commun. 2015;6:5794 pubmed publisher
Godec J, Cowley G, Barnitz R, Alkan O, Root D, Sharpe A, et al. Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation. Proc Natl Acad Sci U S A. 2015;112:512-7 pubmed publisher
Jackson J, Nasa C, Shi W, Huntington N, Bogue C, Alexander W, et al. A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis. Blood. 2015;125:803-14 pubmed publisher
Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, et al. A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice. J Immunol. 2015;194:243-51 pubmed publisher
Ho K, Chiang Y, Lai A, Liao N, Chang Y, Yang Yen H, et al. CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling. Cell Death Dis. 2014;5:e1518 pubmed publisher
Sungalee S, Mamessier E, Morgado E, Grégoire E, Brohawn P, Morehouse C, et al. Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression. J Clin Invest. 2014;124:5337-51 pubmed publisher
Van der Meulen J, Sanghvi V, Mavrakis K, Durinck K, Fang F, Matthijssens F, et al. The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia. Blood. 2015;125:13-21 pubmed publisher
Walsh M, Pearce E, Cejas P, Lee J, Wang L, Choi Y. IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals. J Immunol. 2014;193:3992-4001 pubmed publisher
Degryse S, de Bock C, Cox L, Demeyer S, Gielen O, Mentens N, et al. JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model. Blood. 2014;124:3092-100 pubmed publisher
Rei M, Gonçalves Sousa N, Lança T, Thompson R, Mensurado S, Balkwill F, et al. Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages. Proc Natl Acad Sci U S A. 2014;111:E3562-70 pubmed publisher
Bestas B, Moreno P, Blomberg K, Mohammad D, Saleh A, Sutlu T, et al. Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model. J Clin Invest. 2014;124:4067-81 pubmed publisher
Kobayashi M, Shelley W, Seo W, Vemula S, Lin Y, Liu Y, et al. Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbf? for their development. Proc Natl Acad Sci U S A. 2014;111:12151-6 pubmed publisher
Longman R, Diehl G, Victorio D, Huh J, Galan C, Miraldi E, et al. CX?CR1? mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med. 2014;211:1571-83 pubmed publisher
Baracho G, Cato M, Zhu Z, Jaren O, Hobeika E, Reth M, et al. PDK1 regulates B cell differentiation and homeostasis. Proc Natl Acad Sci U S A. 2014;111:9573-8 pubmed publisher
Philip B, Kokalaki E, Mekkaoui L, Thomas S, Straathof K, Flutter B, et al. A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy. Blood. 2014;124:1277-87 pubmed publisher
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, et al. Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors. J Immunol. 2014;192:5749-60 pubmed publisher
Kharabi Masouleh B, Geng H, Hurtz C, Chan L, Logan A, Chang M, et al. Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2014;111:E2219-28 pubmed publisher
Miller M, Mashayekhi M, Chen L, Zhou P, Liu X, Michelotti M, et al. Basal NF-?B controls IL-7 responsiveness of quiescent naïve T cells. Proc Natl Acad Sci U S A. 2014;111:7397-402 pubmed publisher
Kumar L, Chou J, Yee C, Borzutzky A, Vollmann E, von Andrian U, et al. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med. 2014;211:929-42 pubmed publisher
Inlay M, Serwold T, Mosley A, Fathman J, Dimov I, Seita J, et al. Identification of multipotent progenitors that emerge prior to hematopoietic stem cells in embryonic development. Stem Cell Reports. 2014;2:457-72 pubmed publisher
Klose C, Flach M, Möhle L, Rogell L, Hoyler T, Ebert K, et al. Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell. 2014;157:340-356 pubmed publisher
Zarin P, Wong G, Mohtashami M, Wiest D, Z xfa xf1 iga Pfl xfc cker J. Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals. Proc Natl Acad Sci U S A. 2014;111:5658-63 pubmed publisher
Treanor L, Zhou S, Janke L, Churchman M, Ma Z, Lu T, et al. Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential. J Exp Med. 2014;211:701-13 pubmed publisher
Male V, Nisoli I, Kostrzewski T, Allan D, Carlyle J, Lord G, et al. The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression. J Exp Med. 2014;211:635-42 pubmed publisher
Järås M, Miller P, Chu L, Puram R, Fink E, Schneider R, et al. Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. J Exp Med. 2014;211:605-12 pubmed publisher
Silva A, Cornish G, Ley S, Seddon B. NF-κB signaling mediates homeostatic maturation of new T cells. Proc Natl Acad Sci U S A. 2014;111:E846-55 pubmed publisher
Zhou P, Shaffer D, Alvarez Arias D, Nakazaki Y, Pos W, Torres A, et al. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 2014;506:52-7 pubmed publisher
Hauser J, Grundström C, Grundström T. Allelic exclusion of IgH through inhibition of E2A in a VDJ recombination complex. J Immunol. 2014;192:2460-70 pubmed publisher
McNally J, Elfers E, Terrell C, Grunblatt E, Hildeman D, Jordan M, et al. Eliminating encephalitogenic T cells without undermining protective immunity. J Immunol. 2014;192:73-83 pubmed publisher
Johnson T, Terrell C, Millen S, Katz J, Hildeman D, Jordan M. Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis. J Immunol. 2014;192:84-91 pubmed publisher
Knudson K, Hamilton S, Daniels M, Jameson S, Teixeiro E. Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength. J Immunol. 2013;191:5797-801 pubmed publisher
Cho J, Kim H, Kim K, Yang D, Surh C, Sprent J. Unique features of naive CD8+ T cell activation by IL-2. J Immunol. 2013;191:5559-73 pubmed publisher
Lo Y, Edidin M, Powell J. Selective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles. J Immunol. 2013;191:5107-14 pubmed publisher
Lee S, Phipson B, Hyland C, Leong H, Allan R, Lun A, et al. Polycomb repressive complex 2 (PRC2) suppresses E?-myc lymphoma. Blood. 2013;122:2654-63 pubmed publisher
Colpitts S, Stonier S, Stoklasek T, Root S, Aguila H, Schluns K, et al. Transcriptional regulation of IL-15 expression during hematopoiesis. J Immunol. 2013;191:3017-24 pubmed publisher
Peperzak V, Veraar E, Xiao Y, Babala N, Thiadens K, Brugmans M, et al. CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool. J Immunol. 2013;191:3025-36 pubmed publisher
Du W, Amarachintha S, Sipple J, Schick J, Steinbrecher K, Pang Q. Inflammation-mediated notch signaling skews fanconi anemia hematopoietic stem cell differentiation. J Immunol. 2013;191:2806-17 pubmed publisher
Niebuhr B, Kriebitzsch N, Fischer M, Behrens K, Gunther T, Alawi M, et al. Runx1 is essential at two stages of early murine B-cell development. Blood. 2013;122:413-23 pubmed publisher
Castagnaro L, Lenti E, Maruzzelli S, Spinardi L, Migliori E, Farinello D, et al. Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity. Immunity. 2013;38:782-91 pubmed publisher
Suzuki J, Fujii T, Imao T, Ishihara K, Kuba H, Nagata S. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem. 2013;288:13305-16 pubmed publisher
Han S, Jeong A, Lee S, Park J, Kim K, Choi I, et al. Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells. J Immunol. 2013;190:4877-86 pubmed publisher
Li J, Zhao Z, Carter C, Ehrlich L, Bedford M, Richie E. Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. J Immunol. 2013;190:597-604 pubmed publisher
Yu Y, Wang J, Khaled W, Burke S, Li P, Chen X, et al. Bcl11a is essential for lymphoid development and negatively regulates p53. J Exp Med. 2012;209:2467-83 pubmed publisher
Vinay D, Lee S, Kim C, Oh H, Kwon B. Exposure of a distinct PDCA-1+ (CD317) B cell population to agonistic anti-4-1BB (CD137) inhibits T and B cell responses both in vitro and in vivo. PLoS ONE. 2012;7:e50272 pubmed publisher
Shah D, Mohtashami M, Zuniga Pflucker J. Role of recycling, Mindbomb1 association, and exclusion from lipid rafts of ?-like 4 for effective Notch signaling to drive T cell development. J Immunol. 2012;189:5797-808 pubmed publisher
Austin W, Armijo A, Campbell D, Singh A, Hsieh T, Nathanson D, et al. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med. 2012;209:2215-28 pubmed publisher
Fiorenza S, Kenna T, Comerford I, McColl S, Steptoe R, Leggatt G, et al. A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin. J Immunol. 2012;189:5622-31 pubmed publisher
Rafei M, Rouette A, Brochu S, Vanegas J, Perreault C. Differential effects of ?c cytokines on postselection differentiation of CD8 thymocytes. Blood. 2013;121:107-17 pubmed publisher
Zandi S, Åhsberg J, Tsapogas P, Stjernberg J, Qian H, Sigvardsson M. Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo. Proc Natl Acad Sci U S A. 2012;109:15871-6 pubmed
Miyakoda M, Kimura D, Honma K, Kimura K, Yuda M, Yui K. Development of memory CD8+ T cells and their recall responses during blood-stage infection with Plasmodium berghei ANKA. J Immunol. 2012;189:4396-404 pubmed publisher
Regateiro F, Chen Y, Kendal A, Hilbrands R, Adams E, Cobbold S, et al. Foxp3 expression is required for the induction of therapeutic tissue tolerance. J Immunol. 2012;189:3947-56 pubmed publisher
Xu L, Sokalski K, Hotke K, Christie D, Zarnett O, Piskorz J, et al. Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia. J Immunol. 2012;189:3347-54 pubmed
Ventre E, Brinza L, Schicklin S, Mafille J, Coupet C, Mar xe7 ais A, et al. Negative regulation of NKG2D expression by IL-4 in memory CD8 T cells. J Immunol. 2012;189:3480-9 pubmed
Dervovic D, Ciofani M, Kianizad K, Zuniga Pflucker J. Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells. J Immunol. 2012;189:3411-20 pubmed
Lucas S, Taront S, Magnan C, Fauconnier L, Delacre M, Macia L, et al. Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PLoS ONE. 2012;7:e40351 pubmed publisher
Penaranda C, Kuswanto W, Hofmann J, Kenefeck R, Narendran P, Walker L, et al. IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc Natl Acad Sci U S A. 2012;109:12668-73 pubmed publisher
Haque R, Lei F, Xiong X, Bian Y, Zhao B, Wu Y, et al. Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity. J Immunol. 2012;189:1228-36 pubmed publisher
Chang K, Sanchez Aguilera A, Shen S, Sengupta A, Madhu M, Ficker A, et al. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood. 2012;120:800-11 pubmed publisher
Frascoli M, Marcandalli J, Schenk U, Grassi F. Purinergic P2X7 receptor drives T cell lineage choice and shapes peripheral ?? cells. J Immunol. 2012;189:174-80 pubmed publisher
Wong G, Knowles G, Mak T, Ferrando A, Zuniga Pflucker J. HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCR?-selected mouse thymocytes. Blood. 2012;120:1439-48 pubmed publisher
Shankar S, Wilson M, DiVietro J, Mentink Kane M, Xie Z, Wynn T, et al. RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol. 2012;188:6347-56 pubmed publisher
Zhang F, Lazorchak A, Liu D, Chen F, Su B. Inhibition of the mTORC2 and chaperone pathways to treat leukemia. Blood. 2012;119:6080-8 pubmed publisher
Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki Koizumi M, et al. MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells. Blood. 2012;119:5405-16 pubmed publisher
Pearson C, Silva A, Seddon B. Exogenous amino acids are essential for interleukin-7 induced CD8 T cell growth. [corrected]. PLoS ONE. 2012;7:e33998 pubmed publisher
Cooper C, Hardy R, Reth M, Desiderio S. Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors. Blood. 2012;119:5438-48 pubmed publisher
Zhang J, Mortazavi A, Williams B, Wold B, Rothenberg E. Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity. Cell. 2012;149:467-82 pubmed publisher
Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, MacDonald A, et al. Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells. PLoS ONE. 2012;7:e35466 pubmed publisher
Redmond W, Triplett T, Floyd K, Weinberg A. Dual anti-OX40/IL-2 therapy augments tumor immunotherapy via IL-2R-mediated regulation of OX40 expression. PLoS ONE. 2012;7:e34467 pubmed publisher
Cherrier M, Sawa S, Eberl G. Notch, Id2, and ROR?t sequentially orchestrate the fetal development of lymphoid tissue inducer cells. J Exp Med. 2012;209:729-40 pubmed publisher
Choi J, Ko M, Jeon S, Jeon Y, Park K, Lee C, et al. The SWI/SNF-like BAF complex is essential for early B cell development. J Immunol. 2012;188:3791-803 pubmed publisher
Ruppert S, Chehtane M, Zhang G, Hu H, Li X, Khaled A. JunD/AP-1-mediated gene expression promotes lymphocyte growth dependent on interleukin-7 signal transduction. PLoS ONE. 2012;7:e32262 pubmed publisher
Hu J, Hwang S, Liesa M, Gan B, Sahin E, Jaskelioff M, et al. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 2012;148:651-63 pubmed publisher
Yamaji O, Nagaishi T, Totsuka T, Onizawa M, Suzuki M, Tsuge N, et al. The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis. J Immunol. 2012;188:2524-36 pubmed publisher
Tischner D, Gaggl I, Peschel I, Kaufmann M, Tuzlak S, Drach M, et al. Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice. J Autoimmun. 2012;38:59-69 pubmed publisher
Navarro M, Sinclair L, Feijoo Carnero C, Clarke R, Matthews S, Cantrell D. Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells. Biochem J. 2012;442:649-59 pubmed publisher
Siegert S, Huang H, Yang C, Scarpellino L, Carrie L, Essex S, et al. Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide. PLoS ONE. 2011;6:e27618 pubmed publisher
Tang Y, Peitzsch C, Charoudeh H, Cheng M, Chaves P, Jacobsen S, et al. Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo. Blood. 2012;120:63-75 pubmed publisher
Wang R, Xie H, Huang Z, Ma J, Fang X, Ding Y, et al. T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway. J Immunol. 2011;187:5964-73 pubmed publisher
Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park J, et al. Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J. 2012;31:366-77 pubmed publisher
McLeod I, Zhou X, Li Q, Wang F, He Y. The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7R? surface expression. J Immunol. 2011;187:5051-61 pubmed publisher
Dunkle A, Dzhagalov I, He Y. Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes. Cell Death Dis. 2011;2:e214 pubmed publisher
Heinonen K, Vanegas J, Brochu S, Shan J, Vainio S, Perreault C. Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors. Blood. 2011;118:5163-73 pubmed publisher
Bandaranayake A, Correnti C, Ryu B, Brault M, Strong R, Rawlings D. Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors. Nucleic Acids Res. 2011;39:e143 pubmed publisher
Lang A, Nikolich Zugich J. Functional CD8 T cell memory responding to persistent latent infection is maintained for life. J Immunol. 2011;187:3759-68 pubmed publisher
Nahar R, Ramezani Rad P, Mossner M, Duy C, Cerchietti L, Geng H, et al. Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC. Blood. 2011;118:4174-8 pubmed publisher
Vargas C, Poursine Laurent J, Yang L, Yokoyama W. Development of thymic NK cells from double negative 1 thymocyte precursors. Blood. 2011;118:3570-8 pubmed publisher
Penaranda C, Tang Q, Bluestone J. Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol. 2011;187:2015-22 pubmed publisher
Turchinovich G, Hayday A. Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cells. Immunity. 2011;35:59-68 pubmed publisher
Kmieciak M, Basu D, Payne K, Toor A, Yacoub A, Wang X, et al. Activated NKT cells and NK cells render T cells resistant to myeloid-derived suppressor cells and result in an effective adoptive cellular therapy against breast cancer in the FVBN202 transgenic mouse. J Immunol. 2011;187:708-17 pubmed publisher
Tsapogas P, Zandi S, Åhsberg J, Zetterblad J, Welinder E, Jönsson J, et al. IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors. Blood. 2011;118:1283-90 pubmed publisher
Hsu F, Pajerowski A, Nelson Holte M, Sundsbak R, Shapiro V. NKAP is required for T cell maturation and acquisition of functional competency. J Exp Med. 2011;208:1291-304 pubmed publisher
Heltemes Harris L, Willette M, Ramsey L, Qiu Y, Neeley E, Zhang N, et al. Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia. J Exp Med. 2011;208:1135-49 pubmed publisher
Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, et al. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature. 2011;473:384-8 pubmed publisher
Li Q, Rao R, Araki K, Pollizzi K, Odunsi K, Powell J, et al. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity. 2011;34:541-53 pubmed publisher
Liu Z, Yang A, Wang Z, Bunting K, Davuluri G, Green M, et al. Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3. J Biol Chem. 2011;286:20606-14 pubmed publisher
Calderón L, Boehm T. Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus. Proc Natl Acad Sci U S A. 2011;108:7517-22 pubmed publisher
Lai D, Zhu J, Wang T, Hu Li J, Terabe M, Berzofsky J, et al. KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells. J Exp Med. 2011;208:1093-103 pubmed publisher
Stock A, Booth S, Cerundolo V. Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans. J Exp Med. 2011;208:761-73 pubmed publisher
Lv H, Havari E, Pinto S, Gottumukkala R, Cornivelli L, Raddassi K, et al. Impaired thymic tolerance to ?-myosin directs autoimmunity to the heart in mice and humans. J Clin Invest. 2011;121:1561-73 pubmed publisher
Treanor L, Volanakis E, Zhou S, Lu T, Sherr C, Sorrentino B. Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies. Blood. 2011;117:5453-62 pubmed publisher
Eto D, LAO C, DiToro D, Barnett B, Escobar T, Kageyama R, et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS ONE. 2011;6:e17739 pubmed publisher
Jia W, He Y. Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. J Immunol. 2011;186:5313-22 pubmed publisher
Gibb D, Saleem S, Kang D, Subler M, Conrad D. ADAM10 overexpression shifts lympho- and myelopoiesis by dysregulating site 2/site 3 cleavage products of Notch. J Immunol. 2011;186:4244-52 pubmed publisher
Palmer M, Mahajan V, Chen J, Irvine D, Lauffenburger D. Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunol Cell Biol. 2011;89:581-94 pubmed publisher
Kmieciak M, Toor A, Graham L, Bear H, Manjili M. Ex vivo expansion of tumor-reactive T cells by means of bryostatin 1/ionomycin and the common gamma chain cytokines formulation. J Vis Exp. 2011;: pubmed publisher
Singh V, Jain S, Gowthaman U, Parihar P, Gupta P, Gupta U, et al. Co-administration of IL-1+IL-6+TNF-? with Mycobacterium tuberculosis infected macrophages vaccine induces better protective T cell memory than BCG. PLoS ONE. 2011;6:e16097 pubmed publisher
Saba I, Kosan C, Vassen L, Moroy T. IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1. Blood. 2011;117:3370-81 pubmed publisher
Arsov I, Adebayo A, Kucerova Levisohn M, Haye J, MACNEIL M, Papavasiliou F, et al. A role for autophagic protein beclin 1 early in lymphocyte development. J Immunol. 2011;186:2201-9 pubmed publisher
Guikema J, Gerstein R, Linehan E, Cloherty E, Evan Browning E, Tsuchimoto D, et al. Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge. J Immunol. 2011;186:1943-50 pubmed publisher
Li L, Zhang L, Fan J, Greenberg K, Desiderio S, Rassool F, et al. Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice. Blood. 2011;117:3131-9 pubmed publisher
Jin J, Goldschneider I, Lai L. In vivo administration of the recombinant IL-7/hepatocyte growth factor ? hybrid cytokine efficiently restores thymopoiesis and naive T cell generation in lethally irradiated mice after syngeneic bone marrow transplantation. J Immunol. 2011;186:1915-22 pubmed publisher
Sonnenberg G, Monticelli L, Elloso M, Fouser L, Artis D. CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity. 2011;34:122-34 pubmed publisher
Linkes S, Fry C, Quinn A. Antigen-Experienced CD4lo T Cells Are Linked to Deficient Contraction of the Immune Response in Autoimmune Diabetes. Autoimmune Dis. 2010;2010:920148 pubmed publisher
Kosan C, Saba I, Godmann M, Herold S, Herkert B, Eilers M, et al. Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation. Immunity. 2010;33:917-28 pubmed publisher
Richie Ehrlich L, Serwold T, Weissman I. In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors. Blood. 2011;117:2618-24 pubmed publisher
Janikashvili N, LaCasse C, Larmonier C, Trad M, Herrell A, Bustamante S, et al. Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia. Blood. 2011;117:1555-64 pubmed publisher
Chae H, Siefring J, Hildeman D, Gu Y, Williams D. RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling. PLoS ONE. 2010;5:e13970 pubmed publisher
Zhang N, Bevan M. Dicer controls CD8+ T-cell activation, migration, and survival. Proc Natl Acad Sci U S A. 2010;107:21629-34 pubmed publisher
Cho H, Choi H, Xu H, Felio K, Wang C. Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3. J Immunol. 2011;186:489-98 pubmed publisher
Verbist K, Cole C, Field M, Klonowski K. A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection. J Immunol. 2011;186:174-82 pubmed publisher
Vonarbourg C, Mortha A, Bui V, Hernandez P, Kiss E, Hoyler T, et al. Regulated expression of nuclear receptor ROR?t confers distinct functional fates to NK cell receptor-expressing ROR?t(+) innate lymphocytes. Immunity. 2010;33:736-51 pubmed publisher
Peperzak V, Veraar E, Keller A, Xiao Y, Borst J. The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation. J Immunol. 2010;185:6670-8 pubmed publisher
Rochman Y, Kashyap M, Robinson G, Sakamoto K, Gomez Rodriguez J, Wagner K, et al. Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc Natl Acad Sci U S A. 2010;107:19455-60 pubmed publisher
Gwin K, Frank E, Bossou A, Medina K. Hoxa9 regulates Flt3 in lymphohematopoietic progenitors. J Immunol. 2010;185:6572-83 pubmed publisher
Åhsberg J, Tsapogas P, Qian H, Zetterblad J, Zandi S, Mansson R, et al. Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells. J Biol Chem. 2010;285:36275-84 pubmed publisher
Ji H, Ehrlich L, Seita J, Murakami P, Doi A, Lindau P, et al. Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature. 2010;467:338-42 pubmed publisher
Chappaz S, Gärtner C, Rodewald H, Finke D. Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development. J Immunol. 2010;185:3514-9 pubmed publisher
Lai J, Wlodarska M, Liu D, Abraham N, Johnson P. CD45 regulates migration, proliferation, and progression of double negative 1 thymocytes. J Immunol. 2010;185:2059-70 pubmed publisher
Mohtashami M, Shah D, Nakase H, Kianizad K, Petrie H, Zuniga Pflucker J. Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes. J Immunol. 2010;185:867-76 pubmed publisher
Watarai H, Fujii S, Yamada D, Rybouchkin A, Sakata S, Nagata Y, et al. Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells. J Clin Invest. 2010;120:2610-8 pubmed publisher
Khwaja S, Liu H, Tong C, Jin F, Pear W, van Deursen J, et al. HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice. J Clin Invest. 2010;120:2537-48 pubmed publisher
Wang G, Miyahara Y, Guo Z, Khattar M, Stepkowski S, Chen W. "Default" generation of neonatal regulatory T cells. J Immunol. 2010;185:71-8 pubmed publisher
Duy C, Yu J, Nahar R, Swaminathan S, Kweon S, Polo J, et al. BCL6 is critical for the development of a diverse primary B cell repertoire. J Exp Med. 2010;207:1209-21 pubmed publisher
Gerlach C, van Heijst J, Swart E, Sie D, Armstrong N, Kerkhoven R, et al. One naive T cell, multiple fates in CD8+ T cell differentiation. J Exp Med. 2010;207:1235-46 pubmed publisher
Lio C, Dodson L, Deppong C, Hsieh C, Green J. CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors. J Immunol. 2010;184:6007-13 pubmed publisher
Nozad Charoudeh H, Tang Y, Cheng M, Cilio C, Jacobsen S, Sitnicka E. Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells. Blood. 2010;116:183-92 pubmed publisher
Rathinam C, Flavell R. c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner. Proc Natl Acad Sci U S A. 2010;107:8316-21 pubmed publisher
Macia L, Viltart O, Delacre M, Sachot C, H xe9 liot L, Di Santo J, et al. Interleukin-7, a new cytokine targeting the mouse hypothalamic arcuate nucleus: role in body weight and food intake regulation. PLoS ONE. 2010;5:e9953 pubmed publisher
Higham E, Wittrup K, Chen J. Activation of tolerogenic dendritic cells in the tumor draining lymph nodes by CD8+ T cells engineered to express CD40 ligand. J Immunol. 2010;184:3394-400 pubmed publisher
Zetterblad J, Qian H, Zandi S, Mansson R, Lagergren A, Hansson F, et al. Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication. BMC Genomics. 2010;11:108 pubmed publisher
Yuan J, Crittenden R, Bender T. c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL. J Immunol. 2010;184:2793-804 pubmed publisher
Kovalovsky D, Pezzano M, Ortiz B, Sant Angelo D. A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway. PLoS ONE. 2010;5:e8675 pubmed publisher
Li L, Goetz C, Katerndahl C, Sakaguchi N, Farrar M. A Flt3- and Ras-dependent pathway primes B cell development by inducing a state of IL-7 responsiveness. J Immunol. 2010;184:1728-36 pubmed publisher
Rao R, Li Q, Odunsi K, Shrikant P. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity. 2010;32:67-78 pubmed publisher
Janas M, Varano G, Gudmundsson K, Noda M, Nagasawa T, Turner M. Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4. J Exp Med. 2010;207:247-61 pubmed publisher
Vinay D, Kim C, Chang K, Kwon B. PDCA expression by B lymphocytes reveals important functional attributes. J Immunol. 2010;184:807-15 pubmed publisher
Stadtfeld M, Maherali N, Borkent M, Hochedlinger K. A reprogrammable mouse strain from gene-targeted embryonic stem cells. Nat Methods. 2010;7:53-5 pubmed publisher
Carey B, Markoulaki S, Beard C, Hanna J, Jaenisch R. Single-gene transgenic mouse strains for reprogramming adult somatic cells. Nat Methods. 2010;7:56-9 pubmed publisher
Mansson R, Zandi S, Welinder E, Tsapogas P, Sakaguchi N, Bryder D, et al. Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity. Blood. 2010;115:2601-9 pubmed publisher
Kojima H, Kobayashi A, Sakurai D, Kanno Y, Hase H, Takahashi R, et al. Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow. J Immunol. 2010;184:154-63 pubmed publisher
van Lent A, Dontje W, Nagasawa M, Siamari R, Bakker A, Pouw S, et al. IL-7 enhances thymic human T cell development in "human immune system" Rag2-/-IL-2Rgammac-/- mice without affecting peripheral T cell homeostasis. J Immunol. 2009;183:7645-55 pubmed publisher
Hanna J, Saha K, Pando B, van Zon J, Lengner C, Creyghton M, et al. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature. 2009;462:595-601 pubmed publisher
Watarai H, Rybouchkin A, Hongo N, Nagata Y, Sakata S, Sekine E, et al. Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Valpha14-Jalpha18 TCRalpha gene. Blood. 2010;115:230-7 pubmed publisher
Fahl S, Crittenden R, Allman D, Bender T. c-Myb is required for pro-B cell differentiation. J Immunol. 2009;183:5582-92 pubmed publisher
Mullighan C, Collins Underwood J, Phillips L, Loudin M, Liu W, Zhang J, et al. Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia. Nat Genet. 2009;41:1243-6 pubmed publisher
Nepal R, Tong L, Kolaj B, Edelmann W, Martin A. Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas. Proc Natl Acad Sci U S A. 2009;106:18698-703 pubmed publisher
Lauritsen J, Wong G, Lee S, Lefebvre J, Ciofani M, Rhodes M, et al. Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. Immunity. 2009;31:565-75 pubmed publisher
Giles A, Bender T, Ravichandran K. The adaptor protein Shc plays a key role during early B cell development. J Immunol. 2009;183:5468-76 pubmed publisher
Jones T, Hallgren J, Humbles A, Burwell T, Finkelman F, Alcaide P, et al. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol. 2009;183:5251-60 pubmed publisher
Wolf A, Eller K, Zeiser R, Dürr C, Gerlach U, Sixt M, et al. The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo. J Immunol. 2009;183:3751-60 pubmed publisher
Gutermuth J, Nograles K, Miyagawa F, Nelson E, Cho Y, Katz S. Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V alpha 2 down-regulation. J Immunol. 2009;183:3130-8 pubmed publisher
Russell L, Capasso M, Vater I, Akasaka T, Bernard O, Calasanz M, et al. Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. Blood. 2009;114:2688-98 pubmed publisher
Sarrazin S, Mossadegh Keller N, Fukao T, Aziz A, Mourcin F, Vanhille L, et al. MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells. Cell. 2009;138:300-13 pubmed publisher
Hou Y, DeVoss J, Dao V, Kwek S, Simko J, McNeel D, et al. An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans. J Clin Invest. 2009;119:2031-41 pubmed publisher
Ben Sasson S, Hu Li J, Quiel J, Cauchetaux S, Ratner M, Shapira I, et al. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc Natl Acad Sci U S A. 2009;106:7119-24 pubmed publisher
Wang X, Chang X, Facchinetti V, Zhuang Y, Su B. MEKK3 is essential for lymphopenia-induced T cell proliferation and survival. J Immunol. 2009;182:3597-608 pubmed publisher
Gekas C, Rhodes K, Gereige L, Helgadottir H, Ferrari R, Kurdistani S, et al. Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood. 2009;113:3461-71 pubmed publisher
Stehling Sun S, Dade J, Nutt S, DeKoter R, Camargo F. Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat Immunol. 2009;10:289-96 pubmed publisher
Opiela S, Koru Sengul T, Adkins B. Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants. Blood. 2009;113:5635-43 pubmed publisher
Cen O, Ueda A, Guzman L, Jain J, Bassiri H, Nichols K, et al. The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression. J Immunol. 2009;182:1370-8 pubmed
Fukushima K, Matsumura I, Ezoe S, Tokunaga M, Yasumi M, Satoh Y, et al. FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells. J Biol Chem. 2009;284:7719-32 pubmed publisher
Takatori H, Kanno Y, Watford W, Tato C, Weiss G, Ivanov I, et al. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med. 2009;206:35-41 pubmed publisher
Sada Ovalle I, Chiba A, Gonzales A, Brenner M, Behar S. Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria. PLoS Pathog. 2008;4:e1000239 pubmed publisher
Nakayama J, Yamamoto M, Hayashi K, Satoh H, Bundo K, Kubo M, et al. BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3. Blood. 2009;113:1483-92 pubmed publisher
Day D, Pham K, Ludford Menting M, Oliaro J, Izon D, Russell S, et al. A method for prolonged imaging of motile lymphocytes. Immunol Cell Biol. 2009;87:154-8 pubmed publisher
Krivtsov A, Feng Z, Lemieux M, Faber J, Vempati S, Sinha A, et al. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell. 2008;14:355-68 pubmed publisher
Serwold T, Ehrlich L, Weissman I. Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis. Blood. 2009;113:807-15 pubmed publisher
Schepers K, Swart E, van Heijst J, Gerlach C, Castrucci M, Sie D, et al. Dissecting T cell lineage relationships by cellular barcoding. J Exp Med. 2008;205:2309-18 pubmed publisher
Kometani K, Moriyama M, Nakashima Y, Katayama Y, Wang S, Yamasaki S, et al. Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alphabeta T-cell development. Blood. 2008;112:4565-73 pubmed publisher
Wang H, Lee C, Qi C, Tailor P, Feng J, Abbasi S, et al. IRF8 regulates B-cell lineage specification, commitment, and differentiation. Blood. 2008;112:4028-38 pubmed publisher
Lio C, Hsieh C. A two-step process for thymic regulatory T cell development. Immunity. 2008;28:100-11 pubmed publisher
Kreymborg K, Etzensperger R, Dumoutier L, Haak S, Rebollo A, Buch T, et al. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol. 2007;179:8098-104 pubmed
Suto A, Nakajima H, Tokumasa N, Takatori H, Kagami S, Suzuki K, et al. Murine plasmacytoid dendritic cells produce IFN-gamma upon IL-4 stimulation. J Immunol. 2005;175:5681-9 pubmed
Cornish A, Chong M, Davey G, Darwiche R, Nicola N, Hilton D, et al. Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J Biol Chem. 2003;278:22755-61 pubmed
Ge Q, Palliser D, Eisen H, Chen J. Homeostatic T cell proliferation in a T cell-dendritic cell coculture system. Proc Natl Acad Sci U S A. 2002;99:2983-8 pubmed
product information
Product Type :
Protein
Product Name :
Mouse IL-7 Recombinant Protein, PeproTech
Catalog # :
217-17-50UG
Quantity :
50 ug
Price :
US 722.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Mouse
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Mouse
Storage :
-20 C
Description :
Interleukin 7 (IL-7) is a hematopoietic cytokine that is constitutively produced by stromal cells from the bone marrow and thymus. IL-7 signals through the IL-7R to promote the differentiation of hematopoietic stem cells to lymphoid precursor cells, which give rise to T cells, B cells, and natural killer cells.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
A630026I06Rik; H-IL-7; hlb368; IL7; Il-7; ILN; Interleukin; interleukin 7; Interleukin7; interleukin-7; M-IL-7
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA