IFNAR2 Monoclonal Antibody (MMHAR-2) | Invitrogen 213851 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IFNAR2 Monoclonal Antibody (MMHAR-2)

catalog :

213851

quantity :

50 µg

price :

US 692

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MMHAR-2

reactivity :

human, mouse

application :

neutralization, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; ; loading ...; fig 4b	Wu Y, Zhao W, Liu Y, Tan X, Li X, Zou Q, et al. Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response. EMBO J. 2018;37: pubmed publisher
blocking or activating experiments; human; fig s1c	Wu X, Dao Thi V, Huang Y, Billerbeck E, Saha D, Hoffmann H, et al. Intrinsic Immunity Shapes Viral Resistance of Stem Cells. Cell. 2018;172:423-438.e25 pubmed publisher
blocking or activating experiments; human; loading ...; fig 4e	Stav Noraas T, Edelmann R, Poulsen L, Sundnes O, Phung D, Küchler A, et al. Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery. J Immunol. 2017;198:3318-3325 pubmed publisher
blocking or activating experiments; mouse; loading ...; fig 3e-g	Zhen A, Rezek V, Youn C, Lam B, Chang N, Rick J, et al. Targeting type I interferon-mediated activation restores immune function in chronic HIV infection. J Clin Invest. 2017;127:260-268 pubmed publisher
blocking or activating experiments; human; 1:1000; loading ...; fig 8b	Qu L, Murakami K, Broughman J, Lay M, Guix S, Tenge V, et al. Replication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response. J Virol. 2016;90:8906-23 pubmed publisher
blocking or activating experiments; human	Bowers N, Helton E, Huijbregts R, Goepfert P, Heath S, Hel Z. Immune suppression by neutrophils in HIV-1 infection: role of PD-L1/PD-1 pathway. PLoS Pathog. 2014;10:e1003993 pubmed publisher
	Dupont M, Souriant S, Balboa L, Vu Manh T, Pingris K, Rousset S, et al. Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages. elife. 2020;9: pubmed publisher
	Becker J, Kinast V, Döring M, Lipps C, Durán V, Spanier J, et al. Human monocyte-derived macrophages inhibit HCMV spread independent of classical antiviral cytokines. Virulence. 2018;9:1669-1684 pubmed publisher
	Ghosh R, Roy S, Franco S. PARP1 depletion induces RIG-I-dependent signaling in human cancer cells. PLoS ONE. 2018;13:e0194611 pubmed publisher
	Liu F, Niu Q, Fan X, Liu C, Zhang J, Wei Z, et al. Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor. J Immunol. 2017;199:3293-3305 pubmed publisher
	Decalf J, Desdouits M, Rodrigues V, Gobert F, Gentili M, Marques Ladeira S, et al. Sensing of HIV-1 Entry Triggers a Type I Interferon Response in Human Primary Macrophages. J Virol. 2017;91: pubmed publisher

product information

Product Type :

Antibody

Product Name :

IFNAR2 Monoclonal Antibody (MMHAR-2)

Catalog # :

213851

Quantity :

50 µg

Price :

US 692

Clonality :

Monoclonal

Purity :

Ion-exchange chromatography, Size-exclusion chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Functional Assay: 10 µg/mL, Neutralization: Assay-dependent

Species :

Human

Clone :

MMHAR-2

Isotype :

IgG2a

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

The type I interferons, IFN-alpha and IFN-beta, are a group of structurally and functionally related proteins that are induced by either viruses or double-stranded RNA and are defined by their ability to confer an antiviral state in cells. IFN-alpha and IFN-beta appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN-gamma) binds to a distinct receptor. This distinct receptor, IFN-alphaR, is only weakly responsive to type I interferons, in contrast to IFN-alpha/betaR, which binds to and responds effectively to IFN-beta and to several of the IFN-alpha subtypes. IFN-alpha/betaR is expressed as two alternatively spliced transcripts, designated IFN-alpha/betaRalpha (IFN-alpha/betaR1) and IFN-alpha/betaRbeta (IFN-alpha/betaR2), both of which are involved in signal transduction and ligand binding.

Immunogen :

Human interferon alpha/beta receptor chain 2

Format :

Liquid

Applications w/Dilutions :

Functional Assay: 10 µg/mL, Neutralization: Assay-dependent

Aliases :

AI747302; human interferon alpha/beta receptor; IFN alpha/betaRbeta; IFN R2; IFNABR; IFNalpha/beta R2; IFN-alpha/beta receptor 2; IFNalpha/betaR2; IFN-alpha/betaR2; IFN-alpha/betaRbeta; IFNalpha/beta-Rbeta; IFN-alpha-REC; IFNAR2; Ifnar-2; IFNARB; IFN-R; IFNR2; IFN-R-2; IMD45; interferon (alpha and beta) receptor 2; interferon (alpha, beta and omega) receptor 2; interferon alpha and beta receptor subunit 2; interferon alpha binding protein; Interferon alpha/beta receptor 2; interferon receptor 2c; interferon-alpha/beta receptor 2; interferon-alpha/beta receptor beta chain; type I interferon alpha/beta receptor 2a; type I interferon receptor 2

more info or order :

Invitrogen product webpage