This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Mouse IL-2 Recombinant Protein, PeproTech
catalog :
212-12-1MG
quantity :
1 mg
price :
US 3235.00
citations: 566
Reference
Zhang X, Lao M, Yang H, Sun K, Dong Y, He L, et al. Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance. Autophagy. 2024;:1-21 pubmed publisher
Jiang C, Mei M, Liu Y, Hou M, Jiao J, Tan Y, et al. PSGL-1 is an evolutionarily conserved antiviral restriction factor. MBio. 2023;14:e0038723 pubmed publisher
Zhang L, Dou X, Zheng Z, Ye C, Lu T, Liang H, et al. YTHDF2/m6 A/NF-κB axis controls anti-tumor immunity by regulating intratumoral Tregs. EMBO J. 2023;42:e113126 pubmed publisher
Nishi W, Wakamatsu E, Machiyama H, Matsushima R, Saito K, Yoshida Y, et al. Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters. Nat Commun. 2023;14:3157 pubmed publisher
LaPorte K, Hernandez R, Santos Savio A, Malek T. Robust IL-2-dependent antitumor immunotherapy requires targeting the high-affinity IL-2R on tumor-specific CD8+ T cells. J Immunother Cancer. 2023;11: pubmed publisher
Kiss M, Mindur J, Yates A, Lee D, Fullard J, Anzai A, et al. Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis. Immunity. 2023;56:1502-1514.e8 pubmed publisher
Jin J, Mu Y, Zhang H, Sturmlechner I, Wang C, Jadhav R, et al. CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging. Nat Aging. 2023;3:600-616 pubmed publisher
Sun X, Zhang C, Sun F, Li S, Wang Y, Wang T, et al. IL-33 promotes double negative T cell survival via the NF-κB pathway. Cell Death Dis. 2023;14:242 pubmed publisher
Kreitz J, Friedrich M, Guru A, Lash B, Saito M, MACRAE R, et al. Programmable protein delivery with a bacterial contractile injection system. Nature. 2023;616:357-364 pubmed publisher
Riera Domingo C, Leite Gomes E, Charatsidou I, Zhao P, Carr xe1 G, Cappellesso F, et al. Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding. Sci Adv. 2023;9:eadd5028 pubmed publisher
Fern xe1 ndez Alfara M, Sibilio A, Martín J, Tusquets Ux xf3 E, Malumbres M, Alcalde V, et al. Antitumor T-cell function requires CPEB4-mediated adaptation to chronic endoplasmic reticulum stress. EMBO J. 2023;42:e111494 pubmed publisher
Cheng K, Ma N, Liang J, Ma X, Feng Q, Liu G, et al. Site-Specific Modification of Virus-Like Particles for Exogenous Tumor Antigen Display and Minimizing Preexisting Immunity. Small. 2023;19:e2300125 pubmed publisher
Yang W, Qiu W, Zhang T, Xu K, Gu Z, Zhou Y, et al. Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis. Nat Commun. 2023;14:863 pubmed publisher
Wang J, Xu L, Peng D, Zhu Y, Gu Z, Yao Y, et al. IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury. Inflamm Regen. 2023;43:12 pubmed publisher
Pitmon E, Meehan E, Ahmadi E, Adler A, Wang K. High glucose promotes regulatory T cell differentiation. PLoS ONE. 2023;18:e0280916 pubmed publisher
Meng Z, Niu X, Xia L, Chen Y, Wang Z, Wang H, et al. A 3D Ex Vivo Tumor-Immune Coculture System Mimicking In Vivo Tumor Environmental Stress on CD8+ T Cells Exhaustion. Adv Biol (Weinh). 2023;7:e2200264 pubmed publisher
Quijano Rubio A, Bhuiyan A, Yang H, Leung I, Bello E, Ali L, et al. A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy. Nat Biotechnol. 2023;41:532-540 pubmed publisher
Alluqmani N, Jirovec A, Taha Z, Varette O, Chen A, Serrano D, et al. Vanadyl sulfate-enhanced oncolytic virus immunotherapy mediates the antitumor immune response by upregulating the secretion of pro-inflammatory cytokines and chemokines. Front Immunol. 2022;13:1032356 pubmed publisher
Liu J, Pan L, Hong W, Chen S, Bai P, Luo W, et al. GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression. Nat Commun. 2022;13:7519 pubmed publisher
Hu X, Zou Y, Copland D, Schewitz Bowers L, Li Y, Lait P, et al. Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2. EBioMedicine. 2022;86:104333 pubmed publisher
Lopez Krol A, Nehring H, Krause F, Wempe A, Raifer H, Nist A, et al. Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells. EMBO Rep. 2022;23:e54685 pubmed publisher
Schmitt E, Toth K, Risma S, Kolicheski A, Saucier N, Berr xed os R, et al. A human STAT3 gain-of-function variant confers T cell dysregulation without predominant Treg dysfunction in mice. JCI Insight. 2022;7: pubmed publisher
Tajima M, Strober W. Evaluation of Glutaminolysis in T Cells. Curr Protoc. 2022;2:e540 pubmed publisher
S xe1 nchez Paulete A, Mateus Tique J, Mollaoglu G, Nielsen S, Marks A, Lakshmi A, et al. Targeting Macrophages with CAR T Cells Delays Solid Tumor Progression and Enhances Antitumor Immunity. Cancer Immunol Res. 2022;10:1354-1369 pubmed publisher
Li X, Lu M, Yuan M, Ye J, Zhang W, Xu L, et al. CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapy. Oncoimmunology. 2022;11:2118210 pubmed publisher
Kanno T, Miyako K, Nakajima T, Yokoyama S, Sasamoto S, Asou H, et al. SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4+ T cells. Front Immunol. 2022;13:904875 pubmed publisher
Xiong A, Zhang J, Chen Y, Zhang Y, Yang F. Integrated single-cell transcriptomic analyses reveal that GPNMB-high macrophages promote PN-MES transition and impede T cell activation in GBM. EBioMedicine. 2022;83:104239 pubmed publisher
Hiatt J, Sandborg H, Garrison S, Arnold H, Liao S, Norton J, et al. Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing. Clin Cancer Res. 2022;28:4551-4564 pubmed publisher
Matsumoto K, Kumar V, Varshney S, Nairn A, Ito A, Pennarubia F, et al. Fringe GlcNAc-transferases differentially extend O-fucose on endogenous NOTCH1 in mouse activated T cells. J Biol Chem. 2022;298:102064 pubmed publisher
Zhang R, Wang Y, Liu D, Luo Q, Du P, Zhang H, et al. Sodium Tanshinone IIA Sulfonate as a Potent IDO1/TDO2 Dual Inhibitor Enhances Anti-PD1 Therapy for Colorectal Cancer in Mice. Front Pharmacol. 2022;13:870848 pubmed publisher
Gil Del Alcazar C, Trinh A, Aleckovic M, Rojas Jimenez E, Harper N, Oliphant M, et al. Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer. Cancer Immunol Res. 2022;10:680-697 pubmed publisher
Meléndez E, Chondronasiou D, Mosteiro L, Mart xed nez de Villarreal J, Fern xe1 ndez Alfara M, Lynch C, et al. Natural killer cells act as an extrinsic barrier for in vivo reprogramming. Development. 2022;149: pubmed publisher
Xuan W, Hsu W, Khan F, Dunterman M, Pang L, Wainwright D, et al. Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma. Cancer Immunol Res. 2022;10:770-784 pubmed publisher
Kim H, Davies A, Oh S. In Vitro Visualization of Cell-to-Cell Interactions Between Natural Killer Cells and Sensory Neurons. Methods Mol Biol. 2022;2463:251-268 pubmed publisher
Samborska B, Roy D, Rahbani J, Hussain M, Ma E, Jones R, et al. Creatine transport and creatine kinase activity is required for CD8+ T cell immunity. Cell Rep. 2022;38:110446 pubmed publisher
Zhang S, Yu F, Che A, Tan B, Huang C, Chen Y, et al. Neuroendocrine Regulation of Stress-Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway. Adv Sci (Weinh). 2022;9:e2104132 pubmed publisher
Panda A, Kim Y, Shevach E. Control of Memory Phenotype T Lymphocyte Homeostasis: Role of Costimulation. J Immunol. 2022;208:851-860 pubmed publisher
Kerdidani D, Aerakis E, Verrou K, Angelidis I, Douka K, Maniou M, et al. Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts. J Exp Med. 2022;219: pubmed publisher
Xu W, Li S, Li M, Zhou H, Yang X. Upregulation of CD3ζ and L-selectin in antigen-specific cytotoxic T lymphocytes by eliminating myeloid-derived suppressor cells with doxorubicin to improve killing efficacy of neuroblastoma cells in vitro. J Clin Lab Anal. 2022;36:e24158 pubmed publisher
Celus W, Oliveira A, Rivis S, Van Acker H, Landeloos E, Serneels J, et al. Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer. Cancer Immunol Res. 2022;10:126-141 pubmed publisher
Evrard M, Wynne Jones E, Peng C, Kato Y, Christo S, Fonseca R, et al. Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes. J Exp Med. 2022;219: pubmed publisher
Azevedo C, Cotias A, Arantes A, Ferreira T, Martins M, Olsen P. Assessment of Allergen-Responsive Regulatory T Cells in Experimental Asthma Induced in Different Mouse Strains. Mediators Inflamm. 2021;2021:7584483 pubmed publisher
He X, Zhou S, Dolan M, Shi Y, Wang J, Quinn B, et al. Immunization with short peptide particles reveals a functional CD8+ T-cell neoepitope in a murine renal carcinoma model. J Immunother Cancer. 2021;9: pubmed publisher
Wilfahrt D, Philips R, Lama J, Kizerwetter M, Shapiro M, McCue S, et al. Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation. elife. 2021;10: pubmed publisher
Nakajima T, Kanno T, Yokoyama S, Sasamoto S, Asou H, Tumes D, et al. ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice. J Exp Med. 2021;218: pubmed publisher
Miao M, Masengere H, Yu G, Shan F. Reevaluation of NOD/SCID Mice as NK Cell-Deficient Models. Biomed Res Int. 2021;2021:8851986 pubmed publisher
Stamos D, Clubb L, Mitra A, Chopp L, Nie J, Ding Y, et al. The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development. J Exp Med. 2021;218: pubmed publisher
He X, Zhou S, Quinn B, Huang W, Jahagirdar D, Vega M, et al. Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8+ T-Cell Responses. Adv Sci (Weinh). 2021;8:e2103023 pubmed publisher
Pessoa Rodrigues C, Chatterjee A, Wiese M, Stehle T, Szymanski W, Shvedunova M, et al. Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice. Nat Commun. 2021;12:6212 pubmed publisher
Witkowski M, Tizian C, Ferreira Gomes M, Niemeyer D, Jones T, Heinrich F, et al. Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells. Nature. 2021;600:295-301 pubmed publisher
Guo B, Peng Y, Gu Y, Zhong Y, Su C, Liu L, et al. Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells' maturation and function. Open Life Sci. 2021;16:1064-1081 pubmed publisher
Jang Y, Song H, Seo G, Jo H, Park S, Park H, et al. Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β. J Immunol. 2021;207:2456-2464 pubmed publisher
Zhao X, Liu J, Zhang C, Yu N, Lu Z, Zhang S, et al. Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase. Int J Oral Sci. 2021;13:31 pubmed publisher
Onodera T, Kita S, Adachi Y, Moriyama S, Sato A, Nomura T, et al. A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site. Immunity. 2021;54:2385-2398.e10 pubmed publisher
Berber E, Sumbria D, Newkirk K, Rouse B. Inhibiting Glucose Metabolism Results in Herpes Simplex Encephalitis. J Immunol. 2021;207:1824-1835 pubmed publisher
Friedrich C, Taggenbrock R, Doucet Ladev xe8 ze R, Golda G, Moenius R, Arampatzi P, et al. Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues. Nat Immunol. 2021;22:1256-1267 pubmed publisher
Li Y, Su Z, Zhao W, Zhang X, Momin N, Zhang C, et al. Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity. Nat Cancer. 2020;1:882-893 pubmed publisher
Akasu M, Shimada S, Kabashima A, Akiyama Y, Shimokawa M, Akahoshi K, et al. Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma. Sci Rep. 2021;11:16732 pubmed publisher
Christo S, Evrard M, Park S, Gandolfo L, Burn T, Fonseca R, et al. Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity. Nat Immunol. 2021;22:1140-1151 pubmed publisher
Veatch J, Singhi N, Srivastava S, Szeto J, Jesernig B, Stull S, et al. A therapeutic cancer vaccine delivers antigens and adjuvants to lymphoid tissues using genetically modified T cells. J Clin Invest. 2021;131: pubmed publisher
Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz T, et al. Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. Cell. 2021;184:4753-4771.e27 pubmed publisher
Sobecki M, Krzywinska E, Nagarajan S, Audig xe9 A, Hu x1ef3 nh K, Zacharjasz J, et al. NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence. Nat Commun. 2021;12:4700 pubmed publisher
Gemberling M, Siklenka K, Rodriguez E, Tonn Eisinger K, Barrera A, Liu F, et al. Transgenic mice for in vivo epigenome editing with CRISPR-based systems. Nat Methods. 2021;18:965-974 pubmed publisher
Kim G, Kim W, Lim S, Lee H, Koo J, Nam K, et al. In Vivo Induction of Regulatory T Cells Via CTLA-4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse. Adv Sci (Weinh). 2021;8:2004973 pubmed publisher
He J, Shangguan X, Zhou W, Cao Y, Zheng Q, Tu J, et al. Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. Nat Commun. 2021;12:4371 pubmed publisher
Liu C, Gong Y, Zhang H, Yang H, Zeng Y, Bian Z, et al. Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells. Cell Res. 2021;: pubmed publisher
Marks K, Flaherty S, Patterson K, STRATTON M, Martinez G, Reynolds J. Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration. Cell Rep. 2021;35:109303 pubmed publisher
Lu S, De Neef E, Thomas J, SABIO E, Rousseau B, Gigoux M, et al. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell. 2021;184:4032-4047.e31 pubmed publisher
Anastasiou M, Newton G, Kaur K, Carrillo Salinas F, Smolgovsky S, Bayer A, et al. Endothelial STING controls T cell transmigration in an IFNI-dependent manner. JCI Insight. 2021;6: pubmed publisher
Yakkala C, Dagher J, Sempoux C, Chiang C, Denys A, Kandalaft L, et al. Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma. Front Immunol. 2021;12:695150 pubmed publisher
Debackere K, Marcelis L, Demeyer S, Vanden Bempt M, Mentens N, Gielen O, et al. Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. Nat Commun. 2021;12:3705 pubmed publisher
Xu S, Chaudhary O, Rodríguez Morales P, Sun X, Chen D, Zappasodi R, et al. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors. Immunity. 2021;54:1561-1577.e7 pubmed publisher
Sonoda S, Murata S, Kato H, Zakaria F, Kyumoto Nakamura Y, Uehara N, et al. Targeting of Deciduous Tooth Pulp Stem Cell-Derived Extracellular Vesicles on Telomerase-Mediated Stem Cell Niche and Immune Regulation in Systemic Lupus Erythematosus. J Immunol. 2021;206:3053-3063 pubmed publisher
Nanou A, Bourbouli M, Vetrano S, Schaeper U, Ley S, Kollias G. Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis. Cell Rep. 2021;35:109168 pubmed publisher
Hao F, Tian M, Zhang X, Jin X, Jiang Y, Sun X, et al. Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Sasai M, Ma J, Okamoto M, Nishino K, Nagaoka H, Takashima E, et al. Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells. J Exp Med. 2021;218: pubmed publisher
Ercolano G, Gomez Cadena A, Dumauthioz N, Vanoni G, Kreutzfeldt M, Wyss T, et al. PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions. Nat Commun. 2021;12:2538 pubmed publisher
Li Z, Morman R, Hegermiller E, Sun M, Bartom E, Maienschein Cline M, et al. The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude. J Exp Med. 2021;218: pubmed publisher
Tao H, Pan Y, Chu S, Li L, Xie J, Wang P, et al. Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals. Nat Commun. 2021;12:2029 pubmed publisher
Sripada A, Sirohi K, Michalec L, Guo L, McKay J, Yadav S, et al. Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases. PLoS Biol. 2021;19:e3001063 pubmed publisher
Jiang C, Chen K, Liu A, Huang H, Fan Y, Zhao D, et al. Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy. Nat Commun. 2021;12:1359 pubmed publisher
Dupont M, Guillemot V, Campagne P, Serafini N, Marie S, Montagutelli X, et al. Host genetic control of natural killer cell diversity revealed in the Collaborative Cross. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
He X, Zhou S, Huang W, Seffouh A, Mabrouk M, Morgan M, et al. A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8+ T Cell Epitopes. ACS Nano. 2021;15:4357-4371 pubmed publisher
Xin G, Chen Y, Topchyan P, Kasmani M, Burns R, Volberding P, et al. Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer. Cancer Immunol Res. 2021;9:454-469 pubmed publisher
Li Y, Cong Y, Jia M, He Q, Zhong H, Zhao Y, et al. Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy. Nat Commun. 2021;12:951 pubmed publisher
Rodriguez Garcia A, Lynn R, Poussin M, Eiva M, Shaw L, O Connor R, et al. CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy. Nat Commun. 2021;12:877 pubmed publisher
Bielecki P, Riesenfeld S, Hütter J, Torlai Triglia E, Kowalczyk M, Ricardo Gonzalez R, et al. Skin-resident innate lymphoid cells converge on a pathogenic effector state. Nature. 2021;592:128-132 pubmed publisher
Rustenhoven J, Drieu A, Mamuladze T, de Lima K, Dykstra T, Wall M, et al. Functional characterization of the dural sinuses as a neuroimmune interface. Cell. 2021;184:1000-1016.e27 pubmed publisher
Drube S, M xfc ller S, Weber F, Wegner P, B xf6 ttcher Loschinski R, Gaestel M, et al. IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt+ Treg generation via enhanced IL-6 induction. Immunology. 2021;163:86-97 pubmed publisher
Deuse T, Hu X, Agbor Enoh S, Jang M, Alawi M, Saygi C, et al. The SIRPα-CD47 immune checkpoint in NK cells. J Exp Med. 2021;218: pubmed publisher
Yu W, Chen C, Kou X, Sui B, Yu T, Liu D, et al. Mechanical force-driven TNFα endocytosis governs stem cell homeostasis. Bone Res. 2021;8:44 pubmed publisher
Vimond N, Lasselin J, Anegon I, Guillonneau C, Bezié S. Genetic engineering of human and mouse CD4+ and CD8+ Tregs using lentiviral vectors encoding chimeric antigen receptors. Mol Ther Methods Clin Dev. 2021;20:69-85 pubmed publisher
Karki R, Sharma B, Tuladhar S, Williams E, Zalduondo L, Samir P, et al. Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes. Cell. 2021;184:149-168.e17 pubmed publisher
Wei Z, Du Q, Li P, Liu H, Xia M, Chen Y, et al. Death-associated protein kinase 1 (DAPK1) controls CD8+ T cell activation, trafficking, and antitumor activity. FASEB J. 2021;35:e21138 pubmed publisher
Shen H, Gu C, Liang T, Liu H, Guo F, Liu X. Unveiling the heterogeneity of NKT cells in the liver through single cell RNA sequencing. Sci Rep. 2020;10:19453 pubmed publisher
Karki R, Sharma B, Tuladhar S, Williams E, Zalduondo L, Samir P, et al. Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. bioRxiv. 2020;: pubmed publisher
Montel Hagen A, Sun V, Casero D, Tsai S, Zampieri A, Jackson N, et al. In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells. Cell Rep. 2020;33:108320 pubmed publisher
Bartish M, Tong D, Pan Y, Wallerius M, Liu H, Ristau J, et al. MNK2 governs the macrophage antiinflammatory phenotype. Proc Natl Acad Sci U S A. 2020;117:27556-27565 pubmed publisher
Braun M, Aguilera A, Sundarrajan A, Corvino D, Stannard K, Krumeich S, et al. CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells. Immunity. 2020;53:805-823.e15 pubmed publisher
Browning L, Miller C, Kuczma M, Pietrzak M, Jing Y, Rempala G, et al. Bone Morphogenic Proteins Are Immunoregulatory Cytokines Controlling FOXP3+ Treg Cells. Cell Rep. 2020;33:108219 pubmed publisher
Zeis P, Lian M, Fan X, Herman J, Hernandez D, Gentek R, et al. In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors. Immunity. 2020;53:775-792.e9 pubmed publisher
Wang N, Yi H, Fang L, Jin J, Ma Q, Shen Y, et al. CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model. Front Immunol. 2020;11:1883 pubmed publisher
Sakai R, Ito M, Komai K, Iizuka Koga M, Matsuo K, Nakayama T, et al. Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury. Cell Mol Immunol. 2021;18:1249-1261 pubmed publisher
Piseddu I, R xf6 hrle N, Knott M, Moder S, Eiber S, Schnell K, et al. Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF. J Immunol. 2020;205:2056-2065 pubmed publisher
Bromley S, Akbaba H, Mani V, Mora Buch R, Chasse A, Sama A, et al. CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response. Cell Rep. 2020;32:108085 pubmed publisher
Daams R, Sime W, Leandersson K, Sitnicka E, Massoumi R. Deletion of Nemo-like Kinase in T Cells Reduces Single-Positive CD8+ Thymocyte Population. J Immunol. 2020;205:1830-1841 pubmed publisher
Xia X, Cao G, Sun G, Zhu L, Tian Y, Song Y, et al. GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis. J Clin Invest. 2020;130:5180-5196 pubmed publisher
Chang D, Xing Q, Su Y, Zhao X, Xu W, Wang X, et al. The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation. Immunity. 2020;53:614-626.e4 pubmed publisher
Johnson D, Okondo M, Orth E, Rao S, Huang H, Ball D, et al. DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes. Cell Death Dis. 2020;11:628 pubmed publisher
Campesato L, Budhu S, Tchaicha J, Weng C, Gigoux M, Cohen I, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nat Commun. 2020;11:4011 pubmed publisher
Kupz A, Pai S, Giacomin P, Whan J, Walker R, Hammoudi P, et al. Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells. Sci Rep. 2020;10:13115 pubmed publisher
Kim D, Nguyen Q, Lee J, Lee S, Janocha A, Kim S, et al. Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism. Immunity. 2020;53:581-596.e5 pubmed publisher
Bachmann M, Lamprecht L, Gonther S, Pfeilschifter J, Muhl H. A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury. J Cell Mol Med. 2020;: pubmed publisher
Olesch C, Sirait Fischer E, Berkefeld M, Fink A, Susen R, Ritter B, et al. S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion. J Clin Invest. 2020;130:5461-5476 pubmed publisher
Xu H, Agalioti T, Zhao J, Steglich B, Wahib R, Vesely M, et al. The induction and function of the anti-inflammatory fate of TH17 cells. Nat Commun. 2020;11:3334 pubmed publisher
Li Z, He C, Zhang J, Zhang H, Wei H, Wu S, et al. P2Y6 Deficiency Enhances Dendritic Cell-Mediated Th1/Th17 Differentiation and Aggravates Experimental Autoimmune Encephalomyelitis. J Immunol. 2020;205:387-397 pubmed publisher
Meyer L, Verbist K, Albeituni S, Scull B, Bassett R, Stroh A, et al. JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation. Blood. 2020;136:657-668 pubmed publisher
Mart xed n Leal A, Blanco R, Casas J, S xe1 ez M, Rodr xed guez Bovolenta E, de Rojas I, et al. CCR5 deficiency impairs CD4+ T-cell memory responses and antigenic sensitivity through increased ceramide synthesis. EMBO J. 2020;39:e104749 pubmed publisher
LaMarche N, Kane H, Kohlgruber A, Dong H, Lynch L, Brenner M. Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis. Cell Metab. 2020;32:243-258.e6 pubmed publisher
Grant F, Yang J, Nasrallah R, Clarke J, Sadiyah F, Whiteside S, et al. BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression. J Exp Med. 2020;217: pubmed publisher
Chou Y, Lin C, Dzhagalov I, Chen N, Lin C, Lin C, et al. Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy. Sci Rep. 2020;10:8422 pubmed publisher
Beltra J, Manne S, Abdel Hakeem M, Kurachi M, Giles J, Chen Z, et al. Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms. Immunity. 2020;52:825-841.e8 pubmed publisher
Keller H, Kim H, Jo Y, Gress R, Hong C, Park J. The Abundance and Availability of Cytokine Receptor IL-2Rβ (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells. J Immunol. 2020;204:3227-3235 pubmed publisher
Yin Y, Frank D, Zhou W, Kaur N, French J, Carpino N. An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling. J Biol Chem. 2020;295:8514-8523 pubmed publisher
Wang Z, Wang F, Zhong J, Zhu T, Zheng Y, Zhao T, et al. Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors. Nat Commun. 2020;11:2163 pubmed publisher
Raynor J, Liu C, Dhungana Y, Guy C, Chapman N, Shi H, et al. Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions. J Exp Med. 2020;217: pubmed publisher
Donado C, Cao A, Simmons D, Croker B, Brennan P, Brenner M. A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling. Cell Rep. 2020;31:107466 pubmed publisher
Dang N, Lin Y, Waer M, Sprangers B. Donor Lymphocyte-Derived Natural Killer Cells Control MHC Class I-Negative Melanoma. Cancer Immunol Res. 2020;8:756-768 pubmed publisher
Wang Z, Zhao M, Yin J, Liu L, Hu L, Huang Y, et al. E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases. J Clin Invest. 2020;130:3717-3733 pubmed publisher
Yang L, García Cañaveras J, Chen Z, Wang L, Liang L, Jang C, et al. Serine Catabolism Feeds NADH when Respiration Is Impaired. Cell Metab. 2020;31:809-821.e6 pubmed publisher
Hegde S, Krisnawan V, Herzog B, Zuo C, Breden M, Knolhoff B, et al. Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer. Cancer Cell. 2020;37:289-307.e9 pubmed publisher
Davenport B, Bullock C, McCarthy M, Hawman D, Murphy K, Kedl R, et al. Chikungunya Virus Evades Antiviral CD8+ T Cell Responses To Establish Persistent Infection in Joint-Associated Tissues. J Virol. 2020;94: pubmed publisher
Roy D, Chen J, Mamane V, Ma E, Muhire B, Sheldon R, et al. Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming. Cell Metab. 2020;31:250-266.e9 pubmed publisher
Lubrano Di Ricco M, Ronin E, Collares D, Divoux J, Gr xe9 goire S, Wajant H, et al. Tumor necrosis factor receptor family costimulation increases regulatory T-cell activation and function via NF-κB. Eur J Immunol. 2020;50:972-985 pubmed publisher
Köhler C, Smole U, Kratzer B, Trapin D, Schmetterer K, Pickl W. Allergen alters IL-2/αIL-2-based Treg expansion but not tolerance induction in an allergen-specific mouse model. Allergy. 2020;75:1618-1629 pubmed publisher
Song B, Lee J, Park Y, Kim I, Kim B, Shin K, et al. Differentiation of c-Kit+ CD24+ natural killer cells into myeloid cells in a GATA-2-dependent manner. FASEB J. 2020;34:4462-4481 pubmed publisher
Sledzińska A, Vila de Mucha M, Bergerhoff K, Hotblack A, Demane D, Ghorani E, et al. Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells. Immunity. 2020;52:151-166.e6 pubmed publisher
Huang Y, Li D, Zhang P, Liu M, Liang X, Yang X, et al. IL-18R-dependent and independent pathways account for IL-18-enhanced antitumor ability of CAR-T cells. FASEB J. 2020;34:1768-1782 pubmed publisher
Gamache A, Cronk J, Nash W, Puchalski P, Gillespie A, Wei H, et al. Ly49R activation receptor drives self-MHC-educated NK cell immunity against cytomegalovirus infection. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Greenberg Z, Monlish D, Bartnett R, Yang Y, Shen G, Li W, et al. The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling. J Immunol. 2020;204:58-67 pubmed publisher
Ma E, Verway M, Johnson R, Roy D, Steadman M, Hayes S, et al. Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells. Immunity. 2019;51:856-870.e5 pubmed publisher
Xu W, Zhao X, Wang X, Feng H, Gou M, Jin W, et al. The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility. Immunity. 2019;51:826-839.e5 pubmed publisher
Shi H, Chapman N, Wen J, Guy C, Long L, Dhungana Y, et al. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. 2019;51:1012-1027.e7 pubmed publisher
Belle N, Ji Y, Herbine K, Wei Y, Park J, Zullo K, et al. TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths. Nat Commun. 2019;10:4408 pubmed publisher
Tian D, Yang L, Wang S, Zhu Y, Shi W, Zhang C, et al. Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma. Nat Commun. 2019;10:4246 pubmed publisher
Sun X, Cui Y, Feng H, Liu H, Liu X. TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity. J Exp Med. 2019;216:2819-2837 pubmed publisher
Rivadeneira D, DePeaux K, Wang Y, Kulkarni A, Tabib T, Menk A, et al. Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance. Immunity. 2019;51:548-560.e4 pubmed publisher
Rasoulouniriana D, Santana Magal N, Gutwillig A, Farhat Younis L, Wine Y, Saperia C, et al. A distinct subset of FcγRI-expressing Th1 cells exert antibody-mediated cytotoxic activity. J Clin Invest. 2019;129:4151-4164 pubmed publisher
Vacchio M, Ciucci T, Gao Y, Watanabe M, Balmaceno Criss M, McGinty M, et al. A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation. Immunity. 2019;51:465-478.e6 pubmed publisher
Li J, Yang K, Tam R, Chan V, Lan H, Hori S, et al. Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. Theranostics. 2019;9:4324-4341 pubmed publisher
Katagiri T, Yamazaki S, Fukui Y, Aoki K, Yagita H, Nishina T, et al. JunB plays a crucial role in development of regulatory T cells by promoting IL-2 signaling. Mucosal Immunol. 2019;12:1104-1117 pubmed publisher
Zinzow Kramer W, Weiss A, Au Yeung B. Adaptation by naïve CD4+ T cells to self-antigen-dependent TCR signaling induces functional heterogeneity and tolerance. Proc Natl Acad Sci U S A. 2019;116:15160-15169 pubmed publisher
Czystowska Kuzmicz M, Sosnowska A, Nowis D, Ramji K, Szajnik M, Chlebowska Tuz J, et al. Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma. Nat Commun. 2019;10:3000 pubmed publisher
Wang Z, Ji N, Chen Z, Wu C, Sun Z, Yu W, et al. Next Generation Sequencing for Long Non-coding RNAs Profile for CD4+ T Cells in the Mouse Model of Acute Asthma. Front Genet. 2019;10:545 pubmed publisher
Pilat N, Wiletel M, Weijler A, Steiner R, Mahr B, Warren J, et al. Treg-mediated prolonged survival of skin allografts without immunosuppression. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Železnjak J, Lisnic V, Popovic B, Lisnić B, Babic M, Halenius A, et al. The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors. J Exp Med. 2019;: pubmed publisher
Kaushik D, Bhattacharya A, Mirzaei R, Rawji K, Ahn Y, Rho J, et al. Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis. J Clin Invest. 2019;129:3277-3292 pubmed publisher
Komuczki J, Tuzlak S, Friebel E, Hartwig T, Spath S, Rosenstiel P, et al. Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β. Immunity. 2019;: pubmed publisher
Kotov J, Kotov D, Linehan J, Bardwell V, Gearhart M, Jenkins M. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216:1450-1464 pubmed publisher
van der Veeken J, Zhong Y, Sharma R, Mazutis L, Dao P, PE ER D, et al. Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells. Immunity. 2019;50:1202-1217.e7 pubmed publisher
Yang L, Sun J, Liu Q, Zhu R, Yang Q, Hua J, et al. Synergetic Functional Nanocomposites Enhance Immunotherapy in Solid Tumors by Remodeling the Immunoenvironment. Adv Sci (Weinh). 2019;6:1802012 pubmed publisher
Pang C, Zhu C, Zhang Y, Ge Y, Li S, Huo S, et al. 2,3,7,8-Tetrachloodibenzo-p-dioxin affects the differentiation of CD4 helper T cell. Toxicol Lett. 2019;311:49-57 pubmed publisher
Tuncel J, Benoist C, Mathis D. T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33. J Exp Med. 2019;216:1328-1344 pubmed publisher
Niogret C, Miah S, Rota G, Fonta N, Wang H, Held W, et al. Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells. Nat Commun. 2019;10:1444 pubmed publisher
Srivastava S, Salter A, Liggitt D, Yechan Gunja S, Sarvothama M, Cooper K, et al. Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. Cancer Cell. 2019;35:489-503.e8 pubmed publisher
Yang J, Yang X, Yang J, Li M. Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells. Cell Death Dis. 2019;10:140 pubmed publisher
van den Ham H, Binai N, Zaaraoui Boutahar F, Heck A, Andeweg A. Proteomic Profiling of Mouse Helper T Cell Differentiation. Proteomics. 2019;19:e1800045 pubmed publisher
Adoue V, Binet B, Malbec A, Fourquet J, Romagnoli P, van Meerwijk J, et al. The Histone Methyltransferase SETDB1 Controls T Helper Cell Lineage Integrity by Repressing Endogenous Retroviruses. Immunity. 2019;50:629-644.e8 pubmed publisher
Pai C, Huang J, Lu X, Simons D, Park C, Chang A, et al. Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade. Immunity. 2019;50:477-492.e8 pubmed publisher
Davies A, Kim H, González Cano R, Choi J, Back S, Roh S, et al. Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. Cell. 2019;176:716-728.e18 pubmed publisher
Miyamoto C, Kojo S, Yamashita M, Moro K, Lacaud G, Shiroguchi K, et al. Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation. Nat Commun. 2019;10:447 pubmed publisher
Sakai Y, Miyazawa M, Komura T, Yamada T, Nasti A, Yoshida K, et al. Distinct chemotherapy-associated anti-cancer immunity by myeloid cells inhibition in murine pancreatic cancer models. Cancer Sci. 2019;110:903-912 pubmed publisher
Weckbach L, Grabmaier U, Uhl A, Gess S, Boehm F, Zehrer A, et al. Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis. J Exp Med. 2019;216:350-368 pubmed publisher
Siddiqui I, Schaeuble K, Chennupati V, Fuertes Marraco S, Calderon Copete S, Pais Ferreira D, et al. Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy. Immunity. 2019;50:195-211.e10 pubmed publisher
Yamada T, Nabe S, Toriyama K, Suzuki J, Inoue K, Imai Y, et al. Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells. J Immunol. 2019;202:1088-1098 pubmed publisher
Yuan C, Qu Z, Tang X, Liu Q, Luo W, Huang C, et al. Mycobacterium tuberculosis Mannose-Capped Lipoarabinomannan Induces IL-10-Producing B Cells and Hinders CD4+Th1 Immunity. iScience. 2019;11:13-30 pubmed publisher
Ren W, Liao Y, Ding X, Jiang Y, Yan J, Xia Y, et al. Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection. Mucosal Immunol. 2019;12:531-544 pubmed publisher
Mathies F, Steffens N, Kleinschmidt D, Stuhlmann F, Huber F, Roy U, et al. Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells. J Immunol. 2018;201:3558-3568 pubmed publisher
Li S, Bostick J, Ye J, Qiu J, Zhang B, Urban J, et al. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018;49:915-928.e5 pubmed publisher
Shi H, Liu C, Tan H, Li Y, Nguyen T, Dhungana Y, et al. Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity. Immunity. 2018;49:899-914.e6 pubmed publisher
Yin W, Song Y, Chang X. Single-cell RNA-Seq analysis identifies a noncoding interleukin 4 (IL-4) RNA that post-transcriptionally up-regulates IL-4 production in T helper cells. J Biol Chem. 2019;294:290-298 pubmed publisher
Fatkhullina A, Peshkova I, Dzutsev A, Aghayev T, McCulloch J, Thovarai V, et al. An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis. Immunity. 2018;49:943-957.e9 pubmed publisher
Mulati K, Hamanishi J, Matsumura N, Chamoto K, Mise N, Abiko K, et al. VISTA expressed in tumour cells regulates T cell function. Br J Cancer. 2019;120:115-127 pubmed publisher
Lane R, Femel J, Breazeale A, Loo C, Thibault G, Kaempf A, et al. IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin. J Exp Med. 2018;215:3057-3074 pubmed publisher
DiTommaso T, Cole J, Cassereau L, Buggé J, Hanson J, Bridgen D, et al. Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo. Proc Natl Acad Sci U S A. 2018;115:E10907-E10914 pubmed publisher
Singh A, Khare P, Obaid A, Conlon K, Basrur V, Depinho R, et al. SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2. Nat Commun. 2018;9:4515 pubmed publisher
Wroblewska A, Dhainaut M, Ben Zvi B, Rose S, Park E, Amir E, et al. Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens. Cell. 2018;175:1141-1155.e16 pubmed publisher
Proto J, Doran A, Gusarova G, Yurdagul A, Sozen E, Subramanian M, et al. Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity. 2018;49:666-677.e6 pubmed publisher
Giambra V, Gusscott S, Gracias D, Song R, Lam S, Panelli P, et al. Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity. Cell Stem Cell. 2018;23:714-726.e7 pubmed publisher
Chen S, Yun F, Yao Y, Cao M, Zhang Y, Wang J, et al. USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein. J Exp Med. 2018;215:2850-2867 pubmed publisher
Gawden Bone C, Frazer G, Richard A, Ma C, Strege K, Griffiths G. PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes. Immunity. 2018;49:427-437.e4 pubmed publisher
Lv Q, Shi C, Qiao S, Cao N, Guan C, Dai Y, et al. Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation. Cell Death Dis. 2018;9:890 pubmed publisher
Yokoyama Y, Iwasaki T, Kitano S, Satake A, Nomura S, Furukawa T, et al. IL-2-Anti-IL-2 Monoclonal Antibody Immune Complexes Inhibit Collagen-Induced Arthritis by Augmenting Regulatory T Cell Functions. J Immunol. 2018;201:1899-1906 pubmed publisher
Spangler J, Trotta E, Tomala J, Peck A, Young T, Savvides C, et al. Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy. J Immunol. 2018;201:2094-2106 pubmed publisher
Shi J, Hou S, Fang Q, Liu X, Liu X, Qi H. PD-1 Controls Follicular T Helper Cell Positioning and Function. Immunity. 2018;49:264-274.e4 pubmed publisher
Jung K, Lee H, Son Y, Lee M, Kim Y, Oh S, et al. Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids. Nat Commun. 2018;9:3039 pubmed publisher
Wan X, Pei W, Shahzad K, Zhang L, Song S, Jin X, et al. A Tolerogenic Artificial APC Durably Ameliorates Experimental Autoimmune Encephalomyelitis by Directly and Selectively Modulating Myelin Peptide-Autoreactive CD4+ and CD8+ T Cells. J Immunol. 2018;201:1194-1210 pubmed publisher
Castro W, Chelbi S, Niogret C, Ramón Barros C, Welten S, Osterheld K, et al. The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity. Nat Immunol. 2018;19:809-820 pubmed publisher
Jensen C, Åhsberg J, Sommarin M, Strid T, Somasundaram R, Okuyama K, et al. Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis. J Exp Med. 2018;215:1947-1963 pubmed publisher
Li C, DiSpirito J, Zemmour D, Spallanzani R, Kuswanto W, Benoist C, et al. TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype. Cell. 2018;174:285-299.e12 pubmed publisher
Sun I, Oh M, Zhao L, Patel C, Arwood M, Xu W, et al. mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells. J Immunol. 2018;201:481-492 pubmed publisher
Hu M, Ethridge A, Lipstein R, Kumar S, Wang Y, Jabri B, et al. Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa. J Immunol. 2018;201:747-756 pubmed publisher
Walton Z, Patel C, Brooks R, Yu Y, Ibrahim Hashim A, Riddle M, et al. Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell. 2018;174:72-87.e32 pubmed publisher
Sun G, Sun X, Li W, Liu K, Tian D, Dong Y, et al. Critical role of OX40 in the expansion and survival of CD4 T-cell-derived double-negative T cells. Cell Death Dis. 2018;9:616 pubmed publisher
Haabeth O, Fauskanger M, Manzke M, Lundin K, Corthay A, Bogen B, et al. CD4+ T-cell-Mediated Rejection of MHC Class II-Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs. Cancer Res. 2018;78:4573-4585 pubmed publisher
Taylor A, Carey A, Kudira R, Lages C, Shi T, Lam S, et al. Interleukin 2 Promotes Hepatic Regulatory T Cell Responses and Protects From Biliary Fibrosis in Murine Sclerosing Cholangitis. Hepatology. 2018;68:1905-1921 pubmed publisher
Jiang Y, Liu Y, Lu H, Sun S, Jin W, Wang X, et al. Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28. Nat Commun. 2018;9:1424 pubmed publisher
O Neil R, Saha S, Veach R, Welch R, Woodard L, Rooney C, et al. Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo. Nat Commun. 2018;9:1325 pubmed publisher
Grau M, Valsesia S, Mafille J, Djebali S, Tomkowiak M, Mathieu A, et al. Antigen-Induced but Not Innate Memory CD8 T Cells Express NKG2D and Are Recruited to the Lung Parenchyma upon Viral Infection. J Immunol. 2018;200:3635-3646 pubmed publisher
Suárez Fueyo A, Bradley S, Katsuyama T, Solomon S, Katsuyama E, Kyttaris V, et al. Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype. J Immunol. 2018;200:3077-3086 pubmed publisher
Sun L, Hao Y, Wang Z, Zeng Y. Constructing TC-1-GLUC-LMP2 Model Tumor Cells to Evaluate the Anti-Tumor Effects of LMP2-Related Vaccines. Viruses. 2018;10: pubmed publisher
Choi S, Xu Z, Li W, Yang H, Roopenian D, Morse H, et al. Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4+ T Cell Polarization. J Immunol. 2018;200:3087-3099 pubmed publisher
Stanko K, Iwert C, Appelt C, Vogt K, Schumann J, Strunk F, et al. CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells. Proc Natl Acad Sci U S A. 2018;115:E2940-E2949 pubmed publisher
Bhatt B, Zeng P, Zhu H, Sivaprakasam S, Li S, Xiao H, et al. Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation. J Immunol. 2018;200:2905-2914 pubmed publisher
Menk A, Scharping N, Rivadeneira D, Calderon M, Watson M, Dunstane D, et al. 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses. J Exp Med. 2018;215:1091-1100 pubmed publisher
Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, et al. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype. Nat Commun. 2018;9:873 pubmed publisher
Yu W, Yao D, Yu S, Wang X, Li X, Wang M, et al. Protective humoral and CD4+ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model. Sci Rep. 2018;8:3580 pubmed publisher
Grinberg Bleyer Y, Caron R, Seeley J, De Silva N, Schindler C, Hayden M, et al. The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function. J Immunol. 2018;200:2362-2371 pubmed publisher
Guan T, Dominguez C, Amezquita R, Laidlaw B, Cheng J, Henao Mejia J, et al. ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates. J Exp Med. 2018;215:1153-1168 pubmed publisher
Kim D, Park H, Lim S, Koo J, Lee H, Choi J, et al. Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis. Nat Commun. 2018;9:503 pubmed publisher
Zhang Y, Li N, Suh H, Irvine D. Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity. Nat Commun. 2018;9:6 pubmed publisher
Stier M, Zhang J, Goleniewska K, Cephus J, Rusznak M, Wu L, et al. IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow. J Exp Med. 2018;215:263-281 pubmed publisher
Wu J, Zhang H, Shi X, Xiao X, Fan Y, Minze L, et al. Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction. Immunity. 2017;47:1114-1128.e6 pubmed publisher
Schmid D, Park C, Hartl C, Subedi N, Cartwright A, Puerto R, et al. T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity. Nat Commun. 2017;8:1747 pubmed publisher
Polesso F, Sarker M, Anderson A, Parker D, Murray S. Constitutive expression of NF-κB inducing kinase in regulatory T cells impairs suppressive function and promotes instability and pro-inflammatory cytokine production. Sci Rep. 2017;7:14779 pubmed publisher
Kotani T, Masutani R, Suzuka T, Oda K, Makino S, Ii M. Anti-inflammatory and anti-fibrotic effects of intravenous adipose-derived stem cell transplantation in a mouse model of bleomycin-induced interstitial pneumonia. Sci Rep. 2017;7:14608 pubmed publisher
Ko J, Koh J, So J, Jeon Y, Kim H, Chung D. Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay. Sci Rep. 2017;7:14940 pubmed publisher
Taghavie Moghadam P, Waseem T, Hattler J, Glenn L, Dobrian A, Kaplan M, et al. STAT4 Regulates the CD8+ Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr-/- Mice. J Immunol. 2017;199:3453-3465 pubmed publisher
Ottina E, Peperzak V, Schoeler K, Carrington E, Sgonc R, Pellegrini M, et al. DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice. Nat Commun. 2017;8:1028 pubmed publisher
Ren G, Jin W, Cui K, Rodrigez J, Hu G, Zhang Z, et al. CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression. Mol Cell. 2017;67:1049-1058.e6 pubmed publisher
Mowel W, McCright S, Kotzin J, Collet M, Uyar A, Chen X, et al. Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Immunity. 2017;47:435-449.e8 pubmed publisher
Oh H, Grinberg Bleyer Y, Liao W, Maloney D, Wang P, Wu Z, et al. An NF-?B Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function. Immunity. 2017;47:450-465.e5 pubmed publisher
Widjaja C, Olvera J, Metz P, Phan A, Savas J, de Bruin G, et al. Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. J Clin Invest. 2017;127:3609-3623 pubmed publisher
Wang S, Xia P, Chen Y, Qu Y, Xiong Z, Ye B, et al. Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation. Cell. 2017;171:201-216.e18 pubmed publisher
Salerno F, Paolini N, Stark R, von Lindern M, Wolkers M. Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8+ T cells. Proc Natl Acad Sci U S A. 2017;114:9677-9682 pubmed publisher
Corpuz T, Vazquez Lombardi R, Luong J, Warren J, Stolp J, Christ D, et al. IL-2 Shapes the Survival and Plasticity of IL-17-Producing ?? T Cells. J Immunol. 2017;199:2366-2376 pubmed publisher
Goel S, Decristo M, Watt A, BrinJones H, Sceneay J, Li B, et al. CDK4/6 inhibition triggers anti-tumour immunity. Nature. 2017;548:471-475 pubmed publisher
Wang Q, He J, Flies D, Luo L, Chen L. Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability. Sci Rep. 2017;7:6086 pubmed publisher
Chen J, Martindale J, Cramer C, Gorospe M, Atasoy U, Drew P, et al. The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells. J Biol Chem. 2017;292:14532-14543 pubmed publisher
Onodera A, Kiuchi M, Kokubo K, Kato M, Ogino T, Horiuchi S, et al. Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells. J Immunol. 2017;199:1153-1162 pubmed publisher
Takahashi R, Nakatsukasa H, Shiozawa S, Yoshimura A. SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions. J Immunol. 2017;199:149-158 pubmed publisher
Klann J, Remedios K, Kim S, Metz P, Lopez J, Mack L, et al. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. J Immunol. 2017;198:4639-4651 pubmed publisher
Chien C, Yu H, Chen S, Chiang B. Characterization of c-Maf+Foxp3- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells. Sci Rep. 2017;7:46348 pubmed publisher
Fu G, Xu Q, Qiu Y, Jin X, Xu T, Dong S, et al. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017;214:1453-1469 pubmed publisher
Liu X, Wang J, Wang H, Zhou C, Yu Q, Yin L, et al. Cell penetrable-mouse forkhead box P3 suppresses type 1 T helper cell-mediated immunity in a murine model of delayed-type hypersensitivity. Exp Ther Med. 2017;13:421-428 pubmed publisher
Vaeth M, Yang J, Yamashita M, Zee I, Eckstein M, Knosp C, et al. ORAI2 modulates store-operated calcium entry and T cell-mediated immunity. Nat Commun. 2017;8:14714 pubmed publisher
Stephen T, Payne K, Chaurio R, Allegrezza M, Zhu H, Perez Sanz J, et al. SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells. Immunity. 2017;46:51-64 pubmed publisher
Viant C, Guia S, Hennessy R, Rautela J, Pham K, Bernat C, et al. Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. J Exp Med. 2017;214:491-510 pubmed publisher
Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani R, Jiménez Andrade G, et al. Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem. 2017;292:1762-1772 pubmed publisher
Karki R, Man S, Malireddi R, Kesavardhana S, Zhu Q, Burton A, et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016;540:583-587 pubmed publisher
Inoo K, Inagaki R, Fujiwara K, Sasawatari S, Kamigaki T, Nakagawa S, et al. Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research. Mol Ther Oncolytics. 2016;3:16024 pubmed
Van De Velde L, Subramanian C, Smith A, Barron L, Qualls J, Neale G, et al. T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions. J Biol Chem. 2017;292:15-30 pubmed publisher
Jin R, Blair S, Warunek J, Heffner R, Blader I, Wohlfert E. Regulatory T Cells Promote Myositis and Muscle Damage in Toxoplasma gondii Infection. J Immunol. 2017;198:352-362 pubmed
Lee W, Teo T, Lum F, Andiappan A, Amrun S, R xe9 nia L, et al. Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice. Sci Rep. 2016;6:37603 pubmed publisher
Cho J, Kim H, Ju Y, Kye Y, Lee G, Lee S, et al. CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells. Nat Commun. 2016;7:13373 pubmed publisher
Mundy Bosse B, Scoville S, Chen L, McConnell K, Mao H, Ahmed E, et al. MicroRNA-29b mediates altered innate immune development in acute leukemia. J Clin Invest. 2016;126:4404-4416 pubmed publisher
Chu V, Graf R, Wirtz T, Weber T, Favret J, Li X, et al. Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line. Proc Natl Acad Sci U S A. 2016;113:12514-12519 pubmed
Pérol L, Lindner J, Caudana P, Núñez N, Baeyens A, Valle A, et al. Loss of immune tolerance to IL-2 in type 1 diabetes. Nat Commun. 2016;7:13027 pubmed publisher
Sochalska M, Schuler F, Weiss J, Prchal Murphy M, Sexl V, Villunger A. MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis. Oncogene. 2017;36:2066-2073 pubmed publisher
Morillon Y, Lessey Morillon E, Clark M, Zhang R, Wang B, Burridge K, et al. Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration. J Immunol. 2016;197:3504-3511 pubmed publisher
Lexmond W, Goettel J, Lyons J, Jacobse J, Deken M, Lawrence M, et al. FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. J Clin Invest. 2016;126:4030-4044 pubmed publisher
Byeon H, Lee J, Doh J, Lee S. Hybrid bright-field and hologram imaging of cell dynamics. Sci Rep. 2016;6:33750 pubmed publisher
Pageon S, Tabarin T, Yamamoto Y, Ma Y, Nicovich P, Bridgeman J, et al. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proc Natl Acad Sci U S A. 2016;113:E5454-63 pubmed publisher
Aggelakopoulou M, Kourepini E, Paschalidis N, Simoes D, Kalavrizioti D, Dimisianos N, et al. ER?-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid. J Immunol. 2016;197:2598-609 pubmed publisher
Moodley D, Yoshida H, Mostafavi S, Asinovski N, Ortiz Lopez A, Symanowicz P, et al. Network pharmacology of JAK inhibitors. Proc Natl Acad Sci U S A. 2016;113:9852-7 pubmed publisher
Leclerc M, Naserian S, Pilon C, Thiolat A, Martin G, Pouchy C, et al. Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells. Blood. 2016;128:1651-9 pubmed publisher
Cheng H, Gaddis D, Wu R, McSkimming C, Haynes L, Taylor A, et al. Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis. J Clin Invest. 2016;126:3236-46 pubmed publisher
Kritikou J, Dahlberg C, Baptista M, Wagner A, Banerjee P, Gwalani L, et al. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Sci Rep. 2016;6:30636 pubmed publisher
Kim M, Kurup S, Starbeck Miller G, Harty J. Manipulating Memory CD8 T Cell Numbers by Timed Enhancement of IL-2 Signals. J Immunol. 2016;197:1754-61 pubmed publisher
Liu L, Yi H, Wang C, He H, Li P, Pan H, et al. Integrated Nanovaccine with MicroRNA-148a Inhibition Reprograms Tumor-Associated Dendritic Cells by Modulating miR-148a/DNMT1/SOCS1 Axis. J Immunol. 2016;197:1231-41 pubmed publisher
Chen L, Nicholson Y, Rosborough B, Thomson A, Raimondi G. A Novel mTORC1-Dependent, Akt-Independent Pathway Differentiates the Gut Tropism of Regulatory and Conventional CD4 T Cells. J Immunol. 2016;197:1137-47 pubmed publisher
Ichiyama K, Gonzalez Martin A, Kim B, Jin H, Jin W, Xu W, et al. The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression. Immunity. 2016;44:1284-98 pubmed publisher
Chou T, Chuang Y, Hsieh W, Chang P, Liu H, Mo S, et al. Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1? for Th17 suppression. Nat Commun. 2016;7:11904 pubmed publisher
Choi S, Hutchinson T, Titov A, Seay H, Li S, Brusko T, et al. The Lupus Susceptibility Gene Pbx1 Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation. J Immunol. 2016;197:458-69 pubmed publisher
Kawalkowska J, Quirke A, Ghari F, Davis S, Subramanian V, Thompson P, et al. Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses. Sci Rep. 2016;6:26430 pubmed publisher
Krausgruber T, Schiering C, Adelmann K, Harrison O, Chomka A, Pearson C, et al. T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine. Nat Commun. 2016;7:11627 pubmed publisher
Aggelakopoulou M, Kourepini E, Paschalidis N, Panoutsakopoulou V. ER? in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity. J Immunol. 2016;196:4947-56 pubmed publisher
Verrier T, Satoh Takayama N, Serafini N, Marie S, Di Santo J, Vosshenrich C. Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells. J Immunol. 2016;196:4731-8 pubmed publisher
Cooley L, El Shikh M, Li W, Keim R, Zhang Z, Strauss J, et al. Impaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice. Sci Rep. 2016;6:25840 pubmed publisher
Cortez V, Cervantes Barragan L, Robinette M, Bando J, Wang Y, Geiger T, et al. Transforming Growth Factor-? Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands. Immunity. 2016;44:1127-39 pubmed publisher
Rabacal W, Pabbisetty S, Hoek K, Cendron D, Guo Y, Maseda D, et al. Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival. Proc Natl Acad Sci U S A. 2016;113:5370-5 pubmed publisher
Verbist K, Guy C, Milasta S, Liedmann S, Kaminski M, Wang R, et al. Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. Nature. 2016;532:389-93 pubmed publisher
Zhang Z, Ren S, Tan Y, Li Z, Tang X, Wang T, et al. Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice. Sci Rep. 2016;6:23912 pubmed publisher
Pasi S, Kant R, Surolia A. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response. J Biol Chem. 2016;291:12358-69 pubmed publisher
Kourepini E, Paschalidis N, Simoes D, Aggelakopoulou M, Grogan J, Panoutsakopoulou V. TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease. J Immunol. 2016;196:3570-80 pubmed publisher
Song K, Lee J, Park H, Kim H, Park J, Kwon K, et al. Roles of endothelial A-type lamins in migration of T cells on and under endothelial layers. Sci Rep. 2016;6:23412 pubmed publisher
Barros Martins J, Schmolka N, Fontinha D, Pires de Miranda M, Simas J, Brok I, et al. Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors. J Immunol. 2016;196:3642-52 pubmed publisher
Radtke D, Lacher S, Szumilas N, Sandrock L, Ackermann J, Nitschke L, et al. Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis. J Immunol. 2016;196:2995-3005 pubmed publisher
Jones L, Alli R, Li B, Geiger T. Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation. J Immunol. 2016;196:2973-85 pubmed publisher
Hecht V, Sullivan L, Kimmerling R, Kim D, Hosios A, Stockslager M, et al. Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. J Cell Biol. 2016;212:439-47 pubmed publisher
Akane K, Kojima S, Mak T, Shiku H, Suzuki H. CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity. Proc Natl Acad Sci U S A. 2016;113:2460-5 pubmed publisher
Mascarenhas M, Bacon W, Kapeni C, Fitch S, Kimber G, Cheng S, et al. Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation. Blood. 2016;127:2298-309 pubmed publisher
Cho S, Wu C, Yasuda T, Cruz L, Khan A, Lin L, et al. miR-23∼27∼24 clusters control effector T cell differentiation and function. J Exp Med. 2016;213:235-49 pubmed publisher
Sasidharan Nair V, Song M, Oh K. Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent Manner. J Immunol. 2016;196:2119-31 pubmed publisher
Delconte R, Shi W, Sathe P, Ushiki T, Seillet C, Minnich M, et al. The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15. Immunity. 2016;44:103-115 pubmed publisher
Dépis F, Kwon H, Mathis D, Benoist C. Unstable FoxP3+ T regulatory cells in NZW mice. Proc Natl Acad Sci U S A. 2016;113:1345-50 pubmed publisher
Kimmerling R, Lee Szeto G, Li J, Genshaft A, Kazer S, Payer K, et al. A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages. Nat Commun. 2016;7:10220 pubmed publisher
Everts B, Tussiwand R, Dreesen L, Fairfax K, Huang S, Smith A, et al. Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12. J Exp Med. 2016;213:35-51 pubmed publisher
Herter J, Grabie N, Cullere X, Azcutia V, Rosetti F, Bennett P, et al. AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation. Nat Commun. 2015;6:10182 pubmed publisher
Yin J, Leavenworth J, Li Y, Luo Q, Xie H, Liu X, et al. Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proc Natl Acad Sci U S A. 2015;112:15988-93 pubmed publisher
Yan D, Farache J, Mingueneau M, Mathis D, Benoist C. Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3. Proc Natl Acad Sci U S A. 2015;112:14942-7 pubmed publisher
Song Y, Kumar V, Wei H, Qiu J, Stanley P. Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development. J Immunol. 2016;196:232-43 pubmed publisher
Chan S, Lindquist L, Hansen M, Girtman M, Pease L, Bram R. Calcium-Modulating Cyclophilin Ligand Is Essential for the Survival of Activated T Cells and for Adaptive Immunity. J Immunol. 2015;195:5648-56 pubmed publisher
Zhang Z, Wu N, Lu Y, Davidson D, Colonna M, Veillette A. DNAM-1 controls NK cell activation via an ITT-like motif. J Exp Med. 2015;212:2165-82 pubmed publisher
Manirarora J, Wei C. Combination Therapy Using IL-2/IL-2 Monoclonal Antibody Complexes, Rapamycin, and Islet Autoantigen Peptides Increases Regulatory T Cell Frequency and Protects against Spontaneous and Induced Type 1 Diabetes in Nonobese Diabetic Mice. J Immunol. 2015;195:5203-14 pubmed publisher
Schmaler M, Broggi M, Lagarde N, Stöcklin B, King C, Finke D, et al. IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice. Proc Natl Acad Sci U S A. 2015;112:13330-5 pubmed publisher
Li B, Chen L, Sun H, Yang W, Hu J, He Y, et al. Immunodominant epitope-specific Th1 but not Th17 responses mediate protection against Helicobacter pylori infection following UreB vaccination of BALB/c mice. Sci Rep. 2015;5:14793 pubmed publisher
Kim M, Richer M, Gross B, Norian L, Badovinac V, Harty J. Enhancing Dendritic Cell-based Immunotherapy with IL-2/Monoclonal Antibody Complexes for Control of Established Tumors. J Immunol. 2015;195:4537-44 pubmed publisher
Wang C, Liu X, Li Z, Chai Y, Jiang Y, Wang Q, et al. CD8(+)NKT-like cells regulate the immune response by killing antigen-bearing DCs. Sci Rep. 2015;5:14124 pubmed publisher
Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H, Yoshimura A. Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells. J Exp Med. 2015;212:1623-40 pubmed publisher
Pérez García A, Pérez Durán P, Wossning T, Sernández I, Mur S, Cañamero M, et al. AID-expressing epithelium is protected from oncogenic transformation by an NKG2D surveillance pathway. EMBO Mol Med. 2015;7:1327-36 pubmed publisher
Suzuki M, Morita R, Hirata Y, Shichita T, Yoshimura A. Spred1, a Suppressor of the Ras-ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells. J Immunol. 2015;195:1273-81 pubmed publisher
Li Q, Virtuoso L, Anderson C, Egilmez N. Regulatory Rebound in IL-12-Treated Tumors Is Driven by Uncommitted Peripheral Regulatory T Cells. J Immunol. 2015;195:1293-300 pubmed publisher
Ebel M, Awe O, Kaplan M, Kansas G. Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK. J Immunol. 2015;194:5781-8 pubmed publisher
Zhang L, Manirarora J, Wei C. Evaluation of immunosuppressive function of regulatory T cells using a novel in vitro cytotoxicity assay. Cell Biosci. 2014;4:51 pubmed publisher
Schlie K, Westerback A, Devorkin L, Hughson L, Brandon J, MacPherson S, et al. Survival of effector CD8+ T cells during influenza infection is dependent on autophagy. J Immunol. 2015;194:4277-86 pubmed publisher
Del Blanco B, Angulo Ã, Krangel M, Hernández Munain C. T-cell receptor α enhancer is inactivated in αβ T lymphocytes. Proc Natl Acad Sci U S A. 2015;112:E1744-53 pubmed publisher
Baumann C, Bonilla W, Fröhlich A, Helmstetter C, Peine M, Hegazy A, et al. T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses. Proc Natl Acad Sci U S A. 2015;112:4056-61 pubmed publisher
McCracken M, Vatakis D, Dixit D, McLaughlin J, Zack J, Witte O. Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging. J Clin Invest. 2015;125:1815-26 pubmed publisher
Metidji A, RIEDER S, Glass D, Cremer I, Punkosdy G, Shevach E. IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions. J Immunol. 2015;194:4265-76 pubmed publisher
Vogel S, Schlickeiser S, Jürchott K, Akyuez L, Schumann J, Appelt C, et al. TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production. J Immunol. 2015;194:3136-46 pubmed publisher
Motozono C, Bridgeman J, Price D, Sewell A, Ueno T. Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity. Clin Exp Immunol. 2015;180:560-70 pubmed publisher
Zheng Y, Zou F, Wang J, Yin G, Le V, Fei Z, et al. Photodynamic therapy-mediated cancer vaccination enhances stem-like phenotype and immune escape, which can be blocked by thrombospondin-1 signaling through CD47 receptor protein. J Biol Chem. 2015;290:8975-86 pubmed publisher
Reppert S, Zinser E, Holzinger C, Sandrock L, Koch S, Finotto S. NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis. Eur J Immunol. 2015;45:1426-40 pubmed publisher
Mackay L, Braun A, Macleod B, Collins N, Tebartz C, Bedoui S, et al. Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention. J Immunol. 2015;194:2059-63 pubmed publisher
Waight J, Takai S, Marelli B, Qin G, Hance K, Zhang D, et al. Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans. J Immunol. 2015;194:878-82 pubmed publisher
Gaddipati S, Estrada K, Rao P, Jerome A, Suvas S. IL-2/anti-IL-2 antibody complex treatment inhibits the development but not the progression of herpetic stromal keratitis. J Immunol. 2015;194:273-82 pubmed publisher
Eun S, Lee S, Xu Y, Croft M. 4-1BB ligand signaling to T cells limits T cell activation. J Immunol. 2015;194:134-41 pubmed publisher
Tang W, Wang H, Claudio E, Tassi I, Ha H, Saret S, et al. The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells. Immunity. 2014;41:555-66 pubmed publisher
Chevalier N, Thorburn A, Macia L, Tan J, Juglair L, Yagita H, et al. Inflammation and lymphopenia trigger autoimmunity by suppression of IL-2-controlled regulatory T cell and increase of IL-21-mediated effector T cell expansion. J Immunol. 2014;193:4845-58 pubmed publisher
Van der Meulen J, Sanghvi V, Mavrakis K, Durinck K, Fang F, Matthijssens F, et al. The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia. Blood. 2015;125:13-21 pubmed publisher
Chu C, Wang Y, Zhang X, Ni X, Cao J, Xu W, et al. SAP-regulated T Cell-APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions. J Immunol. 2014;193:3860-71 pubmed publisher
Brennan P, Tatituri R, Heiss C, Watts G, Hsu F, Veerapen N, et al. Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction. Proc Natl Acad Sci U S A. 2014;111:13433-8 pubmed publisher
Degryse S, de Bock C, Cox L, Demeyer S, Gielen O, Mentens N, et al. JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model. Blood. 2014;124:3092-100 pubmed publisher
Sundberg T, Choi H, Song J, Russell C, Hussain M, Graham D, et al. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc Natl Acad Sci U S A. 2014;111:12468-73 pubmed publisher
Rei M, Gonçalves Sousa N, Lança T, Thompson R, Mensurado S, Balkwill F, et al. Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages. Proc Natl Acad Sci U S A. 2014;111:E3562-70 pubmed publisher
Ehrlich A, Castilho T, Goldsmith Pestana K, Chae W, Bothwell A, Sparwasser T, et al. The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection. J Immunol. 2014;193:2961-70 pubmed publisher
Tilahun A, Chowdhary V, David C, Rajagopalan G. Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome. J Immunol. 2014;193:2919-30 pubmed publisher
Seillet C, Rankin L, Groom J, Mielke L, Tellier J, Chopin M, et al. Nfil3 is required for the development of all innate lymphoid cell subsets. J Exp Med. 2014;211:1733-40 pubmed publisher
Huang W, Jeong A, Kannan A, Huang L, August A. IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function. J Immunol. 2014;193:2267-72 pubmed publisher
Dehò L, Leoni C, Brodie T, Montagner S, De Simone M, Polletti S, et al. Two functionally distinct subsets of mast cells discriminated By IL-2-independent CD25 activities. J Immunol. 2014;193:2196-206 pubmed publisher
Okoye I, Czieso S, Ktistaki E, Roderick K, Coomes S, Pelly V, et al. Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity. Proc Natl Acad Sci U S A. 2014;111:E3081-90 pubmed publisher
Longman R, Diehl G, Victorio D, Huh J, Galan C, Miraldi E, et al. CX?CR1? mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med. 2014;211:1571-83 pubmed publisher
Li C, Jiang S, Liu S, Lykken E, Zhao L, Sevilla J, et al. MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation. Proc Natl Acad Sci U S A. 2014;111:E2807-16 pubmed publisher
Kissick H, Sanda M, Dunn L, Pellegrini K, On S, Noel J, et al. Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation. Proc Natl Acad Sci U S A. 2014;111:9887-92 pubmed publisher
Madireddi S, Eun S, Lee S, Nemčovičová I, Mehta A, Zajonc D, et al. Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies. J Exp Med. 2014;211:1433-48 pubmed publisher
Glenn J, Smith M, Calabresi P, Whartenby K. Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis. Stem Cells. 2014;32:2744-55 pubmed publisher
Crites T, Padhan K, Muller J, Krogsgaard M, Gudla P, Lockett S, et al. TCR Microclusters pre-exist and contain molecules necessary for TCR signal transduction. J Immunol. 2014;193:56-67 pubmed publisher
O Brien S, Thomas R, Wertheim G, Zhang F, Shen H, Wells A. Ikaros imposes a barrier to CD8+ T cell differentiation by restricting autocrine IL-2 production. J Immunol. 2014;192:5118-29 pubmed publisher
Nair S, Tomaras G, Sales A, Boczkowski D, Chan C, Plonk K, et al. High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes. Sci Rep. 2014;4:4632 pubmed publisher
Kumar L, Chou J, Yee C, Borzutzky A, Vollmann E, von Andrian U, et al. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med. 2014;211:929-42 pubmed publisher
Klose C, Flach M, Möhle L, Rogell L, Hoyler T, Ebert K, et al. Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell. 2014;157:340-356 pubmed publisher
Srivastava S, Koch M, Pepper M, Campbell D. Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. J Exp Med. 2014;211:961-74 pubmed publisher
Zarin P, Wong G, Mohtashami M, Wiest D, Z xfa xf1 iga Pfl xfc cker J. Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals. Proc Natl Acad Sci U S A. 2014;111:5658-63 pubmed publisher
Cortez V, Cervantes Barragan L, Song C, Gilfillan S, McDonald K, Tussiwand R, et al. CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection. J Exp Med. 2014;211:623-33 pubmed publisher
Male V, Nisoli I, Kostrzewski T, Allan D, Carlyle J, Lord G, et al. The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression. J Exp Med. 2014;211:635-42 pubmed publisher
Vaeth M, Müller G, Stauss D, Dietz L, Klein Hessling S, Serfling E, et al. Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression. J Exp Med. 2014;211:545-61 pubmed publisher
Kobayashi C, Takubo K, Kobayashi H, Nakamura Ishizu A, Honda H, Kataoka K, et al. The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells. Blood. 2014;123:2540-9 pubmed publisher
Gomez Rodriguez J, Wohlfert E, Handon R, Meylan F, Wu J, Anderson S, et al. Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells. J Exp Med. 2014;211:529-43 pubmed publisher
Mackenzie K, Nowakowska D, Leech M, McFarlane A, Wilson C, Fitch P, et al. Effector and central memory T helper 2 cells respond differently to peptide immunotherapy. Proc Natl Acad Sci U S A. 2014;111:E784-93 pubmed publisher
Li H, Jiang Y, Jiang X, Guo X, Ning H, Li Y, et al. CCR7 guides migration of mesenchymal stem cell to secondary lymphoid organs: a novel approach to separate GvHD from GvL effect. Stem Cells. 2014;32:1890-903 pubmed publisher
Ling G, Bennett J, Woollard K, Szajna M, Fossati Jimack L, Taylor P, et al. Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages. Nat Commun. 2014;5:3039 pubmed publisher
Thestrup T, Litzlbauer J, Bartholomäus I, Mues M, Russo L, Dana H, et al. Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes. Nat Methods. 2014;11:175-82 pubmed publisher
Qin X, Liu X, Shan B, Shi L, Sharma S, Wu J, et al. Inhibition of eIF5A results in aberrant uterine natural killer cell function and embryo loss in mice. Am J Reprod Immunol. 2014;71:229-40 pubmed publisher
Starbeck Miller G, Xue H, Harty J. IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo. J Exp Med. 2014;211:105-20 pubmed publisher
Ogawa C, Tone Y, Tsuda M, Peter C, Waldmann H, Tone M. TGF-?-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2. J Immunol. 2014;192:475-83 pubmed publisher
McNally J, Elfers E, Terrell C, Grunblatt E, Hildeman D, Jordan M, et al. Eliminating encephalitogenic T cells without undermining protective immunity. J Immunol. 2014;192:73-83 pubmed publisher
Lee P, Puppi M, Schluns K, Yu Lee L, Dong C, Lacorazza H. The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage. J Immunol. 2014;192:178-88 pubmed publisher
Okiyama N, Furumoto Y, Villarroel V, Linton J, Tsai W, Gutermuth J, et al. Reversal of CD8 T-cell-mediated mucocutaneous graft-versus-host-like disease by the JAK inhibitor tofacitinib. J Invest Dermatol. 2014;134:992-1000 pubmed publisher
Cho J, Kim H, Kim K, Yang D, Surh C, Sprent J. Unique features of naive CD8+ T cell activation by IL-2. J Immunol. 2013;191:5559-73 pubmed publisher
Lo Y, Edidin M, Powell J. Selective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles. J Immunol. 2013;191:5107-14 pubmed publisher
Åhsberg J, Ungerbäck J, Strid T, Welinder E, Stjernberg J, Larsson M, et al. Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner. J Biol Chem. 2013;288:33449-61 pubmed publisher
Frazer L, Sullivan J, Zurenski M, Mintus M, Tomasak T, Prantner D, et al. CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection. J Immunol. 2013;191:4269-79 pubmed publisher
Takeuchi H, Yokota Nakatsuma A, Ohoka Y, Kagechika H, Kato C, Song S, et al. Retinoid X receptor agonists modulate Foxp3? regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation. J Immunol. 2013;191:3725-33 pubmed publisher
Pierini R, Perret M, Djebali S, Juruj C, Michallet M, Forster I, et al. ASC controls IFN-? levels in an IL-18-dependent manner in caspase-1-deficient mice infected with Francisella novicida. J Immunol. 2013;191:3847-57 pubmed publisher
Tamiya T, Ichiyama K, Kotani H, Fukaya T, Sekiya T, Shichita T, et al. Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction. J Immunol. 2013;191:2360-71 pubmed publisher
Yamashita J, Iwamura C, Ito T, Narita M, Hara Y, Sasaki T, et al. Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-? production from CD4 T cells. J Immunol. 2013;191:949-60 pubmed publisher
Holmgaard R, Zamarin D, Munn D, Wolchok J, Allison J. Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J Exp Med. 2013;210:1389-402 pubmed publisher
Li J, Heinrichs J, Leconte J, Haarberg K, Semple K, Liu C, et al. Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice. J Immunol. 2013;191:200-7 pubmed publisher
Sakai Y, Tanaka Y, Yanagihara T, Watanabe M, Duan X, Terasawa M, et al. The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation. Blood. 2013;122:386-93 pubmed publisher
Gasteiger G, Hemmers S, Firth M, Le Floc h A, Huse M, Sun J, et al. IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. J Exp Med. 2013;210:1167-78 pubmed publisher
Gasteiger G, Hemmers S, Bos P, Sun J, Rudensky A. IL-2-dependent adaptive control of NK cell homeostasis. J Exp Med. 2013;210:1179-87 pubmed publisher
Edwards J, Fujii H, Zhou A, Creemers J, Unutmaz D, Shevach E. Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation. J Immunol. 2013;190:5506-15 pubmed publisher
Han S, Jeong A, Lee S, Park J, Kim K, Choi I, et al. Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells. J Immunol. 2013;190:4877-86 pubmed publisher
Jia Y, Takeda K, Han J, Joetham A, Marcus R, Lucas J, et al. Stepwise epigenetic and phenotypic alterations poise CD8+ T cells to mediate airway hyperresponsiveness and inflammation. J Immunol. 2013;190:4056-65 pubmed publisher
Behrends J, Renauld J, Ehlers S, Holscher C. IL-22 is mainly produced by IFN?-secreting cells but is dispensable for host protection against Mycobacterium tuberculosis infection. PLoS ONE. 2013;8:e57379 pubmed publisher
Souza Fonseca Guimaraes F, Parlato M, de Oliveira R, Golenbock D, Fitzgerald K, Shalova I, et al. Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING). J Biol Chem. 2013;288:10715-21 pubmed publisher
Borger J, Filby A, Zamoyska R. Differential polarization of C-terminal Src kinase between naive and antigen-experienced CD8+ T cells. J Immunol. 2013;190:3089-99 pubmed publisher
Guo Z, Khattar M, Schroder P, Miyahara Y, Wang G, He X, et al. A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. J Immunol. 2013;190:3153-62 pubmed publisher
Singh K, Gatzka M, Peters T, Borkner L, Hainzl A, Wang H, et al. Reduced CD18 levels drive regulatory T cell conversion into Th17 cells in the CD18hypo PL/J mouse model of psoriasis. J Immunol. 2013;190:2544-53 pubmed publisher
Loebbermann J, Durant L, Thornton H, Johansson C, Openshaw P. Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells. Proc Natl Acad Sci U S A. 2013;110:2987-92 pubmed publisher
Kim S, Youn J. Rheumatoid Fibroblast-like Synoviocytes Downregulate Foxp3 Expression by Regulatory T Cells Via GITRL/GITR Interaction. Immune Netw. 2012;12:217-21 pubmed publisher
Devey L, Richards J, O Connor R, Borthwick G, Clay S, Howie A, et al. Ischemic preconditioning in the liver is independent of regulatory T cell activity. PLoS ONE. 2012;7:e49647 pubmed publisher
Kanagawa N, Yanagawa T, Nakagawa T, Okada N, Nakagawa S. Tumor vessel-injuring ability improves antitumor effect of cytotoxic T lymphocytes in adoptive immunotherapy. Cancer Gene Ther. 2013;20:57-64 pubmed publisher
Collins S, Waickman A, Basson A, Kupfer A, Licht J, Horton M, et al. Regulation of CD4? and CD8? effector responses by Sprouty-1. PLoS ONE. 2012;7:e49801 pubmed publisher
Chinnery F, King C, Elliott T, Bateman A, James E. Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk. Oncoimmunology. 2012;1:874-883 pubmed
Link J, Ota S, Zhou Z, Daniel C, Sears R, Hurlin P. A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis. Proc Natl Acad Sci U S A. 2012;109:19685-90 pubmed publisher
Fiorenza S, Kenna T, Comerford I, McColl S, Steptoe R, Leggatt G, et al. A combination of local inflammation and central memory T cells potentiates immunotherapy in the skin. J Immunol. 2012;189:5622-31 pubmed publisher
Yao R, Ma Y, Liang W, Li H, Ma Z, Yu X, et al. MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1. PLoS ONE. 2012;7:e46082 pubmed publisher
Perona Wright G, Kohlmeier J, Bassity E, Freitas T, Mohrs K, Cookenham T, et al. Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. Proc Natl Acad Sci U S A. 2012;109:18535-40 pubmed publisher
Rafei M, Rouette A, Brochu S, Vanegas J, Perreault C. Differential effects of ?c cytokines on postselection differentiation of CD8 thymocytes. Blood. 2013;121:107-17 pubmed publisher
Zandi S, Åhsberg J, Tsapogas P, Stjernberg J, Qian H, Sigvardsson M. Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo. Proc Natl Acad Sci U S A. 2012;109:15871-6 pubmed
Regateiro F, Chen Y, Kendal A, Hilbrands R, Adams E, Cobbold S, et al. Foxp3 expression is required for the induction of therapeutic tissue tolerance. J Immunol. 2012;189:3947-56 pubmed publisher
Ramalingam R, Larmonier C, Thurston R, Midura Kiela M, Zheng S, Ghishan F, et al. Dendritic cell-specific disruption of TGF-? receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity. J Immunol. 2012;189:3878-93 pubmed publisher
Vigne S, Palmer G, Martin P, Lamacchia C, Strebel D, Rodriguez E, et al. IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells. Blood. 2012;120:3478-87 pubmed publisher
Le Campion A, Pommier A, Delpoux A, Stouvenel L, Auffray C, Martin B, et al. IL-2 and IL-7 determine the homeostatic balance between the regulatory and conventional CD4+ T cell compartments during peripheral T cell reconstitution. J Immunol. 2012;189:3339-46 pubmed
Dervovic D, Ciofani M, Kianizad K, Zuniga Pflucker J. Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells. J Immunol. 2012;189:3411-20 pubmed
Schlenner S, Weigmann B, Ruan Q, Chen Y, von Boehmer H. Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J Exp Med. 2012;209:1529-35 pubmed publisher
Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, et al. Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J Immunol. 2012;189:2869-78 pubmed publisher
Hu P, Nebreda A, Liu Y, Carlesso N, Kaplan M, Kapur R. p38? protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals. J Biol Chem. 2012;287:33215-26 pubmed
Kwon K, Park H, Song K, Choi J, Ahn H, Park M, et al. Nanotopography-guided migration of T cells. J Immunol. 2012;189:2266-73 pubmed publisher
Jin X, Uchiyama M, Zhang Q, Hirai T, Niimi M. Inchingorei-san (TJ-117) and Artemisiae Capillaris Herba Induced Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice. Evid Based Complement Alternat Med. 2012;2012:689810 pubmed publisher
Gallo R, Khan M, Shi J, Kapur R, Wei L, Bailey J, et al. Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d. J Immunol. 2012;189:1689-98 pubmed publisher
Poovassery J, Bishop G. Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms. J Immunol. 2012;189:1757-64 pubmed publisher
Lin Y, Jones Mason M, Inoue M, Lasorella A, Iavarone A, Li Q, et al. Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis. J Immunol. 2012;189:1400-5 pubmed publisher
Gupta S, Thornley T, Gao W, Larocca R, Turka L, Kuchroo V, et al. Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest. 2012;122:2395-404 pubmed publisher
Shankar S, Wilson M, DiVietro J, Mentink Kane M, Xie Z, Wynn T, et al. RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol. 2012;188:6347-56 pubmed publisher
Andersen K, Nissen J, Betz A. Comparative Genomics Reveals Key Gain-of-Function Events in Foxp3 during Regulatory T Cell Evolution. Front Immunol. 2012;3:113 pubmed publisher
Thomas R, Gamper C, Ladle B, Powell J, Wells A. De novo DNA methylation is required to restrict T helper lineage plasticity. J Biol Chem. 2012;287:22900-9 pubmed publisher
Ottina E, Grespi F, Tischner D, Soratroi C, Geley S, Ploner A, et al. Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice. Blood. 2012;119:6032-42 pubmed publisher
Souza Fonseca Guimaraes F, Parlato M, Fitting C, Cavaillon J, Adib Conquy M. NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis. J Immunol. 2012;188:5850-8 pubmed publisher
Abdi K, Singh N, Matzinger P. Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?. J Immunol. 2012;188:5981-9 pubmed publisher
Ma J, Ding Y, Fang X, Wang R, Sun Z. Protein kinase C-? inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway. J Immunol. 2012;188:5337-47 pubmed publisher
Mycko M, Cichalewska M, Machlanska A, Cwiklinska H, Mariasiewicz M, Selmaj K. MicroRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination. Proc Natl Acad Sci U S A. 2012;109:E1248-57 pubmed publisher
CUI N, Xie S, Han J, MA Z, Chen B, Cai J. Effective adoptive transfer of haploidentical tumor-specific T cells in B16-melanoma bearing mice. Chin Med J (Engl). 2012;125:794-800 pubmed
Wortham B, Eppert B, Motz G, Flury J, Orozco Levi M, Hoebe K, et al. NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease. J Immunol. 2012;188:4468-75 pubmed publisher
Uchiyama M, Jin X, Zhang Q, Hirai T, Amano A, Bashuda H, et al. Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4+CD25+ cells. J Cardiothorac Surg. 2012;7:26 pubmed publisher
Attridge K, Wang C, Wardzinski L, Kenefeck R, Chamberlain J, Manzotti C, et al. IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis. Blood. 2012;119:4656-64 pubmed publisher
Friedman Levi Y, Hoftberger R, Budka H, Mayer Sonnenfeld T, Abramsky O, Ovadia H, et al. Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection. J Neuroinflammation. 2012;9:58 pubmed publisher
Mei H, Jin X, Zhu J, Zeng A, Wu Q, Lu X, et al. ?-defensin 2 as an adjuvant promotes anti-melanoma immune responses and inhibits the growth of implanted murine melanoma in vivo. PLoS ONE. 2012;7:e31328 pubmed publisher
Cedeno Laurent F, Opperman M, Barthel S, Kuchroo V, Dimitroff C. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol. 2012;188:3127-37 pubmed publisher
Zhang B, Kracker S, Yasuda T, Casola S, Vanneman M, Hömig Hölzel C, et al. Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model. Cell. 2012;148:739-51 pubmed publisher
Hu J, Hwang S, Liesa M, Gan B, Sahin E, Jaskelioff M, et al. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 2012;148:651-63 pubmed publisher
Yamaji O, Nagaishi T, Totsuka T, Onizawa M, Suzuki M, Tsuge N, et al. The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis. J Immunol. 2012;188:2524-36 pubmed publisher
Tischner D, Gaggl I, Peschel I, Kaufmann M, Tuzlak S, Drach M, et al. Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice. J Autoimmun. 2012;38:59-69 pubmed publisher
Loebbermann J, Thornton H, Durant L, Sparwasser T, Webster K, Sprent J, et al. Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol. 2012;5:161-72 pubmed publisher
Chen Y, Shen S, Gorentla B, Gao J, Zhong X. Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression. J Immunol. 2012;188:1698-707 pubmed publisher
Cuda C, Li S, Liang S, Yin Y, Potula H, Xu Z, et al. Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans. J Immunol. 2012;188:604-14 pubmed publisher
Goswami R, Jabeen R, Yagi R, Pham D, Zhu J, Goenka S, et al. STAT6-dependent regulation of Th9 development. J Immunol. 2012;188:968-75 pubmed publisher
Purtha W, Tedder T, Johnson S, Bhattacharya D, Diamond M. Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants. J Exp Med. 2011;208:2599-606 pubmed publisher
Khan O, Headley M, Gérard A, Wei W, Liu L, Krummel M. Regulation of T cell priming by lymphoid stroma. PLoS ONE. 2011;6:e26138 pubmed publisher
Mukai Y, Yoshinaga T, Yoshikawa M, Matsuo K, Yoshikawa T, Matsuo K, et al. Induction of endoplasmic reticulum-endosome fusion for antigen cross-presentation induced by poly (?-glutamic acid) nanoparticles. J Immunol. 2011;187:6249-55 pubmed publisher
Sela U, Olds P, Park A, Schlesinger S, Steinman R. Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice. J Exp Med. 2011;208:2489-96 pubmed publisher
LaCasse C, Janikashvili N, Larmonier C, Alizadeh D, Hanke N, Kartchner J, et al. Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-?-dependent mechanism. J Immunol. 2011;187:6310-7 pubmed publisher
Tang Y, Peitzsch C, Charoudeh H, Cheng M, Chaves P, Jacobsen S, et al. Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo. Blood. 2012;120:63-75 pubmed publisher
Grigoriadis G, Vasanthakumar A, Banerjee A, Grumont R, Overall S, Gleeson P, et al. c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells. PLoS ONE. 2011;6:e26851 pubmed publisher
Jiang S, Li C, Olive V, Lykken E, Feng F, Sevilla J, et al. Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. Blood. 2011;118:5487-97 pubmed publisher
Wohlfert E, Grainger J, Bouladoux N, Konkel J, Oldenhove G, Ribeiro C, et al. GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice. J Clin Invest. 2011;121:4503-15 pubmed publisher
Yu S, Zhao J, Cantorna M. Invariant NKT cell defects in vitamin D receptor knockout mice prevents experimental lung inflammation. J Immunol. 2011;187:4907-12 pubmed publisher
Maciver N, Blagih J, Saucillo D, Tonelli L, Griss T, Rathmell J, et al. The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J Immunol. 2011;187:4187-98 pubmed publisher
Kastenmuller W, Gasteiger G, Subramanian N, Sparwasser T, Busch D, Belkaid Y, et al. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol. 2011;187:3186-97 pubmed publisher
Rafei M, Hardy M, Williams P, Vanegas J, Forner K, Dulude G, et al. Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes. J Immunol. 2011;187:3133-44 pubmed publisher
Wang L, Du C, Lv J, Wei W, Cui Y, Xie X. Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis. J Immunol. 2011;187:2336-45 pubmed publisher
Kurachi M, Kurachi J, Suenaga F, Tsukui T, Abe J, Ueha S, et al. Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration. J Exp Med. 2011;208:1605-20 pubmed publisher
Kaminitz A, Yolcu E, Askenasy E, Stein J, Yaniv I, Shirwan H, et al. Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice. PLoS ONE. 2011;6:e21630 pubmed publisher
Ma H, Lu C, ZIEGLER J, Liu A, Sepulveda A, Okada H, et al. Absence of Stat1 in donor CD4? T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice. J Clin Invest. 2011;121:2554-69 pubmed publisher
Kmieciak M, Basu D, Payne K, Toor A, Yacoub A, Wang X, et al. Activated NKT cells and NK cells render T cells resistant to myeloid-derived suppressor cells and result in an effective adoptive cellular therapy against breast cancer in the FVBN202 transgenic mouse. J Immunol. 2011;187:708-17 pubmed publisher
Tsapogas P, Zandi S, Åhsberg J, Zetterblad J, Welinder E, Jönsson J, et al. IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors. Blood. 2011;118:1283-90 pubmed publisher
Haas J, Nistala K, Petermann F, Saran N, Chennupati V, Schmitz S, et al. Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in ?? and ?? T cells. PLoS ONE. 2011;6:e20171 pubmed publisher
Brigl M, Tatituri R, Watts G, Bhowruth V, Leadbetter E, Barton N, et al. Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. J Exp Med. 2011;208:1163-77 pubmed publisher
Goldstein J, Balderas R, Marodon G. Continuous activation of the CD122/STAT-5 signaling pathway during selection of antigen-specific regulatory T cells in the murine thymus. PLoS ONE. 2011;6:e19038 pubmed publisher
Werner J, Busl E, Farkas S, Schlitt H, Geissler E, Hornung M. DX5+NKT cells display phenotypical and functional differences between spleen and liver as well as NK1.1-Balb/c and NK1.1+ C57Bl/6 mice. BMC Immunol. 2011;12:26 pubmed publisher
Chen Q, Kim Y, Laurence A, Punkosdy G, Shevach E. IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo. J Immunol. 2011;186:6329-37 pubmed publisher
Kroetz D, Deepe G. An aberrant thymus in CCR5-/- mice is coupled with an enhanced adaptive immune response in fungal infection. J Immunol. 2011;186:5949-55 pubmed publisher
Wang X, Zhang F, Chen F, Liu D, Zheng Y, Zhang Y, et al. MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades. J Immunol. 2011;186:5791-800 pubmed publisher
Sekiya T, Kashiwagi I, Inoue N, Morita R, Hori S, Waldmann H, et al. The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells. Nat Commun. 2011;2:269 pubmed publisher
Sengupta S, Ulasov I, Thaci B, Ahmed A, Lesniak M. Enhanced transduction and replication of RGD-fiber modified adenovirus in primary T cells. PLoS ONE. 2011;6:e18091 pubmed publisher
Grespi F, Ottina E, Yannoutsos N, Geley S, Villunger A. Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis. PLoS ONE. 2011;6:e18051 pubmed publisher
Lv H, Havari E, Pinto S, Gottumukkala R, Cornivelli L, Raddassi K, et al. Impaired thymic tolerance to ?-myosin directs autoimmunity to the heart in mice and humans. J Clin Invest. 2011;121:1561-73 pubmed publisher
Zhu Y, Gumlaw N, Karman J, Zhao H, Zhang J, Jiang J, et al. Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage. J Biol Chem. 2011;286:14787-94 pubmed publisher
Holderness J, Schepetkin I, Freedman B, Kirpotina L, Quinn M, Hedges J, et al. Polysaccharides isolated from Açaí fruit induce innate immune responses. PLoS ONE. 2011;6:e17301 pubmed publisher
Jordan M, Fletcher J, Jose R, Chowdhury S, Gerlach N, Allison J, et al. Role of SLAM in NKT cell development revealed by transgenic complementation in NOD mice. J Immunol. 2011;186:3953-65 pubmed publisher
Palmer M, Mahajan V, Chen J, Irvine D, Lauffenburger D. Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunol Cell Biol. 2011;89:581-94 pubmed publisher
Wong W, Kurokawa M, Satake M, Kohu K. Down-regulation of Runx1 expression by TCR signal involves an autoregulatory mechanism and contributes to IL-2 production. J Biol Chem. 2011;286:11110-8 pubmed publisher
Takeuchi H, Yokota A, Ohoka Y, Iwata M. Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-?. PLoS ONE. 2011;6:e16089 pubmed publisher
Chen T, Guo J, Yang M, Zhu X, Cao X. Chemokine-containing exosomes are released from heat-stressed tumor cells via lipid raft-dependent pathway and act as efficient tumor vaccine. J Immunol. 2011;186:2219-28 pubmed publisher
Kaminitz A, Askenasy E, Yaniv I, Stein J, Askenasy N. Apoptosis of purified CD4+ T cell subsets is dominated by cytokine deprivation and absence of other cells in new onset diabetic NOD mice. PLoS ONE. 2010;5:e15684 pubmed publisher
Linkes S, Fry C, Quinn A. Antigen-Experienced CD4lo T Cells Are Linked to Deficient Contraction of the Immune Response in Autoimmune Diabetes. Autoimmune Dis. 2010;2010:920148 pubmed publisher
Coloff J, Mason E, Altman B, Gerriets V, Liu T, Nichols A, et al. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. J Biol Chem. 2011;286:5921-33 pubmed publisher
Ohoka Y, Yokota A, Takeuchi H, Maeda N, Iwata M. Retinoic acid-induced CCR9 expression requires transient TCR stimulation and cooperativity between NFATc2 and the retinoic acid receptor/retinoid X receptor complex. J Immunol. 2011;186:733-44 pubmed publisher
Janikashvili N, LaCasse C, Larmonier C, Trad M, Herrell A, Bustamante S, et al. Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia. Blood. 2011;117:1555-64 pubmed publisher
Giroux M, Delisle J, Gauthier S, Heinonen K, Hinsinger J, Houde B, et al. SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage. Blood. 2011;117:1734-44 pubmed publisher
Chae H, Siefring J, Hildeman D, Gu Y, Williams D. RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling. PLoS ONE. 2010;5:e13970 pubmed publisher
Xie P, Kraus Z, Stunz L, Liu Y, Bishop G. TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling. J Immunol. 2011;186:143-55 pubmed publisher
Cui C, Miyoshi S, Tsuji H, Makino H, Kanzaki S, Kami D, et al. Dystrophin conferral using human endothelium expressing HLA-E in the non-immunosuppressive murine model of Duchenne muscular dystrophy. Hum Mol Genet. 2011;20:235-44 pubmed publisher
James E, Yeh A, King C, Korangy F, Bailey I, Boulanger D, et al. Differential suppression of tumor-specific CD8+ T cells by regulatory T cells. J Immunol. 2010;185:5048-55 pubmed publisher
Takeuchi H, Yokota A, Ohoka Y, Kagechika H, Kato C, Song S, et al. Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins. J Immunol. 2010;185:5289-99 pubmed publisher
Le Saout C, Villard M, Cabasse C, Jacquet C, Taylor N, Hernandez J. IL-2 mediates CD4+ T cell help in the breakdown of memory-like CD8+ T cell tolerance under lymphopenic conditions. PLoS ONE. 2010;5:e12659 pubmed publisher
Warncke M, Buchner M, Thaller G, Dodero A, Bulashevska A, Pfeifer D, et al. Control of the specificity of T cell-mediated anti-idiotype immunity by natural regulatory T cells. Cancer Immunol Immunother. 2011;60:49-60 pubmed publisher
Rolf J, Bell S, Kovesdi D, Janas M, Soond D, Webb L, et al. Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. J Immunol. 2010;185:4042-52 pubmed publisher
Phythian Adams A, Cook P, Lundie R, Jones L, Smith K, Barr T, et al. CD11c depletion severely disrupts Th2 induction and development in vivo. J Exp Med. 2010;207:2089-96 pubmed publisher
Johannsen A, Genolet R, Legler D, Luther S, Luescher I. Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice. J Immunol. 2010;185:3445-55 pubmed publisher
Wang G, Miyahara Y, Guo Z, Khattar M, Stepkowski S, Chen W. "Default" generation of neonatal regulatory T cells. J Immunol. 2010;185:71-8 pubmed publisher
Durant L, Watford W, Ramos H, Laurence A, Vahedi G, Wei L, et al. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity. 2010;32:605-15 pubmed publisher
Mace E, Zhang J, Siminovitch K, Takei F. Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells. Blood. 2010;116:1272-9 pubmed publisher
Bersenev A, Wu C, Balcerek J, Jing J, Kundu M, Blobel G, et al. Lnk constrains myeloproliferative diseases in mice. J Clin Invest. 2010;120:2058-69 pubmed publisher
Nozad Charoudeh H, Tang Y, Cheng M, Cilio C, Jacobsen S, Sitnicka E. Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells. Blood. 2010;116:183-92 pubmed publisher
Humphrey R, Newcomb C, Yu S, Hao E, Yu D, Krajewski S, et al. Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells. J Biol Chem. 2010;285:22426-36 pubmed publisher
Okamoto K, Iwai Y, Oh Hora M, Yamamoto M, Morio T, Aoki K, et al. IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature. 2010;464:1381-5 pubmed publisher
Ishihara S, Varma R, Schwartz R. A new fractionation assay, based on the size of formaldehyde-crosslinked, mildly sheared chromatin, delineates the chromatin structure at promoter regions. Nucleic Acids Res. 2010;38:e124 pubmed publisher
Motz G, Eppert B, Wortham B, Amos Kroohs R, Flury J, Wesselkamper S, et al. Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease. J Immunol. 2010;184:4460-9 pubmed publisher
Tartar D, Vanmorlan A, Wan X, Guloglu F, Jain R, Haymaker C, et al. FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes. J Immunol. 2010;184:3377-85 pubmed publisher
Alvarez Arias D, McCarty N, Lu L, Maldonado R, Shinohara M, Cantor H. Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. Proc Natl Acad Sci U S A. 2010;107:2556-61 pubmed publisher
Prokopowicz Z, Arce F, Biedron R, Chiang C, Ciszek M, Katz D, et al. Hypochlorous acid: a natural adjuvant that facilitates antigen processing, cross-priming, and the induction of adaptive immunity. J Immunol. 2010;184:824-35 pubmed publisher
Stadtfeld M, Maherali N, Borkent M, Hochedlinger K. A reprogrammable mouse strain from gene-targeted embryonic stem cells. Nat Methods. 2010;7:53-5 pubmed publisher
Mansson R, Zandi S, Welinder E, Tsapogas P, Sakaguchi N, Bryder D, et al. Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity. Blood. 2010;115:2601-9 pubmed publisher
Isomura I, Palmer S, Grumont R, Bunting K, Hoyne G, Wilkinson N, et al. c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med. 2009;206:3001-14 pubmed publisher
Kenna T, Waldie T, McNally A, Thomson M, Yagita H, Thomas R, et al. Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function. J Immunol. 2010;184:598-606 pubmed publisher
Liao D, Luo Y, Markowitz D, Xiang R, Reisfeld R. Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model. PLoS ONE. 2009;4:e7965 pubmed publisher
Kohu K, Ohmori H, Wong W, Onda D, Wakoh T, Kon S, et al. The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. J Immunol. 2009;183:7817-24 pubmed publisher
Oyamada A, Ikebe H, Itsumi M, Saiwai H, Okada S, Shimoda K, et al. Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis. J Immunol. 2009;183:7539-46 pubmed publisher
Canonigo Balancio A, Fos C, Prod homme T, Bécart S, Altman A. SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis. J Immunol. 2009;183:7259-67 pubmed publisher
Nakaya M, Hashimoto M, Nakagawa R, Wakabayashi Y, Ishizaki T, Takada I, et al. SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis. J Immunol. 2009;183:7047-53 pubmed publisher
McGuire H, Vogelzang A, Hill N, Flodstrom Tullberg M, Sprent J, King C. Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. Proc Natl Acad Sci U S A. 2009;106:19438-43 pubmed publisher
Lauritsen J, Wong G, Lee S, Lefebvre J, Ciofani M, Rhodes M, et al. Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. Immunity. 2009;31:565-75 pubmed publisher
Niedermeier M, Reich B, Rodriguez Gomez M, Denzel A, Schmidbauer K, Göbel N, et al. CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes. Proc Natl Acad Sci U S A. 2009;106:17892-7 pubmed publisher
Ranatunga D, Hedrich C, Wang F, McVicar D, Nowak N, Joshi T, et al. A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome. Proc Natl Acad Sci U S A. 2009;106:17123-8 pubmed publisher
Nolting J, Daniel C, Reuter S, Stuelten C, Li P, Sucov H, et al. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med. 2009;206:2131-9 pubmed publisher
Chaudhri G, Quah B, Wang Y, Tan A, Zhou J, Karupiah G, et al. T cell receptor sharing by cytotoxic T lymphocytes facilitates efficient virus control. Proc Natl Acad Sci U S A. 2009;106:14984-9 pubmed publisher
Wolf A, Eller K, Zeiser R, Dürr C, Gerlach U, Sixt M, et al. The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo. J Immunol. 2009;183:3751-60 pubmed publisher
Gutermuth J, Nograles K, Miyagawa F, Nelson E, Cho Y, Katz S. Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V alpha 2 down-regulation. J Immunol. 2009;183:3130-8 pubmed publisher
Aleyas A, George J, Han Y, Rahman M, Kim S, Han S, et al. Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways. J Immunol. 2009;183:2462-74 pubmed publisher
Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009;15:930-9 pubmed publisher
Semitekolou M, Alissafi T, Aggelakopoulou M, Kourepini E, Kariyawasam H, Kay A, et al. Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease. J Exp Med. 2009;206:1769-85 pubmed publisher
Hou Y, DeVoss J, Dao V, Kwek S, Simko J, McNeel D, et al. An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans. J Clin Invest. 2009;119:2031-41 pubmed publisher
Chang B, Zhao F, He X, Ren H, Braselmann S, Taylor V, et al. JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice. J Immunol. 2009;183:2183-92 pubmed publisher
Hundt M, Harada Y, De Giorgio L, Tanimura N, Zhang W, Altman A. Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. J Immunol. 2009;183:1685-94 pubmed publisher
Sharma R, Sung S, Abaya C, Ju A, Fu S, Ju S. IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103-dependent and independent inflammation. J Immunol. 2009;183:1065-73 pubmed publisher
Mikhak Z, Farsidjani A, Luster A. Endotoxin augmented antigen-induced Th1 cell trafficking amplifies airway neutrophilic inflammation. J Immunol. 2009;182:7946-56 pubmed publisher
Aoki K, Sato N, Yamaguchi A, Kaminuma O, Hosozawa T, Miyatake S. Regulation of DNA demethylation during maturation of CD4+ naive T cells by the conserved noncoding sequence 1. J Immunol. 2009;182:7698-707 pubmed publisher
Yoshimi R, Chang T, Wang H, Atsumi T, Morse H, Ozato K. Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. J Immunol. 2009;182:7527-38 pubmed publisher
Ben Sasson S, Hu Li J, Quiel J, Cauchetaux S, Ratner M, Shapira I, et al. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc Natl Acad Sci U S A. 2009;106:7119-24 pubmed publisher
Maldonado R, Soriano M, Perdomo L, Sigrist K, Irvine D, Decker T, et al. Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse. J Exp Med. 2009;206:877-92 pubmed publisher
Khan M, Gallo R, Renukaradhya G, Du W, Gervay Hague J, Brutkiewicz R. Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation. J Immunol. 2009;182:4744-50 pubmed publisher
Webster K, Walters S, Kohler R, Mrkvan T, Boyman O, Surh C, et al. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med. 2009;206:751-60 pubmed publisher
Wang X, Chang X, Facchinetti V, Zhuang Y, Su B. MEKK3 is essential for lymphopenia-induced T cell proliferation and survival. J Immunol. 2009;182:3597-608 pubmed publisher
Hamada H, Garcia Hernandez M, Reome J, Misra S, Strutt T, McKinstry K, et al. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol. 2009;182:3469-81 pubmed publisher
Yu A, Zhu L, Altman N, Malek T. A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. Immunity. 2009;30:204-17 pubmed publisher
Chen T, Guo J, Han C, Yang M, Cao X. Heat shock protein 70, released from heat-stressed tumor cells, initiates antitumor immunity by inducing tumor cell chemokine production and activating dendritic cells via TLR4 pathway. J Immunol. 2009;182:1449-59 pubmed
Werninghaus K, Babiak A, Gross O, Hölscher C, Dietrich H, Agger E, et al. Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. J Exp Med. 2009;206:89-97 pubmed publisher
Gérard A, van der Kammen R, Janssen H, Ellenbroek S, Collard J. The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration. Blood. 2009;113:6138-47 pubmed publisher
Ramirez K, Capozzo A, Lloyd S, Sztein M, Nataro J, Pasetti M. Mucosally delivered Salmonella typhi expressing the Yersinia pestis F1 antigen elicits mucosal and systemic immunity early in life and primes the neonatal immune system for a vigorous anamnestic response to parenteral F1 boost. J Immunol. 2009;182:1211-22 pubmed
Mace E, Monkley S, Critchley D, Takei F. A dual role for talin in NK cell cytotoxicity: activation of LFA-1-mediated cell adhesion and polarization of NK cells. J Immunol. 2009;182:948-56 pubmed
Takatori H, Kanno Y, Watford W, Tato C, Weiss G, Ivanov I, et al. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med. 2009;206:35-41 pubmed publisher
Peacock J, Palmer J, Fink D, Ip S, Pietras E, Mui A, et al. PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15. Mol Cell Biol. 2009;29:1222-34 pubmed publisher
Zhou D, Medoff B, Chen L, Li L, Zhang X, Praskova M, et al. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A. 2008;105:20321-6 pubmed publisher
Kao H, Lin J, Littman D, Shaw A, Allen P. Regulated movement of CD4 in and out of the immunological synapse. J Immunol. 2008;181:8248-57 pubmed
Nagahara K, Arikawa T, Oomizu S, Kontani K, Nobumoto A, Tateno H, et al. Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions. J Immunol. 2008;181:7660-9 pubmed
Andersen K, Butcher T, Betz A. Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells. PLoS Biol. 2008;6:e276 pubmed publisher
Zhao Y, Coloff J, Ferguson E, Jacobs S, Cui K, Rathmell J. Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. J Biol Chem. 2008;283:36344-53 pubmed publisher
Sakthivel S, Singh U, Singh S, Taub D, Novakovic K, Lillard J. CXCL10 blockade protects mice from cyclophosphamide-induced cystitis. J Immune Based Ther Vaccines. 2008;6:6 pubmed publisher
Marques S, Alenquer M, Stevenson P, Simas J. A single CD8+ T cell epitope sets the long-term latent load of a murid herpesvirus. PLoS Pathog. 2008;4:e1000177 pubmed publisher
Kawamura K, Yao K, Shukaliak Quandt J, Huh J, Baig M, Quigley L, et al. Different development of myelin basic protein agonist- and antagonist-specific human TCR transgenic T cells in the thymus and periphery. J Immunol. 2008;181:5462-72 pubmed
Kamimura D, Bevan M. Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection. J Immunol. 2008;181:5433-41 pubmed
Tsai C, Chiu Y, Hsu T, Lin I, Hsieh S, Lin K. Galectin-1 promotes immunoglobulin production during plasma cell differentiation. J Immunol. 2008;181:4570-9 pubmed
Tonkin D, He J, Barbour G, Haskins K. Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo. J Immunol. 2008;181:4516-22 pubmed
Chong M, Rasmussen J, Rudensky A, Rundensky A, Littman D. The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med. 2008;205:2005-17 pubmed publisher
Hara H, Ishihara C, Takeuchi A, Xue L, Morris S, Penninger J, et al. Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9. J Immunol. 2008;181:918-30 pubmed
Lio C, Hsieh C. A two-step process for thymic regulatory T cell development. Immunity. 2008;28:100-11 pubmed publisher
Shimaoka T, Seino K, Kume N, Minami M, Nishime C, Suematsu M, et al. Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells. J Immunol. 2007;179:8172-9 pubmed
Kreymborg K, Etzensperger R, Dumoutier L, Haak S, Rebollo A, Buch T, et al. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol. 2007;179:8098-104 pubmed
Woolf E, Brenner O, Goldenberg D, Levanon D, Groner Y. Runx3 regulates dendritic epidermal T cell development. Dev Biol. 2007;303:703-14 pubmed
Gu F, Neufeld R, Amsden B. Sustained release of bioactive therapeutic proteins from a biodegradable elastomeric device. J Control Release. 2007;117:80-9 pubmed
Park H, Jung Y, Park O, Lee Y, Choi J, Choi Y. Interaction of Fas ligand and Fas expressed on osteoclast precursors increases osteoclastogenesis. J Immunol. 2005;175:7193-201 pubmed
Suto A, Nakajima H, Tokumasa N, Takatori H, Kagami S, Suzuki K, et al. Murine plasmacytoid dendritic cells produce IFN-gamma upon IL-4 stimulation. J Immunol. 2005;175:5681-9 pubmed
Cornish A, Chong M, Davey G, Darwiche R, Nicola N, Hilton D, et al. Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J Biol Chem. 2003;278:22755-61 pubmed
product information
Product Type :
Protein
Product Name :
Mouse IL-2 Recombinant Protein, PeproTech
Catalog # :
212-12-1MG
Quantity :
1 mg
Price :
US 3235.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Mouse
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Mouse
Storage :
-20 C
Description :
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA