Mouse IL-1 alpha Recombinant Protein, PeproTech | Invitrogen 211-11A-50UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Mouse IL-1 alpha Recombinant Protein, PeproTech

catalog :

211-11A-50UG

quantity :

50 ug

price :

US 544.00

citations: 33

Reference
Fang Y, Ding X, Zhang Y, Cai L, Ge Y, Ma K, et al. Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway. J Neuroinflammation. 2022;19:23 pubmed publisher
Nagatake T, Kishino S, Urano E, Murakami H, Kitamura N, Konishi K, et al. Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques. Mucosal Immunol. 2022;15:289-300 pubmed publisher
Piseddu I, R xf6 hrle N, Knott M, Moder S, Eiber S, Schnell K, et al. Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF. J Immunol. 2020;205:2056-2065 pubmed publisher
Draberova H, Janusova S, Knizkova D, Semberova T, Pribikova M, Ujevic A, et al. Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop. EMBO J. 2020;39:e104202 pubmed publisher
Pein M, Insua Rodríguez J, Hongu T, Riedel A, Meier J, Wiedmann L, et al. Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs. Nat Commun. 2020;11:1494 pubmed publisher
Martin P, Palmer G, Rodriguez E, Palomo J, Lemeille S, Goldstein J, et al. Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α. J Immunol. 2020;204:967-979 pubmed publisher
Wang P, Gamero A, Jensen L. IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners. Nat Commun. 2019;10:4700 pubmed publisher
Denton A, Innocentin S, Carr E, Bradford B, Lafouresse F, Mabbott N, et al. Type I interferon induces CXCL13 to support ectopic germinal center formation. J Exp Med. 2019;216:621-637 pubmed publisher
Giles D, Duncker P, Wilkinson N, Washnock Schmid J, Segal B. CNS-resident classical DCs play a critical role in CNS autoimmune disease. J Clin Invest. 2018;128:5322-5334 pubmed publisher
Zhao J, Zhang L, Mu X, Doebelin C, Nguyen W, Wallace C, et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018;16:e2004663 pubmed publisher
Dagenais M, Dupaul Chicoine J, Douglas T, Champagne C, Morizot A, Saleh M. The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis. Oncoimmunology. 2017;6:e1287247 pubmed publisher
Hu X, García M, Weng L, Jung X, Murakami J, Kumar B, et al. Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche. Nat Commun. 2016;7:13095 pubmed publisher
Shimizu K, Nakajima A, Sudo K, Liu Y, Mizoroki A, Ikarashi T, et al. IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages. J Immunol. 2015;194:3156-68 pubmed publisher
Gobbetti T, Coldewey S, Chen J, McArthur S, Le Faouder P, Cenac N, et al. Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proc Natl Acad Sci U S A. 2014;111:18685-90 pubmed publisher
Bourdeaux C, Lurquin C, Jacquemart I, Leth xe9 B, Brasseur F, van Baren N, et al. Local immunostimulation leading to rejection of accepted male skin grafts by female mice as a model for cancer immunotherapy. Proc Natl Acad Sci U S A. 2014;111:3502-7 pubmed publisher
Ikeda S, Saijo S, Murayama M, Shimizu K, Akitsu A, Iwakura Y. Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-?-induced Foxp3 expression. J Immunol. 2014;192:1449-58 pubmed publisher
Koning J, Kooij G, de Vries H, Nolte M, Mebius R. Mesenchymal stem cells are mobilized from the bone marrow during inflammation. Front Immunol. 2013;4:49 pubmed publisher
Abdi K, Singh N, Matzinger P. Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?. J Immunol. 2012;188:5981-9 pubmed publisher
Ramon H, Beal A, Liu Y, Worthen G, Oliver P. The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines. J Immunol. 2012;188:4023-31 pubmed publisher
Pathak S, Borodkin V, Albarbarawi O, Campbell D, Ibrahim A, van Aalten D. O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. EMBO J. 2012;31:1394-404 pubmed publisher
Sprague L, Muccioli M, Pate M, Meles E, McGinty J, Nandigam H, et al. The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells. BMC Immunol. 2011;12:35 pubmed publisher
Singh V, Jain S, Gowthaman U, Parihar P, Gupta P, Gupta U, et al. Co-administration of IL-1+IL-6+TNF-? with Mycobacterium tuberculosis infected macrophages vaccine induces better protective T cell memory than BCG. PLoS ONE. 2011;6:e16097 pubmed publisher
Doisne J, Soulard V, Becourt C, Amniai L, Henrot P, Havenar Daughton C, et al. Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria. J Immunol. 2011;186:662-6 pubmed publisher
Tan C, Aziz M, Lovaas J, Vistica B, Shi G, Wawrousek E, et al. Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site. J Immunol. 2010;185:6795-801 pubmed publisher
Okamoto K, Iwai Y, Oh Hora M, Yamamoto M, Morio T, Aoki K, et al. IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature. 2010;464:1381-5 pubmed publisher
Shi G, Ramaswamy M, Vistica B, Cox C, Tan C, Wawrousek E, et al. Unlike Th1, Th17 cells mediate sustained autoimmune inflammation and are highly resistant to restimulation-induced cell death. J Immunol. 2009;183:7547-56 pubmed publisher
Martinez G, Zhang Z, Chung Y, Reynolds J, Lin X, Jetten A, et al. Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation. J Biol Chem. 2009;284:35283-6 pubmed publisher
Liu Z, Li Z, Mao K, Zou J, Wang Y, Tao Z, et al. Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling. J Immunol. 2009;183:6320-9 pubmed publisher
Gomez Rodriguez J, Sahu N, Handon R, Davidson T, Anderson S, Kirby M, et al. Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity. 2009;31:587-97 pubmed publisher
Maue A, Eaton S, Lanthier P, Sweet K, Blumerman S, Haynes L. Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells. J Immunol. 2009;182:6129-35 pubmed publisher
Ben Sasson S, Hu Li J, Quiel J, Cauchetaux S, Ratner M, Shapira I, et al. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc Natl Acad Sci U S A. 2009;106:7119-24 pubmed publisher
Lee J, Kim H, Yang D, Jung K, Kim H, Kim H, et al. Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling. J Biol Chem. 2009;284:13725-34 pubmed publisher
Shi G, Cox C, Vistica B, Tan C, Wawrousek E, Gery I. Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells. J Immunol. 2008;181:7205-13 pubmed

product information

Product Type :

Protein

Product Name :

Mouse IL-1 alpha Recombinant Protein, PeproTech

Catalog # :

211-11A-50UG

Quantity :

50 ug

Price :

US 544.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Mouse

Applications :

ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent

Species :

Mouse

Storage :

-20 C

Description :

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Format :

Lyophilized

Applications w/Dilutions :

ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent

Aliases :

CTLA8; hematopoietin-1; IL 1 a; IL 1a; IL1; IL-1 alpha; IL17; IL1A; Il-1a; IL-1alpha; IL1-ALPHA; IL1F1; IL1a; ILN; Interleukin; interleukin 1 alpha; interleukin 1, alpha; interleukin 17; interleukin 1a; interleukin 1-alpha; interleukin 1-alpha (AA 1 - 152); Interleukin1 alpha; interleukin-1 alpha; interleukin-1 alpha precursor; Interleukin-17A; preinterleukin 1 alpha; pre-interleukin-1 alpha; pro-interleukin-1-alpha; RP23-160G19.8