This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Mouse IL-33 Recombinant Protein, PeproTech
catalog :
210-33-250
quantity :
2.5 x 100 ug
price :
US 2105.00
citations: 52
Reference
Gurtner A, Borrelli C, Gonzalez Perez I, Bach K, Acar I, N xfa xf1 ez N, et al. Active eosinophils regulate host defence and immune responses in colitis. Nature. 2023;615:151-157 pubmed publisher
Liu C, Gong Y, Zhang H, Yang H, Zeng Y, Bian Z, et al. Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells. Cell Res. 2021;: pubmed publisher
Schumacher M, Hsieh J, Liu C, Appel K, Waddell A, Almohazey D, et al. Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33. Nat Commun. 2021;12:836 pubmed publisher
Drube S, M xfc ller S, Weber F, Wegner P, B xf6 ttcher Loschinski R, Gaestel M, et al. IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt+ Treg generation via enhanced IL-6 induction. Immunology. 2021;163:86-97 pubmed publisher
Leimkühler N, Gleitz H, Ronghui L, Snoeren I, Fuchs S, Nagai J, et al. Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis. Cell Stem Cell. 2020;: pubmed publisher
Sabbaghi F, Ullner L, Bohn T, Hahlbrock J, Bopp T, Schmitt E, et al. In Activated Murine Mast Cells, NFATc2 Is Critical for the Production of Autocrine IL-3, Thereby Promoting the Expression of IL-9. J Immunol. 2021;206:67-76 pubmed publisher
Teufelberger A, Van Nevel S, Hulpiau P, Nordengr xfc n M, Savvides S, De Graeve S, et al. Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33. Front Immunol. 2020;11:582044 pubmed publisher
Bromley S, Akbaba H, Mani V, Mora Buch R, Chasse A, Sama A, et al. CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response. Cell Rep. 2020;32:108085 pubmed publisher
Nasser H, Adhikary P, Abdel Daim A, Noyori O, Panaampon J, Kariya R, et al. Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages. Cell Death Discov. 2020;6:63 pubmed publisher
Zhou W, Zhang J, Toki S, Goleniewska K, Norlander A, Newcomb D, et al. COX Inhibition Increases Alternaria-Induced Pulmonary Group 2 Innate Lymphoid Cell Responses and IL-33 Release in Mice. J Immunol. 2020;205:1157-1166 pubmed publisher
Li T, Zhang Z, Bartolacci J, Dwyer G, Liu Q, Mathews L, et al. Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection. J Clin Invest. 2020;130:5397-5412 pubmed publisher
Panova V, Gogoi M, Rodriguez Rodriguez N, Sivasubramaniam M, Jolin H, Heycock M, et al. Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11. Mucosal Immunol. 2021;14:26-37 pubmed publisher
Helbig C, Weber F, Andreas N, Herdegen T, Gaestel M, Kamradt T, et al. The IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells. Sci Rep. 2020;10:8152 pubmed publisher
Jin R, Xu J, Gao Q, Mao X, Yin J, Lu K, et al. IL-33-induced neutrophil extracellular traps degrade fibronectin in a murine model of bronchopulmonary dysplasia. Cell Death Discov. 2020;6:33 pubmed publisher
Bando J, Gilfillan S, Di Luccia B, Fachi J, Sécca C, Cella M, et al. ILC2s are the predominant source of intestinal ILC-derived IL-10. J Exp Med. 2020;217: pubmed publisher
Andreas N, Potthast M, Geiselhöringer A, Garg G, de Jong R, Riewaldt J, et al. RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells. J Immunol. 2019;203:2602-2613 pubmed publisher
Zhang C, Raveney B, Hohjoh H, Tomi C, Oki S, Yamamura T. Extrapituitary prolactin promotes generation of Eomes-positive helper T cells mediating neuroinflammation. Proc Natl Acad Sci U S A. 2019;116:21131-21139 pubmed publisher
Fu T, Zheng H, Zhang H, Chen Z, Li B, Yang Z. Oncostatin M expression in the mouse uterus during early pregnancy promotes embryo implantation and decidualization. FEBS Lett. 2019;593:2040-2050 pubmed publisher
Minutti C, Modak R, MacDonald F, Li F, Smyth D, Dorward D, et al. A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation. Immunity. 2019;50:645-654.e6 pubmed publisher
Wang Y, Richter L, Becker M, Amador C, Hyde R. IL1RL1 is dynamically expressed on Cbfb-MYH11+ leukemia stem cells and promotes cell survival. Sci Rep. 2019;9:1729 pubmed publisher
Miyamoto C, Kojo S, Yamashita M, Moro K, Lacaud G, Shiroguchi K, et al. Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation. Nat Commun. 2019;10:447 pubmed publisher
Cohen M, Giladi A, Gorki A, Solodkin D, Zada M, Hladik A, et al. Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting. Cell. 2018;175:1031-1044.e18 pubmed publisher
Willetts L, Felix L, Jacobsen E, Puttagunta L, Condjella R, Zellner K, et al. Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice. Commun Biol. 2018;1:83 pubmed publisher
McCarthy P, Phair I, Greger C, Pardali K, McGuire V, Clark A, et al. IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3. Immunol Cell Biol. 2019;97:54-71 pubmed publisher
Zhou W, Zhang J, Toki S, Goleniewska K, Johnson M, Bloodworth M, et al. The PGI2 Analog Cicaprost Inhibits IL-33-Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4+ T Cells. J Immunol. 2018;201:1936-1945 pubmed publisher
Reinhart R, Kaufmann T. IL-4 enhances survival of in vitro-differentiated mouse basophils through transcription-independent signaling downstream of PI3K. Cell Death Dis. 2018;9:713 pubmed publisher
Göpfert C, Andreas N, Weber F, Häfner N, Yakovleva T, Gaestel M, et al. The p38-MK2/3 Module Is Critical for IL-33-Induced Signaling and Cytokine Production in Dendritic Cells. J Immunol. 2018;200:1198-1206 pubmed publisher
Stier M, Zhang J, Goleniewska K, Cephus J, Rusznak M, Wu L, et al. IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow. J Exp Med. 2018;215:263-281 pubmed publisher
Minutti C, Drube S, Blair N, Schwartz C, McCrae J, McKenzie A, et al. Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion. Immunity. 2017;47:710-722.e6 pubmed publisher
Zhu X, Zhao Y, Jiang Y, Qin T, Chen J, Chu X, et al. Dectin-1 signaling inhibits osteoclastogenesis via IL-33-induced inhibition of NFATc1. Oncotarget. 2017;8:53366-53374 pubmed publisher
Wang S, Xia P, Chen Y, Qu Y, Xiong Z, Ye B, et al. Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation. Cell. 2017;171:201-216.e18 pubmed publisher
Han M, Rajput C, Hong J, Lei J, Hinde J, Wu Q, et al. The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice. J Immunol. 2017;199:1308-1318 pubmed publisher
Malik A, Sharma D, Zhu Q, Karki R, Guy C, Vogel P, et al. IL-33 regulates the IgA-microbiota axis to restrain IL-1?-dependent colitis and tumorigenesis. J Clin Invest. 2016;126:4469-4481 pubmed publisher
Drube S, Kraft F, Dudeck J, Müller A, Weber F, Göpfert C, et al. MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation. J Immunol. 2016;197:3662-3668 pubmed
Jackson Jones L, Rückerl D, Svedberg F, Duncan S, Maizels R, Sutherland T, et al. IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha. Eur J Immunol. 2016;46:2311-2321 pubmed publisher
Friesen T, Ji Q, Fink P. Recent thymic emigrants are tolerized in the absence of inflammation. J Exp Med. 2016;213:913-20 pubmed publisher
Mertz K, Mager L, Wasmer M, Thiesler T, Koelzer V, Ruzzante G, et al. The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice. Oncoimmunology. 2016;5:e1062966 pubmed
Xiang Y, Eyers F, Herbert C, Tay H, Foster P, Yang M. MicroRNA-487b Is a Negative Regulator of Macrophage Activation by Targeting IL-33 Production. J Immunol. 2016;196:3421-8 pubmed publisher
Kim J, Kim W, Moon U, Kim H, Choi H, Sin J, et al. Intratumorally Establishing Type 2 Innate Lymphoid Cells Blocks Tumor Growth. J Immunol. 2016;196:2410-23 pubmed publisher
Doisne J, Balmas E, Boulenouar S, Gaynor L, Kieckbusch J, Gardner L, et al. Composition, Development, and Function of Uterine Innate Lymphoid Cells. J Immunol. 2015;195:3937-45 pubmed publisher
Cohen E, Scott I, Majithiya J, Rapley L, Kemp B, England E, et al. Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation. Nat Commun. 2015;6:8327 pubmed publisher
Suzuki M, Morita R, Hirata Y, Shichita T, Yoshimura A. Spred1, a Suppressor of the Ras-ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells. J Immunol. 2015;195:1273-81 pubmed publisher
Dickinson J, Alevy Y, Malvin N, Patel K, Gunsten S, Holtzman M, et al. IL13 activates autophagy to regulate secretion in airway epithelial cells. Autophagy. 2016;12:397-409 pubmed publisher
Yu Y, Wang C, Clare S, Wang J, Lee S, Brandt C, et al. The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development. J Exp Med. 2015;212:865-74 pubmed publisher
Subramanian H, Gupta K, Parameswaran N, Ali H. Regulation of Fc?RI signaling in mast cells by G protein-coupled receptor kinase 2 and its RH domain. J Biol Chem. 2014;289:20917-27 pubmed
Ohta S, Imamura M, Xing W, Boyce J, Balestrieri B. Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation. J Immunol. 2013;190:5927-38 pubmed publisher
Li M, Li Y, Liu X, Gao X, Wang Y. IL-33 blockade suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice. J Neuroimmunol. 2012;247:25-31 pubmed publisher
Nelson M, Christmann B, Werner J, Metz A, Trevor J, Lowell C, et al. IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. J Immunol. 2011;186:2372-81 pubmed publisher
Stolarski B, Kurowska Stolarska M, Kewin P, Xu D, Liew F. IL-33 exacerbates eosinophil-mediated airway inflammation. J Immunol. 2010;185:3472-80 pubmed publisher
McLaren J, Michael D, Salter R, Ashlin T, Calder C, Miller A, et al. IL-33 reduces macrophage foam cell formation. J Immunol. 2010;185:1222-9 pubmed publisher
Wang G, Miyahara Y, Guo Z, Khattar M, Stepkowski S, Chen W. "Default" generation of neonatal regulatory T cells. J Immunol. 2010;185:71-8 pubmed publisher
Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell R, et al. Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages. J Immunol. 2009;183:7890-7 pubmed publisher
product information
Product Type :
Protein
Product Name :
Mouse IL-33 Recombinant Protein, PeproTech
Catalog # :
210-33-250
Quantity :
2.5 x 100 ug
Price :
US 2105.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Mouse
Applications :
Functional Assay: Assay-dependent
Species :
Mouse
Storage :
-20 C
Description :
IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. IL-33 is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. IL-33 binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6. IL-33 activates NF-kappaB and MAP kinases, and drives production of TH2-associated cytokines from in vitro polarized TH2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules found in tonsils, Peyer's patches and mesenteric lymph nodes and is almost undetectable in placenta. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE. Studies have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine, and an intracellular nuclear factor with transcriptional regulatory properties.
Format :
Lyophilized
Applications w/Dilutions :
Functional Assay: Assay-dependent
Aliases :
9230117N10Rik; C9orf26; DVS27; DVS27-related protein; H-IL-33; IL1F11; IL-1F11; Il33; IL-33; ILN; Interleukin; interleukin 33; interleukin-1 family member 11; Interleukin33; Interleukin-33; Interleukin-33 (109-270); Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33(102-266); Interleukin-33(109-266); NFEHEV; NFHEV; NF-HEV; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules; RGD1311155; RP11-575C20.2
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA