This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Mouse IL-17A Recombinant Protein, PeproTech
catalog :
210-17-5UG
quantity :
5 ug
price :
US 93.50
citations: 49
Reference
Chen S, Yu L, Deng Y, Liu Y, Wang L, Li D, et al. Early IL-17A Prevention Rather Than Late IL-17A Neutralization Attenuates Toluene Diisocyanate-Induced Mixed Granulocytic Asthma. Allergy Asthma Immunol Res. 2022;14:528-548 pubmed publisher
Willinger Y, Turgeman G. Interleukine-17 Modulates Neurogenesis and Behavior Following Exposure to Trauma in Mice. Cells. 2022;11: pubmed publisher
Kluwig D, Huth S, Abdallah A, Pfaff C, Fietkau K, Huth L, et al. Establishment of an Intradermal Ear Injection Model of IL-17A and IL-36γ as a Tool to Investigate the Psoriatic Cytokine Network. Life (Basel). 2021;11: pubmed publisher
Tan J, Dai A, Pan L, Zhang L, Wang Z, Ke T, et al. Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction. J Immunol Res. 2021;2021:9919024 pubmed publisher
Debackere K, Marcelis L, Demeyer S, Vanden Bempt M, Mentens N, Gielen O, et al. Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. Nat Commun. 2021;12:3705 pubmed publisher
Lou Q, Zhao M, Xu Q, Xie S, Liang Y, Chen J, et al. Retinoic Acid Inhibits Tumor-Associated Mesenchymal Stromal Cell Transformation in Melanoma. Front Cell Dev Biol. 2021;9:658757 pubmed publisher
Senda N, Yanai H, Hibino S, Li L, Mizushima Y, Miyagaki T, et al. HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Kidder K, Bian Z, Shi L, Liu Y. Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ. J Immunol. 2020;205:2821-2833 pubmed publisher
Cheng M, Chen Y, Huang D, Chen W, Xu W, Chen Y, et al. Intrinsically altered lung-resident γδT cells control lung melanoma by producing interleukin-17A in the elderly. Aging Cell. 2020;19:e13099 pubmed publisher
Dahlgren M, Jones S, Cautivo K, Dubinin A, Ortiz Carpena J, Farhat S, et al. Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches. Immunity. 2019;50:707-722.e6 pubmed publisher
Stanisavljević S, Čepić A, Bojic S, Veljovic K, Mihajlovic S, Đedović N, et al. Oral neonatal antibiotic treatment perturbs gut microbiota and aggravates central nervous system autoimmunity in Dark Agouti rats. Sci Rep. 2019;9:918 pubmed publisher
Mulati K, Hamanishi J, Matsumura N, Chamoto K, Mise N, Abiko K, et al. VISTA expressed in tumour cells regulates T cell function. Br J Cancer. 2019;120:115-127 pubmed publisher
Rothberg J, Maganti H, Jrade H, Porter C, Palidwor G, Cafariello C, et al. Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis. Cell Discov. 2018;4:21 pubmed publisher
Tusi B, Wolock S, Weinreb C, Hwang Y, Hidalgo D, Zilionis R, et al. Population snapshots predict early haematopoietic and erythroid hierarchies. Nature. 2018;555:54-60 pubmed publisher
Yang Z, Liu M, Wang W, Wang Y, Cao B, Gao Y, et al. Pseudolaric acid B attenuates atopic dermatitis-like skin lesions by inhibiting interleukin-17-induced inflammation. Sci Rep. 2017;7:7918 pubmed publisher
Tsai P, Zhang B, He W, Zha J, Odenwald M, Singh G, et al. IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance. Cell Host Microbe. 2017;21:671-681.e4 pubmed publisher
Zhu F, Willette Brown J, Song N, Lomada D, Song Y, Xue L, et al. Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis. Cell Host Microbe. 2017;21:478-493.e7 pubmed publisher
Maruyama K, Kawasaki T, Hamaguchi M, Hashimoto M, Furu M, Ito H, et al. Bone-protective Functions of Netrin 1 Protein. J Biol Chem. 2016;291:23854-23868 pubmed
Subbarayal B, Chauhan S, Di Zazzo A, Dana R. IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity. J Immunol. 2016;197:3464-3470 pubmed
Niu S, Bian Z, Tremblay A, Luo Y, Kidder K, Mansour A, et al. Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice. J Immunol. 2016;197:3293-3301 pubmed
Matsumura K, Iwai H, Kato Miyazawa M, Kirikae F, Zhao J, Yanagawa T, et al. Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis. J Immunol. 2016;197:3233-3244 pubmed
Bhattacharya N, Yuan R, Prestwood T, Penny H, DiMaio M, Reticker Flynn N, et al. Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer. Immunity. 2016;45:641-655 pubmed publisher
Ulivieri C, Savino M, Luccarini I, Fanigliulo E, Aldinucci A, Bonechi E, et al. The Adaptor Protein Rai/ShcC Promotes Astrocyte-Dependent Inflammation during Experimental Autoimmune Encephalomyelitis. J Immunol. 2016;197:480-90 pubmed publisher
Ono T, Okamoto K, Nakashima T, Nitta T, Hori S, Iwakura Y, et al. IL-17-producing γδ T cells enhance bone regeneration. Nat Commun. 2016;7:10928 pubmed publisher
Pacios S, Xiao W, Mattos M, Lim J, Tarapore R, Alsadun S, et al. Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B. Sci Rep. 2015;5:16694 pubmed publisher
Somma D, Mastrovito P, Grieco M, Lavorgna A, Pignalosa A, Formisano L, et al. CIKS/DDX3X interaction controls the stability of the Zc3h12a mRNA induced by IL-17. J Immunol. 2015;194:3286-94 pubmed publisher
Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, et al. Temporal expression of growth factors triggered by epiregulin regulates inflammation development. J Immunol. 2015;194:1039-46 pubmed publisher
Cheng M, Qian L, Shen G, Bian G, Xu T, Xu W, et al. Microbiota modulate tumoral immune surveillance in lung through a ??T17 immune cell-dependent mechanism. Cancer Res. 2014;74:4030-41 pubmed publisher
Jie Z, Liang Y, Hou L, Dong C, Iwakura Y, Soong L, et al. Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection. J Immunol. 2014;192:3289-300 pubmed publisher
Åhsberg J, Ungerbäck J, Strid T, Welinder E, Stjernberg J, Larsson M, et al. Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner. J Biol Chem. 2013;288:33449-61 pubmed publisher
Tan Z, Qian X, Jiang R, Liu Q, Wang Y, Chen C, et al. IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. J Immunol. 2013;191:1835-44 pubmed publisher
Paiva R, Lino A, Bergman M, Caramalho I, Sousa A, Zelenay S, et al. Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery. Proc Natl Acad Sci U S A. 2013;110:6494-9 pubmed publisher
Koning J, Kooij G, de Vries H, Nolte M, Mebius R. Mesenchymal stem cells are mobilized from the bone marrow during inflammation. Front Immunol. 2013;4:49 pubmed publisher
Bian Z, Guo Y, Luo Y, Tremblay A, Zhang X, Dharma S, et al. CD47 deficiency does not impede polymorphonuclear neutrophil transmigration but attenuates granulopoiesis at the postacute stage of colitis. J Immunol. 2013;190:411-7 pubmed publisher
Holoshitz J, Liu Y, Fu J, Joseph J, Ling S, Colletta A, et al. An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity. J Immunol. 2013;190:48-57 pubmed publisher
Paust H, Turner J, Riedel J, Disteldorf E, Peters A, Schmidt T, et al. Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis. Kidney Int. 2012;82:72-83 pubmed publisher
Stange J, Hepworth M, Rausch S, Zajic L, Kuhl A, Uyttenhove C, et al. IL-22 mediates host defense against an intestinal intracellular parasite in the absence of IFN-? at the cost of Th17-driven immunopathology. J Immunol. 2012;188:2410-8 pubmed publisher
Bian Z, Guo Y, Ha B, Zen K, Liu Y. Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions. J Immunol. 2012;188:844-53 pubmed publisher
Mi S, Li Z, Yang H, Liu H, Wang J, Ma Y, et al. Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms. J Immunol. 2011;187:3003-14 pubmed publisher
Takeuchi H, Yokota A, Ohoka Y, Iwata M. Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-?. PLoS ONE. 2011;6:e16089 pubmed publisher
He Y, Li J, Zhuang W, Yin L, Chen C, Li J, et al. The inhibitory effect against collagen-induced arthritis by Schistosoma japonicum infection is infection stage-dependent. BMC Immunol. 2010;11:28 pubmed publisher
Zhang S, Kim C, Batra S, McKerrow J, Loke P. Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines. PLoS Negl Trop Dis. 2010;4:e648 pubmed publisher
Wang J, Ouyang Y, Guner Y, Ford H, Grishin A. Ubiquitin-editing enzyme A20 promotes tolerance to lipopolysaccharide in enterocytes. J Immunol. 2009;183:1384-92 pubmed publisher
von Vietinghoff S, Ley K. IL-17A controls IL-17F production and maintains blood neutrophil counts in mice. J Immunol. 2009;183:865-73 pubmed publisher
Perona Wright G, Jenkins S, O Connor R, Zienkiewicz D, McSorley H, Maizels R, et al. A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. J Immunol. 2009;182:2808-15 pubmed publisher
Hou W, Kang H, Kim B. Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. J Exp Med. 2009;206:313-28 pubmed publisher
Stritesky G, Yeh N, Kaplan M. IL-23 promotes maintenance but not commitment to the Th17 lineage. J Immunol. 2008;181:5948-55 pubmed
Lindemann M, Hu Z, Benczik M, Liu K, Gaffen S. Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway. J Biol Chem. 2008;283:14100-8 pubmed publisher
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product information
Product Type :
Protein
Product Name :
Mouse IL-17A Recombinant Protein, PeproTech
Catalog # :
210-17-5UG
Quantity :
5 ug
Price :
US 93.50
Clonality :
Recombinant
Purity :
purified
Reactivity :
Mouse
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Mouse
Storage :
-20 C
Description :
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
Ctla8; CTLA-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin-17; Interleukin17A; interleukin-17A; R-IL-17-A
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA