This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Mouse IL-15 Recombinant Protein, PeproTech
catalog :
210-15-50UG
quantity :
50 ug
price :
US 542.00
citations: 187
Reference
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Page N, Klimek B, De Roo M, Steinbach K, Soldati H, Lemeille S, et al. Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells. Immunity. 2018;48:937-950.e8 pubmed publisher
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Domínguez Andrés J, Feo Lucas L, Minguito de la Escalera M, Gonzalez L, López Bravo M, Ardavin C. Inflammatory Ly6Chigh Monocytes Protect against Candidiasis through IL-15-Driven NK Cell/Neutrophil Activation. Immunity. 2017;46:1059-1072.e4 pubmed publisher
Spranger S, Dai D, Horton B, Gajewski T. Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy. Cancer Cell. 2017;31:711-723.e4 pubmed publisher
Robinette M, Bando J, Song W, Ulland T, Gilfillan S, Colonna M. IL-15 sustains IL-7R-independent ILC2 and ILC3 development. Nat Commun. 2017;8:14601 pubmed publisher
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Iraolagoitia X, Spallanzani R, Torres N, Araya R, Ziblat A, Domaica C, et al. NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells. J Immunol. 2016;197:953-61 pubmed publisher
van den Boorn J, Jakobs C, Hagen C, Renn M, Luiten R, Melief C, et al. Inflammasome-Dependent Induction of Adaptive NK Cell Memory. Immunity. 2016;44:1406-21 pubmed publisher
Keppel M, Cooper M. Assessment of NK Cell Metabolism. Methods Mol Biol. 2016;1441:27-42 pubmed publisher
Rabacal W, Pabbisetty S, Hoek K, Cendron D, Guo Y, Maseda D, et al. Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival. Proc Natl Acad Sci U S A. 2016;113:5370-5 pubmed publisher
Hecht V, Sullivan L, Kimmerling R, Kim D, Hosios A, Stockslager M, et al. Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. J Cell Biol. 2016;212:439-47 pubmed publisher
Hamblet C, Makowski S, Tritapoe J, Pomerantz J. NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3. J Immunol. 2016;196:2614-26 pubmed publisher
Dépis F, Kwon H, Mathis D, Benoist C. Unstable FoxP3+ T regulatory cells in NZW mice. Proc Natl Acad Sci U S A. 2016;113:1345-50 pubmed publisher
Corpuz T, Stolp J, Kim H, Pinget G, Gray D, Cho J, et al. Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines. J Immunol. 2016;196:645-54 pubmed publisher
Salmond R, Brownlie R, Meyuhas O, Zamoyska R. Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation. J Immunol. 2015;195:4615-22 pubmed publisher
Stegmann K, de Souza J, Riley E. IL-18-induced expression of high-affinity IL-2R on murine NK cells is essential for NK-cell IFN-γ production during murine Plasmodium yoelii infection. Eur J Immunol. 2015;45:3431-40 pubmed publisher
Doisne J, Balmas E, Boulenouar S, Gaynor L, Kieckbusch J, Gardner L, et al. Composition, Development, and Function of Uterine Innate Lymphoid Cells. J Immunol. 2015;195:3937-45 pubmed publisher
Wang C, Liu X, Li Z, Chai Y, Jiang Y, Wang Q, et al. CD8(+)NKT-like cells regulate the immune response by killing antigen-bearing DCs. Sci Rep. 2015;5:14124 pubmed publisher
Barra M, Richards D, Hansson J, Hofer A, Delacher M, Hettinger J, et al. Transcription Factor 7 Limits Regulatory T Cell Generation in the Thymus. J Immunol. 2015;195:3058-70 pubmed publisher
Richer M, Pewe L, Hancox L, Hartwig S, Varga S, Harty J. Inflammatory IL-15 is required for optimal memory T cell responses. J Clin Invest. 2015;125:3477-90 pubmed publisher
Haynes L, Verma S, McDonald B, Wu R, Tacke R, Nowyhed H, et al. Cardif (MAVS) Regulates the Maturation of NK Cells. J Immunol. 2015;195:2157-67 pubmed publisher
Preston G, Sinclair L, Kaskar A, Hukelmann J, Navarro M, Ferrero I, et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015;34:2008-24 pubmed publisher
Ebel M, Awe O, Kaplan M, Kansas G. Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK. J Immunol. 2015;194:5781-8 pubmed publisher
Motozono C, Bridgeman J, Price D, Sewell A, Ueno T. Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity. Clin Exp Immunol. 2015;180:560-70 pubmed publisher
Leong J, Schneider S, Sullivan R, Parikh B, Anthony B, Singh A, et al. PTEN regulates natural killer cell trafficking in vivo. Proc Natl Acad Sci U S A. 2015;112:E700-9 pubmed publisher
Keppel M, Saucier N, Mah A, Vogel T, Cooper M. Activation-specific metabolic requirements for NK Cell IFN-γ production. J Immunol. 2015;194:1954-62 pubmed publisher
Jackson J, Nasa C, Shi W, Huntington N, Bogue C, Alexander W, et al. A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis. Blood. 2015;125:803-14 pubmed publisher
Gillgrass A, Gill N, Babian A, Ashkar A. The absence or overexpression of IL-15 drastically alters breast cancer metastasis via effects on NK cells, CD4 T cells, and macrophages. J Immunol. 2014;193:6184-91 pubmed publisher
Donnelly R, Loftus R, Keating S, Liou K, Biron C, Gardiner C, et al. mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function. J Immunol. 2014;193:4477-84 pubmed publisher
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Carrillo Galvez A, Cobo M, Cuevas Ocaña S, Gutiérrez Guerrero A, Sánchez Gilabert A, Bongarzone P, et al. Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity. Stem Cells. 2015;33:183-95 pubmed publisher
Cowan J, McCarthy N, Parnell S, White A, Bacon A, Serge A, et al. Differential requirement for CCR4 and CCR7 during the development of innate and adaptive ??T cells in the adult thymus. J Immunol. 2014;193:1204-12 pubmed publisher
Klose C, Flach M, Möhle L, Rogell L, Hoyler T, Ebert K, et al. Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell. 2014;157:340-356 pubmed publisher
Stojanovic A, Fiegler N, Brunner Weinzierl M, Cerwenka A. CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-? production in response to mature dendritic cells. J Immunol. 2014;192:4184-91 pubmed publisher
Male V, Nisoli I, Kostrzewski T, Allan D, Carlyle J, Lord G, et al. The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression. J Exp Med. 2014;211:635-42 pubmed publisher
Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 2014;507:508-12 pubmed publisher
Crotta S, Gkioka A, Male V, Duarte J, Davidson S, Nisoli I, et al. The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development. J Immunol. 2014;192:2677-88 pubmed publisher
White A, Jenkinson W, Cowan J, Parnell S, Bacon A, Jones N, et al. An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells. J Immunol. 2014;192:2659-66 pubmed publisher
Nolz J, Harty J. IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking. J Clin Invest. 2014;124:1013-26 pubmed publisher
Zhou P, Shaffer D, Alvarez Arias D, Nakazaki Y, Pos W, Torres A, et al. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 2014;506:52-7 pubmed publisher
Knudson K, Hamilton S, Daniels M, Jameson S, Teixeiro E. Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength. J Immunol. 2013;191:5797-801 pubmed publisher
Sullivan R, Fogel L, Leong J, Schneider S, Wong R, Romee R, et al. MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways. J Immunol. 2013;191:5904-13 pubmed publisher
Pichavant M, R xe9 my G, Bekaert S, Le Rouzic O, Kervoaze G, Vilain E, et al. Oxidative stress-mediated iNKT-cell activation is involved in COPD pathogenesis. Mucosal Immunol. 2014;7:568-78 pubmed publisher
Cho J, Kim H, Kim K, Yang D, Surh C, Sprent J. Unique features of naive CD8+ T cell activation by IL-2. J Immunol. 2013;191:5559-73 pubmed publisher
Åhsberg J, Ungerbäck J, Strid T, Welinder E, Stjernberg J, Larsson M, et al. Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner. J Biol Chem. 2013;288:33449-61 pubmed publisher
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product information
Product Type :
Protein
Product Name :
Mouse IL-15 Recombinant Protein, PeproTech
Catalog # :
210-15-50UG
Quantity :
50 ug
Price :
US 542.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Mouse
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Mouse
Storage :
-20 C
Description :
IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
AI503618; il 15; Il15; IL-15; ILN; Interleukin; interleukin 15; Interleukin15; interleukin-15; MGC9721; M-IL-15
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA