Mouse IL-12 p40 Recombinant Protein, PeproTech | Invitrogen 210-12P40H-2UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Mouse IL-12 p40 Recombinant Protein, PeproTech

catalog :

210-12P40H-2UG

quantity :

2 ug

price :

US 93.50

citations: 3

Reference
Hasegawa H, Mizoguchi I, Orii N, Inoue S, Katahira Y, Yoneto T, et al. IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development. Sci Rep. 2021;11:5266 pubmed publisher
Sun B, Chang H, Salinger A, Tomita B, Bawadekar M, Holmes C, et al. Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination. JCI Insight. 2019;4: pubmed publisher
Komuczki J, Tuzlak S, Friebel E, Hartwig T, Spath S, Rosenstiel P, et al. Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β. Immunity. 2019;: pubmed publisher

product information

Product Type :

Protein

Product Name :

Mouse IL-12 p40 Recombinant Protein, PeproTech

Catalog # :

210-12P40H-2UG

Quantity :

2 ug

Price :

US 93.50

Clonality :

Recombinant

Purity :

purified

Reactivity :

Mouse

Applications :

Functional Assay: Assay-dependent

Species :

Mouse

Storage :

-20 C

Description :

IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kDa cytokine receptor like subunit encoded by this gene, and a 35 kDa subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Format :

Lyophilized

Applications w/Dilutions :

Functional Assay: Assay-dependent

Aliases :

CLMF; CLMF p35; CLMF p40; CLMF2; cytotoxic lymphocyte maturation factor 40 kDa subunit; Il12; IL12 p40; IL-12 p40 subunit; IL-12 subunit p35; IL-12 subunit p40; IL12, subunit p40; IL-12.p40; IL12A; IL-12A; Il12b; IL-12B; Il12p40; IL-12p40; IL-12p40 subunit; IMD28; IMD29; Interleukin; interleukin 12 p40 subunit; interleukin 12 subunit p40; interleukin 12, p40; interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 beta chain; interleukin-12 beta chain precursor; interleukin-12 p40; interleukin-12 p40 chain; interleukin-12 p40 subunit; interleukin-12 subunit beta; interleukin-12 subunit p40; interleukin-12p40; interleukin-23 p40 subunit; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF; NKSF1; NKSF2; p40; RP23-388G23.1