This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human IL-34 Recombinant Protein, PeproTech
catalog :
200-34-100UG
quantity :
100 ug
price :
US 1204.00
citations: 36
Reference
Farahani E, Reinert L, Narita R, Serrero M, Skouboe M, van der Horst D, et al. The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation. Cell Rep. 2024;43:113792 pubmed publisher
Yang X, Wen J, Yang H, Jones I, Zhu X, Liu W, et al. Functional characterization of Alzheimer's disease genetic variants in microglia. Nat Genet. 2023;55:1735-1744 pubmed publisher
Kang Y, Diep Y, Tran M, Tran V, Ambrin G, Ngo H, et al. Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration. Nat Protoc. 2023;18:2838-2867 pubmed publisher
Chen S, Wong Y. Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors. Methods Mol Biol. 2023;2683:53-68 pubmed publisher
Breitmeyer R, Vogel S, Heider J, Hartmann S, W xfc st R, Keller A, et al. Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction. Commun Biol. 2023;6:472 pubmed publisher
Wieder N, Fried J, Kim C, Sidhom E, Brown M, Marshall J, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell Metab. 2023;35:887-905.e11 pubmed publisher
Wallach T, Raden M, Hinkelmann L, Brehm M, Rabsch D, Weidling H, et al. Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia. Front Immunol. 2022;13:1066456 pubmed publisher
Dr xe4 ger N, Sattler S, Huang C, Teter O, Leng K, Hashemi S, et al. A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Nat Neurosci. 2022;25:1149-1162 pubmed publisher
Boudesco C, Nonneman A, Cinti A, Picardi P, Redaelli L, Swijsen S, et al. Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells. Glia. 2022;70:2290-2308 pubmed publisher
Solomon S, Sampathkumar N, Carre I, Mondal M, Chennell G, Vernon A, et al. Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses. Cell Mol Life Sci. 2022;79:453 pubmed publisher
Jin M, Xu R, Wang L, Alam M, Ma Z, Zhu S, et al. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell Stem Cell. 2022;29:1135-1153.e8 pubmed publisher
Jairaman A, McQuade A, Granzotto A, Kang Y, Chadarevian J, GANDHI S, et al. TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia. elife. 2022;11: pubmed publisher
Morozzi G, Rothen J, Toussaint G, de Lange K, Westritschnig K, Doelemeyer A, et al. STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia. iScience. 2021;24:103434 pubmed publisher
Magusali N, Graham A, Piers T, Panichnantakul P, Yaman U, Shoai M, et al. A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene. Brain. 2021;144:3727-3741 pubmed publisher
Popova G, Soliman S, Kim C, Keefe M, Hennick K, Jain S, et al. Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids. Cell Stem Cell. 2021;28:2153-2166.e6 pubmed publisher
Bassil R, Shields K, Granger K, Zein I, Ng S, Chih B. Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia. Nat Commun. 2021;12:5220 pubmed publisher
Parajuli B, Saito H, Shinozaki Y, Shigetomi E, Miwa H, Yoneda S, et al. Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice. Glia. 2021;69:2332-2348 pubmed publisher
SHERIDAN S, Thanos J, De Guzman R, McCrea L, Horng J, Fu T, et al. Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure. Transl Psychiatry. 2021;11:179 pubmed publisher
Trapecar M, Wogram E, Svoboda D, Communal C, Omer A, Lungjangwa T, et al. Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases. Sci Adv. 2021;7: pubmed publisher
Akiyama H, Jalloh S, Park S, Lei M, Mostoslavsky G, Gummuluru S. Expression of HIV-1 Intron-Containing RNA in Microglia Induces Inflammatory Responses. J Virol. 2020;: pubmed publisher
Morshed N, Ralvenius W, Nott A, Watson L, Rodriguez F, Akay L, et al. Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration. Mol Syst Biol. 2020;16:e9819 pubmed publisher
Panagiotakopoulou V, Ivanyuk D, De Cicco S, Haq W, Arsic A, Yu C, et al. Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells. Nat Commun. 2020;11:5163 pubmed publisher
Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, et al. Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. J Exp Med. 2020;217: pubmed publisher
Chatterjee T, Knappik A, Sandford E, Tewari M, Choi S, Strong W, et al. Direct kinetic fingerprinting and digital counting of single protein molecules. Proc Natl Acad Sci U S A. 2020;117:22815-22822 pubmed publisher
Muliyil S, Levet C, Düsterhöft S, Dulloo I, Cowley S, Freeman M. ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration. EMBO J. 2020;39:e104415 pubmed publisher
Nzou G, Wicks R, VanOstrand N, Mekky G, Seale S, El Taibany A, et al. Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction. Sci Rep. 2020;10:9766 pubmed publisher
Knupp A, Mishra S, Martinez R, Braggin J, Szabó M, Kinoshita C, et al. Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing. Cell Rep. 2020;31:107719 pubmed publisher
Konttinen H, Cabral da Silva M, Ohtonen S, Wojciechowski S, Shakirzyanova A, Caligola S, et al. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia. Stem Cell Reports. 2019;13:669-683 pubmed publisher
Hasselmann J, Coburn M, England W, Figueroa Velez D, Kiani Shabestari S, Tu C, et al. Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. Neuron. 2019;103:1016-1033.e10 pubmed publisher
Kveler K, Starosvetsky E, Ziv Kenet A, Kalugny Y, Gorelik Y, Shalev Malul G, et al. Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed. Nat Biotechnol. 2018;36:651-659 pubmed publisher
Lin Y, Seo J, Gao F, Feldman H, Wen H, Penney J, et al. APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. Neuron. 2018;98:1141-1154.e7 pubmed publisher
Nzou G, Wicks R, Wicks E, Seale S, Sane C, Chen A, et al. Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling. Sci Rep. 2018;8:7413 pubmed publisher
Brownjohn P, Smith J, Solanki R, Lohmann E, Houlden H, Hardy J, et al. Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. Stem Cell Reports. 2018;10:1294-1307 pubmed publisher
Haenseler W, Sansom S, Buchrieser J, Newey S, Moore C, Nicholls F, et al. A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response. Stem Cell Reports. 2017;8:1727-1742 pubmed publisher
Abud E, Ramirez R, Martinez E, Healy L, Nguyen C, Newman S, et al. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 2017;94:278-293.e9 pubmed publisher
Hwang S, Choi B, Kang S, Chang J, Kim Y, Chung Y, et al. Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis. Arthritis Res Ther. 2012;14:R14 pubmed publisher
product information
Product Type :
Protein
Product Name :
Human IL-34 Recombinant Protein, PeproTech
Catalog # :
200-34-100UG
Quantity :
100 ug
Price :
US 1204.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
Functional Assay: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
IL-34 is secreted as a dimeric protein and currently belongs to no known cytokine family. It signals via the M-CSF Receptor, also known as CSF-1R and CD115, which is shared with M-CSF. IL-34 has no amino acid sequence homology to M-CSF, but they exhibit similarities in secondary structure and share overlapping functions. IL-34 has been shown to promote myeloid survival, proliferation, and differentiation, and to play a role in osteoclast formation. IL-34 expression has been detected in various tissues and is most abundant in the spleen.
Format :
Lyophilized
Applications w/Dilutions :
Functional Assay: Assay-dependent
Aliases :
2010004A03Rik; AI593503; C16orf77; IL34; IL-34; ILN; Interleukin; interleukin 34; Interleukin34; interleukin-34
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA