This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human IL-33 Recombinant Protein, PeproTech
catalog :
200-33-100UG
quantity :
100 ug
price :
US 1204.00
citations: 25
Reference
Gao J, Li Y, Guan X, Mohammed Z, Gomez G, Hui Y, et al. IL-33 priming and antigenic stimulation synergistically promote the transcription of proinflammatory cytokine and chemokine genes in human skin mast cells. BMC Genomics. 2023;24:592 pubmed publisher
Goldsteen P, Sabogal Guaqueta A, Mulder P, Bos I, Eggens M, van der Koog L, et al. Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies. Front Pharmacol. 2022;13:991072 pubmed publisher
Lin E, Hong C. IL-33 Enhances ACE2 Expression on Epidermal Keratinocytes in Atopic Dermatitis: A Plausible Issue for SARS-CoV-2 Transmission in Inflamed Atopic Skin. Biomedicines. 2022;10: pubmed publisher
Liu G, Chen Y, Wang Y, Deng X, Xiao Q, Zhang L, et al. Angiotensin II enhances group 2 innate lymphoid cell responses via AT1a during airway inflammation. J Exp Med. 2022;219: pubmed publisher
Qiu J, Zhang J, Ji Y, Sun H, Gu Z, Sun Q, et al. Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity. Mucosal Immunol. 2021;14:1306-1322 pubmed publisher
Dustin C, Habibovic A, Hristova M, Schiffers C, Morris C, Lin M, et al. Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge. J Immunol. 2021;206:2989-2999 pubmed publisher
He Z, Song Y, Yi Y, Qiu F, Wang J, Li J, et al. Blockade of IL-33 signalling attenuates osteoarthritis. Clin Transl Immunology. 2020;9:e1185 pubmed publisher
Swann J, Koneva L, Regan Komito D, Sansom S, Powrie F, Griseri T. IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors. J Exp Med. 2020;217: pubmed publisher
Liu G, Deng X, Li X, Cao Y, Xing Y, Zhou P, et al. Expansion of Group 2 Innate Lymphoid Cells in Patients with End-Stage Renal Disease and Their Clinical Significance. J Immunol. 2020;205:36-44 pubmed publisher
Nakajima S, Ishimaru K, Kobayashi A, Yu G, Nakamura Y, Oh oka K, et al. Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis. Sci Rep. 2019;9:18423 pubmed publisher
Cildir G, Toubia J, Yip K, Zhou M, Pant H, Hissaria P, et al. Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases. Immunity. 2019;51:949-965.e6 pubmed publisher
Bonne Ann xe9 e S, Bush M, Nutman T. Differential Modulation of Human Innate Lymphoid Cell (ILC) Subsets by IL-10 and TGF-β. Sci Rep. 2019;9:14305 pubmed publisher
Buckley M, Williams J, Chan Y, Laubertova L, Gallagher H, Moss J, et al. The interleukin-33-mediated inhibition of expression of two key genes implicated in atherosclerosis in human macrophages requires MAP kinase, phosphoinositide 3-kinase and nuclear factor-κB signaling pathways. Sci Rep. 2019;9:11317 pubmed publisher
Ha E, Choi J, Kwon H, Park H, Lah S, Moon K, et al. Endothelial Sox17 promotes allergic airway inflammation. J Allergy Clin Immunol. 2019;: pubmed publisher
Lopez Yrigoyen M, Yang C, Fidanza A, Cassetta L, Taylor A, McCahill A, et al. Genetic programming of macrophages generates an in vitro model for the human erythroid island niche. Nat Commun. 2019;10:881 pubmed publisher
Boudaud M, Turcotte S, Stankova J, Rola Pleszczynski M. IL-33 Upregulates Cysteinyl Leukotriene Receptor Type 1 Expression in Human Peripheral Blood CD4+ T Lymphocytes. J Immunol. 2018;201:2787-2798 pubmed publisher
Travers J, Rochman M, Miracle C, Habel J, Brusilovsky M, Caldwell J, et al. Chromatin regulates IL-33 release and extracellular cytokine activity. Nat Commun. 2018;9:3244 pubmed publisher
Arae K, Morita H, Unno H, Motomura K, Toyama S, Okada N, et al. Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1? production by DCs. Sci Rep. 2018;8:11721 pubmed publisher
Rogers M, Lamens K, Shafagati N, Johnson M, Oury T, Joyce S, et al. CD4+ Regulatory T Cells Exert Differential Functions during Early and Late Stages of the Immune Response to Respiratory Viruses. J Immunol. 2018;201:1253-1266 pubmed publisher
Xu X, Shang Q, Chen X, Nie W, Zou Z, Huang A, et al. Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients. Cell Mol Immunol. 2015;12:309-16 pubmed publisher
Maier E, Werner D, Duschl A, Bohle B, Horejs Hoeck J. Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-?B-dependent way. J Immunol. 2014;193:645-54 pubmed publisher
Connolly D, O Neill L, McGettrick A. The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling. J Biol Chem. 2013;288:5616-23 pubmed publisher
Yagami A, Orihara K, Morita H, Futamura K, Hashimoto N, Matsumoto K, et al. IL-33 mediates inflammatory responses in human lung tissue cells. J Immunol. 2010;185:5743-50 pubmed publisher
McLaren J, Michael D, Salter R, Ashlin T, Calder C, Miller A, et al. IL-33 reduces macrophage foam cell formation. J Immunol. 2010;185:1222-9 pubmed publisher
Turnquist H, Cardinal J, Macedo C, Rosborough B, Sumpter T, Geller D, et al. mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS. Blood. 2010;115:4758-69 pubmed publisher
product information
Product Type :
Protein
Product Name :
Human IL-33 Recombinant Protein, PeproTech
Catalog # :
200-33-100UG
Quantity :
100 ug
Price :
US 1204.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. IL-33 is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. IL-33 binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6. IL-33 activates NF-kappaB and MAP kinases, and drives production of TH2-associated cytokines from in vitro polarized TH2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules found in tonsils, Peyer's patches and mesenteric lymph nodes and is almost undetectable in placenta. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE. Studies have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine, and an intracellular nuclear factor with transcriptional regulatory properties.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
9230117N10Rik; C9orf26; DVS27; DVS27-related protein; H-IL-33; IL1F11; IL-1F11; Il33; IL-33; ILN; Interleukin; interleukin 33; interleukin-1 family member 11; Interleukin33; Interleukin-33; Interleukin-33 (109-270); Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33(102-266); Interleukin-33(109-266); NFEHEV; NFHEV; NF-HEV; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules; RGD1311155; RP11-575C20.2
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA