This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human IL-23 Recombinant Protein, PeproTech
catalog :
200-23-50UG
quantity :
50 ug
price :
US 1098.00
citations: 84
Reference
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Sun R, Abraham C. IL23 Promotes Antimicrobial Pathways in Human Macrophages, Which Are Reduced With the IBD-Protective IL23R R381Q Variant. Cell Mol Gastroenterol Hepatol. 2020;: pubmed publisher
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Yin W, Song Y, Chang X. Single-cell RNA-Seq analysis identifies a noncoding interleukin 4 (IL-4) RNA that post-transcriptionally up-regulates IL-4 production in T helper cells. J Biol Chem. 2019;294:290-298 pubmed publisher
Ding J, Zhou T, Zheng X, Wang X, Tong X, Luo C, et al. The Effects of High Mobility Group Box-1 Protein on Peripheral Treg/Th17 Balance in Patients with Atherosclerosis. Acta Cardiol Sin. 2018;34:399-408 pubmed publisher
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Li B, Wang X, Choi I, Wang Y, Liu S, Pham A, et al. miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. J Clin Invest. 2017;127:3702-3716 pubmed publisher
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Pasi S, Kant R, Surolia A. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response. J Biol Chem. 2016;291:12358-69 pubmed publisher
Drujont L, Lemoine A, Moreau A, Bienvenu G, Lancien M, Cens T, et al. RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus. Sci Rep. 2016;6:23682 pubmed publisher
Olson M, Verdan F, Hufford M, Dent A, Kaplan M. STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells. J Immunol. 2016;196:3297-304 pubmed publisher
Mailer R, Joly A, Liu S, Elias S, Tegner J, Andersson J. IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3. Sci Rep. 2015;5:14674 pubmed publisher
Zhang Z, Cheng L, Zhao J, Li G, Zhang L, Chen W, et al. Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion. J Clin Invest. 2015;125:3692-703 pubmed publisher
Hammitzsch A, Tallant C, Fedorov O, O Mahony A, Brennan P, Hay D, et al. CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses. Proc Natl Acad Sci U S A. 2015;112:10768-73 pubmed publisher
Yoon J, Sudo K, Kuroda M, Kato M, Lee I, Han J, et al. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Nat Commun. 2015;6:7600 pubmed publisher
Adoro S, Cubillos Ruiz J, Chen X, Deruaz M, Vrbanac V, Song M, et al. IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection. Nat Commun. 2015;6:7562 pubmed publisher
Barnes M, Li C, Xu Y, An J, Huang Y, Cyster J. The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function. J Exp Med. 2015;212:1011-20 pubmed publisher
Cook P, Owen H, Deaton A, Borger J, Brown S, Clouaire T, et al. A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells. Nat Commun. 2015;6:6920 pubmed publisher
Fiebiger B, Maamary J, Pincetic A, Ravetch J. Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs. Proc Natl Acad Sci U S A. 2015;112:E2385-94 pubmed publisher
Ding X, Yan Y, Li X, Li K, Ciric B, Yang J, et al. Silencing IFN-γ binding/signaling in astrocytes versus microglia leads to opposite effects on central nervous system autoimmunity. J Immunol. 2015;194:4251-64 pubmed publisher
Reppert S, Zinser E, Holzinger C, Sandrock L, Koch S, Finotto S. NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis. Eur J Immunol. 2015;45:1426-40 pubmed publisher
Wang Y, Xing F, Ye S, Xiao J, Di J, Zeng S, et al. Jagged-1 signaling suppresses the IL-6 and TGF-β treatment-induced Th17 cell differentiation via the reduction of RORγt/IL-17A/IL-17F/IL-23a/IL-12rb1. Sci Rep. 2015;5:8234 pubmed publisher
Stephen T, Rutkowski M, Allegrezza M, Perales Puchalt A, Tesone A, Svoronos N, et al. Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression. Immunity. 2014;41:427-439 pubmed publisher
Sarkar S, Justa S, Brucks M, Endres J, Fox D, Zhou X, et al. Interleukin (IL)-17A, F and AF in inflammation: a study in collagen-induced arthritis and rheumatoid arthritis. Clin Exp Immunol. 2014;177:652-61 pubmed publisher
Pham D, Walline C, Hollister K, Dent A, Blum J, Firulli A, et al. The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor ? chain. J Biol Chem. 2013;288:27423-33 pubmed publisher
Yamashita J, Iwamura C, Ito T, Narita M, Hara Y, Sasaki T, et al. Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-? production from CD4 T cells. J Immunol. 2013;191:949-60 pubmed publisher
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Eigenbrod T, Bode K, Dalpke A. Early inhibition of IL-1? expression by IFN-? is mediated by impaired binding of NF-?B to the IL-1? promoter but is independent of nitric oxide. J Immunol. 2013;190:6533-41 pubmed publisher
Ye P, Chen W, Wu J, Huang X, Li J, Wang S, et al. GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency. J Clin Invest. 2013;123:2317-31 pubmed publisher
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Chang J, Burkett P, Borges C, Kuchroo V, Turka L, Chang C. MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling. Proc Natl Acad Sci U S A. 2013;110:2270-5 pubmed publisher
Hasegawa E, Sonoda K, Shichita T, Morita R, Sekiya T, Kimura A, et al. IL-23-independent induction of IL-17 from ??T cells and innate lymphoid cells promotes experimental intraocular neovascularization. J Immunol. 2013;190:1778-87 pubmed publisher
Reardon C, Duncan G, Brüstle A, Brenner D, Tusche M, Olofsson P, et al. Lymphocyte-derived ACh regulates local innate but not adaptive immunity. Proc Natl Acad Sci U S A. 2013;110:1410-5 pubmed publisher
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Zhang X, Han S, Kang Y, Guo M, Hong S, Liu F, et al. SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection. Cell Mol Immunol. 2012;9:390-8 pubmed publisher
Pham D, Vincentz J, Firulli A, Kaplan M. Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function. J Immunol. 2012;189:832-40 pubmed publisher
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Van Belle T, Esplugues E, Liao J, Juntti T, Flavell R, Von Herrath M. Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model. J Immunol. 2011;187:2915-22 pubmed publisher
Giroux M, Delisle J, Gauthier S, Heinonen K, Hinsinger J, Houde B, et al. SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage. Blood. 2011;117:1734-44 pubmed publisher
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product information
Product Type :
Protein
Product Name :
Human IL-23 Recombinant Protein, PeproTech
Catalog # :
200-23-50UG
Quantity :
50 ug
Price :
US 1098.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
Functional Assay: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 that is disulfide-linked with to two subunits, a p19 subunit unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 interacts with IL-12Rbeta1 and a beta2-like receptor subunit with STAT4 binding domain, IL-23R. IL-23 is secreted by activated mouse and human dendritic cells and is involved in the inflammation process and associated with autoimmune diseases. Mouse IL-23 was found not to induce significant amounts of IFN-gamma, induces strong proliferation of memory T cells (but not naive T cells), and activate mouse memory T cells to produce the proinflammatory cytokine IL-17. On the other hand, human IL-23 induces proliferation of memory T cells, induces moderate levels of IFN-gamma, and is produced by naive and memory T cells. IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance, and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines. IL-23 interacts with the receptors IL-12R beta1 and IL-23R to activate the Jak-Stat signaling cascade. IL-23 has been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.
Format :
Lyophilized
Applications w/Dilutions :
Functional Assay: Assay-dependent
Aliases :
IL23; IL-23; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; P19; SGRF; UNQ2498/PRO5798
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA