This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human IL-17A Recombinant Protein, PeproTech
catalog :
200-17-250UG
quantity :
250 ug
price :
US 1216.00
citations: 78
Reference
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Zeng J, Zhang Y, Zhang H, Zhang Y, Gao L, Tong X, et al. RPL22 Overexpression Promotes Psoriasis-Like Lesion by Inducing Keratinocytes Abnormal Biological Behavior. Front Immunol. 2021;12:699900 pubmed publisher
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Das S, Surve V, Marathe S, Wad S, Karulkar A, Srinivasan S, et al. IL-9 Abrogates the Metastatic Potential of Breast Cancer by Controlling Extracellular Matrix Remodeling and Cellular Contractility. J Immunol. 2021;206:2740-2752 pubmed publisher
Mills R, Humphrey S, Fortuna P, Lor M, Foster S, Quaife Ryan G, et al. BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection. Cell. 2021;184:2167-2182.e22 pubmed publisher
Zhang T, Yang L, Ke Y, Lei J, Shen S, Shao S, et al. EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation. Cell Death Dis. 2020;11:826 pubmed publisher
Lo Y, Li C, Chen H, Chiang C, Huang C, Tu T, et al. Galectin-8 is upregulated in keratinocyte by IL-17A and promotes proliferation by regulating mitosis in psoriasis. J Invest Dermatol. 2020;: pubmed publisher
Bouhaddou M, Memon D, Meyer B, White K, Rezelj V, Correa Marrero M, et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020;182:685-712.e19 pubmed publisher
Nakahara T, Kido Nakahara M, Ulzii D, Miake S, Fujishima K, Sakai S, et al. Topical application of endothelin receptor a antagonist attenuates imiquimod-induced psoriasiform skin inflammation. Sci Rep. 2020;10:9510 pubmed publisher
Volkmann J, Schmitz J, Nordlohne J, Dong L, Helmke A, Sen P, et al. Kidney injury enhances renal G-CSF expression and modulates granulopoiesis and human neutrophil CD177 in vivo. Clin Exp Immunol. 2020;199:97-108 pubmed publisher
Zhang Y, Zhang Y, Li C, Fu S, Yang C, Song Y, et al. NOD1 modulates decidual stromal cell function to maintain pregnancy in the early trimester. Cell Biochem Funct. 2019;37:464-473 pubmed publisher
Mangino G, Iuliano M, Carlomagno S, Bernardini N, Rosa P, Chiantore M, et al. Interleukin-17A affects extracellular vesicles release and cargo in human keratinocytes. Exp Dermatol. 2019;28:1066-1073 pubmed publisher
Guo S, Liu J, Jiang T, Lee D, Wang R, Zhou X, et al. (5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients. Sci Rep. 2019;9:11155 pubmed publisher
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Hao R, Song Y, Li R, Wu Y, Yang X, Li X, et al. MLN4924 protects against interleukin-17A-induced pulmonary inflammation by disrupting ACT1-mediated signaling. Am J Physiol Lung Cell Mol Physiol. 2019;316:L1070-L1080 pubmed publisher
Suyama K, Sakai D, Hirayama N, Nakamura Y, Matsushita E, Terayama H, et al. Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease. J Cell Mol Med. 2018;22:5539-5551 pubmed publisher
Chen C, Wu N, Duan Q, Yang H, Wang X, Yang P, et al. C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes. Sci Rep. 2018;8:8590 pubmed publisher
Zhang W, Yi X, An Y, Guo S, Li S, Song P, et al. MicroRNA-17-92 cluster promotes the proliferation and the chemokine production of keratinocytes: implication for the pathogenesis of psoriasis. Cell Death Dis. 2018;9:567 pubmed publisher
Li H, Wu N, Lee G, Hung C. The Therapeutic Potential and Molecular Mechanism of Isoflavone Extract against Psoriasis. Sci Rep. 2018;8:6335 pubmed publisher
Pfaff C, Marquardt Y, Fietkau K, Baron J, Luscher B. The psoriasis-associated IL-17A induces and cooperates with IL-36 cytokines to control keratinocyte differentiation and function. Sci Rep. 2017;7:15631 pubmed publisher
Zeitvogel J, Jokmin N, Rieker S, Klug I, Brandenberger C, Werfel T. GATA3 regulates FLG and FLG2 expression in human primary keratinocytes. Sci Rep. 2017;7:11847 pubmed publisher
Barik S, Ellis J, Cascio J, Miller M, Ukah T, Cattin Roy A, et al. IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis. J Immunol. 2017;199:2236-2248 pubmed publisher
Huang Q, Duan L, Qian X, Fan J, Lv Z, Zhang X, et al. IL-17 Promotes Angiogenic Factors IL-6, IL-8, and Vegf Production via Stat1 in Lung Adenocarcinoma. Sci Rep. 2016;6:36551 pubmed publisher
Cantaert T, Schickel J, Bannock J, Ng Y, Massad C, Delmotte F, et al. Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint. J Clin Invest. 2016;126:4289-4302 pubmed publisher
Feng X, Shi Y, Xu L, Peng Q, Wang F, Wang X, et al. Modulation of IL-6 induced RANKL expression in arthritic synovium by a transcription factor SOX5. Sci Rep. 2016;6:32001 pubmed publisher
Fernandez R, Maecker H. Cytokine-stimulated Phosphoflow of PBMC Using CyTOF Mass Cytometry. Bio Protoc. 2015;5: pubmed
Egan C, Sodhi C, Good M, Lin J, Jia H, Yamaguchi Y, et al. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest. 2016;126:495-508 pubmed
Liu J, Zhou F, Chen Q, Kang A, Lu M, Liu W, et al. Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice. Sci Rep. 2015;5:13558 pubmed publisher
Garg A, Amatya N, Chen K, Cruz J, Grover P, Whibley N, et al. MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation. Immunity. 2015;43:475-87 pubmed publisher
Adoro S, Cubillos Ruiz J, Chen X, Deruaz M, Vrbanac V, Song M, et al. IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection. Nat Commun. 2015;6:7562 pubmed publisher
Sivanathan K, Rojas Canales D, Hope C, Krishnan R, Carroll R, Gronthos S, et al. Interleukin-17A-Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function. Stem Cells. 2015;33:2850-63 pubmed publisher
Salvatore G, Bernoud Hubac N, Bissay N, Debard C, Daira P, Meugnier E, et al. Human monocyte-derived dendritic cells turn into foamy dendritic cells with IL-17A. J Lipid Res. 2015;56:1110-22 pubmed publisher
Rodgers D, McGrath M, Pineda M, Al Riyami L, Rzepecka J, Lumb F, et al. The parasitic worm product ES-62 targets myeloid differentiation factor 88-dependent effector mechanisms to suppress antinuclear antibody production and proteinuria in MRL/lpr mice. Arthritis Rheumatol. 2015;67:1023-35 pubmed publisher
Estève D, Boulet N, Volat F, Zakaroff Girard A, Ledoux S, Coupaye M, et al. Human white and brite adipogenesis is supported by MSCA1 and is impaired by immune cells. Stem Cells. 2015;33:1277-91 pubmed publisher
Gobbetti T, Coldewey S, Chen J, McArthur S, Le Faouder P, Cenac N, et al. Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proc Natl Acad Sci U S A. 2014;111:18685-90 pubmed publisher
Stephen T, Rutkowski M, Allegrezza M, Perales Puchalt A, Tesone A, Svoronos N, et al. Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression. Immunity. 2014;41:427-439 pubmed publisher
de Simone V, Franzè E, Ronchetti G, Colantoni A, Fantini M, Di Fusco D, et al. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene. 2015;34:3493-503 pubmed publisher
Sakaguchi M, Murata H, Aoyama Y, Hibino T, Putranto E, Ruma I, et al. DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes. J Biol Chem. 2014;289:23389-402 pubmed publisher
Zhang Y, Chen H, Sun C, Wang H, Liu M, Li Y, et al. Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy. PLoS ONE. 2014;9:e99612 pubmed publisher
Han Y, Ye A, Bi L, Wu J, Yu K, Zhang S. Th17 cells and interleukin-17 increase with poor prognosis in patients with acute myeloid leukemia. Cancer Sci. 2014;105:933-42 pubmed publisher
Boggio E, Clemente N, Mondino A, Cappellano G, Orilieri E, Gigliotti C, et al. IL-17 protects T cells from apoptosis and contributes to development of ALPS-like phenotypes. Blood. 2014;123:1178-86 pubmed publisher
Cochaud S, Giustiniani J, Thomas C, Laprévotte E, Garbar C, Savoye A, et al. IL-17A is produced by breast cancer TILs and promotes chemoresistance and proliferation through ERK1/2. Sci Rep. 2013;3:3456 pubmed publisher
Olsson Åkefeldt S, Maisse C, Belot A, Mazzorana M, Salvatore G, Bissay N, et al. Chemoresistance of human monocyte-derived dendritic cells is regulated by IL-17A. PLoS ONE. 2013;8:e56865 pubmed publisher
Ryzhakov G, Blazek K, Lai C, Udalova I. IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling. J Immunol. 2012;189:4852-8 pubmed publisher
Zhang S, Yuan J, Yu M, Fan H, Guo Z, Yang R, et al. IL-17A facilitates platelet function through the ERK2 signaling pathway in patients with acute coronary syndrome. PLoS ONE. 2012;7:e40641 pubmed publisher
Liu A, Lee M, McManus B, Choy J. Induction of endothelial nitric oxide synthase expression by IL-17 in human vascular endothelial cells: implications for vascular remodeling in transplant vasculopathy. J Immunol. 2012;188:1544-50 pubmed publisher
Ryzhakov G, Lai C, Blazek K, To K, Hussell T, Udalova I. IL-17 boosts proinflammatory outcome of antiviral response in human cells. J Immunol. 2011;187:5357-62 pubmed publisher
Chauhan S, Jin Y, Goyal S, Lee H, Fuchsluger T, Lee H, et al. A novel pro-lymphangiogenic function for Th17/IL-17. Blood. 2011;118:4630-4 pubmed publisher
Chevalier N, Jarrossay D, Ho E, Avery D, Ma C, Yu D, et al. CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J Immunol. 2011;186:5556-68 pubmed publisher
Lobito A, Ramani S, Tom I, Bazan J, Luis E, Fairbrother W, et al. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. J Biol Chem. 2011;286:18969-81 pubmed publisher
Ito H, Yamada H, Shibata T, Mitomi H, Nomoto S, Ozaki S. Dual role of interleukin-17 in pannus growth and osteoclastogenesis in rheumatoid arthritis. Arthritis Res Ther. 2011;13:R14 pubmed publisher
Meyer Hoffert U, Zimmermann A, Czapp M, Bartels J, Koblyakova Y, Gläser R, et al. Flagellin delivery by Pseudomonas aeruginosa rhamnolipids induces the antimicrobial protein psoriasin in human skin. PLoS ONE. 2011;6:e16433 pubmed publisher
Edwards L, Nistala K, Mills D, Stephenson H, Zilbauer M, Wren B, et al. Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection. PLoS ONE. 2010;5:e15398 pubmed publisher
Ersvaer E, Liseth K, Skavland J, Gjertsen B, Bruserud Ø. Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. BMC Immunol. 2010;11:38 pubmed publisher
Ho A, Shen F, Conti H, Patel N, Childs E, Peterson A, et al. IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail. J Immunol. 2010;185:1063-70 pubmed publisher
Zhang Q, Yamaza T, Kelly A, Shi S, Wang S, Brown J, et al. Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis. PLoS ONE. 2009;4:e7798 pubmed publisher
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Brucklacher Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E. Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression. J Immunol. 2009;183:5494-501 pubmed publisher
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Ohtani T, Memezawa A, Okuyama R, Sayo T, Sugiyama Y, Inoue S, et al. Increased hyaluronan production and decreased E-cadherin expression by cytokine-stimulated keratinocytes lead to spongiosis formation. J Invest Dermatol. 2009;129:1412-20 pubmed publisher
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Hemminki A, Kanerva A, Liu B, Wang M, Alvarez R, Siegal G, et al. Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression. Cancer Res. 2003;63:847-53 pubmed
Maertzdorf J, Osterhaus A, Verjans G. IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. J Immunol. 2002;169:5897-903 pubmed
product information
Product Type :
Protein
Product Name :
Human IL-17A Recombinant Protein, PeproTech
Catalog # :
200-17-250UG
Quantity :
250 ug
Price :
US 1216.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
Ctla8; CTLA-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin-17; Interleukin17A; interleukin-17A; R-IL-17-A
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA