This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human IL-3 Recombinant Protein, PeproTech
catalog :
200-03-1MG
quantity :
1 mg
price :
US 3470.00
citations: 411
Reference
Tambe M, Unterberger S, Kriegbaum M, V xe4 nttinen I, Olgac E, V xe4 h xe4 Koskela M, et al. Venetoclax triggers sublethal apoptotic signaling in venetoclax-resistant acute myeloid leukemia cells and induces vulnerability to PARP inhibition and azacitidine. Cell Death Dis. 2024;15:750 pubmed publisher
Arias A, Neehus A, Ogishi M, Meynier V, Krebs A, Lazarov T, et al. Tuberculosis in otherwise healthy adults with inherited TNF deficiency. Nature. 2024;633:417-425 pubmed publisher
Xie X, Gou F, Zheng Z, Zhang Y, Zhang Y, Dong F, et al. Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth. iScience. 2024;27:110445 pubmed publisher
Guo H, Feng R, Zhang Y, Yu Y, Lu W, Liu J, et al. A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML. Cell Rep Med. 2024;5:101592 pubmed publisher
Fowler J, Zheng S, Nguyen A, Chen A, Xiong X, Chai T, et al. Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells. Dev Cell. 2024;59:1110-1131.e22 pubmed publisher
Hetzel M, Gensch I, Ackermann M, Lachmann N. Adaptation of Human iPSC-Derived Macrophages Toward an Alveolar Macrophage-Like Phenotype Post-Intra-Pulmonary Transfer into Murine Models. Methods Mol Biol. 2024;2713:463-479 pubmed publisher
Chinchalongporn W, Chruewkamlow N, Sermsathanasawadi N, Vorateera K, Jintaworn S, Wongwanit C, et al. The quality and quantity media-cultured mononuclear cell transplantation is safe and effective in ischemic hindlimb mouse model. JVS Vasc Sci. 2023;4:100129 pubmed publisher
Li Y, Ochoa C, Zhu Y, Kramer A, Wilson M, Fang Y, et al. Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design. iScience. 2023;26:107952 pubmed publisher
Pellegrino E, Aylan B, Bussi C, Fearns A, Bernard E, Athanasiadi N, et al. Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages. J Cell Biol. 2023;222: pubmed publisher
Yang X, Wen J, Yang H, Jones I, Zhu X, Liu W, et al. Functional characterization of Alzheimer's disease genetic variants in microglia. Nat Genet. 2023;55:1735-1744 pubmed publisher
Tian L, Li H, Zhao P, Liu Y, Lu Y, Zhong R, et al. C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages. iScience. 2023;26:107771 pubmed publisher
Jung H, Suknuntha K, Kim Y, Liu P, Dettle S, Sedzro D, et al. SOX18-enforced expression diverts hemogenic endothelium-derived progenitors from T towards NK lymphoid pathways. iScience. 2023;26:106621 pubmed publisher
Wang W, Li X, Qin X, Miao Y, Zhang Y, Li S, et al. Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity. Br J Haematol. 2023;202:328-343 pubmed publisher
Breitmeyer R, Vogel S, Heider J, Hartmann S, W xfc st R, Keller A, et al. Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction. Commun Biol. 2023;6:472 pubmed publisher
Wieder N, Fried J, Kim C, Sidhom E, Brown M, Marshall J, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell Metab. 2023;35:887-905.e11 pubmed publisher
Azad P, Zhou D, Tu H, Villafuerte F, Traver D, Rana T, et al. Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B. J Clin Invest. 2023;133: pubmed publisher
Riera Domingo C, Leite Gomes E, Charatsidou I, Zhao P, Carr xe1 G, Cappellesso F, et al. Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding. Sci Adv. 2023;9:eadd5028 pubmed publisher
Fan Y, Mizoguchi Y, Tatematsu M, Linder M, Frenz S, Choi J, et al. Analyzing mitochondrial respiration of human induced pluripotent stem cell-derived myeloid progenitors using Seahorse technology. STAR Protoc. 2023;4:102073 pubmed publisher
Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, et al. METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism. Cell Stem Cell. 2023;30:52-68.e13 pubmed publisher
Shiroshita K, Kobayashi H, Watanuki S, Karigane D, Sorimachi Y, Fujita S, et al. A culture platform to study quiescent hematopoietic stem cells following genome editing. Cell Rep Methods. 2022;2:100354 pubmed publisher
van Gils N, Verhagen H, Broux M, Marti xe1 xf1 ez T, Denkers F, Vermue E, et al. Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters. iScience. 2022;25:105013 pubmed publisher
Li Y, Zeng S, Dunn Z, Zhou Y, Li Z, Yu J, et al. Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers. iScience. 2022;25:104859 pubmed publisher
Dr xe4 ger N, Sattler S, Huang C, Teter O, Leng K, Hashemi S, et al. A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Nat Neurosci. 2022;25:1149-1162 pubmed publisher
Jin M, Xu R, Wang L, Alam M, Ma Z, Zhu S, et al. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell Stem Cell. 2022;29:1135-1153.e8 pubmed publisher
Skokowa J, Hernandez Alvarez B, Coles M, Ritter M, Nasri M, Haaf J, et al. A topological refactoring design strategy yields highly stable granulopoietic proteins. Nat Commun. 2022;13:2948 pubmed publisher
Dannenmann B, Skokowa J. Generation, expansion, and drug treatment of hematopoietic progenitor cells derived from human iPSCs. STAR Protoc. 2022;3:101400 pubmed publisher
Canals Hernaez D, Hughes M, Li Y, Mainero Rocca I, Dean P, Brassard J, et al. Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models. Front Oncol. 2022;12:856424 pubmed publisher
Dorna J, Kaufmann A, Bockmann V, Raifer H, West J, Matrosovich M, et al. Effects of Receptor Specificity and Conformational Stability of Influenza A Virus Hemagglutinin on Infection and Activation of Different Cell Types in Human PBMCs. Front Immunol. 2022;13:827760 pubmed publisher
Santucci P, Aylan B, Botella L, Bernard E, Bussi C, Pellegrino E, et al. Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis. MBio. 2022;13:e0011722 pubmed publisher
Murugesan G, Davidson L, Jannetti L, Crocker P, Weigle B. Quantitative Proteomics of Polarised Macrophages Derived from Induced Pluripotent Stem Cells. Biomedicines. 2022;10: pubmed publisher
Feng L, Li C, Zeng L, Gao D, Sun Y, Zhong L, et al. MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα. Signal Transduct Target Ther. 2022;7:21 pubmed publisher
Broderick L, Clay G, Blum R, Liu Y, McVicar R, Papes F, et al. Disease-associated mutations in topoisomerase IIβ result in defective NK cells. J Allergy Clin Immunol. 2022;149:2171-2176.e3 pubmed publisher
Wang Y, Huo T, Tseng Y, Dang L, Yu Z, Yu W, et al. Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis. Commun Biol. 2022;5:72 pubmed publisher
Ackermann M, Rafiei Hashtchin A, Manstein F, Carvalho Oliveira M, Kempf H, Zweigerdt R, et al. Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors. Nat Protoc. 2022;17:513-539 pubmed publisher
Stavast C, van Zuijen I, Karkoulia E, xd6 z xe7 elik A, Van Hoven Beijen A, Leon L, et al. The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis. Leukemia. 2022;36:687-700 pubmed publisher
Hamrick S, Kim C, Tester D, Giudicessi J, Ackerman M. A Patient-Specific Re-Engineered Cardiomyocyte Model Confirms the Circumstance-Dependent Arrhythmia Risk Associated with the African-Specific Common SCN5A Polymorphism (p.S1103Y): Implications for the Increased Sudden Deaths Observed in Black Individ. Heart Rhythm. 2021;: pubmed publisher
Li Y, Zhou Y, Kim Y, Zhu Y, Ma F, Yu J, et al. Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy. Cell Rep Med. 2021;2:100449 pubmed publisher
Georgolopoulos G, Psatha N, Iwata M, Nishida A, Som T, Yiangou M, et al. Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation. Nat Commun. 2021;12:6790 pubmed publisher
Tsui M, Min W, Ng S, Dobbs K, Notarangelo L, Dror Y, et al. The Use of Induced Pluripotent Stem Cells to Study the Effects of Adenosine Deaminase Deficiency on Human Neutrophil Development. Front Immunol. 2021;12:748519 pubmed publisher
Chruewkamlow N, Pruekprasert K, Phutthakunphithak P, Acharayothin O, Prapassaro T, Hongku K, et al. Novel culture media enhances mononuclear cells from patients with chronic limb-threatening ischemia to increase vasculogenesis and anti-inflammatory effect. Stem Cell Res Ther. 2021;12:520 pubmed publisher
Simeoni F, Romero Camarero I, Camera F, Amaral F, Sinclair O, Papachristou E, et al. Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia. Cell Rep. 2021;36:109725 pubmed publisher
D xed az de la Guardia R, Velasco Hernandez T, Guti xe9 rrez Ag xfc era F, Roca Ho H, Molina O, Nombela Arrieta C, et al. Engraftment characterization of risk-stratified AML in NSGS mice. Blood Adv. 2021;5:4842-4854 pubmed publisher
Pouyanfard S, Meshgin N, Cruz L, Diggle K, Hashemi H, Pham T, et al. Human induced pluripotent stem cell-derived macrophages ameliorate liver fibrosis. Stem Cells. 2021;39:1701-1717 pubmed publisher
Zoccolillo M, Brigida I, Barzaghi F, Scala S, Hernandez R, Basso Ricci L, et al. Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency. Blood Adv. 2021;5:3174-3187 pubmed publisher
Boutin J, Rosier J, Cappellen D, Prat F, Toutain J, Pennamen P, et al. CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells. Nat Commun. 2021;12:4922 pubmed publisher
de Castro Fonseca M, de Oliveira J, Araujo B, Canateli C, do Prado P, Amorim Neto D, et al. Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X. iScience. 2021;24:102841 pubmed publisher
Kim H, Kim J, Seol B, Song C, Jeong J, Cho Y. Directly reprogrammed natural killer cells for cancer immunotherapy. Nat Biomed Eng. 2021;5:1360-1376 pubmed publisher
Wegner J, Zillinger T, Schlee Guimaraes T, Bartok E, Schlee M. An epigenetic GPI anchor defect impairs TLR4 signaling in the B cell transdifferentiation model for primary human monocytes BLaER1. Sci Rep. 2021;11:14983 pubmed publisher
Steinberg D, Repudi S, Saleem A, Kustanovich I, Viukov S, Abudiab B, et al. Modeling genetic epileptic encephalopathies using brain organoids. EMBO Mol Med. 2021;13:e13610 pubmed publisher
Wang X, Negrou E, Maloney M, Bondar V, Andrews S, Montalban M, et al. Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10. Sci Rep. 2021;11:12900 pubmed publisher
Zhao H, Zhang Y, Xing T, Tang S, Wen Q, Lyu Z, et al. M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity. Signal Transduct Target Ther. 2021;6:234 pubmed publisher
Kwon Y, Ahn H, Lee J, Yang H, Cho H, Kim S, et al. HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells. Stem Cells Int. 2021;2021:8873383 pubmed publisher
Di Marcantonio D, Martinez E, Kanefsky J, Huhn J, Gabbasov R, Gupta A, et al. ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia. Mol Cell. 2021;81:2752-2764.e6 pubmed publisher
Masselli E, Carubbi C, Pozzi G, Percesepe A, Campanelli R, Villani L, et al. Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis. Cancers (Basel). 2021;13: pubmed publisher
Cheng Y, Xie W, Pickering B, Chu K, Savino A, Yang X, et al. N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cancer Cell. 2021;39:958-972.e8 pubmed publisher
Zhang X, Luo M, Dastagir S, Nixon M, Khamhoung A, Schmidt A, et al. Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic. Nat Commun. 2021;12:2637 pubmed publisher
Thom xe9 C, Ferreira G, Pereira Martins D, Augusto Dos Santos G, Almeida Silveira D, Weinh xe4 user I, et al. The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia. Mol Cell Proteomics. 2021;20:100091 pubmed publisher
Le Coz C, Nguyen D, Su C, Nolan B, Albrecht A, Xhani S, et al. Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients. J Exp Med. 2021;218: pubmed publisher
Mian S, Abarrategi A, Kong K, Rouault Pierre K, WOOD H, Oedekoven C, et al. Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells. Blood Cancer Discov. 2021;2:135-145 pubmed publisher
Choi J, Lysakovskaia K, Stik G, Demel C, S xf6 ding J, Tian T, et al. Evidence for additive and synergistic action of mammalian enhancers during cell fate determination. elife. 2021;10: pubmed publisher
Goldfarb A, Freeman K, Sahu R, Elagib K, Holy M, Arneja A, et al. Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia. Nat Commun. 2021;12:1645 pubmed publisher
Chen I. Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts. Bio Protoc. 2020;10:e3854 pubmed publisher
Velten L, Story B, Hern xe1 ndez Malmierca P, Raffel S, Leonce D, Milbank J, et al. Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics. Nat Commun. 2021;12:1366 pubmed publisher
Van Egeren D, Escabi J, Nguyen M, Liu S, Reilly C, Patel S, et al. Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms. Cell Stem Cell. 2021;28:514-523.e9 pubmed publisher
Xie B, Khoyratty T, Abu Shah E, F Cespedes P, MacLean A, Pirgova G, et al. The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation. J Immunol. 2021;206:1515-1527 pubmed publisher
Tanaka R, Ito Hirano R, Fujimura S, Arita K, Hagiwara H, Mita T, et al. Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing. Stem Cells Transl Med. 2021;10:895-909 pubmed publisher
Zhou B, Qin Y, Zhou J, Ruan J, Xiong F, Dong J, et al. Bortezomib suppresses self-renewal and leukemogenesis of leukemia stem cell by NF-ĸB-dependent inhibition of CDK6 in MLL-rearranged myeloid leukemia. J Cell Mol Med. 2021;25:3124-3135 pubmed publisher
Jung H, Uenishi G, Park M, Liu P, Suknuntha K, Raymond M, et al. SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis. Cell Rep. 2021;34:108758 pubmed publisher
Simkin D, Marshall K, Vanoye C, Desai R, Bustos B, Piyevsky B, et al. Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy. elife. 2021;10: pubmed publisher
Hofmans M, Lammens T, Depreter B, Wu Y, Erlacher M, Caye A, et al. Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia. Sci Rep. 2021;11:2801 pubmed publisher
Trizzino M, Zucco A, Deliard S, Wang F, Barbieri E, Veglia F, et al. EGR1 is a gatekeeper of inflammatory enhancers in human macrophages. Sci Adv. 2021;7: pubmed publisher
Trapecar M, Wogram E, Svoboda D, Communal C, Omer A, Lungjangwa T, et al. Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases. Sci Adv. 2021;7: pubmed publisher
Rao S, Yao Y, Soares de Brito J, Yao Q, Shen A, Watkinson R, et al. Dissecting ELANE neutropenia pathogenicity by human HSC gene editing. Cell Stem Cell. 2021;: pubmed publisher
Galat Y, Gu H, Perepitchka M, Taylor R, Yoon J, Glukhova X, et al. Crispr editing of the gli1 first intron abrogates gli1 expression and differentially alters lineage commitment. Stem Cells. 2021;: pubmed publisher
Ma Y, Liu S, Gao J, Chen C, Zhang X, Yuan H, et al. Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia. Dev Cell. 2021;56:478-493.e11 pubmed publisher
Sharma R, Dever D, Lee C, Azizi A, Pan Y, Camarena J, et al. The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells. Nat Commun. 2021;12:472 pubmed publisher
Liu F, Pishesha N, Poon Z, Kaushik T, Van Vliet K. Material Viscoelastic Properties Modulate the Mesenchymal Stem Cell Secretome for Applications in Hematopoietic Recovery. ACS Biomater Sci Eng. 2017;3:3292-3306 pubmed publisher
Fattorelli N, Martínez Muriana A, Wolfs L, Geric I, De Strooper B, Mancuso R. Stem-cell-derived human microglia transplanted into mouse brain to study human disease. Nat Protoc. 2021;16:1013-1033 pubmed publisher
Louka E, Povinelli B, Rodriguez Meira A, Buck G, Wen W, Wang G, et al. Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia. J Exp Med. 2021;218: pubmed publisher
Hernandez Alvarez B, Skokowa J, Coles M, Mir P, Nasri M, Maksymenko K, et al. Design of novel granulopoietic proteins by topological rescaffolding. PLoS Biol. 2020;18:e3000919 pubmed publisher
Yao Y, Yang J, Qin Q, Tang C, Li Z, Chen L, et al. Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation. Commun Biol. 2020;3:790 pubmed publisher
Agarwal S, Vierbuchen T, Ghosh S, Chan J, Jiang Z, Kandasamy R, et al. The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans. Nat Commun. 2020;11:6348 pubmed publisher
Tremblay C, Chiu S, Saw J, McCalmont H, Litalien V, Boyle J, et al. Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells. Nat Commun. 2020;11:6211 pubmed publisher
Dagher T, Maslah N, Edmond V, Cassinat B, Vainchenker W, Giraudier S, et al. JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML. J Exp Med. 2021;218: pubmed publisher
Guan X, Wang L, Wang H, Wang H, Dai W, Jiang Y. Good Manufacturing Practice-Grade of Megakaryocytes Produced by a Novel Ex Vivo Culturing Platform. Clin Transl Sci. 2020;13:1115-1126 pubmed publisher
Crosse E, Gordon Keylock S, Rybtsov S, Binagui Casas A, Felchle H, Nnadi N, et al. Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development. Cell Stem Cell. 2020;27:822-839.e8 pubmed publisher
Nikolaev M, Mitrofanova O, Broguiere N, Geraldo S, Dutta D, Tabata Y, et al. Homeostatic mini-intestines through scaffold-guided organoid morphogenesis. Nature. 2020;585:574-578 pubmed publisher
Su A, Ling F, Vaganay C, Sodaro G, Benaksas C, Dal Bello R, et al. The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies. Cancer Discov. 2020;10:1894-1911 pubmed publisher
Jones C, Stevens B, Pollyea D, Culp Hill R, Reisz J, Nemkov T, et al. Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells. Cell Stem Cell. 2020;27:748-764.e4 pubmed publisher
Frame J, Kubaczka C, Long T, Esain V, Soto R, Hachimi M, et al. Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Dev Cell. 2020;: pubmed publisher
Johnson D, Okondo M, Orth E, Rao S, Huang H, Ball D, et al. DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes. Cell Death Dis. 2020;11:628 pubmed publisher
Rai R, Romito M, Rivers E, Turchiano G, Blattner G, Vetharoy W, et al. Targeted gene correction of human hematopoietic stem cells for the treatment of Wiskott - Aldrich Syndrome. Nat Commun. 2020;11:4034 pubmed publisher
Bahri R, Bulfone Paus S. Mast Cell Activation Test (MAT). Methods Mol Biol. 2020;2163:227-238 pubmed publisher
Xiao Y, van Halteren A, Lei X, Borst J, Steenwijk E, de Wit T, et al. Bone marrow-derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis. Blood. 2020;136:2188-2199 pubmed publisher
Kronstein Wiedemann R, Nowakowska P, Milanov P, Gubbe K, Seifried E, Bugert P, et al. Regulation of ABO blood group antigen expression by miR-331-3p and miR-1908-5p during hematopoietic stem cell differentiation. Stem Cells. 2020;38:1348-1362 pubmed publisher
Zhang Y, Guo Y, Gough S, Zhang J, Vann K, Li K, et al. Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nat Commun. 2020;11:3339 pubmed publisher
Qiao X, van der Zanden S, Wander D, Borràs D, Song J, Li X, et al. Uncoupling DNA damage from chromatin damage to detoxify doxorubicin. Proc Natl Acad Sci U S A. 2020;117:15182-15192 pubmed publisher
Pearson F, Tullett K, Leal Rojas I, Haigh O, Masterman K, Walpole C, et al. Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells. Clin Transl Immunology. 2020;9:e1141 pubmed publisher
Su R, Dong L, Li Y, Gao M, Han L, Wunderlich M, et al. Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion. Cancer Cell. 2020;38:79-96.e11 pubmed publisher
Han H, Xu Y, Liao S, Xiao H, Chen X, Lu X, et al. Increased number and activation of peripheral basophils in adult-onset minimal change disease. J Cell Mol Med. 2020;24:7841-7849 pubmed publisher
Deb P, Dai J, Singh S, Kalyoussef E, Fitzgerald Bocarsly P. Triggering of the cGAS-STING Pathway in Human Plasmacytoid Dendritic Cells Inhibits TLR9-Mediated IFN Production. J Immunol. 2020;205:223-236 pubmed publisher
Huang P, Zhao Y, Zhong J, Zhang X, Liu Q, Qiu X, et al. Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells. Proc Natl Acad Sci U S A. 2020;117:12868-12876 pubmed publisher
Shen C, Sheng Y, Zhu A, Robinson S, Jiang X, Dong L, et al. RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia. Cell Stem Cell. 2020;27:64-80.e9 pubmed publisher
Gebru M, Atkinson J, Young M, Zhang L, Tang Z, Liu Z, et al. Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia. Blood. 2020;136:1067-1079 pubmed publisher
Zabkiewicz J, Lazenby M, Edwards G, Bygrave C, Omidvar N, Zhuang L, et al. Combination of a mitogen-activated protein kinase inhibitor with the tyrosine kinase inhibitor pacritinib combats cell adhesion-based residual disease and prevents re-expansion of FLT3-ITD acute myeloid leukaemia. Br J Haematol. 2020;191:231-242 pubmed publisher
Di Matteo F, Pipicelli F, Kyrousi C, Tovecci I, Penna E, Crispino M, et al. Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy. EMBO Mol Med. 2020;12:e11419 pubmed publisher
Waclawiczek A, Hamilton A, Rouault Pierre K, Abarrategi A, Albornoz M, Miraki Moud F, et al. Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia. J Clin Invest. 2020;130:3038-3050 pubmed publisher
Belling J, Heidenreich L, Tian Z, Mendoza A, Chiou T, Gong Y, et al. Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells. Proc Natl Acad Sci U S A. 2020;117:10976-10982 pubmed publisher
Dong X, Zhao K, Zheng W, Xu C, Zhang M, Yin R, et al. EDAG mediates Hsp70 nuclear localization in erythroblasts and rescues dyserythropoiesis in myelodysplastic syndrome. FASEB J. 2020;34:8416-8427 pubmed publisher
Garcia Rodriguez K, Bahri R, Sattentau C, Roberts I, Goenka A, Bulfone Paus S. Human mast cells exhibit an individualized pattern of antimicrobial responses. Immun Inflamm Dis. 2020;8:198-210 pubmed publisher
Lin K, Rutter J, Xie A, Pardieu B, Winn E, Bello R, et al. Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer. Nat Genet. 2020;52:408-417 pubmed publisher
Redondo Monte E, Wilding A, Leubolt G, Kerbs P, Bagnoli J, Hartmann L, et al. ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells. Oncogene. 2020;39:3195-3205 pubmed publisher
Guzniczak E, Otto O, Whyte G, Chandra T, Robertson N, Willoughby N, et al. Purifying stem cell-derived red blood cells: a high-throughput label-free downstream processing strategy based on microfluidic spiral inertial separation and membrane filtration. Biotechnol Bioeng. 2020;117:2032-2045 pubmed publisher
Mitchell J, Takata H, Muir R, Colby D, Kroon E, Crowell T, et al. Plasmacytoid dendritic cells sense HIV replication before detectable viremia following treatment interruption. J Clin Invest. 2020;130:2845-2858 pubmed publisher
Liu C, Chou C, Chen C, Chen C, Yang S, Ko Y, et al. Aberrant distribution and function of plasmacytoid dendritic cells in patients with ankylosing spondylitis are associated with unfolded protein response. Kaohsiung J Med Sci. 2020;36:441-449 pubmed publisher
Themeli M, Chhatta A, Boersma H, Prins H, Cordes M, de Wilt E, et al. iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests. Stem Cell Reports. 2020;14:300-311 pubmed publisher
Araki R, Hoki Y, Suga T, Obara C, Sunayama M, Imadome K, et al. Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency. Nat Commun. 2020;11:197 pubmed publisher
Herster F, Bittner Z, Archer N, Dickhöfer S, Eisel D, Eigenbrod T, et al. Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis. Nat Commun. 2020;11:105 pubmed publisher
Nugent A, Lin K, van Lengerich B, Lianoglou S, Przybyla L, Davis S, et al. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. Neuron. 2020;105:837-854.e9 pubmed publisher
Lange L, Hoffmann D, Schwarzer A, Ha T, Philipp F, Lenz D, et al. Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential. Stem Cell Reports. 2020;14:122-137 pubmed publisher
Nguyen C, Bauer K, Hackl H, Schlerka A, Koller E, Hladik A, et al. All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia. Cell Death Dis. 2019;10:944 pubmed publisher
Wang Y, Lu T, Sun G, Zheng Y, Yang S, Zhang H, et al. Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells. Nat Commun. 2019;10:5594 pubmed publisher
Williams M, Amaral F, Simeoni F, Somervaille T. A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia. J Clin Invest. 2020;130:1217-1232 pubmed publisher
Papaioannou D, Petri A, Dovey O, Terreri S, Wang E, Collins F, et al. The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nat Commun. 2019;10:5351 pubmed publisher
Alshamleh I, Krause N, Richter C, Kurrle N, Serve H, Gunther U, et al. Real-Time NMR Spectroscopy for Studying Metabolism. Angew Chem Int Ed Engl. 2020;59:2304-2308 pubmed publisher
Li Y, Thomas D, Deutzmann A, Majeti R, Felsher D, Dill D. Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index. Sci Rep. 2019;9:16775 pubmed publisher
Tarumoto Y, Lin S, Wang J, Milazzo J, Xu Y, Lu B, et al. Salt-Inducible Kinase inhibition suppresses acute myeloid leukemia progression in vivo. Blood. 2019;: pubmed publisher
Sharon D, Cathelin S, Mirali S, Di Trani J, Yanofsky D, Keon K, et al. Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response. Sci Transl Med. 2019;11: pubmed publisher
Xiong Z, Xie Y, Yang Y, Xue Y, Wang D, Lin S, et al. Efficient gene correction of an aberrant splice site in β-thalassaemia iPSCs by CRISPR/Cas9 and single-strand oligodeoxynucleotides. J Cell Mol Med. 2019;23:8046-8057 pubmed publisher
Zhu Y, Smith D, Zhou Y, Li Y, Yu J, Lee D, et al. Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell. 2019;25:542-557.e9 pubmed publisher
He L, Beghi F, Baral V, D xe9 pond M, Zhang Y, Joulin V, et al. CABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners. Stem Cell Reports. 2019;13:274-290 pubmed publisher
Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C, Papaemmanuil E, et al. Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome. Cancer Cell. 2019;36:123-138.e10 pubmed publisher
Hu T, Morita K, Hill M, Jiang Y, Kitano A, Saito Y, et al. PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia-initiating cells. Blood. 2019;134:614-625 pubmed publisher
Wisgrill L, Wessely I, Netzl A, Pummer L, Sadeghi K, Spittler A, et al. Diminished secretion and function of IL-29 is associated with impaired IFN-α response of neonatal plasmacytoid dendritic cells. J Leukoc Biol. 2019;106:1177-1185 pubmed publisher
Mintz M, Felce J, Chou M, Mayya V, Xu Y, Shui J, et al. The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis. Immunity. 2019;: pubmed publisher
Ludwig L, Lareau C, Bao E, Nandakumar S, Muus C, Ulirsch J, et al. Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis. Cell Rep. 2019;27:3228-3240.e7 pubmed publisher
Pellin D, Loperfido M, Baricordi C, Wolock S, Montepeloso A, Weinberg O, et al. A comprehensive single cell transcriptional landscape of human hematopoietic progenitors. Nat Commun. 2019;10:2395 pubmed publisher
Luo Z, Gao M, Huang N, Wang X, Yang Z, Yang H, et al. Efficient disruption of bcr-abl gene by CRISPR RNA-guided FokI nucleases depresses the oncogenesis of chronic myeloid leukemia cells. J Exp Clin Cancer Res. 2019;38:224 pubmed publisher
Bencheikh L, Diop M, Rivière J, Imanci A, Pierron G, Souquere S, et al. Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages. Nat Commun. 2019;10:1935 pubmed publisher
Hsu J, Reilly A, Hayes B, Clough C, Konnick E, Torok Storb B, et al. Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes. Blood. 2019;: pubmed publisher
Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019;35:677-691.e10 pubmed publisher
Easterbrook J, Rybtsov S, Gordon Keylock S, Ivanovs A, Taoudi S, Anderson R, et al. Analysis of the Spatiotemporal Development of Hematopoietic Stem and Progenitor Cells in the Early Human Embryo. Stem Cell Reports. 2019;12:1056-1068 pubmed publisher
Aho E, Wang J, Gogliotti R, Howard G, Phan J, Acharya P, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019;26:2916-2928.e13 pubmed publisher
Martinez A, Miller W. Enabling Large-Scale Ex Vivo Production of Megakaryocytes from CD34+ Cells Using Gas-Permeable Surfaces. Stem Cells Transl Med. 2019;8:658-670 pubmed publisher
Lopez Millan B, Sanchez Martínez D, Roca Ho H, Gutiérrez Agüera F, Molina O, Díaz de la Guardia R, et al. NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia. Leukemia. 2019;: pubmed publisher
Rodrigo R, Mendis N, Ibrahim M, Ma C, Kreinin E, Roma A, et al. Knockdown of BNIP3L or SQSTM1 alters cellular response to mitochondria target drugs. Autophagy. 2019;15:900-907 pubmed publisher
Ackermann M, Kempf H, Hetzel M, Hesse C, Hashtchin A, Brinkert K, et al. Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections. Nat Commun. 2018;9:5088 pubmed publisher
Paupert J, Espinosa E, Cenac N, Robert V, Laharrague P, Evrard S, et al. Rapid and Efficient Production of Human Functional Mast Cells through a Three-Dimensional Culture of Adipose Tissue-Derived Stromal Vascular Cells. J Immunol. 2018;201:3815-3821 pubmed publisher
Jones C, Stevens B, D Alessandro A, Reisz J, Culp Hill R, Nemkov T, et al. Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells. Cancer Cell. 2018;34:724-740.e4 pubmed publisher
Petrillo C, Thorne L, Unali G, Schiroli G, Giordano A, Piras F, et al. Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells. Cell Stem Cell. 2018;23:820-832.e9 pubmed publisher
Lomova A, Clark D, Campo Fernandez B, Flores Bjurström C, Kaufman M, Fitz Gibbon S, et al. Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair. Stem Cells. 2019;37:284-294 pubmed publisher
Balcerek J, Jiang J, Li Y, Jiang Q, Holdreith N, Singh B, et al. Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia. Nat Commun. 2018;9:3915 pubmed publisher
Shastri A, Choudhary G, Teixeira M, Gordon Mitchell S, Ramachandra N, Bernard L, et al. Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells. J Clin Invest. 2018;128:5479-5488 pubmed publisher
Tusa I, Cheloni G, Poteti M, Gozzini A, DeSouza N, Shan Y, et al. Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells. Stem Cell Reports. 2018;11:929-943 pubmed publisher
Banús Mulet A, Etxabe A, Cornet Masana J, Torrente M, Lara Castillo M, Palomo L, et al. Serotonin receptor type 1B constitutes a therapeutic target for MDS and CMML. Sci Rep. 2018;8:13883 pubmed publisher
Stevens B, Khan N, D Alessandro A, Nemkov T, Winters A, Jones C, et al. Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes. Nat Commun. 2018;9:3694 pubmed publisher
Toofan P, Busch C, Morrison H, O Brien S, Jørgensen H, Copland M, et al. Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal. Cell Death Dis. 2018;9:927 pubmed publisher
Kauts M, De Leo B, Rodríguez Seoane C, Ronn R, Glykofrydis F, Maglitto A, et al. Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells. Stem Cell Reports. 2018;11:1009-1020 pubmed publisher
Shiozawa Y, Malcovati L, Galli A, Sato Otsubo A, Kataoka K, Sato Y, et al. Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia. Nat Commun. 2018;9:3649 pubmed publisher
Laustsen A, Bak R, Krapp C, Kjær L, Egedahl J, Petersen C, et al. Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function. Nat Commun. 2018;9:3525 pubmed publisher
Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, et al. Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin. Nat Commun. 2018;9:3524 pubmed publisher
Minzel W, Venkatachalam A, Fink A, Hung E, Brachya G, Burstain I, et al. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. 2018;175:171-185.e25 pubmed publisher
Eicke D, Baigger A, Schulze K, Latham S, Halloin C, Zweigerdt R, et al. Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors. Sci Rep. 2018;8:10146 pubmed publisher
Johnson D, Taabazuing C, Okondo M, Chui A, Rao S, Brown F, et al. DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia. Nat Med. 2018;24:1151-1156 pubmed publisher
Pulikkan J, Hegde M, Ahmad H, Belaghzal H, Illendula A, Yu J, et al. CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Cell. 2018;174:172-186.e21 pubmed publisher
Corrigan D, Luchsinger L, Justino de Almeida M, Williams L, Strikoudis A, Snoeck H. PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature. J Clin Invest. 2018;128:3250-3264 pubmed publisher
Sumide K, Matsuoka Y, Kawamura H, Nakatsuka R, Fujioka T, Asano H, et al. A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells. Nat Commun. 2018;9:2202 pubmed publisher
Kim M, Yu K, Kenderian S, Ruella M, Chen S, Shin T, et al. Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia. Cell. 2018;173:1439-1453.e19 pubmed publisher
Maclean G, McEldoon J, Huang J, Allred J, Canver M, Orkin S. Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells. Sci Rep. 2018;8:8001 pubmed publisher
Skucha A, Ebner J, Schmöllerl J, Roth M, Eder T, César Razquin A, et al. MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity. Nat Commun. 2018;9:1983 pubmed publisher
Uenishi G, Jung H, Kumar A, Park M, Hadland B, McLeod E, et al. NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells. Nat Commun. 2018;9:1828 pubmed publisher
Zellweger F, Buschor P, Hobi G, Brigger D, Dahinden C, Villiger P, et al. IL-3 but not monomeric IgE regulates Fc?RI levels and cell survival in primary human basophils. Cell Death Dis. 2018;9:510 pubmed publisher
Schubert F, Rapp J, Brauns Schubert P, Schlicher L, Stock K, Wissler M, et al. Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling. Cell Death Dis. 2018;9:470 pubmed publisher
L italien L, Orozco O, Abrams T, Cantagallo L, Connor A, Desai J, et al. Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies. Clin Cancer Res. 2018;24:3465-3474 pubmed publisher
Zhang Y, Xia F, Liu X, Yu Z, Xie L, Liu L, et al. JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/?-catenin/CCND1 signaling. J Clin Invest. 2018;128:1737-1751 pubmed publisher
Khajuria R, Munschauer M, Ulirsch J, Fiorini C, Ludwig L, McFarland S, et al. Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis. Cell. 2018;173:90-103.e19 pubmed publisher
Lummertz da Rocha E, Rowe R, Lundin V, Malleshaiah M, Jha D, Rambo C, et al. Reconstruction of complex single-cell trajectories using CellRouter. Nat Commun. 2018;9:892 pubmed publisher
Pellefigues C, Dema B, Lamri Y, Saidoune F, Chavarot N, Lohéac C, et al. Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs. Nat Commun. 2018;9:725 pubmed publisher
Chennupati V, Veiga D, Maslowski K, Andina N, Tardivel A, Yu E, et al. Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation. J Clin Invest. 2018;128:1597-1614 pubmed publisher
Chen L, Chen J, Huang Y, Gu Y, Qiu J, Qian H, et al. The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations. Mol Cell. 2018;69:412-425.e6 pubmed publisher
Wang H, Liu C, Liu X, Wang M, Wu D, Gao J, et al. MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1. Stem Cell Reports. 2018;10:447-460 pubmed publisher
Vo L, Kinney M, Liu X, Zhang Y, Barragan J, Sousa P, et al. Regulation of embryonic haematopoietic multipotency by EZH1. Nature. 2018;553:506-510 pubmed publisher
Böiers C, Richardson S, Laycock E, Zriwil A, Turati V, Brown J, et al. A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1. Dev Cell. 2018;44:362-377.e7 pubmed publisher
Khalil S, Delehanty L, Grado S, Holy M, White Z, Freeman K, et al. Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor. J Exp Med. 2018;215:661-679 pubmed publisher
Wu X, Dao Thi V, Huang Y, Billerbeck E, Saha D, Hoffmann H, et al. Intrinsic Immunity Shapes Viral Resistance of Stem Cells. Cell. 2018;172:423-438.e25 pubmed publisher
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, et al. R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling. Cell. 2018;172:90-105.e23 pubmed publisher
Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers K, et al. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 2018;172:106-120.e21 pubmed publisher
Zeng J, Tang S, Toh L, Wang S. Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells. Stem Cell Reports. 2017;9:1796-1812 pubmed publisher
di Tullio A, Rouault Pierre K, Abarrategi A, Mian S, Grey W, Gribben J, et al. The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia. Nat Commun. 2017;8:1679 pubmed publisher
Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, et al. BCAT1 restricts ?KG levels in AML stem cells leading to IDHmut-like DNA hypermethylation. Nature. 2017;551:384-388 pubmed publisher
Angelos M, Abrahante J, Blum R, Kaufman D. Single Cell Resolution of Human Hematoendothelial Cells Defines Transcriptional Signatures of Hemogenic Endothelium. Stem Cells. 2018;36:206-217 pubmed publisher
Zhao H, Wang X, Yi P, Si Y, Tan P, He J, et al. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nat Commun. 2017;8:1428 pubmed publisher
Li Y, Jin C, Bai H, Gao Y, Sun S, Chen L, et al. Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation. Blood. 2017;: pubmed publisher
Guzniczak E, Mohammad Zadeh M, Dempsey F, Jimenez M, Bock H, Whyte G, et al. High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing. Sci Rep. 2017;7:14457 pubmed publisher
Zhou J, Lu X, Tan T, Chng W. XIAP inhibition sensitizes acute myeloid leukemia cells response to TRAIL and chemotherapy through potentiated induction of pro-apoptotic machinery. Mol Oncol. 2017;: pubmed publisher
Gaidt M, Ebert T, Chauhan D, Ramshorn K, Pinci F, Zuber S, et al. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Cell. 2017;171:1110-1124.e18 pubmed publisher
Zitti B, Molfetta R, Fionda C, Quatrini L, Stabile H, Lecce M, et al. Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells. Sci Rep. 2017;7:10445 pubmed publisher
Wiśnik E, Płoszaj T, Robaszkiewicz A. Downregulation of PARP1 transcription by promoter-associated E2F4-RBL2-HDAC1-BRM complex contributes to repression of pluripotency stem cell factors in human monocytes. Sci Rep. 2017;7:9483 pubmed publisher
Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin G, Wang J, et al. Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. Cell. 2017;170:1079-1095.e20 pubmed publisher
Dahlin J, Ekoff M, Grootens J, Löf L, Amini R, Hagberg H, et al. KIT signaling is dispensable for human mast cell progenitor development. Blood. 2017;130:1785-1794 pubmed publisher
Rogers M, Spagnuolo P, Wang T, Angka L. A potential bioactive hard-stock fat replacer comprised of a molecular gel. Food Sci Nutr. 2017;5:579-587 pubmed publisher
Angelos M, Ruh P, Webber B, Blum R, Ryan C, Bendzick L, et al. Aryl hydrocarbon receptor inhibition promotes hematolymphoid development from human pluripotent stem cells. Blood. 2017;129:3428-3439 pubmed publisher
Dhenge A, Limbkar K, Melinkeri S, Kale V, Limaye L. Arachidonic acid and Docosahexanoic acid enhance platelet formation from human apheresis-derived CD34+ cells. Cell Cycle. 2017;16:979-990 pubmed publisher
O Brien K, Farrar J, Vlachos A, Anderson S, Tsujiura C, Lichtenberg J, et al. Molecular convergence in ex vivo models of Diamond-Blackfan anemia. Blood. 2017;129:3111-3120 pubmed publisher
Ueshima C, Kataoka T, Takei Y, Hirata M, Sugimoto A, Hirokawa M, et al. CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells. Cancer Med. 2017;6:845-856 pubmed publisher
Gori J, Butler J, Kunar B, Poulos M, Ginsberg M, Nolan D, et al. Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates. Stem Cells Transl Med. 2017;6:864-876 pubmed publisher
Kim A, Ulirsch J, Wilmes S, Unal E, Moraga I, Karakukcu M, et al. Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell. 2017;168:1053-1064.e15 pubmed publisher
Ho C, Chhabra A, Starkl P, Schnorr P, Wilmes S, Moraga I, et al. Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling. Cell. 2017;168:1041-1052.e18 pubmed publisher
Chen X, Clark J, Wunderlich M, Fan C, Davis A, Chen S, et al. Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine. Autophagy. 2017;13:955-966 pubmed publisher
Spencer D, Russler Germain D, Ketkar S, Helton N, Lamprecht T, Fulton R, et al. CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression. Cell. 2017;168:801-816.e13 pubmed publisher
Akoto C, Davies D, Swindle E. Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations. Clin Exp Allergy. 2017;47:351-360 pubmed publisher
Azad P, Zhao H, Cabrales P, Ronen R, Zhou D, Poulsen O, et al. Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. J Exp Med. 2016;213:2729-2744 pubmed
Suurmond J, Habets K, Dorjée A, Huizinga T, Toes R. Expansion of Th17 Cells by Human Mast Cells Is Driven by Inflammasome-Independent IL-1?. J Immunol. 2016;197:4473-4481 pubmed
Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, et al. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. J Clin Invest. 2016;126:4537-4553 pubmed publisher
Gregory M, D Alessandro A, Alvarez Calderon F, Kim J, Nemkov T, Adane B, et al. ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2016;113:E6669-E6678 pubmed
Adair J, Waters T, Haworth K, Kubek S, Trobridge G, Hocum J, et al. Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy. Nat Commun. 2016;7:13173 pubmed publisher
Pazdrak K, Straub C, Maroto R, Stafford S, White W, Calhoun W, et al. Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling. J Immunol. 2016;197:3782-3791 pubmed
Stevens M, Maire C, Chou N, Murakami M, Knoff D, Kikuchi Y, et al. Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate. Nat Biotechnol. 2016;34:1161-1167 pubmed publisher
Jin Y, Zhou J, Xu F, Jin B, Cui L, Wang Y, et al. Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia. J Clin Invest. 2016;126:3961-3980 pubmed publisher
Sykes D, Kfoury Y, Mercier F, Wawer M, Law J, Haynes M, et al. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. 2016;167:171-186.e15 pubmed publisher
Ahmadian Baghbaderani B, Tian X, Scotty Cadet J, Shah K, Walde A, Tran H, et al. A Newly Defined and Xeno-Free Culture Medium Supports Every-Other-Day Medium Replacement in the Generation and Long-Term Cultivation of Human Pluripotent Stem Cells. PLoS ONE. 2016;11:e0161229 pubmed publisher
Brendel C, Guda S, Renella R, Bauer D, Canver M, Kim Y, et al. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest. 2016;126:3868-3878 pubmed publisher
Ou Z, Niu X, He W, Chen Y, Song B, Xian Y, et al. The Combination of CRISPR/Cas9 and iPSC Technologies in the Gene Therapy of Human ?-thalassemia in Mice. Sci Rep. 2016;6:32463 pubmed publisher
Shi H, Yamamoto S, Sheng M, Bai J, Zhang P, Chen R, et al. ASXL1 plays an important role in erythropoiesis. Sci Rep. 2016;6:28789 pubmed publisher
Pikman Y, Puissant A, Alexe G, Furman A, Chen L, Frumm S, et al. Targeting MTHFD2 in acute myeloid leukemia. J Exp Med. 2016;213:1285-306 pubmed publisher
Jeon O, Panicker L, Lu Q, Chae J, Feldman R, Elisseeff J. Human iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials. Sci Rep. 2016;6:26761 pubmed publisher
Chen J, Gao X, Yang L, Fu W, Liang L, Li J, et al. Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation. Sci Rep. 2016;6:26003 pubmed publisher
Lombardo G, Dentelli P, Togliatto G, Rosso A, Gili M, Gallo S, et al. Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action. Sci Rep. 2016;6:25689 pubmed publisher
Saxena S, Ronn R, Guibentif C, Moraghebi R, Woods N. Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation. Stem Cell Reports. 2016;6:692-703 pubmed publisher
Korfi K, Smith M, Swan J, Somervaille T, Dhomen N, Marais R. BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors. Cell Death Dis. 2016;7:e2177 pubmed publisher
Bararia D, Kwok H, Welner R, Numata A, Sárosi M, Yang H, et al. Acetylation of C/EBPα inhibits its granulopoietic function. Nat Commun. 2016;7:10968 pubmed publisher
Moreno Lorenzana D, Avilés Vazquez S, Sandoval Esquivel M, Alvarado Moreno A, Ortiz Navarrete V, Torres Martínez H, et al. CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI. Cell Cycle. 2016;15:1276-87 pubmed publisher
Samudio I, Rezvani K, Shaim H, Hofs E, Ngom M, Bu L, et al. UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells. Blood. 2016;127:2575-86 pubmed publisher
Zhu N, Chen M, Eng R, DeJong J, Sinha A, Rahnamay N, et al. MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C. J Clin Invest. 2016;126:997-1011 pubmed publisher
Sweeney C, Teng R, Wang H, Merling R, Lee J, Choi U, et al. Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis. Stem Cells. 2016;34:1513-26 pubmed publisher
D Souza S, Maufort J, Kumar A, Zhang J, Smuga Otto K, Thomson J, et al. GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells. Stem Cell Reports. 2016;6:243-56 pubmed publisher
Mian S, Rouault Pierre K, Smith A, Seidl T, Pizzitola I, Kizilors A, et al. SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment. Nat Commun. 2015;6:10004 pubmed publisher
Chesnais V, Renneville A, Toma A, Lambert J, Passet M, Dumont F, et al. Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion. Blood. 2016;127:749-60 pubmed publisher
Dahlin J, Malinovschi A, Öhrvik H, Sandelin M, Janson C, Alving K, et al. Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors. Blood. 2016;127:383-91 pubmed publisher
Garate Z, Quintana Bustamante O, Crane A, Olivier E, Poirot L, Galetto R, et al. Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells. Stem Cell Reports. 2015;5:1053-1066 pubmed publisher
Prel A, Caval V, Gayon R, Ravassard P, Duthoit C, Payen E, et al. Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles. Mol Ther Methods Clin Dev. 2015;2:15039 pubmed publisher
Chen Q, Ye W, Jian Tan W, Mei Yong K, Liu M, Qi Tan S, et al. Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human. Sci Rep. 2015;5:15118 pubmed publisher
Hoffmann D, G xf6 hring G, Heuser M, Ganser A, Schambach A, Morgan M. Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an AML Diagnostic Sample Containing the t(8;21) Translocation. Stem Cells. 2016;34:797-9 pubmed publisher
Buechele C, Breese E, Schneidawind D, Lin C, Jeong J, Duque Afonso J, et al. MLL leukemia induction by genome editing of human CD34+ hematopoietic cells. Blood. 2015;126:1683-94 pubmed publisher
Sjögren S, Siva K, Soneji S, George A, Winkler M, Jaako P, et al. Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia. Br J Haematol. 2015;171:517-29 pubmed publisher
Pundir P, MacDonald C, Kulka M. The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production. J Immunol. 2015;195:2774-87 pubmed publisher
Nayak R, Trump L, Aronow B, Myers K, Mehta P, Kalfa T, et al. Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells. J Clin Invest. 2015;125:3103-16 pubmed publisher
Lopes J, Stylianou M, Nilsson G, Urban C. Opportunistic pathogen Candida albicans elicits a temporal response in primary human mast cells. Sci Rep. 2015;5:12287 pubmed publisher
Mende N, Kuchen E, Lesche M, Grinenko T, Kokkaliaris K, Hanenberg H, et al. CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo. J Exp Med. 2015;212:1171-83 pubmed publisher
Kim Y, Kim H, Baek E, Kurita R, Cha H, Nakamura Y, et al. Rh D blood group conversion using transcription activator-like effector nucleases. Nat Commun. 2015;6:7451 pubmed publisher
Guo H, Zhang J, Zhang X, Wang Y, Yu H, Yin X, et al. SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7. J Immunol. 2015;194:4737-49 pubmed publisher
Rouzbeh S, Kobari L, Cambot M, Mazurier C, Hebert N, Faussat A, et al. Molecular signature of erythroblast enucleation in human embryonic stem cells. Stem Cells. 2015;33:2431-41 pubmed publisher
Borkin D, He S, Miao H, Kempińska K, Pollock J, Chase J, et al. Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo. Cancer Cell. 2015;27:589-602 pubmed publisher
McClellan J, Dove C, Gentles A, Ryan C, Majeti R. Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages. Proc Natl Acad Sci U S A. 2015;112:4074-9 pubmed publisher
Sanber K, Knight S, Stephen S, Bailey R, Escors D, Minshull J, et al. Construction of stable packaging cell lines for clinical lentiviral vector production. Sci Rep. 2015;5:9021 pubmed publisher
Chou B, Gu H, Gao Y, Dowey S, Wang Y, Shi J, et al. A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach. Stem Cells Transl Med. 2015;4:320-32 pubmed publisher
Ferrell P, Xi J, Ma C, Adlakha M, Kaufman D. The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells. Stem Cells. 2015;33:1130-41 pubmed publisher
Fisser M, Rommer A, Steinleitner K, Heller G, Herbst F, Wiese M, et al. Induction of the proapoptotic tumor suppressor gene Cell Adhesion Molecule 1 by chemotherapeutic agents is repressed in therapy resistant acute myeloid leukemia. Mol Carcinog. 2015;54:1815-9 pubmed publisher
Sinha S, Thomas D, Yu L, Gentles A, Jung N, Corces Zimmerman M, et al. Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition. Blood. 2015;125:316-26 pubmed publisher
Zdzieblo D, Li X, Lin Q, Zenke M, Illich D, Becker M, et al. Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming. Stem Cells. 2014;32:3112-25 pubmed publisher
Gough D, Marié I, Lobry C, Aifantis I, Levy D. STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation. Blood. 2014;124:2252-61 pubmed publisher
Verma R, Su S, McCrann D, Green J, Leu K, Young P, et al. RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development. J Exp Med. 2014;211:1715-22 pubmed publisher
Burridge P, Matsa E, Shukla P, Lin Z, Churko J, Ebert A, et al. Chemically defined generation of human cardiomyocytes. Nat Methods. 2014;11:855-60 pubmed publisher
Zheng W, Dong X, Yin R, Xu F, Ning H, Zhang M, et al. EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300. Stem Cells. 2014;32:2278-89 pubmed publisher
Lee W, Malleret B, Lau Y, Mauduit M, Fong M, Cho J, et al. Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes. Blood. 2014;123:e100-9 pubmed publisher
Berres M, Lim K, Peters T, Price J, Takizawa H, Salmon H, et al. BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups. J Exp Med. 2014;211:669-83 pubmed publisher
Fujiwara T, Saitoh H, Inoue A, Kobayashi M, Okitsu Y, Katsuoka Y, et al. 3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiation. J Biol Chem. 2014;289:8121-34 pubmed publisher
Nievergall E, Ramshaw H, Yong A, Biondo M, Busfield S, Vairo G, et al. Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells. Blood. 2014;123:1218-28 pubmed publisher
Velu C, Chaubey A, Phelan J, Horman S, Wunderlich M, Guzman M, et al. Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity. J Clin Invest. 2014;124:222-36 pubmed publisher
Krupka C, Kufer P, Kischel R, Zugmaier G, Bögeholz J, Köhnke T, et al. CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330. Blood. 2014;123:356-65 pubmed publisher
Laperrousaz B, Jeanpierre S, Sagorny K, Voeltzel T, Ramas S, Kaniewski B, et al. Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression. Blood. 2013;122:3767-77 pubmed publisher
Nuzzo F, Radu C, Baralle M, Spiezia L, Hackeng T, Simioni P, et al. Antisense-based RNA therapy of factor V deficiency: in vitro and ex vivo rescue of a F5 deep-intronic splicing mutation. Blood. 2013;122:3825-31 pubmed publisher
Gong J, Yu J, Lin H, Zhang X, Yin X, Xiao Z, et al. The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia. Cell Death Differ. 2014;21:100-12 pubmed publisher
Casucci M, Nicolis Di Robilant B, Falcone L, Camisa B, Norelli M, Genovese P, et al. CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma. Blood. 2013;122:3461-72 pubmed publisher
Centlivre M, Legrand N, Klamer S, Liu Y, Jasmijn von Eije K, Böhne M, et al. Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1. Mol Ther Nucleic Acids. 2013;2:e120 pubmed publisher
Sato T, Kitawaki T, Fujita H, Iwata M, Iyoda T, Inaba K, et al. Human CD1c? myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D?. J Immunol. 2013;191:3152-60 pubmed publisher
Fernandez I, Ooi T, Roy K. Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous Notch and tetramer-TCR signaling. Stem Cells. 2014;32:93-104 pubmed publisher
Chacón Martínez C, Kiessling N, Winterhoff M, Faix J, MULLER REICHERT T, Jessberger R. The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics. J Biol Chem. 2013;288:28687-703 pubmed publisher
Richardson C, Delehanty L, Bullock G, Rival C, Tung K, KIMPEL D, et al. Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response. J Clin Invest. 2013;123:3614-23 pubmed publisher
Kung Sutherland M, Walter R, Jeffrey S, Burke P, Yu C, Kostner H, et al. SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML. Blood. 2013;122:1455-63 pubmed publisher
Subramanian H, Gupta K, Lee D, Bayir A, Ahn H, Ali H. β-Defensins activate human mast cells via Mas-related gene X2. J Immunol. 2013;191:345-52 pubmed publisher
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Imai K, Hayashi T, et al. Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells. J Immunol. 2013;190:6164-72 pubmed publisher
Bolton Gillespie E, Schemionek M, Klein H, Flis S, Hoser G, Lange T, et al. Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells. Blood. 2013;121:4175-83 pubmed publisher
Givi M, Blokhuis B, da Silva C, Adcock I, Garssen J, Folkerts G, et al. Cigarette smoke suppresses the surface expression of c-kit and FcεRI on mast cells. Mediators Inflamm. 2013;2013:813091 pubmed publisher
Harada Y, Inoue D, Ding Y, Imagawa J, Doki N, Matsui H, et al. RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes. Blood. 2013;121:3434-46 pubmed publisher
Pick M, Azzola L, Osborne E, Stanley E, Elefanty A. Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium. PLoS ONE. 2013;8:e55530 pubmed publisher
Szabo A, Gogolak P, Pazmandi K, Kis Toth K, Riedl K, Wizel B, et al. The two-component adjuvant IC31® boosts type i interferon production of human monocyte-derived dendritic cells via ligation of endosomal TLRs. PLoS ONE. 2013;8:e55264 pubmed publisher
Gao X, Lin J, Ning Q, Gao L, Yao Y, Zhou J, et al. A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells. PLoS ONE. 2013;8:e55481 pubmed publisher
Xi J, Zhu H, Liu D, Nan X, Zheng W, Liu K, et al. Infusion of megakaryocytic progenitor products generated from cord blood hematopoietic stem/progenitor cells: results of the phase 1 study. PLoS ONE. 2013;8:e54941 pubmed publisher
Merling R, Sweeney C, Choi U, De Ravin S, Myers T, Otaizo Carrasquero F, et al. Transgene-free iPSCs generated from small volume peripheral blood nonmobilized CD34+ cells. Blood. 2013;121:e98-107 pubmed publisher
Mace E, Hsu A, Monaco Shawver L, Makedonas G, Rosen J, Dropulic L, et al. Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset. Blood. 2013;121:2669-77 pubmed publisher
Lobry C, Ntziachristos P, Ndiaye Lobry D, Oh P, Cimmino L, Zhu N, et al. Notch pathway activation targets AML-initiating cell homeostasis and differentiation. J Exp Med. 2013;210:301-19 pubmed publisher
Magnusson M, Sierra M, Sasidharan R, Prashad S, Romero M, Saarikoski P, et al. Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability. PLoS ONE. 2013;8:e53912 pubmed publisher
Klco J, Spencer D, Lamprecht T, Sarkaria S, Wylie T, Magrini V, et al. Genomic impact of transient low-dose decitabine treatment on primary AML cells. Blood. 2013;121:1633-43 pubmed publisher
Nakajima Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, et al. Role of SOX17 in hematopoietic development from human embryonic stem cells. Blood. 2013;121:447-58 pubmed publisher
Yamagata Y, Parietti V, Stockholm D, Corre G, Poinsignon C, Touleimat N, et al. Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications. PLoS ONE. 2012;7:e48943 pubmed publisher
Li X, Ha C, Fu D, Xiao M. Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation. PLoS ONE. 2012;7:e48700 pubmed publisher
Kashiwakura J, Okayama Y, Furue M, Kabashima K, Shimada S, Ra C, et al. Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens. Allergy Asthma Immunol Res. 2012;4:332-40 pubmed publisher
Mizrahi K, Stein J, Yaniv I, Kaplan O, Askenasy N. TNF-? has tropic rather than apoptotic activity in human hematopoietic progenitors: involvement of TNF receptor-1 and caspase-8. Stem Cells. 2013;31:156-66 pubmed publisher
Dowey S, Huang X, Chou B, Ye Z, Cheng L. Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression. Nat Protoc. 2012;7:2013-21 pubmed publisher
Kaieda S, Wang J, Shnayder R, Fishgal N, Hei H, Lee R, et al. Interleukin-33 primes mast cells for activation by IgG immune complexes. PLoS ONE. 2012;7:e47252 pubmed publisher
Roy A, Cowan G, Mead A, Filippi S, Bohn G, Chaidos A, et al. Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. Proc Natl Acad Sci U S A. 2012;109:17579-84 pubmed publisher
Thiollier C, Lopez C, Gerby B, Ignacimouttou C, Poglio S, Duffourd Y, et al. Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models. J Exp Med. 2012;209:2017-31 pubmed publisher
Shi B, Ren G, Hu Y, Wang S, Zhang Z, Yuan Z. HBsAg inhibits IFN-? production in plasmacytoid dendritic cells through TNF-? and IL-10 induction in monocytes. PLoS ONE. 2012;7:e44900 pubmed
Yang T, Jian W, Luo Y, Fu X, NOGUCHI C, Bungert J, et al. Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity. J Biol Chem. 2012;287:40279-91 pubmed publisher
Vatolin S, Khan S, Reu F. Direct chromatin PCR (DC-PCR): hypotonic conditions allow differentiation of chromatin states during thermal cycling. PLoS ONE. 2012;7:e44690 pubmed publisher
Williams A, Li L, Nguyen B, Brown P, Levis M, Small D. Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia. Blood. 2012;120:3069-79 pubmed publisher
Gori J, Chandrasekaran D, Kowalski J, Adair J, Beard B, D Souza S, et al. Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells. Blood. 2012;120:e35-44 pubmed
Baba Y, Maeda K, Yashiro T, Inage E, Kasakura K, Suzuki R, et al. GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression. J Biol Chem. 2012;287:32689-96 pubmed
Skavland J, Jørgensen K, Hadziavdic K, Hovland R, Jonassen I, Bruserud O, et al. Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia. Blood Cancer J. 2011;1:e4 pubmed publisher
Gao H, Wu X, Sun Y, Zhou S, Silberstein L, Zhu Z. Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells. J Biol Chem. 2012;287:29979-87 pubmed publisher
Skrzeczyńska Moncznik J, Wlodarczyk A, Zabieglo K, Kapinska Mrowiecka M, Marewicz E, Dubin A, et al. Secretory leukocyte proteinase inhibitor-competent DNA deposits are potent stimulators of plasmacytoid dendritic cells: implication for psoriasis. J Immunol. 2012;189:1611-7 pubmed publisher
Will B, Zhou L, Vogler T, Ben Neriah S, Schinke C, Tamari R, et al. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations. Blood. 2012;120:2076-86 pubmed publisher
Aggarwal R, Lu J, Kanji S, Joseph M, Das M, Noble G, et al. Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities. PLoS ONE. 2012;7:e39365 pubmed publisher
Ramos Mejia V, Montes R, Bueno C, Ayllon V, Real P, Rodriguez R, et al. Residual expression of the reprogramming factors prevents differentiation of iPSC generated from human fibroblasts and cord blood CD34+ progenitors. PLoS ONE. 2012;7:e35824 pubmed publisher
Cesana D, Sgualdino J, Rudilosso L, Merella S, Naldini L, Montini E. Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations. J Clin Invest. 2012;122:1667-76 pubmed publisher
Scaramuzza S, Biasco L, Ripamonti A, Castiello M, Loperfido M, Draghici E, et al. Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome. Mol Ther. 2013;21:175-84 pubmed publisher
Kalb M, Glaser A, Stary G, Koszik F, Stingl G. TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-?-mediated antitumor reactivity. J Immunol. 2012;188:1583-91 pubmed publisher
Punzo F, Bertoli Avella A, Scianguetta S, Della Ragione F, Casale M, Ronzoni L, et al. Congenital dyserythropoietic anemia type II: molecular analysis and expression of the SEC23B gene. Orphanet J Rare Dis. 2011;6:89 pubmed publisher
Mack A, Kroboth S, Rajesh D, Wang W. Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors. PLoS ONE. 2011;6:e27956 pubmed publisher
Subramanian H, Gupta K, Guo Q, Price R, Ali H. Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization. J Biol Chem. 2011;286:44739-49 pubmed publisher
Rådinger M, Smrž D, Metcalfe D, Gilfillan A. Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis. J Immunol. 2011;187:5587-95 pubmed publisher
Chen H, Sun H, You F, Sun W, Zhou X, Chen L, et al. Activation of STAT6 by STING is critical for antiviral innate immunity. Cell. 2011;147:436-46 pubmed publisher
Grebien F, Hantschel O, Wojcik J, Kaupe I, Kovacic B, Wyrzucki A, et al. Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell. 2011;147:306-19 pubmed publisher
Sarma N, Yaseen N. Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability. J Biol Chem. 2011;286:38989-9001 pubmed publisher
Mali R, Ramdas B, Ma P, Shi J, Munugalavadla V, Sims E, et al. Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL. Cancer Cell. 2011;20:357-69 pubmed publisher
Giarratana M, Rouard H, Dumont A, Kiger L, Safeukui I, Le Pennec P, et al. Proof of principle for transfusion of in vitro-generated red blood cells. Blood. 2011;118:5071-9 pubmed publisher
Fleischman A, Aichberger K, Luty S, Bumm T, Petersen C, Doratotaj S, et al. TNF? facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms. Blood. 2011;118:6392-8 pubmed publisher
Yu H, Zhao H, Wu Z, Zhang J. Eos negatively regulates human ?-globin gene transcription during erythroid differentiation. PLoS ONE. 2011;6:e22907 pubmed publisher
Zhou J, Bi C, Cheong L, Mahara S, Liu S, Tay K, et al. The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML. Blood. 2011;118:2830-9 pubmed publisher
Sheng Z, Ma L, Sun J, Zhu L, Green M. BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription. Blood. 2011;118:2840-8 pubmed publisher
Wu X, Gao H, Ke W, Giese R, Zhu Z. The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation. J Clin Invest. 2011;121:2599-613 pubmed publisher
Matthes T, Dunand Sauthier I, Santiago Raber M, Krause K, Donze O, Passweg J, et al. Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow. Blood. 2011;118:1838-44 pubmed publisher
Melichar H, Li O, Ross J, Haber H, Cado D, Nolla H, et al. Comparative study of hematopoietic differentiation between human embryonic stem cell lines. PLoS ONE. 2011;6:e19854 pubmed publisher
Zhou J, Bi C, Chng W, Cheong L, Liu S, Mahara S, et al. PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy. PLoS ONE. 2011;6:e19798 pubmed publisher
Suzukawa M, Nagase H, Ogahara I, Han K, Tashimo H, Shibui A, et al. Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils. J Immunol. 2011;186:5254-60 pubmed publisher
Yu J, Chau K, Vodyanik M, Jiang J, Jiang Y. Efficient feeder-free episomal reprogramming with small molecules. PLoS ONE. 2011;6:e17557 pubmed publisher
Montes R, Ayllon V, Gutierrez Aranda I, Prat I, Hernández Lamas M, Ponce L, et al. Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia. Blood. 2011;117:4746-58 pubmed publisher
Choi K, Vodyanik M, Slukvin I. Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells. Nat Protoc. 2011;6:296-313 pubmed publisher
Gibbs K, Gilbert P, Sachs K, Zhao F, Blau H, Weissman I, et al. Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments. Blood. 2011;117:4226-33 pubmed publisher
Tanturli M, Giuntoli S, Barbetti V, Rovida E, Dello Sbarba P. Hypoxia selects bortezomib-resistant stem cells of chronic myeloid leukemia. PLoS ONE. 2011;6:e17008 pubmed publisher
Hu K, Yu J, Suknuntha K, Tian S, Montgomery K, Choi K, et al. Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood. 2011;117:e109-19 pubmed publisher
Bock C, Kiskinis E, Verstappen G, Gu H, Boulting G, Smith Z, et al. Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell. 2011;144:439-52 pubmed publisher
Ehnert S, Seeliger C, Vester H, Schmitt A, Saidy Rad S, Lin J, et al. Autologous serum improves yield and metabolic capacity of monocyte-derived hepatocyte-like cells: possible implication for cell transplantation. Cell Transplant. 2011;20:1465-77 pubmed publisher
Cantù C, Ierardi R, Alborelli I, Fugazza C, Cassinelli L, Piconese S, et al. Sox6 enhances erythroid differentiation in human erythroid progenitors. Blood. 2011;117:3669-79 pubmed publisher
Sun H, Kapuria V, Peterson L, Fang D, Bornmann W, Bartholomeusz G, et al. Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis. Blood. 2011;117:3151-62 pubmed publisher
Yeung J, Esposito M, Gandillet A, Zeisig B, Griessinger E, Bonnet D, et al. ?-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer Cell. 2010;18:606-18 pubmed publisher
Klimchenko O, Di Stefano A, Geoerger B, Hamidi S, Opolon P, Robert T, et al. Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions. Blood. 2011;117:3065-75 pubmed publisher
Nishimura K, Sano M, Ohtaka M, Furuta B, Umemura Y, Nakajima Y, et al. Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming. J Biol Chem. 2011;286:4760-71 pubmed publisher
Chen T, Kambal A, Krysiak K, Walshauser M, Raju G, Tibbitts J, et al. Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice. Blood. 2011;117:1530-9 pubmed publisher
Kristensen D, Skalkam M, Audouze K, Lesn xe9 L, Desdoits Lethimonier C, Frederiksen H, et al. Many putative endocrine disruptors inhibit prostaglandin synthesis. Environ Health Perspect. 2011;119:534-41 pubmed publisher
Lauterbach H, Bathke B, Gilles S, Traidl Hoffmann C, Luber C, Fejer G, et al. Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC. J Exp Med. 2010;207:2703-17 pubmed publisher
Berahovich R, Zabel B, Penfold M, Lewén S, Wang Y, Miao Z, et al. CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol. 2010;185:5130-9 pubmed publisher
Kis L, Gerasimcik N, Salamon D, Persson E, Nagy N, Klein G, et al. STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma. Blood. 2011;117:165-74 pubmed publisher
Cavazzana Calvo M, Payen E, Negre O, Wang G, Hehir K, Fusil F, et al. Transfusion independence and HMGA2 activation after gene therapy of human ?-thalassaemia. Nature. 2010;467:318-22 pubmed publisher
Santer D, Hall B, George T, Tangsombatvisit S, Liu C, Arkwright P, et al. C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes. J Immunol. 2010;185:4738-49 pubmed publisher
Gulliksson M, Carvalho R, Ullerås E, Nilsson G. Mast cell survival and mediator secretion in response to hypoxia. PLoS ONE. 2010;5:e12360 pubmed publisher
Abdul Nabi A, Yassin E, Varghese N, Deshmukh H, Yaseen N. In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AML. PLoS ONE. 2010;5:e12464 pubmed publisher
Nissim Ben Efraim A, Eliashar R, Levi Schaffer F. Hypoxia modulates human eosinophil function. Clin Mol Allergy. 2010;8:10 pubmed publisher
Van Handel B, Prashad S, Hassanzadeh Kiabi N, Huang A, Magnusson M, Atanassova B, et al. The first trimester human placenta is a site for terminal maturation of primitive erythroid cells. Blood. 2010;116:3321-30 pubmed publisher
Ersvaer E, Liseth K, Skavland J, Gjertsen B, Bruserud Ø. Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. BMC Immunol. 2010;11:38 pubmed publisher
Hanley T, Blay Puryear W, Gummuluru S, Viglianti G. PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection. PLoS Pathog. 2010;6:e1000981 pubmed publisher
Felli N, Cianetti L, Pelosi E, Carè A, Liu C, Calin G, et al. Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states. BMC Syst Biol. 2010;4:85 pubmed publisher
Deal E, Jaimes M, Crawford S, Estes M, Greenberg H. Rotavirus structural proteins and dsRNA are required for the human primary plasmacytoid dendritic cell IFNalpha response. PLoS Pathog. 2010;6:e1000931 pubmed publisher
Kondo A, Yamashita T, Tamura H, Zhao W, Tsuji T, Shimizu M, et al. Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes. Blood. 2010;116:1124-31 pubmed publisher
Chang Y, Hua W, Yao C, Hwang S, Hung Y, Kuan C, et al. Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells. J Biol Chem. 2010;285:20595-606 pubmed publisher
Yu C, Liu Y, Miao Z, Yin M, Lu W, Lv Y, et al. Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors. Blood. 2010;116:4786-94 pubmed publisher
Bullock G, Delehanty L, Talbot A, Gonias S, Tong W, Rouault T, et al. Iron control of erythroid development by a novel aconitase-associated regulatory pathway. Blood. 2010;116:97-108 pubmed publisher
Macey M, Sturgill J, Morales J, Falanga Y, Morales J, Norton S, et al. IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis. J Immunol. 2010;184:4688-95 pubmed publisher
Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, et al. Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. J Immunol. 2010;184:3526-34 pubmed publisher
Fabricius D, Neubauer M, Mandel B, Schütz C, Viardot A, Vollmer A, et al. Prostaglandin E2 inhibits IFN-alpha secretion and Th1 costimulation by human plasmacytoid dendritic cells via E-prostanoid 2 and E-prostanoid 4 receptor engagement. J Immunol. 2010;184:677-84 pubmed publisher
RÃ¥dinger M, Kuehn H, Kim M, Metcalfe D, Gilfillan A. Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells. J Immunol. 2010;184:564-72 pubmed publisher
Pratz K, Sato T, Murphy K, Stine A, Rajkhowa T, Levis M. FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML. Blood. 2010;115:1425-32 pubmed publisher
Jahrsdorfer B, Vollmer A, Blackwell S, Maier J, Sontheimer K, Beyer T, et al. Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion. Blood. 2010;115:1156-65 pubmed publisher
Robert G, Ben Sahra I, Puissant A, Colosetti P, Belhacene N, Gounon P, et al. Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS ONE. 2009;4:e7889 pubmed publisher
Fauriat C, Ivarsson M, Ljunggren H, Malmberg K, Michaelsson J. Education of human natural killer cells by activating killer cell immunoglobulin-like receptors. Blood. 2010;115:1166-74 pubmed publisher
Flister M, Wilber A, Hall K, Iwata C, Miyazono K, Nisato R, et al. Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1. Blood. 2010;115:418-29 pubmed publisher
Jansson L, Larsson J. W41/W41 blastocyst complementation: a system for genetic modeling of hematopoiesis. Blood. 2010;115:47-50 pubmed publisher
Ding Y, Harada Y, Imagawa J, Kimura A, Harada H. AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms. Blood. 2009;114:5201-5 pubmed publisher
Das H, George J, Joseph M, Das M, Abdulhameed N, Blitz A, et al. Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model. PLoS ONE. 2009;4:e7325 pubmed publisher
Tsukamoto N, Okada S, Onami Y, Sasaki Y, Umezawa K, Kawakami Y. Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells. Clin Cancer Res. 2009;15:5733-43 pubmed publisher
Tian X, Hexum M, Penchev V, Taylor R, Shultz L, Kaufman D. Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells. Stem Cells. 2009;27:2675-85 pubmed publisher
Will B, Kawahara M, Luciano J, Bruns I, Parekh S, Erickson Miller C, et al. Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome. Blood. 2009;114:3899-908 pubmed publisher
Hatzistavrou T, Micallef S, Ng E, Vadolas J, Stanley E, Elefanty A. ErythRED, a hESC line enabling identification of erythroid cells. Nat Methods. 2009;6:659-62 pubmed publisher
Oehler V, Guthrie K, Cummings C, Sabo K, Wood B, Gooley T, et al. The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells. Blood. 2009;114:3299-308 pubmed publisher
Hagn M, Schwesinger E, Ebel V, Sontheimer K, Maier J, Beyer T, et al. Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21. J Immunol. 2009;183:1838-45 pubmed publisher
Eberhard Y, McDermott S, Wang X, Gronda M, Venugopal A, Wood T, et al. Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood. 2009;114:3064-73 pubmed publisher
Starnes L, Sorrentino A, Pelosi E, Ballarino M, Morsilli O, Biffoni M, et al. NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression. Blood. 2009;114:1753-63 pubmed publisher
Kato A, Chustz R, Ogasawara T, Kulka M, Saito H, Schleimer R, et al. Dexamethasone and FK506 inhibit expression of distinct subsets of chemokines in human mast cells. J Immunol. 2009;182:7233-43 pubmed publisher
Boehmler A, Drost A, Jaggy L, Seitz G, Wiesner T, Denzlinger C, et al. The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells. J Immunol. 2009;182:6789-98 pubmed publisher
Sundstrom J, Hair G, Ansari A, Secor W, Gilfillan A, Metcalfe D, et al. IgE-FcepsilonRI interactions determine HIV coreceptor usage and susceptibility to infection during ontogeny of mast cells. J Immunol. 2009;182:6401-9 pubmed publisher
Woll P, Grzywacz B, Tian X, Marcus R, Knorr D, Verneris M, et al. Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity. Blood. 2009;113:6094-101 pubmed publisher
Loh Y, Agarwal S, Park I, Urbach A, Huo H, Heffner G, et al. Generation of induced pluripotent stem cells from human blood. Blood. 2009;113:5476-9 pubmed publisher
Cui Y, Kerby A, McDuff F, Ye H, Turner S. NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner. Blood. 2009;113:5217-27 pubmed publisher
Vagima Y, Avigdor A, Goichberg P, Shivtiel S, Tesio M, Kalinkovich A, et al. MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization. J Clin Invest. 2009;119:492-503 pubmed publisher
Pendino F, Nguyen E, Jonassen I, Dysvik B, Azouz A, Lanotte M, et al. Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. Blood. 2009;113:3172-81 pubmed publisher
Cheng E, Luo Q, Bruscia E, Renda M, Troy J, Massaro S, et al. Role for MKL1 in megakaryocytic maturation. Blood. 2009;113:2826-34 pubmed publisher
Soriani A, Zingoni A, Cerboni C, Iannitto M, Ricciardi M, Di Gialleonardo V, et al. ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. Blood. 2009;113:3503-11 pubmed publisher
Moshaver B, van Rhenen A, Kelder A, van der Pol M, Terwijn M, Bachas C, et al. Identification of a small subpopulation of candidate leukemia-initiating cells in the side population of patients with acute myeloid leukemia. Stem Cells. 2008;26:3059-67 pubmed publisher
Kuehn H, Swindle E, Kim M, Beaven M, Metcalfe D, Gilfillan A. The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells. J Immunol. 2008;181:7706-12 pubmed
Gobbi G, Mirandola P, Carubbi C, Micheloni C, Malinverno C, Lunghi P, et al. Phorbol ester-induced PKCepsilon down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation. Blood. 2009;113:3080-7 pubmed publisher
Junttila I, Mizukami K, Dickensheets H, Meier Schellersheim M, Yamane H, Donnelly R, et al. Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med. 2008;205:2595-608 pubmed publisher
Saeki K, Saeki K, Nakahara M, Matsuyama S, Nakamura N, Yogiashi Y, et al. A feeder-free and efficient production of functional neutrophils from human embryonic stem cells. Stem Cells. 2009;27:59-67 pubmed publisher
Su Z, Frye C, Bae K, Kelley V, Vieweg J. Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions. Clin Cancer Res. 2008;14:6207-17 pubmed publisher
Moldenhauer A, Genter G, Lun A, Bal G, Kiesewetter H, Salama A. Hematopoietic progenitor cells and interleukin-stimulated endothelium: expansion and differentiation of myeloid precursors. BMC Immunol. 2008;9:56 pubmed publisher
Sakuishi K, Oki S, Araki M, Porcelli S, Miyake S, Yamamura T. Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation. J Immunol. 2007;179:3452-62 pubmed
Della Chiesa M, Romagnani C, Thiel A, Moretta L, Moretta A. Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses. Blood. 2006;108:3851-8 pubmed
Hsieh F, Sharma P, Gibbons A, Goggans T, Erzurum S, Haque S. Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells. Proc Natl Acad Sci U S A. 2005;102:14380-5 pubmed
van Beek J, van Meurs M, t Hart B, Brok H, Neal J, Chatagner A, et al. Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation. J Immunol. 2005;174:2353-65 pubmed
Hartnell A, Heinemann A, Conroy D, Wait R, Sturm G, Caversaccio M, et al. Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2. J Immunol. 2004;173:6448-57 pubmed
Hemminki A, Kanerva A, Liu B, Wang M, Alvarez R, Siegal G, et al. Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression. Cancer Res. 2003;63:847-53 pubmed
product information
Product Type :
Protein
Product Name :
Human IL-3 Recombinant Protein, PeproTech
Catalog # :
200-03-1MG
Quantity :
1 mg
Price :
US 3470.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Species :
Human
Storage :
-20 C
Description :
Interleukin 3 (IL-3), also called Mast Cell Growth Factor (MCGF), Multi-Colony Stimulating Factor (multi-CSF), or Eosinophil-CSF (E-CSF), is produced by activated T cells, mast cells and eosinophils. IL-3 is a hematopoietic growth factor that stimulates colony formation of erythroid, megakaryocyte, neutrophil, eosinophil, basophil, mast cell and monocytic lineages. Most of these functions are enhanced or dependent on co-stimulation with other cytokines. Human and mouse IL-3 share only 29% sequence identity at the amino acid level. The bioactivity of IL-3 is highly species specific. For example, human IL-3 has no activity on mouse cells. IL-3 is a potent growth promoting cytokine. IL-3 is capable of supporting the proliferation of a broad range of hematopoietic cell types, and is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Functional Assay: Assay-dependent, Western Blot: Assay-dependent
Aliases :
BP/BPA; BPA; Colony stimulating factor multiple; colony-stimulating factor, multiple; Csfmu; Eo-CSF; HCGF; hematopoietic growth factor; Il3; Il-3; ILN; Interleukin; interleukin 3; Interleukin 3 (colony stimulating factor; Interleukin3; interleukin-3; Mast cell growth factor; mast-cell growth factor; MCGF; MGC79398; MGC79399; MGF; Multi CSF; MULTI-CSF; Multilineage colony stimulating factor; multilineage-colony-stimulating factor; multiple); multipotential colony-stimulating factor; P cell stimulating factor; P-cell stimulating factor; P-cell-stimulating factor; PCSA; PSF
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA