ZO-1 Polyclonal Antibody | Invitrogen 18-7430 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ZO-1 Polyclonal Antibody

catalog :

18-7430

quantity :

500 µL

price :

US 500

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 4	Ahmed C, ILDEFONSO C, Johnson H, Lewin A. A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis. PLoS ONE. 2020;15:e0227524 pubmed publisher
immunocytochemistry; human; 1:100; loading ...; fig 1d	Choudhary P, Gutteridge A, Impey E, Storer R, Owen R, Whiting P, et al. Targeting the cAMP and Transforming Growth Factor-? Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2016;5:925-37 pubmed publisher
	Jia L, Diao Y, Fang Y, Yang K, Wang L, Huang Y. Methodological study of directed differentiation of pluripotent stem cells into corneal endothelial cells. Ann Transl Med. 2022;10:482 pubmed publisher
	Zhang H, Su B, Jiao L, Xu Z, Zhang C, Nie J, et al. Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model: the first pre-clinical study for safety and efficacy in China. Ann Transl Med. 2021;9:245 pubmed publisher
	Sasaki N, Miyamoto K, Maslowski K, Ohno H, Kanai T, Sato T. Development of a Scalable Coculture System for Gut Anaerobes and Human Colon Epithelium. Gastroenterology. 2020;159:388-390.e5 pubmed publisher
	Devocelle A, Lecru L, Francois H, Desterke C, Gallerne C, Eid P, et al. Inhibition of TGF-β1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-β1-Induced EMT in Renal Fibrosis. Int J Cell Biol. 2019;2019:9151394 pubmed publisher
	Jun B, Mukherjee P, Asatryan A, Kautzmann M, Heap J, Gordon W, et al. Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity. Sci Rep. 2017;7:5279 pubmed publisher
	Choudhary P, Booth H, Gutteridge A, Surmacz B, Louca I, Steer J, et al. Directing Differentiation of Pluripotent Stem Cells Toward Retinal Pigment Epithelium Lineage. Stem Cells Transl Med. 2017;6:490-501 pubmed publisher
	Choudhary P, Dodsworth B, Sidders B, Gutteridge A, Michaelides C, Duckworth J, et al. A FOXM1 Dependent Mesenchymal-Epithelial Transition in Retinal Pigment Epithelium Cells. PLoS ONE. 2015;10:e0130379 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ZO-1 Polyclonal Antibody

Catalog # :

18-7430

Quantity :

500 µL

Price :

US 500

Clonality :

Polyclonal

Purity :

purified

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1:250-1:1,000, Immunohistochemistry (Paraffin): Assay-dependent

Species :

Human

Isotype :

IgG

Storage :

4° C

Description :

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.

Immunogen :

Peptide sequence from the N-terminal region of human ZO-1.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:250-1:1,000, Immunohistochemistry (Paraffin): Assay-dependent

Aliases :

DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1

more info or order :

Invitrogen product webpage