E-Cadherin Monoclonal Antibody (4A2C7) | Invitrogen 18-0223 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

E-Cadherin Monoclonal Antibody (4A2C7)

catalog :

18-0223

quantity :

1 mL

price :

US 654.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4A2C7

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

citations: 15

Reference
Sheikh Ahmad M, Shalata Y, Bejar J, Kreizman Shefer H, Sirhan M, Laniado M, et al. The Correlation between Proliferative Immunohistochemical Markers and Papillary Thyroid Carcinoma Aggressiveness. Medicina (Kaunas). 2023;59: pubmed publisher
Schreiber J, Liaukouskaya N, Fuhrmann L, Hauser A, Jung M, Huber T, et al. BET Proteins Regulate Expression of Osr1 in Early Kidney Development. Biomedicines. 2021;9: pubmed publisher
Stevens M, Zhang Z, Johansson E, Ray S, Jagpal A, Ruff B, et al. Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk. Nat Commun. 2020;11:4092 pubmed publisher
Flynn L, Barr M, Baird A, Smyth P, Casey O, Blackshields G, et al. Prostate cancer-derived holoclones: a novel and effective model for evaluating cancer stemness. Sci Rep. 2020;10:11329 pubmed publisher
Nair Menon J, Daulagala A, Connor D, Rutledge L, Penix T, Bridges M, et al. Predominant Distribution of the RNAi Machinery at Apical Adherens Junctions in Colonic Epithelia Is Disrupted in Cancer. Int J Mol Sci. 2020;21: pubmed publisher
Pelon F, Bourachot B, Kieffer Y, Magagna I, Mermet Meillon F, Bonnet I, et al. Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms. Nat Commun. 2020;11:404 pubmed publisher
Filimonow K, Saiz N, Suwinska A, Wyszomirski T, Grabarek J, Ferretti E, et al. No evidence of involvement of E-cadherin in cell fate specification or the segregation of Epi and PrE in mouse blastocysts. PLoS ONE. 2019;14:e0212109 pubmed publisher
Fujiwara M, Kanayama K, Hirokawa Y, Shiraishi T. ASF-4-1 fibroblast-rich culture increases chemoresistance and mTOR expression of pancreatic cancer BxPC-3 cells at the invasive front in vitro, and promotes tumor growth and invasion in vivo. Oncol Lett. 2016;11:2773-2779 pubmed
Chen B, Zaveri P, Longtine M, Nelson D. N-myc downstream-regulated gene 1 (NDRG1) mediates pomegranate juice protection from apoptosis in hypoxic BeWo cells but not in primary human trophoblasts. Placenta. 2015;36:847-53 pubmed publisher
Litbarg N, Vujicic S, Setty S, Sethupathi P, Dunea G, Arruda J, et al. A novel model of surgical injury in adult rat kidney: a "pouch model". Sci Rep. 2013;3:2890 pubmed publisher
Xu J, Lim S, Ng M, Ali S, Kausalya J, Limviphuvadh V, et al. ZO-1 regulates Erk, Smad1/5/8, Smad2, and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells. Stem Cells. 2012;30:1885-900 pubmed publisher
Longtine M, Chen B, Odibo A, Zhong Y, Nelson D. Caspase-mediated apoptosis of trophoblasts in term human placental villi is restricted to cytotrophoblasts and absent from the multinucleated syncytiotrophoblast. Reproduction. 2012;143:107-21 pubmed publisher
Leshem O, Madar S, Kogan Sakin I, Kamer I, Goldstein I, Brosh R, et al. TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model. PLoS ONE. 2011;6:e21650 pubmed publisher
Churko J, Langlois S, Pan X, Shao Q, Laird D. The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants. Biochem J. 2010;429:473-83 pubmed publisher
Zhong X, Zhang L, Jia S, Shi T, Niu Z, Du H, et al. Positive association of up-regulated Cripto-1 and down-regulated E-cadherin with tumour progression and poor prognosis in gastric cancer. Histopathology. 2008;52:560-8 pubmed publisher

product information

Product Type :

Antibody

Product Name :

E-Cadherin Monoclonal Antibody (4A2C7)

Catalog # :

18-0223

Quantity :

1 mL

Price :

US 654.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:50-1:200

Species :

Human

Clone :

4A2C7

Storage :

2-8 C

Description :

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.

Immunogen :

Recombinant protein corresponding to the cytoplasmic domain of human E-cadherin

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:200

Aliases :

AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin