Alpha-synuclein Monoclonal Antibody (LB509) | Invitrogen 18-0215 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Alpha-synuclein Monoclonal Antibody (LB509)

catalog :

18-0215

quantity :

1 mL

price :

US 738.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

LB509

The same clone is also sold as:

BioLegend: 807707, 807702, 807710, 807701, 807703, 807709

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

citations: 10

Reference
Li Z, Cui L, Jin M, Hu D, Hou X, Liu S, et al. A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease. Dis Model Mech. 2022;15: pubmed publisher
Zhu X, Zhong Y, Ge Y, Lu K, Lu S. CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in ?-Synuclein Causing Parkinson's Disease. Sci Rep. 2018;8:12420 pubmed publisher
Macdonald I, Maxwell S, Reid G, Cash M, DeBay D, Darvesh S. Quantification of Butyrylcholinesterase Activity as a Sensitive and Specific Biomarker of Alzheimer's Disease. J Alzheimers Dis. 2017;58:491-505 pubmed publisher
Ip C, Klaus L, Karikari A, Visanji N, Brotchie J, Lang A, et al. AAV1/2-induced overexpression of A53T-?-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease. Acta Neuropathol Commun. 2017;5:11 pubmed publisher
Prusiner S, Woerman A, Mordes D, Watts J, Rampersaud R, Berry D, et al. Evidence for Î±-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A. 2015;112:E5308-17 pubmed publisher
Fiesel F, Ando M, Hudec R, Hill A, Castanedes Casey M, Caulfield T, et al. (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation. EMBO Rep. 2015;16:1114-30 pubmed publisher
Shannon K, Keshavarzian A, Mutlu E, Dodiya H, Daian D, Jaglin J, et al. Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease. Mov Disord. 2012;27:709-15 pubmed publisher
Oinas M, Sulkava R, Polvikoski T, Kalimo H, Paetau A. Reappraisal of a consecutive autopsy series of patients with primary degenerative dementia: Lewy-related pathology. APMIS. 2007;115:820-7 pubmed
Zhu J, Kulich S, Oury T, Chu C. Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases. Am J Pathol. 2002;161:2087-98 pubmed
van Der Putten H, Wiederhold K, Probst A, Barbieri S, Mistl C, Danner S, et al. Neuropathology in mice expressing human alpha-synuclein. J Neurosci. 2000;20:6021-9 pubmed

product information

Product Type :

Antibody

Product Name :

Alpha-synuclein Monoclonal Antibody (LB509)

Catalog # :

18-0215

Quantity :

1 mL

Price :

US 738.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:50-1:200

Species :

Human

Clone :

LB509

Storage :

2-8 C

Description :

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

Immunogen :

Lewy Bodies purified from patients suffering dementia with Lewy Bodies

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:200

Aliases :

Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)