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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TCR alpha/beta Monoclonal Antibody (IP26), APC, eBioscience
catalog :
17-9986-42
quantity :
100 Tests
price :
US 317
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
IP26
reactivity :
human
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 23
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 2c
Komdeur F, Wouters M, Workel H, Tijans A, Terwindt A, Brunekreeft K, et al. CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy. Oncotarget. 2016;7:75130-75144 pubmed publisher
  • flow cytometry; human; fig 4
Owens G, Erickson K, Malone C, Pan C, Huynh M, Chang J, et al. Evidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis. J Neuroinflammation. 2015;12:134 pubmed publisher
Rackaityte E, Halkias J, Fukui E, Mendoza V, Hayzelden C, Crawford E, et al. Viable bacterial colonization is highly limited in the human intestine in utero. Nat Med. 2020;26:599-607 pubmed publisher
Janssen A, Villacorta Hidalgo J, Beringer D, van Dooremalen S, Fernando F, van Diest E, et al. γδ T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity. Cancer Immunol Res. 2020;8:530-543 pubmed publisher
Halkias J, Rackaityte E, Hillman S, Aran D, Mendoza V, Marshall L, et al. CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells. J Clin Invest. 2019;130:3562-3577 pubmed publisher
Hart M, Walch Rückheim B, Friedmann K, Rheinheimer S, Tänzer T, Glombitza B, et al. miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling. Cell Death Dis. 2019;10:46 pubmed publisher
Straetemans T, Kierkels G, Doorn R, Jansen K, Heijhuurs S, Dos Santos J, et al. GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR. Front Immunol. 2018;9:1062 pubmed publisher
Claireaux M, Galperin M, Benati D, Nouel A, Mukhopadhyay M, Klingler J, et al. A High Frequency of HIV-Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers. MBio. 2018;9: pubmed publisher
Rowe J, Delmonte O, Keles S, Stadinski B, Dobbs A, Henderson L, et al. Patients with CD3G mutations reveal a role for human CD3γ in Treg diversity and suppressive function. Blood. 2018;: pubmed publisher
Mukhopadhyay M, Galperin M, Patgaonkar M, Vasan S, Ho D, Nouël A, et al. DNA Vaccination by Electroporation Amplifies Broadly Cross-Restricted Public TCR Clonotypes Shared with HIV Controllers. J Immunol. 2017;199:3437-3452 pubmed publisher
Jandl C, Liu S, Canete P, Warren J, Hughes W, Vogelzang A, et al. IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2. Nat Commun. 2017;8:14647 pubmed publisher
Owens G, Chang J, Huynh M, Chirwa T, Vinters H, Mathern G. Evidence for Resident Memory T Cells in Rasmussen Encephalitis. Front Immunol. 2016;7:64 pubmed publisher
Volk T, Pannicke U, Reisli I, Bulashevska A, Ritter J, Björkman A, et al. DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency. Hum Mol Genet. 2015;24:7361-72 pubmed publisher
Thaventhiran T, Alhumeed N, Yeang H, Sethu S, Downey J, Alghanem A, et al. Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist. MAbs. 2014;6:1290-9 pubmed publisher
Berkowska M, Heeringa J, Hajdarbegovic E, van der Burg M, Thio H, van Hagen P, et al. Human IgE(+) B cells are derived from T cell-dependent and T cell-independent pathways. J Allergy Clin Immunol. 2014;134:688-697.e6 pubmed publisher
Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, et al. 60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells. J Biol Chem. 2013;288:15537-46 pubmed publisher
Miki Y, Gion Y, Mukae Y, Hayashi A, Sato H, Yoshino T, et al. Morphologic, flow cytometric, functional, and molecular analyses of S100B positive lymphocytes, unique cytotoxic lymphocytes containing S100B protein. Eur J Haematol. 2013;90:99-110 pubmed publisher
Kawabe S, Ito Y, Gotoh K, Kojima S, Matsumoto K, Kinoshita T, et al. Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T/natural killer cell lymphoproliferative diseases. Cancer Sci. 2012;103:1481-8 pubmed publisher
Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, MacDonald A, et al. Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells. PLoS ONE. 2012;7:e35466 pubmed publisher
Meek B, Van Elssen C, Huijskens M, van der Stegen S, Tonnaer S, Lumeij S, et al. T cells fail to develop in the human skin-cell explants system; an inconvenient truth. BMC Immunol. 2011;12:17 pubmed publisher
Zloza A, Jagoda M, Lyons G, Graves M, Kohlhapp F, O Sullivan J, et al. CD8 co-receptor promotes susceptibility of CD8+ T cells to transforming growth factor-? (TGF-?)-mediated suppression. Cancer Immunol Immunother. 2011;60:291-7 pubmed publisher
Kuttruff S, Koch S, Kelp A, Pawelec G, Rammensee H, Steinle A. NKp80 defines and stimulates a reactive subset of CD8 T cells. Blood. 2009;113:358-69 pubmed publisher
Fan C, Huang C, Chiu W, Lai C, Liou G, Li H, et al. Production of multivalent protein binders using a self-trimerizing collagen-like peptide scaffold. FASEB J. 2008;22:3795-804 pubmed publisher
product information
Product Type :
Antibody
Product Name :
TCR alpha/beta Monoclonal Antibody (IP26), APC, eBioscience
Catalog # :
17-9986-42
Quantity :
100 Tests
Price :
US 317
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 µL (0.5 µg)/test
Species :
Human
Clone :
IP26
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma/delta/eta and zeta subunits, all of which are required for efficient surface expression. T cell activation through the TCR induces cellular differentiation and/or proliferation and the production of lymphokines and cytokines. Both the CD3 and TCR zeta subunits are proposed to be responsible for the intracellular signal transduction events. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and associate with the CD3 subunits in the endoplasmic reticulum to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.5 µg)/test
Aliases :
FLJ22602; IMD7; LOC290071; MGC117436; MGC22624; MGC23964; MGC71411; RATTCB; RATTCBC1; RGD1359684; similar to RIKEN cDNA A430107P09 gene; T cell receptor beta locus; T3/TCR complex; TCB; TCBC1; t-cell antigen receptor; T-cell receptor alpha constant; T-cell receptor beta chain; T-cell receptor V alpha; tcr alpha; TCR alpha/ beta; TCR beta; TCRA; Tcrb; TRA; Tra29; TRAC; TRB; TRB@; TRCA
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA