This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TLR4/MD-2 Complex Monoclonal Antibody (MTS510), APC, eBioscience
catalog :
17-9924-82
quantity :
100 ug
price :
US 434.00
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
MTS510

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 79
Reference
Szabo Pardi T, Barron L, Lenert M, Burton M. Sensory Neuron TLR4 mediates the development of nerve-injury induced mechanical hypersensitivity in female mice. Brain Behav Immun. 2021;97:42-60 pubmed publisher
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Kumazoe M, Nakamura Y, Yamashita M, Suzuki T, Takamatsu K, Huang Y, et al. Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216. J Biol Chem. 2017;292:4077-4088 pubmed publisher
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Deguchi A, Tomita T, Omori T, Komatsu A, Ohto U, Takahashi S, et al. Serum amyloid A3 binds MD-2 to activate p38 and NF-?B pathways in a MyD88-dependent manner. J Immunol. 2013;191:1856-64 pubmed publisher
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Seillet C, Rouquié N, Foulon E, Douin Echinard V, Krust A, Chambon P, et al. Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor ?. J Immunol. 2013;190:5459-70 pubmed publisher
Liu B, Fu Y, Feng S, Zhang X, Liu Z, Cao Y, et al. Involvement of RP105 and toll-like receptors in the activation of mouse peritoneal macrophages by Staphylococcus aureus. Scand J Immunol. 2013;78:8-16 pubmed publisher
Corbitt N, Kimura S, Isse K, Specht S, Chedwick L, Rosborough B, et al. Gut bacteria drive Kupffer cell expansion via MAMP-mediated ICAM-1 induction on sinusoidal endothelium and influence preservation-reperfusion injury after orthotopic liver transplantation. Am J Pathol. 2013;182:180-91 pubmed publisher
Kuan Y, Lee W, Hung C, Yang C, Sheu F. Investigating the function of a novel protein from Anoectochilus formosanus which induced macrophage differentiation through TLR4-mediated NF-?B activation. Int Immunopharmacol. 2012;14:114-20 pubmed publisher
Chen G, Hwang S, Su H, Kuo C, Luo W, Lo K, et al. Defective antiviral responses of induced pluripotent stem cells to baculoviral vector transduction. J Virol. 2012;86:8041-9 pubmed publisher
Paul J, Karmakar S, De T. TLR-mediated distinct IFN-?/IL-10 pattern induces protective immunity against murine visceral leishmaniasis. Eur J Immunol. 2012;42:2087-99 pubmed publisher
Chen M, Chang W, Kuan Y, Lin S, Hsu H, Lee C. Resveratrol inhibits LPS-induced epithelial-mesenchymal transition in mouse melanoma model. Innate Immun. 2012;18:685-93 pubmed
Tsukiyama T, Matsuda Tsukiyama M, Bohgaki M, Terai S, Tanaka S, Hatakeyama S. Ymer acts as a multifunctional regulator in nuclear factor-?B and Fas signaling pathways. Mol Med. 2012;18:587-97 pubmed publisher
Bain C, Mowat A. CD200 receptor and macrophage function in the intestine. Immunobiology. 2012;217:643-51 pubmed publisher
Levin M, Jirholt P, Wramstedt A, Johansson M, Lundberg A, Trajkovska M, et al. Rip2 deficiency leads to increased atherosclerosis despite decreased inflammation. Circ Res. 2011;109:1210-8 pubmed publisher
Kobayashi F, Watanabe E, Nakagawa Y, Yamanishi S, Norose Y, Fukunaga Y, et al. Production of autoantibodies by murine B-1a cells stimulated with Helicobacter pylori urease through toll-like receptor 2 signaling. Infect Immun. 2011;79:4791-801 pubmed publisher
Kim E, Hong H, Cho D, Han J, Kim S, Kim T. Enhancement of toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells. Immunology. 2011;134:73-81 pubmed publisher
Xing Q, de Vos P, Faas M, Ye Q, Ren Y. LPS promotes pre-osteoclast activity by up-regulating CXCR4 via TLR-4. J Dent Res. 2011;90:157-62 pubmed publisher
Fan J, Edsen Moore M, Turner L, Cook R, Legge K, Waldschmidt T, et al. Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation. Alcohol Clin Exp Res. 2011;35:47-59 pubmed publisher
Grabowski J, Vazquez D, Costantini T, Cauvi D, Charles W, Bickler S, et al. Tumor necrosis factor expression is ameliorated after exposure to an acidic environment. J Surg Res. 2012;173:127-34 pubmed publisher
Gomez C, Karavitis J, Palmer J, Faunce D, Ramirez L, Nomellini V, et al. Interleukin-6 contributes to age-related alteration of cytokine production by macrophages. Mediators Inflamm. 2010;2010:475139 pubmed publisher
Rettew J, McCall S, Marriott I. GPR30/GPER-1 mediates rapid decreases in TLR4 expression on murine macrophages. Mol Cell Endocrinol. 2010;328:87-92 pubmed publisher
Zhang Z, Li W, Sun D, Zhao L, Zhang R, Wang Y, et al. Toll-like receptor 4 signaling in dysfunction of cardiac microvascular endothelial cells under hypoxia/reoxygenation. Inflamm Res. 2011;60:37-45 pubmed publisher
Zhu X, Owen J, Wilson M, Li H, Griffiths G, Thomas M, et al. Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol. J Lipid Res. 2010;51:3196-206 pubmed publisher
Anthony D, Andrews D, Chow M, Watt S, House C, Akira S, et al. A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J Immunol. 2010;185:1794-803 pubmed publisher
Price L, Wenner C, Sloper D, Slaton J, Novack J. Role for toll-like receptor 4 in TNF-alpha secretion by murine macrophages in response to polysaccharide Krestin, a Trametes versicolor mushroom extract. Fitoterapia. 2010;81:914-9 pubmed publisher
Davies J, Macsharry J, Shanahan F. Differential regulation of Toll-like receptor signalling in spleen and Peyer's patch dendritic cells. Immunology. 2010;131:438-48 pubmed publisher
Burton O, Gibbs S, Miller N, Jones F, Wen L, Dunne D, et al. Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens. Eur J Immunol. 2010;40:2221-9 pubmed publisher
Loser K, Vogl T, Voskort M, Lueken A, Kupas V, Nacken W, et al. The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nat Med. 2010;16:713-7 pubmed publisher
Ohkusu Tsukada K, Ohta S, Kawakami Y, Toda M. Adjuvant effects of formalin-inactivated HSV through activation of dendritic cells and inactivation of myeloid-derived suppressor cells in cancer immunotherapy. Int J Cancer. 2011;128:119-31 pubmed publisher
Saunders S, Barlow J, Walsh C, Bellsoi A, Smith P, McKenzie A, et al. C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide. J Immunol. 2010;184:2627-37 pubmed publisher
Kurowska Stolarska M, Stolarski B, Kewin P, Murphy G, Corrigan C, Ying S, et al. IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J Immunol. 2009;183:6469-77 pubmed publisher
Bauernfeind F, Horvath G, Stutz A, Alnemri E, MacDonald K, Speert D, et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol. 2009;183:787-91 pubmed publisher
Takashima K, Matsunaga N, Yoshimatsu M, Hazeki K, Kaisho T, Uekata M, et al. Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model. Br J Pharmacol. 2009;157:1250-62 pubmed publisher
Lee S, Hong B, Sharabi A, Huang X, Chen S. Embryonic stem cells and mammary luminal progenitors directly sense and respond to microbial products. Stem Cells. 2009;27:1604-15 pubmed publisher
Zhang H, Rosenberg S, Coffey F, He Y, Manser T, Hardy R, et al. A role for cFLIP in B cell proliferation and stress MAPK regulation. J Immunol. 2009;182:207-15 pubmed
Turnquist H, Sumpter T, Tsung A, Zahorchak A, Nakao A, Nau G, et al. IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells. J Immunol. 2008;181:62-72 pubmed
Cross J, Kott K, Miletic T, Johnson P. CD45 regulates TLR-induced proinflammatory cytokine and IFN-beta secretion in dendritic cells. J Immunol. 2008;180:8020-9 pubmed
Arranz A, Juarranz Y, Leceta J, Gomariz R, Martinez C. VIP balances innate and adaptive immune responses induced by specific stimulation of TLR2 and TLR4. Peptides. 2008;29:948-56 pubmed publisher
Treese C, Mittag A, Lange F, Tarnok A, Loesche A, Emmrich F, et al. Characterization of fibroblasts responsible for cartilage destruction in arthritis. Cytometry A. 2008;73:351-60 pubmed publisher
Milne C, Corfe S, Paige C. Heparan sulfate and heparin enhance ERK phosphorylation and mediate preBCR-dependent events during B lymphopoiesis. J Immunol. 2008;180:2839-47 pubmed
Rettew J, Huet Hudson Y, Marriott I. Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity. Biol Reprod. 2008;78:432-7 pubmed
Ukai T, Yumoto H, Gibson F, Genco C. Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2-dependent tumor necrosis factor-alpha production. Infect Immun. 2008;76:812-9 pubmed
Kitazawa T, Fukushima A, Okugawa S, Yanagimoto S, Tsukada K, Tatsuno K, et al. Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase. Microbes Infect. 2007;9:1410-4 pubmed
Elftman M, Norbury C, Bonneau R, Truckenmiller M. Corticosterone impairs dendritic cell maturation and function. Immunology. 2007;122:279-90 pubmed
Ribeiro Gomes F, Moniz de Souza M, Alexandre Moreira M, Dias W, Lopes M, Nunes M, et al. Neutrophils activate macrophages for intracellular killing of Leishmania major through recruitment of TLR4 by neutrophil elastase. J Immunol. 2007;179:3988-94 pubmed
Shu S, Lian Z, Chuang Y, Yang G, Moritoki Y, Comstock S, et al. The role of CD11c(+) hepatic dendritic cells in the induction of innate immune responses. Clin Exp Immunol. 2007;149:335-43 pubmed
Liu X, Ukai T, Yumoto H, Davey M, Goswami S, Gibson F, et al. Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Atherosclerosis. 2008;196:146-54 pubmed
Eguchi M, Sekiya Y, Suzuki M, Yamamoto T, Matsui H. An oral Salmonella vaccine promotes the down-regulation of cell surface Toll-like receptor 4 (TLR4) and TLR2 expression in mice. FEMS Immunol Med Microbiol. 2007;50:300-8 pubmed
Petursdottir D, Hardardottir I. Dietary fish oil increases the number of splenic macrophages secreting TNF-alpha and IL-10 but decreases the secretion of these cytokines by splenic T cells from mice. J Nutr. 2007;137:665-70 pubmed
Nemoto E, Darveau R, Foster B, Nogueira Filho G, Somerman M. Regulation of cementoblast function by P. gingivalis lipopolysaccharide via TLR2. J Dent Res. 2006;85:733-8 pubmed
Turner J, Langley R, Johnston K, Egerton G, Wanji S, Taylor M. Wolbachia endosymbiotic bacteria of Brugia malayi mediate macrophage tolerance to TLR- and CD40-specific stimuli in a MyD88/TLR2-dependent manner. J Immunol. 2006;177:1240-9 pubmed
Lin K, Kao Y, Kuo H, Yang W, Chou A, Lin H, et al. Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1. J Biol Chem. 2006;281:24111-23 pubmed
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Huber M, Kalis C, Keck S, Jiang Z, Georgel P, Du X, et al. R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells. Eur J Immunol. 2006;36:701-11 pubmed
Nishiya T, Kajita E, Miwa S. Ligand-independent oligomerization of TLR4 regulated by a short hydrophobic region adjacent to the transmembrane domain. Biochem Biophys Res Commun. 2006;341:1128-34 pubmed
Viriyakosol S, Matthias M, Swancutt M, Kirkland T, Vinetz J. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun. 2006;74:887-95 pubmed
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Qi H, Shelhamer J. Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages. J Biol Chem. 2005;280:38969-75 pubmed
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Shimura H, Nitahara A, Ito A, Tomiyama K, Ito M, Kawai K. Up-regulation of cell surface Toll-like receptor 4-MD2 expression on dendritic epidermal T cells after the emigration from epidermis during cutaneous inflammation. J Dermatol Sci. 2005;37:101-10 pubmed
Chelvarajan R, Collins S, Van Willigen J, Bondada S. The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function. J Leukoc Biol. 2005;77:503-12 pubmed
product information
Product Type :
Antibody
Product Name :
TLR4/MD-2 Complex Monoclonal Antibody (MTS510), APC, eBioscience
Catalog # :
17-9924-82
Quantity :
100 ug
Price :
US 434.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Mouse
Clone :
MTS510
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
ARMD10; CD284; Esop1; ESOP-1; hToll; lipopolysaccharide response; Lps; Ly87; Ly96; Ly-96; Lymphocyte antigen 96; Md2; MD-2; myeloid differentiation factor-2; myeloid differentiation protein-2; protein MD-2; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; Toll-like receptor 4
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA