HLA-DQ Monoclonal Antibody (SK10), APC, eBioscience | Invitrogen 17-9881-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HLA-DQ Monoclonal Antibody (SK10), APC, eBioscience

catalog :

17-9881-41

quantity :

25 Tests

price :

US 139

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

SK10

reactivity :

human

application :

flow cytometry

citations: 6

Reference
Hudec M, Riegerov xe1 K, Pala J, K xfa tna V, x10c ern xe1 M, O Leary V. Celiac Disease Defined by Over-Sensitivity to Gliadin Activation and Superior Antigen Presentation of Dendritic Cells. Int J Mol Sci. 2021;22: pubmed publisher
Jung J, Choi B, Sayeed H, Suh C, Kim Y, Kim H, et al. Characteristic patterns of HLA presentation and T cell differentiation in adult-onset Still's disease. Int J Immunopathol Pharmacol. 2018;32:2058738418791284 pubmed publisher
Trynka G, Wijmenga C, van Heel D. A genetic perspective on coeliac disease. Trends Mol Med. 2010;16:537-50 pubmed publisher
Lavant E, Carlson J. A new automated human leukocyte antigen genotyping strategy to identify DR-DQ risk alleles for celiac disease and type 1 diabetes mellitus. Clin Chem Lab Med. 2009;47:1489-95 pubmed publisher
Chou Y, Edwards D, Weinberg A, Vandenbark A, Kotzin B, Fontenot A, et al. Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. J Immunol. 2005;174:4316-24 pubmed
Turesson C, Englund P, Jacobsson L, Sturfelt G, Truedsson L, Nennesmo I, et al. Increased endothelial expression of HLA-DQ and interleukin 1alpha in extra-articular rheumatoid arthritis. Results from immunohistochemical studies of skeletal muscle. Rheumatology (Oxford). 2001;40:1346-54 pubmed

product information

Product Type :

Antibody

Product Name :

HLA-DQ Monoclonal Antibody (SK10), APC, eBioscience

Catalog # :

17-9881-41

Quantity :

25 Tests

Price :

US 139

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.5 µg)/test

Species :

Human

Clone :

SK10

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

HLA-DQ is one of the HLA (human leukocyte antigen) molecules belonging to class II of the major histocompatibility protein (MHC) surface proteins. HLA-DQ and the other MHC class II molecules are heterodimeric proteins consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages) and present peptides endocytosed, digested, and loaded onto the proteins prior to their migration to the cell surface. Other human MHC class II molecules are HLA-DP, HLA-DM, HLA-DR, HLA-DOA, and HLA-DOB. HLA-DQ displays significant variability, particularly in the beta subunit within the region that affects the peptides bound and presented by the protein. Different classes of DQ based on similar beta subunits allow for the grouping of these variants into serotypes, which can often be recognized by antibodies raised against these subunits. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.5 µg)/test

Aliases :

BoLA-DQA; BOLA-DQA1; BOLA-DQA2; BOLA-DQA2 protein; BOLA-DQA3; BOLA-DQA5; BOLA-DQB; CELIAC1; HLA class II antigen; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA-DQB; HLA-DQB1; HLA-DRB1; IDDM1; lymphocyte antigen; major histocompatability complex class II; major histocompatibility complex, class II, DQ alpha 1 precursor; major histocompatibility complex, class II, DQ alpha 2; major histocompatibility complex, class II, DQ alpha 5; major histocompatibility complex, class II, DQ alpha, type 1; major histocompatibility complex, class II, DQ alpha, type 3; major histocompatibility complex, class II, DQ beta; major histocompatibility complex, class II, DQ beta 1; MHC class II antigen; MHC class II antigen DQB1; MHC class II antigen HLA-DQ-beta-1; MHC class II antigen precursor; MHC class II DQ beta chain; MHC class II DQA; MHC class II DQA precursor; MHC class II DQA1 precursor; MHC class II DQA2 (BoLA-DQA2); MHC class II DQA2 precursor; MHC class II DQB precursor; MHC class II HLA-DQ beta glycoprotein; MHC class2 antigen; MHC DQ beta; similar to MHC class II DQA2 (BoLA-DQA2); Unknown (protein for MGC:127488); Unknown (protein for MGC:137100)