product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Ly-6G Monoclonal Antibody (1A8-Ly6g), APC, eBioscience
catalog :
17-9668-82
quantity :
100 µg
price :
US 345
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
1A8-Ly6g
reactivity :
mouse
application :
flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 35
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:100; loading ...; fig 1k
Ryu S, Shchukina I, Youm Y, Qing H, Hilliard B, Dlugos T, et al. Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. elife. 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig s5b
  • flow cytometry; mouse; 1:1000; loading ...; fig s3d
Tyagi A, Sharma S, Wu K, Wu S, Xing F, Liu Y, et al. Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung. Nat Commun. 2021;12:474 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4
Neuper T, Neureiter D, Sarajlic M, Strandt H, Bauer R, Schwarz H, et al. IL-31 transgenic mice show reduced allergen-induced lung inflammation. Eur J Immunol. 2021;51:191-196 pubmed publisher
  • flow cytometry; mouse; 1:1000; loading ...; fig 5s1c
Wei J, Mattapallil M, Horai R, Jittayasothorn Y, Modi A, Sen H, et al. A novel role for lipoxin A4 in driving a lymph node-eye axis that controls autoimmunity to the neuroretina. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig s1a, s2d, s3d
Asrat S, Kaur N, Liu X, Ben L, Kajimura D, Murphy A, et al. Chronic allergen exposure drives accumulation of long-lived IgE plasma cells in the bone marrow, giving rise to serological memory. Sci Immunol. 2020;5: pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 4a
Shi L, Wang J, Ding N, Zhang Y, Zhu Y, Dong S, et al. Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy. Nat Commun. 2019;10:5421 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6a
Safronova A, Araujo A, Camanzo E, Moon T, Elliott M, Beiting D, et al. Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii. Nat Immunol. 2019;20:64-72 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5r
Chinta K, Rahman M, Saini V, Glasgow J, Reddy V, Lever J, et al. Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis. Cell Rep. 2018;25:1938-1952.e5 pubmed publisher
  • flow cytometry; mouse; 1:1600; fig s2
Mothes B, Bucher K, Ammon Treiber S, Schwab M, Piekorz R, Hirsch E, et al. p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation. PLoS ONE. 2016;11:e0159310 pubmed publisher
  • flow cytometry; mouse; fig S9i
Schliehe C, Flynn E, Vilagos B, Richson U, Swaminanthan S, Bosnjak B, et al. The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nat Immunol. 2015;16:67-74 pubmed publisher
Bagayoko S, Leon Icaza S, Pinilla M, Hessel A, Santoni K, Pericat D, et al. Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology. PLoS Pathog. 2021;17:e1009927 pubmed publisher
Guo Q, Zhao Y, Li J, Liu J, Yang X, Guo X, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host Microbe. 2021;29:222-235.e4 pubmed publisher
Rolfes V, Ribeiro L, Hawwari I, Böttcher L, Rosero N, Maasewerd S, et al. Platelets Fuel the Inflammasome Activation of Innate Immune Cells. Cell Rep. 2020;31:107615 pubmed publisher
Lee S, Yang Y, Milano S, Nguyen T, Ahn C, Sim J, et al. Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence. Cell Host Microbe. 2020;27:937-949.e6 pubmed publisher
Yacov N, Kafri P, Salem Y, Propheta Meiran O, Feldman B, Breitbart E, et al. MOSPD2 is a therapeutic target for the treatment of CNS inflammation. Clin Exp Immunol. 2020;201:105-120 pubmed publisher
Ge Y, Wang H, Ren J, Liu W, Chen L, Chen H, et al. Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety. J Immunother Cancer. 2020;8: pubmed publisher
Zhang C, Jin H, Wang Y, Li C, Zhao X, Li Y, et al. Critical role of OX40 in drug-induced acute liver injury. Br J Pharmacol. 2020;177:3183-3196 pubmed publisher
Elsayed R, Kurago Z, Cutler C, Arce R, Gerber J, Celis E, et al. Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw. FASEB J. 2020;34:2595-2608 pubmed publisher
Brown A, Conrad K, Allende D, Gromovsky A, Zhang R, Neumann C, et al. Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice. J Nutr. 2020;150:775-783 pubmed publisher
Tomlinson J, Golshadi M, Donahue C, Dong L, Cheetham J. Evaluation of two methods to isolate Schwann cells from murine sciatic nerve. J Neurosci Methods. 2020;331:108483 pubmed publisher
McKenzie M, Ghisi M, Oxley E, Ngo S, Cimmino L, Esnault C, et al. Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia. Cell Stem Cell. 2019;25:258-272.e9 pubmed publisher
Ren G, Zhang X, Xiao Y, Zhang W, Wang Y, Ma W, et al. ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination. EMBO J. 2019;38: pubmed publisher
Peng L, Xie Z, Pei J, Wang B, Gao Y, Qu Y. Puerarin alters the function of monocytes/macrophages and exhibits chondroprotection in mice. Mol Med Rep. 2019;19:2876-2882 pubmed publisher
Reddy V, Chinta K, Saini V, Glasgow J, Hull T, Traylor A, et al. Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection. Front Immunol. 2018;9:860 pubmed publisher
Valdearcos M, Douglass J, Robblee M, Dorfman M, Stifler D, Bennett M, et al. Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metab. 2017;26:185-197.e3 pubmed publisher
Seaman S, Zhu Z, Saha S, Zhang X, Yang M, Hilton M, et al. Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature. Cancer Cell. 2017;31:501-515.e8 pubmed publisher
King A, Houlihan D, Kavanagh D, Haldar D, Luu N, Owen A, et al. Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. Gastroenterology. 2017;153:233-248.e16 pubmed publisher
Zha Q, Wei H, Li C, Liang Y, Xu L, Bai W, et al. ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages. Front Immunol. 2016;7:597 pubmed publisher
Shime H, Matsumoto M, Seya T. Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway. Cell Death Differ. 2017;24:385-396 pubmed publisher
Liyanage S, Gardner P, Ribeiro J, Cristante E, Sampson R, Luhmann U, et al. Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models. Exp Eye Res. 2016;151:160-70 pubmed publisher
Damlund D, Metzdorff S, Hasselby J, Wiese M, Lundsager M, Nielsen D, et al. Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL/6 Mice. J Diabetes Res. 2016;2016:6321980 pubmed publisher
Sun D, Zhang M, Liu G, Wu H, Zhu X, Zhou H, et al. Real-Time Imaging of Interactions of Neutrophils with Cryptococcus neoformans Demonstrates a Crucial Role of Complement C5a-C5aR Signaling. Infect Immun. 2016;84:216-29 pubmed publisher
Hickey M. Has Ly6G finally found a job?. Blood. 2012;120:1352-3 pubmed publisher
Wang J, Bair A, King S, Shnayder R, Huang Y, Shieh C, et al. Ly6G ligation blocks recruitment of neutrophils via a ?2-integrin-dependent mechanism. Blood. 2012;120:1489-98 pubmed publisher
Daley J, Thomay A, Connolly M, Reichner J, Albina J. Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice. J Leukoc Biol. 2008;83:64-70 pubmed
product information
Product Type :
Antibody
Product Name :
Ly-6G Monoclonal Antibody (1A8-Ly6g), APC, eBioscience
Catalog # :
17-9668-82
Quantity :
100 µg
Pricing :
US 345
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test
Species :
Mouse
Clone :
1A8-Ly6g
Isotype :
IgG2a, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
Ly6G (Lymphocyte antigen 6 complex locus G6D) is a component of the myeloid differentiation antigen Gr-1, together with Ly6C. The Ly6G protein has a molecular weight of approximately 21-25 kDa and is expressed by myeloid derived cells in the bone marrow. Ly6G is a good marker for detection of peripheral neutrophils, monocytes and granulocytes. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. The physiological role of Ly6G remains unclear but studies have shown its involvement in anti-tumor response, and studies with neutrophils suggest that Ly6G ligation may have an inhibitory effect on local immune responses.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test
Aliases :
Gr1; Gr-1; Ly6g; Ly-6G; ly-6G.1; lymphocyte antigen 6 complex, locus G; lymphocyte antigen 6G
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA