Phospho-STAT4 (Tyr693) Monoclonal Antibody (4LURPIE), APC, eBioscience | Invitrogen 17-9044-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-STAT4 (Tyr693) Monoclonal Antibody (4LURPIE), APC, eBioscience

catalog :

17-9044-42

quantity :

100 Tests

price :

US 352

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

4LURPIE

reactivity :

human, mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 2	Zhao G, Liu L, Su B, Zhang T, Chen P, Li W, et al. The dynamic changes of interferon lambdas related genes and proteins in JAK/STAT pathway in both acute and chronic HIV-1 infected patients. AIDS Res Ther. 2017;14:31 pubmed publisher
	Saraiva M, Christensen J, Veldhoen M, Murphy T, Murphy K, O GARRA A. Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity. 2009;31:209-19 pubmed publisher
	RAMOS H, Davis A, George T, Farrar J. IFN-alpha is not sufficient to drive Th1 development due to lack of stable T-bet expression. J Immunol. 2007;179:3792-803 pubmed
	Berenson L, Gavrieli M, Farrar J, Murphy T, Murphy K. Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-alpha. J Immunol. 2006;177:5195-203 pubmed
	Harrington L, Hatton R, Mangan P, Turner H, Murphy T, Murphy K, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6:1123-32 pubmed

product information

Product Type :

Antibody

Product Name :

Phospho-STAT4 (Tyr693) Monoclonal Antibody (4LURPIE), APC, eBioscience

Catalog # :

17-9044-42

Quantity :

100 Tests

Price :

US 352

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 5 µL (0.25 µg)/test

Species :

Human, Mouse

Clone :

4LURPIE

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein is most similar to STAT1 (52%) and STAT3 (47%). Functionally, STAT4 is similar to other STAT family members in that it can be tyrosine phosphorylated by Jak1 or Jak2. STAT4 forms homodimers and heterodimers with related STAT family members. Tyrosine phosphorylated STAT4 can bind the IFN-gamma activated site (GAS). Serine phosphorylation of STAT is also required for maximal transcriptional activity. STAT4 expression is restricted to the thymus, spleen and testis. Until recently the cytokine(s) responsible for activation of STAT4 had not been identified. STAT4 is now known to be activated by the cytokine interleukin 12 (IL-12). IL-12 is required for the T-cell independent induction of IFN-gamma which is a key step in the initial suppression of bacterial and parasitic infections. In addition, IL-12 is required for the development of a Th1 response which is necessary for effective host defense against intracellular pathogens. STAT4-deficient mice display impaired IL-12 development of Th1 cells and enhanced development of Th2 cells. A recent study in mouse has shown that in response to viral infection IFN-a/b activation of STAT4 is required for IFN-g production.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.25 µg)/test

Aliases :

CIS4; HSPC060; OTTHUMP00000163553; Signal transducer and activator of transcription 4; SLEB11; SOCS4; SOCS6; SSI4; STAI4; STAT; Stat4; STATI4

more info or order :

Invitrogen product webpage