Phospho-SLP-76 (Tyr128) Monoclonal Antibody (HNDZ55), APC, eBioscience | Invitrogen 17-9037-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-SLP-76 (Tyr128) Monoclonal Antibody (HNDZ55), APC, eBioscience

catalog :

17-9037-42

quantity :

100 Tests

price :

US 413.00

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

HNDZ55

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Burns J, Corbo E, Degen J, Gohil M, Anterasian C, Schraven B, et al. The SLP-76 Src homology 2 domain is required for T cell development and activation. J Immunol. 2011;187:4459-66 pubmed publisher
Wu G, Corbo E, Schmidt M, Smith Garvin J, Riese M, Jordan M, et al. Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses. Eur J Immunol. 2011;41:2064-73 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-SLP-76 (Tyr128) Monoclonal Antibody (HNDZ55), APC, eBioscience

Catalog # :

17-9037-42

Quantity :

100 Tests

Price :

US 413.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.5 ug)/test

Species :

Human

Clone :

HNDZ55

Isotype :

IgG2b, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.5 ug)/test

Aliases :

76 kDa tyrosine phosphoprotein; AI323664; BB161688; Lcp2; Lymphocyte cytosolic protein 2; lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD); SH2 domain-containing leukocyte protein of 76 kDa; SH2 domain-containing leukocyte protein of 76kD; SLP76; SLP-76; SLP-76 tyrosine phosphoprotein; twm