This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-STAT3 (Tyr705) Monoclonal Antibody (LUVNKLA), APC, eBioscience
catalog :
17-9033-42
quantity :
100 Tests
price :
US 431.00
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
LUVNKLA
reactivity :
human, mouse
application :
flow cytometry
citations: 13
Reference
Murgo E, De Santis E, Sansico F, Melocchi V, Colangelo T, Padovano C, et al. The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia. J Exp Clin Cancer Res. 2023;42:218 pubmed publisher
Mirlekar B, Wang Y, Li S, Zhou M, Entwistle S, De Buysscher T, et al. Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity. Cell Rep Med. 2022;3:100744 pubmed publisher
Vogel A, Martin K, Soukup K, Halfmann A, Kerndl M, Brunner J, et al. JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction. Cell Rep. 2022;38:110420 pubmed publisher
Chu Y, Nayyar G, Jiang S, Rosenblum J, Soon Shiong P, Safrit J, et al. Combinatorial immunotherapy of N-803 (IL-15 superagonist) and dinutuximab with ex vivo expanded natural killer cells significantly enhances in vitro cytotoxicity against GD2+ pediatric solid tumors and in vivo survival of xenografted immunodeficient . J Immunother Cancer. 2021;9: pubmed publisher
Eken A, Cansever M, Okus F, Erdem S, Nain E, Azizoglu Z, et al. ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients. Allergy. 2020;75:921-932 pubmed publisher
Lemarquis A, Theodors F, Einarsdóttir H, Ludviksson B. Mapping of Signaling Pathways Linked to sIgAD Reveals Impaired IL-21 Driven STAT3 B-Cell Activation. Front Immunol. 2019;10:403 pubmed publisher
Li Y, Zhao C, Liu J, Lu Z, Lu M, Gu J, et al. CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity. Oncol Rep. 2019;41:2679-2688 pubmed publisher
Zhang C, Ye S, Ni J, Cai T, Liu Y, Huang D, et al. STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion. Cell Death Differ. 2019;: pubmed publisher
Glal D, Sudhakar J, Lu H, Liu M, Chiang H, Liu Y, et al. ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases. Front Immunol. 2018;9:2522 pubmed publisher
Ferrao R, Wallweber H, Lupardus P. Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation. elife. 2018;7: pubmed publisher
Spitzner M, Ebner R, Wolff H, Ghadimi B, Wienands J, Grade M. STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy. Cancers (Basel). 2014;6:1986-2011 pubmed publisher
Liu X, Lee Y, Yu C, Egwuagu C. Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. J Immunol. 2008;180:6070-6 pubmed
Fornek J, Tygrett L, Waldschmidt T, Poli V, Rickert R, Kansas G. Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. Blood. 2006;107:1085-91 pubmed
product information
Product Type :
Antibody
Product Name :
Phospho-STAT3 (Tyr705) Monoclonal Antibody (LUVNKLA), APC, eBioscience
Catalog # :
17-9033-42
Quantity :
100 Tests
Price :
US 431.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Flow Cytometry: 5 uL (0.25 ug)/test
Species :
Human, Mouse
Clone :
LUVNKLA
Isotype :
IgG2b, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-binding protein are required for the transcriptional activation by STAT3. STAT3 can also be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity. In humans, the STAT3 gene is located on the q arm of chromosome 17. STAT3 has been shown to be activated by IFN-alpha but not IFN-beta. The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB). STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3 while the PIAS3 protein is a specific inhibitor of STAT3. Three alternatively spliced transcript variants encoding distinct isoforms of STAT3 have been described. Deletion of the STAT3 gene in knock-out mice was lethal at the early embryonic stage.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.25 ug)/test
Aliases :
1110034C02Rik; acute phase response factor; acute-phase response factor; ADMIO; ADMIO1; APRF; AW109958; DNA-binding protein APRF; FLJ20882; HIES; MGC16063; signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer; activator of transcription; acute-phase response factor; signal transduction and activation of transcription 3; STAT; STAT3; STAT-3; stat3 protein; STAT3b1; STAT3b2; transcription factor; Unknown (protein for MGC:128731); wu:fc15d02; wu:fl59g06; z-Stat3
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA