Phospho-Syk (Tyr348) Monoclonal Antibody (moch1ct), APC, eBioscience | Invitrogen 17-9014-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-Syk (Tyr348) Monoclonal Antibody (moch1ct), APC, eBioscience

catalog :

17-9014-41

quantity :

25 Tests

price :

US 171.00

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

moch1ct

reactivity :

human, mouse

application :

flow cytometry

citations: 9

Reference
Xu Y, Song D, Wang W, Li S, Yue T, Xia T, et al. Clec12a inhibits MSU-induced immune activation through lipid raft expulsion. Life Sci Alliance. 2023;6: pubmed publisher
Almutairi A, Wallace J, Jaber F, Alosaimi M, Jones J, Sallam M, et al. Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency. J Allergy Clin Immunol. 2020;145:1696-1699.e6 pubmed publisher
Eken A, Okus Z, Erdem S, Azizoglu Z, Haliloglu Y, Bicer A, et al. IL-15 negatively regulates curdlan-induced IL-23 production by human monocyte-derived dendritic cells and subsequent Th17 response. North Clin Istanb. 2019;6:379-387 pubmed publisher
Kiss M, Ozsvar Kozma M, Porsch F, Göderle L, Papac Milicevic N, Bartolini Gritti B, et al. Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production. Front Immunol. 2019;10:1607 pubmed publisher
Tsiantoulas D, Kiss M, Bartolini Gritti B, Bergthaler A, Mallat Z, Jumaa H, et al. Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development. Sci Rep. 2017;7:3540 pubmed publisher
MÃ³csai A, Ruland J, Tybulewicz V. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol. 2010;10:387-402 pubmed publisher
Dennehy K, Ferwerda G, Faro Trindade I, Pyz E, Willment J, Taylor P, et al. Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. Eur J Immunol. 2008;38:500-6 pubmed publisher
Palacios E, Weiss A. Distinct roles for Syk and ZAP-70 during early thymocyte development. J Exp Med. 2007;204:1703-15 pubmed
Cornall R, Cheng A, Pawson T, Goodnow C. Role of Syk in B-cell development and antigen-receptor signaling. Proc Natl Acad Sci U S A. 2000;97:1713-8 pubmed

product information

Product Type :

Antibody

Product Name :

Phospho-Syk (Tyr348) Monoclonal Antibody (moch1ct), APC, eBioscience

Catalog # :

17-9014-41

Quantity :

25 Tests

Price :

US 171.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 5 uL (0.06 ug)/test

Species :

Human, Mouse

Clone :

moch1ct

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.06 ug)/test

Aliases :

DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK